YOR036W / PEP12

Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR036W / PEP12

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:-3.78|P-value:7.74E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.72|P-value:9.34E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.81|P-value:7.24E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:7.32|P-value:4.85E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.05|P-value:2.12E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:5.82|P-value:5.73E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.26|P-value:1.85E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.59|P-value:1.11E-10 ID:SGTC_119|Compound:0121-0043|FD-Score:8.18|P-value:4.14E-12 ID:SGTC_124|Compound:0136-0217|FD-Score:9.16|P-value:9.51E-15 ID:SGTC_129|Compound:0088-0017|FD-Score:4.36|P-value:1.37E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:5.79|P-value:6.49E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:-6.85|P-value:5.01E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:4.88|P-value:2.32E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:4.28|P-value:1.74E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.32|P-value:4.43E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:5.04|P-value:1.29E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.60|P-value:5.19E-16 ID:SGTC_232|Compound:clozapine|FD-Score:4.25|P-value:1.94E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:5.96|P-value:3.23E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:6.45|P-value:3.59E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.31|P-value:4.55E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.12|P-value:2.88E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.72|P-value:4.05E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.11|P-value:2.91E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.91|P-value:5.40E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:7.20|P-value:8.77E-10 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.98|P-value:2.87E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.13|P-value:2.78E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.20|P-value:1.09E-7 ID:SGTC_459|Compound:nigericin|FD-Score:5.82|P-value:5.80E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:4.64|P-value:5.35E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.10|P-value:3.06E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.56|P-value:1.37E-10 ID:SGTC_561|Compound:1550-0330|FD-Score:4.09|P-value:3.14E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.20|P-value:2.24E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:12.20|P-value:1.11E-24 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.51|P-value:8.19E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-5.37|P-value:3.59E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.01|P-value:1.38E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:5.17|P-value:7.88E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:17.20|P-value:2.25E-47 ID:SGTC_768|Compound:0384-0033|FD-Score:3.84|P-value:6.67E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.79|P-value:7.82E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:7.21|P-value:8.52E-10 ID:SGTC_841|Compound:0251-0215|FD-Score:6.52|P-value:2.61E-8 ID:SGTC_888|Compound:0916-0002|FD-Score:4.64|P-value:5.25E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.37|P-value:1.27E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.87|P-value:2.38E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:4.43|P-value:1.06E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.20|P-value:2.23E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.74|P-value:3.72E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.98|P-value:4.42E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:6.59|P-value:1.88E-8 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.00|P-value:4.23E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.93|P-value:5.05E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:5.29|P-value:4.87E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.36|P-value:1.35E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.61|P-value:1.40E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.61|P-value:5.93E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:6.69|P-value:1.13E-8 ID:SGTC_1394|Compound:3474-0001|FD-Score:-4.72|P-value:3.90E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.57|P-value:6.67E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.32|P-value:4.93E-10 ID:SGTC_1523|Compound:st012844|FD-Score:3.84|P-value:6.68E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:9.93|P-value:5.35E-17 ID:SGTC_1658|Compound:st012944|FD-Score:6.09|P-value:1.77E-7 ID:SGTC_1677|Compound:st019204|FD-Score:7.54|P-value:1.49E-10 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.29|P-value:7.54E-8 ID:SGTC_1687|Compound:st020778|FD-Score:21.00|P-value:1.45E-69 ID:SGTC_1699|Compound:st031318|FD-Score:-4.13|P-value:2.76E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.98|P-value:2.69E-9 ID:SGTC_1760|Compound:st045453|FD-Score:13.20|P-value:2.00E-28 ID:SGTC_1800|Compound:st050079|FD-Score:4.00|P-value:4.22E-4 ID:SGTC_1801|Compound:st050089|FD-Score:9.32|P-value:3.33E-15 ID:SGTC_1803|Compound:st050068|FD-Score:6.67|P-value:1.25E-8 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.22|P-value:2.11E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.78|P-value:3.23E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-6.17|P-value:1.22E-7 ID:SGTC_2077|Compound:5212015|FD-Score:8.61|P-value:3.14E-13 ID:SGTC_2119|Compound:5528445|FD-Score:-4.78|P-value:3.24E-5 ID:SGTC_2141|Compound:5621638|FD-Score:5.69|P-value:1.01E-6 ID:SGTC_2151|Compound:5563267|FD-Score:4.32|P-value:1.54E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.19|P-value:1.16E-7 ID:SGTC_2242|Compound:6630449|FD-Score:5.06|P-value:1.20E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-6.13|P-value:1.51E-7 ID:SGTC_2257|Compound:7960413|FD-Score:5.43|P-value:2.92E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.81|P-value:7.26E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.12|P-value:2.88E-4 ID:SGTC_2381|Compound:9035592|FD-Score:5.69|P-value:1.00E-6 ID:SGTC_2398|Compound:5228213|FD-Score:5.36|P-value:3.71E-6 ID:SGTC_2430|Compound:5571206|FD-Score:3.73|P-value:9.10E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.37|P-value:1.30E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:7.02|P-value:2.21E-9 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.33|P-value:1.49E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-4.08|P-value:3.23E-4 ID:SGTC_2526|Compound:patulin|FD-Score:15.20|P-value:2.88E-37 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.82|P-value:3.23E-11 