YOR033C / EXO1

5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR033C / EXO1

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-7.62|P-value:1.76E-15 ID:SGTC_52|Compound:0329-0193|FD-Score:-4.36|P-value:3.32E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:5.31|P-value:2.49E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.76|P-value:5.07E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:-6.13|P-value:1.26E-10 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.29|P-value:3.32E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.29|P-value:3.27E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.46|P-value:1.94E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.42|P-value:2.26E-4 ID:SGTC_401|Compound:neomycin|FD-Score:5.30|P-value:2.69E-8 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.65|P-value:9.17E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.67|P-value:7.46E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.17|P-value:5.75E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:5.36|P-value:1.84E-8 ID:SGTC_608|Compound:k048-0125|FD-Score:3.99|P-value:2.12E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.75|P-value:6.08E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.04|P-value:8.12E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.70|P-value:5.96E-7 ID:SGTC_890|Compound:0929-0006|FD-Score:3.05|P-value:8.99E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.75|P-value:5.22E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.81|P-value:4.68E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.15|P-value:6.16E-8 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.75|P-value:6.01E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.73|P-value:6.50E-5 ID:SGTC_1668|Compound:st014914|FD-Score:3.14|P-value:6.42E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.98|P-value:1.89E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.54|P-value:1.41E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.28|P-value:2.87E-8 ID:SGTC_1845|Compound:st056753|FD-Score:5.11|P-value:7.63E-8 ID:SGTC_1936|Compound:st074407|FD-Score:3.66|P-value:8.82E-5 ID:SGTC_1952|Compound:st077036|FD-Score:3.71|P-value:7.13E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.04|P-value:8.20E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.03|P-value:8.41E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.44|P-value:2.13E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.11|P-value:7.08E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.17|P-value:5.17E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.33|P-value:3.25E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.60|P-value:1.13E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.42|P-value:2.29E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.29|P-value:3.68E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:5.13|P-value:6.90E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.53|P-value:1.29E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.12|P-value:6.89E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.01|P-value:9.17E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.58|P-value:1.23E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.17|P-value:8.27E-6 ID:SGTC_2971|Compound:9092186|FD-Score:4.02|P-value:1.86E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.12|P-value:7.00E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.18|P-value:5.59E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.23|P-value:4.16E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-2.99|P-value:9.73E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.85|P-value:3.86E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.69|P-value:6.61E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-7.62|P-value:1.76E-15 ID:SGTC_52|Compound:0329-0193|FD-Score:-4.36|P-value:3.32E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:5.31|P-value:2.49E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.76|P-value:5.07E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:-6.13|P-value:1.26E-10 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.29|P-value:3.32E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.29|P-value:3.27E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.46|P-value:1.94E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.42|P-value:2.26E-4 ID:SGTC_401|Compound:neomycin|FD-Score:5.30|P-value:2.69E-8 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.65|P-value:9.17E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.67|P-value:7.46E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.17|P-value:5.75E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:5.36|P-value:1.84E-8 ID:SGTC_608|Compound:k048-0125|FD-Score:3.99|P-value:2.12E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.75|P-value:6.08E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.04|P-value:8.12E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.70|P-value:5.96E-7 ID:SGTC_890|Compound:0929-0006|FD-Score:3.05|P-value:8.99E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.75|P-value:5.22E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.81|P-value:4.68E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.15|P-value:6.16E-8 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.75|P-value:6.01E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.73|P-value:6.50E-5 ID:SGTC_1668|Compound:st014914|FD-Score:3.14|P-value:6.42E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.98|P-value:1.89E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.54|P-value:1.41E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.28|P-value:2.87E-8 ID:SGTC_1845|Compound:st056753|FD-Score:5.11|P-value:7.63E-8 ID:SGTC_1936|Compound:st074407|FD-Score:3.66|P-value:8.82E-5 ID:SGTC_1952|Compound:st077036|FD-Score:3.71|P-value:7.13E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.04|P-value:8.20E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.03|P-value:8.41E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.44|P-value:2.13E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.11|P-value:7.08E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.17|P-value:5.17E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.33|P-value:3.25E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.60|P-value:1.13E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.42|P-value:2.29E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.29|P-value:3.68E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:5.13|P-value:6.90E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.53|P-value:1.29E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.12|P-value:6.89E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.01|P-value:9.17E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.58|P-value:1.23E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.17|P-value:8.27E-6 ID:SGTC_2971|Compound:9092186|FD-Score:4.02|P-value:1.86E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.12|P-value:7.00E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.18|P-value:5.59E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.23|P-value:4.16E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-2.99|P-value:9.73E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.85|P-value:3.86E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.69|P-value:6.61E-5

Top fitness defect scores for YOR033C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_594 1487-1584 5.36 10.8 µM 1.84E-8 8 4.14E-8
2 SGTC_65 0798-0905 5.31 35.0 µM 2.49E-8 calcium & mitochondrial duress 45 5.50E-8
3 SGTC_401 neomycin 5.30 50.0 µM 2.69E-8 2 5.92E-8
4 SGTC_1738 st035555 5.28 74.0 µM 2.87E-8 TSC3-RPN4 11 6.29E-8
5 SGTC_1248 0469-0687 5.15 58.6 µM 6.16E-8 8 1.30E-7
6 SGTC_2497 7-hydroxyflavone 5.13 100.0 µM 6.90E-8 6 1.44E-7
7 SGTC_1845 st056753 5.11 3.0 µM 7.63E-8 TSC3-RPN4 18 1.59E-7
8 SGTC_2971 9092186 4.02 9.9 µM 1.86E-5 ergosterol biosynthesis 30 2.91E-5
9 SGTC_608 k048-0125 3.99 159.0 µM 2.12E-5 29 3.29E-5
10 SGTC_3058 9093861 3.85 49.5 µM 3.86E-5 19 5.81E-5
11 SGTC_1085 doxorubicin 3.81 7.7 µM 4.68E-5 anthracycline transcription coupled DNA repair 25 6.98E-5
12 SGTC_1476 4112-3294 3.75 3.3 µM 6.01E-5 60S ribosome export 22 8.84E-5
13 SGTC_659 k018-0002 3.75 107.0 µM 6.08E-5 22 8.94E-5
14 SGTC_1495 4469-0029 3.73 237.0 µM 6.50E-5 124 9.52E-5
15 SGTC_1952 st077036 3.71 64.1 µM 7.13E-5 42 1.04E-4
16 SGTC_1936 st074407 3.66 74.3 µM 8.82E-5 DNA damage response 48 1.27E-4
17 SGTC_494 Boc-Gly-Val-Val-CHO 3.65 140.0 µM 9.17E-5 12 1.32E-4
18 SGTC_2261 9010538 3.60 184.7 µM 1.13E-4 26 1.61E-4
19 SGTC_2798 7813637 3.58 45.5 µM 1.23E-4 46 1.74E-4
20 SGTC_1734 st037168 3.54 69.4 µM 1.41E-4 39 1.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 7.96E-39 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.201 6.19E-32 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.198 5.92E-31 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.185 3.05E-27 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.180 8.42E-26 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.174 2.84E-24 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.169 5.89E-23 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.163 1.83E-21 YOR014W RTS1 hom B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A
0.156 1.20E-19 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.151 1.30E-18 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.143 7.36E-17 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.142 1.45E-16 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.142 1.58E-16 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.135 4.68E-15 YIR035C_p YIR035C_p hom Putative cytoplasmic short-chain dehydrogenase/reductase
0.132 1.45E-14 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis