YOR035C / SHE4

Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR035C / SHE4

Click on Significant Values for Screen Details ID:SGTC_98|Compound:0074-0023|FD-Score:5.50|P-value:4.41E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:4.64|P-value:4.94E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.45|P-value:7.96E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.85|P-value:1.49E-5 ID:SGTC_264|Compound:promethazine|FD-Score:5.36|P-value:6.75E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:5.86|P-value:1.41E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:4.47|P-value:7.65E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:6.10|P-value:6.38E-6 ID:SGTC_394|Compound:menadione|FD-Score:5.16|P-value:1.19E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.46|P-value:7.87E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:6.05|P-value:7.72E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:5.11|P-value:1.38E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.78|P-value:3.36E-4 ID:SGTC_500|Compound:h-89|FD-Score:6.10|P-value:6.53E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:5.71|P-value:2.26E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:4.94|P-value:2.21E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:8.55|P-value:3.90E-10 ID:SGTC_630|Compound:4356-0227|FD-Score:5.08|P-value:1.48E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.71|P-value:4.10E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:9.74|P-value:1.12E-12 ID:SGTC_690|Compound:glyoxal|FD-Score:5.48|P-value:4.60E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:7.06|P-value:2.05E-7 ID:SGTC_790|Compound:1575-0012|FD-Score:7.22|P-value:1.10E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.91|P-value:2.41E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.81|P-value:3.13E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.85|P-value:2.79E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.19|P-value:1.10E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:5.13|P-value:1.29E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:7.09|P-value:1.83E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.18|P-value:5.33E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.52|P-value:4.09E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.86|P-value:1.35E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.96|P-value:1.03E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:5.11|P-value:1.38E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.48|P-value:7.49E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:8.07|P-value:3.40E-9 ID:SGTC_1466|Compound:k213-0079|FD-Score:7.27|P-value:9.22E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:-4.73|P-value:1.97E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:5.64|P-value:2.85E-5 ID:SGTC_1635|Compound:st007035|FD-Score:9.19|P-value:1.80E-11 ID:SGTC_1643|Compound:st009866|FD-Score:4.38|P-value:9.56E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.49|P-value:5.22E-10 ID:SGTC_1687|Compound:st020778|FD-Score:7.50|P-value:3.72E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.42|P-value:4.52E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.18|P-value:1.14E-4 ID:SGTC_1760|Compound:st045453|FD-Score:7.38|P-value:5.91E-8 ID:SGTC_1762|Compound:st045503|FD-Score:6.02|P-value:8.44E-6 ID:SGTC_1773|Compound:st048542|FD-Score:11.70|P-value:1.68E-17 ID:SGTC_1803|Compound:st050068|FD-Score:4.90|P-value:2.43E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.38|P-value:5.96E-8 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.01|P-value:1.80E-4 ID:SGTC_2006|Compound:4011487|FD-Score:11.00|P-value:7.98E-16 ID:SGTC_2007|Compound:4011539|FD-Score:5.42|P-value:5.60E-5 ID:SGTC_2028|Compound:5153890|FD-Score:6.10|P-value:6.46E-6 ID:SGTC_2077|Compound:5212015|FD-Score:8.17|P-value:2.21E-9 ID:SGTC_2090|Compound:5301565|FD-Score:7.14|P-value:1.55E-7 ID:SGTC_2092|Compound:5303694|FD-Score:4.75|P-value:3.70E-4 ID:SGTC_2189|Compound:6047310|FD-Score:4.70|P-value:4.23E-4 ID:SGTC_2200|Compound:6600604|FD-Score:13.00|P-value:2.73E-21 ID:SGTC_2289|Compound:7946404|FD-Score:4.64|P-value:4.92E-4 ID:SGTC_2399|Compound:5884133|FD-Score:10.60|P-value:1.08E-14 ID:SGTC_2472|Compound:5377652|FD-Score:7.23|P-value:1.09E-7 ID:SGTC_2485|Compound:5633444|FD-Score:-4.42|P-value:4.58E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:5.32|P-value:7.59E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-4.55|P-value:3.24E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.85|P-value:2.81E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.79|P-value:1.79E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:5.43|P-value:5.34E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.38|P-value:9.49E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.71|P-value:4.12E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.61|P-value:5.32E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:9.22|P-value:1.57E-11 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.87|P-value:2.70E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.60|P-value:4.20E-20 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.99|P-value:9.42E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.81|P-value:3.18E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-4.77|P-value:1.75E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-5.74|P-value:9.40E-6 ID:SGTC_2844|Compound:9010103|FD-Score:-5.81|P-value:7.29E-6 ID:SGTC_2851|Compound:9015922|FD-Score:5.57|P-value:3.56E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-4.29|P-value:6.28E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.74|P-value:3.77E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.67|P-value:4.56E-4 ID:SGTC_2935|Compound:9038016|FD-Score:6.42|P-value:2.19E-6 ID:SGTC_2966|Compound:9084041|FD-Score:5.50|P-value:4.41E-5 ID:SGTC_2980|Compound:9014342|FD-Score:6.81|P-value:5.35E-7 ID:SGTC_2993|Compound:9054257|FD-Score:4.36|P-value:9.88E-4 ID:SGTC_3018|Compound:9082602|FD-Score:5.33|P-value:7.24E-5 ID:SGTC_3054|Compound:9094397|FD-Score:4.75|P-value:3.69E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.54|P-value:3.93E-5 ID:SGTC_3207|Compound:9114163|FD-Score:4.64|P-value:4.94E-4 ID:SGTC_3235|Compound:9132602|FD-Score:6.80|P-value:5.58E-7 ID:SGTC_3237|Compound:9133362|FD-Score:4.52|P-value:6.69E-4 ID:SGTC_3281|Compound:9140613|FD-Score:5.08|P-value:1.48E-4 ID:SGTC_3288|Compound:9119690|FD-Score:6.16|P-value:5.38E-6 ID:SGTC_3304|Compound:9125678|FD-Score:5.19|P-value:1.11E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:5.50|P-value:4.41E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:4.64|P-value:4.94E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.45|P-value:7.96E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.85|P-value:1.49E-5 ID:SGTC_264|Compound:promethazine|FD-Score:5.36|P-value:6.75E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:5.86|P-value:1.41E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:4.47|P-value:7.65E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:6.10|P-value:6.38E-6 ID:SGTC_394|Compound:menadione|FD-Score:5.16|P-value:1.19E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.46|P-value:7.87E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:6.05|P-value:7.72E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:5.11|P-value:1.38E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.78|P-value:3.36E-4 ID:SGTC_500|Compound:h-89|FD-Score:6.10|P-value:6.53E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:5.71|P-value:2.26E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:4.94|P-value:2.21E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:8.55|P-value:3.90E-10 ID:SGTC_630|Compound:4356-0227|FD-Score:5.08|P-value:1.48E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.71|P-value:4.10E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:9.74|P-value:1.12E-12 ID:SGTC_690|Compound:glyoxal|FD-Score:5.48|P-value:4.60E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:7.06|P-value:2.05E-7 ID:SGTC_790|Compound:1575-0012|FD-Score:7.22|P-value:1.10E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.91|P-value:2.41E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.81|P-value:3.13E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.85|P-value:2.79E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.19|P-value:1.10E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:5.13|P-value:1.29E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:7.09|P-value:1.83E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.18|P-value:5.33E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.52|P-value:4.09E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.86|P-value:1.35E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.96|P-value:1.03E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:5.11|P-value:1.38E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.48|P-value:7.49E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:8.07|P-value:3.40E-9 ID:SGTC_1466|Compound:k213-0079|FD-Score:7.27|P-value:9.22E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:-4.73|P-value:1.97E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:5.64|P-value:2.85E-5 ID:SGTC_1635|Compound:st007035|FD-Score:9.19|P-value:1.80E-11 ID:SGTC_1643|Compound:st009866|FD-Score:4.38|P-value:9.56E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.49|P-value:5.22E-10 ID:SGTC_1687|Compound:st020778|FD-Score:7.50|P-value:3.72E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.42|P-value:4.52E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.18|P-value:1.14E-4 ID:SGTC_1760|Compound:st045453|FD-Score:7.38|P-value:5.91E-8 ID:SGTC_1762|Compound:st045503|FD-Score:6.02|P-value:8.44E-6 ID:SGTC_1773|Compound:st048542|FD-Score:11.70|P-value:1.68E-17 ID:SGTC_1803|Compound:st050068|FD-Score:4.90|P-value:2.43E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.38|P-value:5.96E-8 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.01|P-value:1.80E-4 ID:SGTC_2006|Compound:4011487|FD-Score:11.00|P-value:7.98E-16 ID:SGTC_2007|Compound:4011539|FD-Score:5.42|P-value:5.60E-5 ID:SGTC_2028|Compound:5153890|FD-Score:6.10|P-value:6.46E-6 ID:SGTC_2077|Compound:5212015|FD-Score:8.17|P-value:2.21E-9 ID:SGTC_2090|Compound:5301565|FD-Score:7.14|P-value:1.55E-7 ID:SGTC_2092|Compound:5303694|FD-Score:4.75|P-value:3.70E-4 ID:SGTC_2189|Compound:6047310|FD-Score:4.70|P-value:4.23E-4 ID:SGTC_2200|Compound:6600604|FD-Score:13.00|P-value:2.73E-21 ID:SGTC_2289|Compound:7946404|FD-Score:4.64|P-value:4.92E-4 ID:SGTC_2399|Compound:5884133|FD-Score:10.60|P-value:1.08E-14 ID:SGTC_2472|Compound:5377652|FD-Score:7.23|P-value:1.09E-7 ID:SGTC_2485|Compound:5633444|FD-Score:-4.42|P-value:4.58E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:5.32|P-value:7.59E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-4.55|P-value:3.24E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.85|P-value:2.81E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.79|P-value:1.79E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:5.43|P-value:5.34E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.38|P-value:9.49E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.71|P-value:4.12E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.61|P-value:5.32E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:9.22|P-value:1.57E-11 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.87|P-value:2.70E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.60|P-value:4.20E-20 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.99|P-value:9.42E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.81|P-value:3.18E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-4.77|P-value:1.75E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-5.74|P-value:9.40E-6 ID:SGTC_2844|Compound:9010103|FD-Score:-5.81|P-value:7.29E-6 ID:SGTC_2851|Compound:9015922|FD-Score:5.57|P-value:3.56E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-4.29|P-value:6.28E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.74|P-value:3.77E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.67|P-value:4.56E-4 ID:SGTC_2935|Compound:9038016|FD-Score:6.42|P-value:2.19E-6 ID:SGTC_2966|Compound:9084041|FD-Score:5.50|P-value:4.41E-5 ID:SGTC_2980|Compound:9014342|FD-Score:6.81|P-value:5.35E-7 ID:SGTC_2993|Compound:9054257|FD-Score:4.36|P-value:9.88E-4 ID:SGTC_3018|Compound:9082602|FD-Score:5.33|P-value:7.24E-5 ID:SGTC_3054|Compound:9094397|FD-Score:4.75|P-value:3.69E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.54|P-value:3.93E-5 ID:SGTC_3207|Compound:9114163|FD-Score:4.64|P-value:4.94E-4 ID:SGTC_3235|Compound:9132602|FD-Score:6.80|P-value:5.58E-7 ID:SGTC_3237|Compound:9133362|FD-Score:4.52|P-value:6.69E-4 ID:SGTC_3281|Compound:9140613|FD-Score:5.08|P-value:1.48E-4 ID:SGTC_3288|Compound:9119690|FD-Score:6.16|P-value:5.38E-6 ID:SGTC_3304|Compound:9125678|FD-Score:5.19|P-value:1.11E-4

Top fitness defect scores for YOR035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2200 6600604 13.00 21.9 µM 2.73E-21 tubulin folding & SWR complex 8 5.79E-39
2 SGTC_2679 rapamycin 12.60 1.0 nM 4.20E-20 12 1.00E-36
3 SGTC_1773 st048542 11.70 73.6 µM 1.68E-17 5 8.05E-32
4 SGTC_2006 4011487 11.00 200.0 µM 7.98E-16 endomembrane recycling 11 1.17E-28
5 SGTC_2399 5884133 10.60 200.0 µM 1.08E-14 cell wall signaling 12 1.60E-26
6 SGTC_639 0833-0042 9.74 114.0 µM 1.12E-12 4 9.98E-23
7 SGTC_2615 purpurogallin-4-carboxylic acid 9.22 100.0 µM 1.57E-11 redox potentiating 11 1.44E-20
8 SGTC_1635 st007035 9.19 42.4 µM 1.80E-11 86 1.88E-20
9 SGTC_548 1436-0017 8.55 110.0 µM 3.90E-10 TSC3-RPN4 4 6.13E-18
10 SGTC_1672 st016598 8.49 6.5 µM 5.22E-10 endomembrane recycling 18 1.06E-17
11 SGTC_2077 5212015 8.17 200.0 µM 2.21E-9 12 1.60E-16
12 SGTC_1394 3474-0001 8.07 65.7 µM 3.40E-9 endomembrane recycling 5 3.63E-16
13 SGTC_1687 st020778 7.50 55.4 µM 3.72E-8 76 3.26E-14
14 SGTC_1760 st045453 7.38 10.4 µM 5.91E-8 NEO1-PIK1 64 7.80E-14
15 SGTC_1844 rapamycin 7.38 4.0 nM 5.96E-8 65 7.93E-14
16 SGTC_1466 k213-0079 7.27 57.5 µM 9.22E-8 3 1.80E-13
17 SGTC_2472 5377652 7.23 49.4 µM 1.09E-7 TRP & mitochondrial translation 15 2.47E-13
18 SGTC_790 1575-0012 7.22 79.1 µM 1.10E-7 TSC3-RPN4 2 2.52E-13
19 SGTC_2090 5301565 7.14 104.5 µM 1.55E-7 TSC3-RPN4 13 4.79E-13
20 SGTC_975 1335-0046 7.09 28.5 µM 1.83E-7 RPP1 & pyrimidine depletion 2 6.50E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.320 1.76E-80 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.320 4.18E-80 YLR370C ARC18 hom Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.238 2.96E-44 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.236 1.10E-43 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.227 3.29E-40 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.226 4.34E-40 YLR338W_d OPI9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
0.220 6.55E-38 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.210 1.39E-34 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.206 1.87E-33 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.203 1.42E-32 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.203 1.46E-32 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.199 4.08E-31 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.192 4.87E-29 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.189 2.57E-28 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.184 5.50E-27 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1