YOR034C / AKR2

Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR034C / AKR2

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:-3.19|P-value:3.11E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:2.95|P-value:6.76E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-2.89|P-value:9.57E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.05|P-value:5.85E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.22|P-value:2.69E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.80|P-value:1.96E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.04|P-value:4.98E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:2.95|P-value:6.96E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.56|P-value:5.81E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:2.89|P-value:8.61E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.34|P-value:1.64E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.34|P-value:1.68E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.54|P-value:7.10E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.71|P-value:2.88E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.38|P-value:1.23E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.10|P-value:5.24E-6 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.43|P-value:1.14E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-3.70|P-value:3.55E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.86|P-value:1.45E-5 ID:SGTC_1882|Compound:5615643|FD-Score:2.91|P-value:7.90E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.22|P-value:2.44E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.36|P-value:1.35E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.46|P-value:8.71E-5 ID:SGTC_2176|Compound:5809774|FD-Score:3.79|P-value:2.05E-5 ID:SGTC_2283|Compound:7944793|FD-Score:2.92|P-value:7.78E-4 ID:SGTC_2341|Compound:7987486|FD-Score:2.89|P-value:8.50E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-5.76|P-value:2.87E-10 ID:SGTC_2344|Compound:7990960|FD-Score:-5.50|P-value:1.65E-9 ID:SGTC_2376|Compound:9072922|FD-Score:3.43|P-value:1.03E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.90|P-value:9.34E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.12|P-value:3.53E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.81|P-value:2.06E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:2.95|P-value:6.78E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-2.96|P-value:7.35E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.23|P-value:2.27E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.34|P-value:1.47E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.43|P-value:9.28E-7 ID:SGTC_2973|Compound:9094665|FD-Score:3.23|P-value:2.30E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.97|P-value:8.33E-6 ID:SGTC_3212|Compound:9128307|FD-Score:4.58|P-value:3.61E-7 ID:SGTC_3305|Compound:9127027|FD-Score:3.80|P-value:1.92E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.19|P-value:3.11E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:2.95|P-value:6.76E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-2.89|P-value:9.57E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.05|P-value:5.85E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.22|P-value:2.69E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.80|P-value:1.96E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.04|P-value:4.98E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:2.95|P-value:6.96E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.56|P-value:5.81E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:2.89|P-value:8.61E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.34|P-value:1.64E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.34|P-value:1.68E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.54|P-value:7.10E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.71|P-value:2.88E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.38|P-value:1.23E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.10|P-value:5.24E-6 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.43|P-value:1.14E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-3.70|P-value:3.55E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.86|P-value:1.45E-5 ID:SGTC_1882|Compound:5615643|FD-Score:2.91|P-value:7.90E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.22|P-value:2.44E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.36|P-value:1.35E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.46|P-value:8.71E-5 ID:SGTC_2176|Compound:5809774|FD-Score:3.79|P-value:2.05E-5 ID:SGTC_2283|Compound:7944793|FD-Score:2.92|P-value:7.78E-4 ID:SGTC_2341|Compound:7987486|FD-Score:2.89|P-value:8.50E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-5.76|P-value:2.87E-10 ID:SGTC_2344|Compound:7990960|FD-Score:-5.50|P-value:1.65E-9 ID:SGTC_2376|Compound:9072922|FD-Score:3.43|P-value:1.03E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.90|P-value:9.34E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.12|P-value:3.53E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.81|P-value:2.06E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:2.95|P-value:6.78E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-2.96|P-value:7.35E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.23|P-value:2.27E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.34|P-value:1.47E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.43|P-value:9.28E-7 ID:SGTC_2973|Compound:9094665|FD-Score:3.23|P-value:2.30E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.97|P-value:8.33E-6 ID:SGTC_3212|Compound:9128307|FD-Score:4.58|P-value:3.61E-7 ID:SGTC_3305|Compound:9127027|FD-Score:3.80|P-value:1.92E-5

Top fitness defect scores for YOR034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3212 9128307 4.58 49.5 µM 3.61E-7 29 2.36E-6
2 SGTC_196 k015-0023 4.05 18.1 µM 5.85E-6 PDR1 16 2.60E-5
3 SGTC_3194 9111903 3.97 49.5 µM 8.33E-6 23 3.52E-5
4 SGTC_1703 st026983 3.86 48.3 µM 1.45E-5 11 5.67E-5
5 SGTC_3305 9127027 3.80 53.8 µM 1.92E-5 20 7.24E-5
6 SGTC_533 1222-0222 3.80 6.7 µM 1.96E-5 PDR1 34 7.37E-5
7 SGTC_2176 5809774 3.79 34.0 µM 2.05E-5 mitochondrial processes 15 7.66E-5
8 SGTC_1427 4048-4900 3.71 550.0 nM 2.88E-5 33 1.03E-4
9 SGTC_852 0418-0143 3.56 439.0 µM 5.81E-5 calcium & mitochondrial duress 88 1.88E-4
10 SGTC_2116 5511452 3.46 16.9 µM 8.71E-5 25 2.67E-4
11 SGTC_2376 9072922 3.43 81.3 µM 1.03E-4 53 3.07E-4
12 SGTC_1432 4049-0298 3.38 68.4 µM 1.23E-4 16 3.58E-4
13 SGTC_1971 st069429 3.36 63.5 µM 1.35E-4 60S ribosome export 28 3.89E-4
14 SGTC_2792 7535235 3.34 81.8 µM 1.47E-4 fatty acid desaturase (OLE1) 55 4.20E-4
15 SGTC_2772 vinpocetine 3.23 57.1 µM 2.27E-4 49 6.10E-4
16 SGTC_2973 9094665 3.23 18.0 µM 2.30E-4 NEO1 60 6.16E-4
17 SGTC_1965 Pectolinarigenin 3.22 58.4 µM 2.44E-4 RPP1 & pyrimidine depletion 23 6.48E-4
18 SGTC_2608 thymoquinone 3.12 42.7 µM 3.53E-4 45 8.92E-4
19 SGTC_793 0488-0545 3.04 106.0 µM 4.98E-4 48 0.00120
20 SGTC_1019 4262-0212 2.97 3.4 µM 6.30E-4 ergosterol depletion effects on membrane 132 0.00147

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.87E-12 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.111 1.19E-10 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.103 1.99E-9 YLR381W CTF3 hom Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6
0.102 3.42E-9 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.098 1.11E-8 YLR049C_p YLR049C_p hom Putative protein of unknown function
0.094 5.28E-8 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.080 3.71E-6 YGL259W_p YPS5_p hom Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
0.078 5.35E-6 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.072 2.86E-5 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.070 4.75E-5 YHR038W RRF1 hom Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
0.068 7.59E-5 YPL074W YTA6 hom Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress
0.068 7.78E-5 YGL041C-B_p YGL041C-B_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.068 8.19E-5 YHR133C NSG1 hom Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress
0.068 8.27E-5 YOR055W_d YOR055W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.067 9.70E-5 YLR320W MMS22 hom Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation