YOR034C-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR034C-A / YOR034C-A

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-3.94|P-value:2.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:10.90|P-value:3.60E-22 ID:SGTC_75|Compound:0159-0059|FD-Score:4.92|P-value:6.44E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:5.31|P-value:1.26E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:-5.91|P-value:8.77E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:4.45|P-value:3.98E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-5.01|P-value:4.80E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.77|P-value:4.35E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.61|P-value:7.16E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-7.25|P-value:7.39E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:5.22|P-value:1.85E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.83|P-value:3.42E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-6.44|P-value:6.35E-9 ID:SGTC_263|Compound:alizarin|FD-Score:3.96|P-value:2.23E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.75|P-value:1.77E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.59|P-value:7.72E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.03|P-value:1.78E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.79|P-value:1.46E-7 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.80|P-value:3.96E-4 ID:SGTC_484|Compound:loperamide|FD-Score:-4.04|P-value:1.77E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.70|P-value:2.28E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:4.24|P-value:8.70E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.18|P-value:1.07E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.00|P-value:2.08E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.30|P-value:7.02E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:4.13|P-value:1.26E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.26|P-value:8.32E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.52|P-value:4.98E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.79|P-value:1.09E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.26|P-value:8.16E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.95|P-value:2.36E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.31|P-value:6.71E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.02|P-value:4.38E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.71|P-value:5.11E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.64|P-value:6.61E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.78|P-value:1.16E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-5.53|P-value:5.08E-7 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.83|P-value:3.48E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-5.73|P-value:2.06E-7 ID:SGTC_1625|Compound:st003711|FD-Score:7.16|P-value:1.13E-10 ID:SGTC_1633|Compound:st005664|FD-Score:3.68|P-value:5.57E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.76|P-value:2.73E-18 ID:SGTC_1636|Compound:st007707|FD-Score:4.16|P-value:1.13E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.77|P-value:1.62E-7 ID:SGTC_1666|Compound:st014829|FD-Score:3.61|P-value:6.80E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.69|P-value:5.42E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-5.07|P-value:3.78E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.73|P-value:4.80E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.41|P-value:4.74E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.92|P-value:6.69E-6 ID:SGTC_2143|Compound:5623677|FD-Score:3.56|P-value:8.08E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.52|P-value:8.97E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.64|P-value:1.99E-5 ID:SGTC_2211|Compound:7117706|FD-Score:3.94|P-value:2.39E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.69|P-value:5.42E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.64|P-value:1.99E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-3.93|P-value:2.62E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.90|P-value:2.77E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.44|P-value:4.22E-5 ID:SGTC_2463|Compound:5473429|FD-Score:4.04|P-value:1.69E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.24|P-value:8.91E-5 ID:SGTC_2511|Compound:berberine|FD-Score:-4.26|P-value:8.35E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.87|P-value:2.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.64|P-value:1.94E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.46|P-value:5.69E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-5.45|P-value:7.22E-7 ID:SGTC_2896|Compound:9052656|FD-Score:4.39|P-value:5.05E-5 ID:SGTC_3005|Compound:9076496|FD-Score:-4.01|P-value:1.97E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.92|P-value:2.59E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-6.21|P-value:2.01E-8 ID:SGTC_3152|Compound:9099253|FD-Score:-3.99|P-value:2.10E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.82|P-value:3.58E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.72|P-value:4.93E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.79|P-value:3.97E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.94|P-value:2.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:10.90|P-value:3.60E-22 ID:SGTC_75|Compound:0159-0059|FD-Score:4.92|P-value:6.44E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:5.31|P-value:1.26E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:-5.91|P-value:8.77E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:4.45|P-value:3.98E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-5.01|P-value:4.80E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.77|P-value:4.35E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.61|P-value:7.16E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-7.25|P-value:7.39E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:5.22|P-value:1.85E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.83|P-value:3.42E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-6.44|P-value:6.35E-9 ID:SGTC_263|Compound:alizarin|FD-Score:3.96|P-value:2.23E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.75|P-value:1.77E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.59|P-value:7.72E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.03|P-value:1.78E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.79|P-value:1.46E-7 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.80|P-value:3.96E-4 ID:SGTC_484|Compound:loperamide|FD-Score:-4.04|P-value:1.77E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.70|P-value:2.28E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:4.24|P-value:8.70E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.18|P-value:1.07E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.00|P-value:2.08E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.30|P-value:7.02E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:4.13|P-value:1.26E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.26|P-value:8.32E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.52|P-value:4.98E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.79|P-value:1.09E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.26|P-value:8.16E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.95|P-value:2.36E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.31|P-value:6.71E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.02|P-value:4.38E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.71|P-value:5.11E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.64|P-value:6.61E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.78|P-value:1.16E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-5.53|P-value:5.08E-7 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.83|P-value:3.48E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-5.73|P-value:2.06E-7 ID:SGTC_1625|Compound:st003711|FD-Score:7.16|P-value:1.13E-10 ID:SGTC_1633|Compound:st005664|FD-Score:3.68|P-value:5.57E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.76|P-value:2.73E-18 ID:SGTC_1636|Compound:st007707|FD-Score:4.16|P-value:1.13E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.77|P-value:1.62E-7 ID:SGTC_1666|Compound:st014829|FD-Score:3.61|P-value:6.80E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.69|P-value:5.42E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-5.07|P-value:3.78E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.73|P-value:4.80E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.41|P-value:4.74E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.92|P-value:6.69E-6 ID:SGTC_2143|Compound:5623677|FD-Score:3.56|P-value:8.08E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.52|P-value:8.97E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.64|P-value:1.99E-5 ID:SGTC_2211|Compound:7117706|FD-Score:3.94|P-value:2.39E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.69|P-value:5.42E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.64|P-value:1.99E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-3.93|P-value:2.62E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.90|P-value:2.77E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.44|P-value:4.22E-5 ID:SGTC_2463|Compound:5473429|FD-Score:4.04|P-value:1.69E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.24|P-value:8.91E-5 ID:SGTC_2511|Compound:berberine|FD-Score:-4.26|P-value:8.35E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.87|P-value:2.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.64|P-value:1.94E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.46|P-value:5.69E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-5.45|P-value:7.22E-7 ID:SGTC_2896|Compound:9052656|FD-Score:4.39|P-value:5.05E-5 ID:SGTC_3005|Compound:9076496|FD-Score:-4.01|P-value:1.97E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.92|P-value:2.59E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-6.21|P-value:2.01E-8 ID:SGTC_3152|Compound:9099253|FD-Score:-3.99|P-value:2.10E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.82|P-value:3.58E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.72|P-value:4.93E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.79|P-value:3.97E-4

Top fitness defect scores for YOR034C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 10.90 9.0 µM 3.60E-22 cell wall 68 9.21E-28
2 SGTC_1635 st007035 9.76 42.4 µM 2.73E-18 77 8.06E-23
3 SGTC_1625 st003711 7.16 30.1 µM 1.13E-10 calcium & mitochondrial duress 3 3.94E-13
4 SGTC_453 enantio-paf c16 5.79 10.0 µM 1.46E-7 60 3.49E-9
5 SGTC_1658 st012944 5.77 20.0 µM 1.62E-7 iron homeostasis 33 4.01E-9
6 SGTC_268 camptothecin 5.75 39.6 µM 1.77E-7 DNA damage response 35 4.47E-9
7 SGTC_568 1193-0097 5.70 7.5 µM 2.28E-7 ERAD & cell cycle 65 6.16E-9
8 SGTC_1119 parthenolide 5.52 318.5 nM 4.98E-7 TSC3-RPN4 15 1.66E-8
9 SGTC_103 0844-0104 5.31 51.8 µM 1.26E-6 ERAD & cell cycle 95 5.39E-8
10 SGTC_236 1509-0011 5.22 5.3 µM 1.85E-6 316 8.72E-8
11 SGTC_1493 4348-0038 5.02 111.0 µM 4.38E-6 RSC complex & mRNA processing 8 2.60E-7
12 SGTC_75 0159-0059 4.92 199.0 µM 6.44E-6 fatty acid desaturase (OLE1) 12 4.24E-7
13 SGTC_2111 5486399 4.92 200.0 µM 6.69E-6 15 4.44E-7
14 SGTC_1245 0418-0076 4.79 17.2 µM 1.09E-5 ERG2 14 8.21E-7
15 SGTC_1529 apigenin 4.78 74.0 µM 1.16E-5 16 8.90E-7
16 SGTC_2688 kanamycin b 4.64 96.7 µM 1.94E-5 calcium & mitochondrial duress 279 1.71E-6
17 SGTC_2161 5662504 4.64 8.5 µM 1.99E-5 tubulin folding & SWR complex 13 1.76E-6
18 SGTC_2286 7945697 4.64 125.0 µM 1.99E-5 35 1.76E-6
19 SGTC_138 0850-0259 4.45 40.9 µM 3.98E-5 cell wall 168 4.22E-6
20 SGTC_2384 9036245 4.44 200.0 µM 4.22E-5 24 4.56E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 6.26E-73 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.204 5.70E-33 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.201 6.64E-32 YKL121W_p DGR2_p hom Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
0.196 2.71E-30 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.193 2.34E-29 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.187 7.70E-28 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.187 8.58E-28 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.184 6.56E-27 YBR208C DUR1,2 hom Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
0.183 9.83E-27 YHR104W GRE3 hom Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.183 1.05E-26 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.182 1.76E-26 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.179 1.77E-25 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.176 7.12E-25 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.176 8.56E-25 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.175 1.28E-24 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs