YOR032C / HMS1

Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR032C / HMS1

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.80|P-value:1.61E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-4.41|P-value:1.47E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.30|P-value:8.96E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.06|P-value:8.56E-7 ID:SGTC_282|Compound:k297-0036|FD-Score:4.18|P-value:3.82E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.43|P-value:1.40E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.74|P-value:1.99E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.93|P-value:1.01E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.47|P-value:5.18E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.39|P-value:6.60E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.85|P-value:1.35E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.36|P-value:7.39E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:4.35|P-value:1.90E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.28|P-value:9.64E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.50|P-value:9.67E-8 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.72|P-value:2.14E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:-3.34|P-value:7.82E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.62|P-value:3.05E-4 ID:SGTC_1636|Compound:st007707|FD-Score:6.36|P-value:8.66E-10 ID:SGTC_1728|Compound:st035614|FD-Score:-4.34|P-value:1.99E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.30|P-value:8.83E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.41|P-value:6.35E-4 ID:SGTC_1780|Compound:st038448|FD-Score:4.13|P-value:4.74E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.35|P-value:7.47E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.82|P-value:1.46E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.38|P-value:6.71E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.76|P-value:1.88E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.27|P-value:9.68E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.09|P-value:5.38E-5 ID:SGTC_2854|Compound:9024559|FD-Score:3.50|P-value:4.69E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.49|P-value:4.73E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-4.08|P-value:5.56E-5 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.80|P-value:1.61E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-4.41|P-value:1.47E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.30|P-value:8.96E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.06|P-value:8.56E-7 ID:SGTC_282|Compound:k297-0036|FD-Score:4.18|P-value:3.82E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.43|P-value:1.40E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.74|P-value:1.99E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.93|P-value:1.01E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.47|P-value:5.18E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.39|P-value:6.60E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.85|P-value:1.35E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.36|P-value:7.39E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:4.35|P-value:1.90E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.28|P-value:9.64E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.50|P-value:9.67E-8 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.72|P-value:2.14E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:-3.34|P-value:7.82E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.62|P-value:3.05E-4 ID:SGTC_1636|Compound:st007707|FD-Score:6.36|P-value:8.66E-10 ID:SGTC_1728|Compound:st035614|FD-Score:-4.34|P-value:1.99E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.30|P-value:8.83E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.41|P-value:6.35E-4 ID:SGTC_1780|Compound:st038448|FD-Score:4.13|P-value:4.74E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.35|P-value:7.47E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.82|P-value:1.46E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.38|P-value:6.71E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.76|P-value:1.88E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.27|P-value:9.68E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.09|P-value:5.38E-5 ID:SGTC_2854|Compound:9024559|FD-Score:3.50|P-value:4.69E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.49|P-value:4.73E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-4.08|P-value:5.56E-5

Top fitness defect scores for YOR032C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1636 st007707 6.36 68.9 µM 8.66E-10 18 9.97E-11
2 SGTC_1118 chelidonine 5.50 707.5 nM 9.67E-8 5 1.90E-8
3 SGTC_171 k064-0041 5.06 9.7 µM 8.56E-7 heme requiring 15 2.14E-7
4 SGTC_585 0kpi-0023 4.43 191.0 µM 1.40E-5 11 4.79E-6
5 SGTC_944 3370-0224 4.35 231.0 µM 1.90E-5 18 6.72E-6
6 SGTC_282 k297-0036 4.18 65.7 µM 3.82E-5 2 1.46E-5
7 SGTC_1780 st038448 4.13 24.5 µM 4.74E-5 iron homeostasis 13 1.85E-5
8 SGTC_2850 9015429 4.09 58.4 µM 5.38E-5 10 2.13E-5
9 SGTC_736 0958-0254 3.93 92.6 µM 1.01E-4 Golgi 33 4.27E-5
10 SGTC_809 3998-0021 3.85 90.0 µM 1.35E-4 RNA processing & uracil transport 14 5.94E-5
11 SGTC_30 5-(2-thienylidene)-Rhodanine 3.80 28.7 µM 1.61E-4 8 7.20E-5
12 SGTC_2761 levamisole 3.76 97.9 µM 1.88E-4 21 8.56E-5
13 SGTC_605 1315-0399 3.74 119.0 µM 1.99E-4 Golgi 31 9.09E-5
14 SGTC_1407 3909-7909 3.72 12.3 µM 2.14E-4 60S ribosome export 17 9.85E-5
15 SGTC_2854 9024559 3.50 71.4 µM 4.69E-4 39 2.35E-4
16 SGTC_741 4582-0002 3.47 126.0 µM 5.18E-4 23 2.63E-4
17 SGTC_1757 st041620 3.41 31.8 µM 6.35E-4 44 3.29E-4
18 SGTC_752 1896-0090 3.39 130.0 µM 6.60E-4 TSC3-RPN4 31 3.44E-4
19 SGTC_1080 nisoldipine 3.28 24.4 µM 9.64E-4 TSC3-RPN4 52 5.23E-4
20 SGTC_216 k038-0035 3.26 28.4 µM 0.00103 ubiquinone biosynthesis & proteasome 70 5.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 7.05E-16 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.136 2.64E-15 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.125 4.12E-13 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.114 3.46E-11 YGR256W GND2 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication
0.106 7.30E-10 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 1.64E-7 YKR005C_p YKR005C_p hom Putative protein of unknown function
0.090 1.80E-7 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.089 2.15E-7 YGR247W CPD1 hom Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress
0.087 4.86E-7 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.88E-7 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.083 1.62E-6 YKR050W TRK2 hom Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication
0.082 2.11E-6 YDL114W_p YDL114W_p hom Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene
0.081 2.55E-6 YLL058W_p YLL058W_p hom Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
0.079 4.77E-6 YDR157W_d YDR157W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.10E-6 YMR005W TAF4 het TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate