YOR031W / CRS5

Copper-binding metallothionein, required for wild-type copper resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR031W / CRS5

Click on Significant Values for Screen Details ID:SGTC_425|Compound:3825-7017|FD-Score:3.21|P-value:3.39E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.17|P-value:4.02E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.08|P-value:5.67E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.11|P-value:4.68E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.86|P-value:2.21E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:3.58|P-value:7.59E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.59|P-value:7.37E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:3.65|P-value:5.66E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.93|P-value:1.45E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:4.35|P-value:2.10E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.67|P-value:3.41E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.33|P-value:2.12E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:6.01|P-value:9.84E-11 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.76|P-value:3.49E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.97|P-value:1.22E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.43|P-value:1.31E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.04|P-value:6.50E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.41|P-value:1.42E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.41|P-value:1.53E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:2.98|P-value:8.09E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-2.94|P-value:8.84E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.44|P-value:1.36E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.71|P-value:4.42E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.30|P-value:2.70E-6 ID:SGTC_1523|Compound:st012844|FD-Score:4.47|P-value:1.11E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.52|P-value:9.87E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-3.06|P-value:5.70E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.22|P-value:3.27E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.00|P-value:7.66E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.17|P-value:5.10E-6 ID:SGTC_1696|Compound:st025591|FD-Score:3.76|P-value:3.55E-5 ID:SGTC_1809|Compound:st050081|FD-Score:-3.45|P-value:1.22E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.18|P-value:3.86E-4 ID:SGTC_1968|Compound:st069590|FD-Score:5.60|P-value:1.59E-9 ID:SGTC_2035|Compound:5154463|FD-Score:6.13|P-value:4.41E-11 ID:SGTC_2109|Compound:5483026|FD-Score:3.30|P-value:2.39E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.28|P-value:2.40E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.69|P-value:4.77E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.22|P-value:3.37E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.28|P-value:2.40E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.03|P-value:6.41E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.33|P-value:2.31E-6 ID:SGTC_2812|Compound:7970281|FD-Score:4.47|P-value:1.15E-6 ID:SGTC_3081|Compound:9117243|FD-Score:3.42|P-value:1.50E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.31|P-value:2.50E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.59|P-value:6.81E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.15|P-value:4.37E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.90|P-value:1.86E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.26|P-value:3.24E-6 ID:SGTC_3281|Compound:9140613|FD-Score:3.52|P-value:9.82E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.08|P-value:8.05E-6 ID:SGTC_3343|Compound:9148379|FD-Score:3.47|P-value:1.21E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.21|P-value:3.39E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.17|P-value:4.02E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.08|P-value:5.67E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.11|P-value:4.68E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.86|P-value:2.21E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:3.58|P-value:7.59E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.59|P-value:7.37E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:3.65|P-value:5.66E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.93|P-value:1.45E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:4.35|P-value:2.10E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.67|P-value:3.41E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.33|P-value:2.12E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:6.01|P-value:9.84E-11 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.76|P-value:3.49E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.97|P-value:1.22E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.43|P-value:1.31E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.04|P-value:6.50E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.41|P-value:1.42E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.41|P-value:1.53E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:2.98|P-value:8.09E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-2.94|P-value:8.84E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.44|P-value:1.36E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.71|P-value:4.42E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.30|P-value:2.70E-6 ID:SGTC_1523|Compound:st012844|FD-Score:4.47|P-value:1.11E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.52|P-value:9.87E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-3.06|P-value:5.70E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.22|P-value:3.27E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.00|P-value:7.66E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.17|P-value:5.10E-6 ID:SGTC_1696|Compound:st025591|FD-Score:3.76|P-value:3.55E-5 ID:SGTC_1809|Compound:st050081|FD-Score:-3.45|P-value:1.22E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.18|P-value:3.86E-4 ID:SGTC_1968|Compound:st069590|FD-Score:5.60|P-value:1.59E-9 ID:SGTC_2035|Compound:5154463|FD-Score:6.13|P-value:4.41E-11 ID:SGTC_2109|Compound:5483026|FD-Score:3.30|P-value:2.39E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.28|P-value:2.40E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.69|P-value:4.77E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.22|P-value:3.37E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.28|P-value:2.40E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.03|P-value:6.41E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.33|P-value:2.31E-6 ID:SGTC_2812|Compound:7970281|FD-Score:4.47|P-value:1.15E-6 ID:SGTC_3081|Compound:9117243|FD-Score:3.42|P-value:1.50E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.31|P-value:2.50E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.59|P-value:6.81E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.15|P-value:4.37E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.90|P-value:1.86E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.26|P-value:3.24E-6 ID:SGTC_3281|Compound:9140613|FD-Score:3.52|P-value:9.82E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.08|P-value:8.05E-6 ID:SGTC_3343|Compound:9148379|FD-Score:3.47|P-value:1.21E-4

Top fitness defect scores for YOR031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2035 5154463 6.13 94.6 µM 4.41E-11 2 4.48E-10
2 SGTC_1140 3229-1848 6.01 3.0 µM 9.84E-11 2 9.18E-10
3 SGTC_1968 st069590 5.60 43.6 µM 1.59E-9 3 1.10E-8
4 SGTC_1523 st012844 4.47 44.7 µM 1.11E-6 60S ribosome export 8 3.86E-6
5 SGTC_2812 7970281 4.47 58.4 µM 1.15E-6 15 3.99E-6
6 SGTC_961 1252-1571 4.35 372.0 µM 2.10E-6 23 6.82E-6
7 SGTC_2809 7964133 4.33 13.0 µM 2.31E-6 60S ribosome export 25 7.44E-6
8 SGTC_3136 9095672 4.31 49.5 µM 2.50E-6 17 7.98E-6
9 SGTC_1509 1326-1131 4.30 80.0 µM 2.70E-6 8 8.55E-6
10 SGTC_3254 9136651 4.26 49.5 µM 3.24E-6 DNA damage response 18 1.01E-5
11 SGTC_1695 st026914 4.17 34.5 µM 5.10E-6 14 1.51E-5
12 SGTC_3336 9143619 4.08 71.4 µM 8.05E-6 18 2.27E-5
13 SGTC_3205 9113483 3.90 49.5 µM 1.86E-5 30 4.82E-5
14 SGTC_684 1140-0066 3.86 328.0 µM 2.21E-5 Golgi 26 5.62E-5
15 SGTC_1146 3579-1023 3.76 7.0 µM 3.49E-5 19 8.46E-5
16 SGTC_1696 st025591 3.76 34.8 µM 3.55E-5 SWF1 & branched chain AA biosynthesis 33 8.60E-5
17 SGTC_1505 k297-0037 3.71 20.6 µM 4.42E-5 22 1.05E-4
18 SGTC_2411 st077133 3.69 39.9 µM 4.77E-5 RNA pol III & RNase P/MRP 37 1.12E-4
19 SGTC_927 2425-1185 3.65 123.0 µM 5.66E-5 36 1.31E-4
20 SGTC_925 2064-1272 3.59 59.6 µM 7.37E-5 33 1.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.32E-12 YMR062C ARG7 hom Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
0.119 5.28E-12 YLL005C SPO75 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.114 3.60E-11 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.088 3.29E-7 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.077 7.07E-6 YNL142W MEP2 hom Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.077 8.84E-6 YOR189W IES4 hom Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
0.075 1.41E-5 YJL118W YJL118W hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
0.074 2.01E-5 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.071 4.22E-5 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.070 5.31E-5 YMR316C-B_d YMR316C-B_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069 6.78E-5 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.067 9.62E-5 YFL011W HXT10 hom Putative hexose transporter, expressed at low levels and expression is repressed by glucose
0.067 1.07E-4 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.066 1.39E-4 YER183C FAU1 hom 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
0.065 1.71E-4 YJR141W_p YJR141W_p het Essential protein of unknown function