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.14|P-value:8.69E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.12|P-value:9.37E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.17|P-value:7.81E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:4.40|P-value:1.18E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.80|P-value:7.51E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.72|P-value:9.20E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.86|P-value:6.30E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.85|P-value:6.47E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.94|P-value:5.06E-4 ID:SGTC_2914|Compound:7968218|FD-Score:6.23|P-value:9.54E-8 ID:SGTC_2924|Compound:9010168|FD-Score:-5.30|P-value:4.59E-6 ID:SGTC_2926|Compound:9010726|FD-Score:5.89|P-value:4.34E-7 ID:SGTC_2932|Compound:9016711|FD-Score:4.16|P-value:2.58E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.45|P-value:1.01E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-5.15|P-value:8.34E-6 ID:SGTC_3178|Compound:9107506|FD-Score:4.35|P-value:1.42E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.77|P-value:8.04E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-6.42|P-value:3.89E-8 ID:SGTC_3211|Compound:9128781|FD-Score:-3.80|P-value:7.46E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.58|P-value:6.60E-5 ID:SGTC_3317|Compound:9138495|FD-Score:4.27|P-value:1.80E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:-3.78|P-value:7.74E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.72|P-value:9.34E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.81|P-value:7.24E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:7.32|P-value:4.85E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.05|P-value:2.12E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:5.82|P-value:5.73E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.26|P-value:1.85E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.59|P-value:1.11E-10 ID:SGTC_119|Compound:0121-0043|FD-Score:8.18|P-value:4.14E-12 ID:SGTC_124|Compound:0136-0217|FD-Score:9.16|P-value:9.51E-15 ID:SGTC_129|Compound:0088-0017|FD-Score:4.36|P-value:1.37E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:5.79|P-value:6.49E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:-6.85|P-value:5.01E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:4.88|P-value:2.32E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:4.28|P-value:1.74E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.32|P-value:4.43E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:5.04|P-value:1.29E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.60|P-value:5.19E-16 ID:SGTC_232|Compound:clozapine|FD-Score:4.25|P-value:1.94E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:5.96|P-value:3.23E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:6.45|P-value:3.59E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.31|P-value:4.55E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.12|P-value:2.88E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.72|P-value:4.05E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.11|P-value:2.91E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.91|P-value:5.40E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:7.20|P-value:8.77E-10 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.98|P-value:2.87E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.13|P-value:2.78E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.20|P-value:1.09E-7 ID:SGTC_459|Compound:nigericin|FD-Score:5.82|P-value:5.80E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:4.64|P-value:5.35E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.10|P-value:3.06E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.56|P-value:1.37E-10 ID:SGTC_561|Compound:1550-0330|FD-Score:4.09|P-value:3.14E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.20|P-value:2.24E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:12.20|P-value:1.11E-24 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.51|P-value:8.19E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-5.37|P-value:3.59E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.01|P-value:1.38E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:5.17|P-value:7.88E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:17.20|P-value:2.25E-47 ID:SGTC_768|Compound:0384-0033|FD-Score:3.84|P-value:6.67E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.79|P-value:7.82E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:7.21|P-value:8.52E-10 ID:SGTC_841|Compound:0251-0215|FD-Score:6.52|P-value:2.61E-8 ID:SGTC_888|Compound:0916-0002|FD-Score:4.64|P-value:5.25E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.37|P-value:1.27E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.87|P-value:2.38E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:4.43|P-value:1.06E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.20|P-value:2.23E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.74|P-value:3.72E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.98|P-value:4.42E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:6.59|P-value:1.88E-8 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.00|P-value:4.23E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.93|P-value:5.05E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:5.29|P-value:4.87E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.36|P-value:1.35E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.61|P-value:1.40E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.61|P-value:5.93E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:6.69|P-value:1.13E-8 ID:SGTC_1394|Compound:3474-0001|FD-Score:-4.72|P-value:3.90E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.57|P-value:6.67E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.32|P-value:4.93E-10 ID:SGTC_1523|Compound:st012844|FD-Score:3.84|P-value:6.68E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:9.93|P-value:5.35E-17 ID:SGTC_1658|Compound:st012944|FD-Score:6.09|P-value:1.77E-7 ID:SGTC_1677|Compound:st019204|FD-Score:7.54|P-value:1.49E-10 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.29|P-value:7.54E-8 ID:SGTC_1687|Compound:st020778|FD-Score:21.00|P-value:1.45E-69 ID:SGTC_1699|Compound:st031318|FD-Score:-4.13|P-value:2.76E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.98|P-value:2.69E-9 ID:SGTC_1760|Compound:st045453|FD-Score:13.20|P-value:2.00E-28 ID:SGTC_1800|Compound:st050079|FD-Score:4.00|P-value:4.22E-4 ID:SGTC_1801|Compound:st050089|FD-Score:9.32|P-value:3.33E-15 ID:SGTC_1803|Compound:st050068|FD-Score:6.67|P-value:1.25E-8 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.22|P-value:2.11E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.78|P-value:3.23E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-6.17|P-value:1.22E-7 ID:SGTC_2077|Compound:5212015|FD-Score:8.61|P-value:3.14E-13 ID:SGTC_2119|Compound:5528445|FD-Score:-4.78|P-value:3.24E-5 ID:SGTC_2141|Compound:5621638|FD-Score:5.69|P-value:1.01E-6 ID:SGTC_2151|Compound:5563267|FD-Score:4.32|P-value:1.54E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.19|P-value:1.16E-7 ID:SGTC_2242|Compound:6630449|FD-Score:5.06|P-value:1.20E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-6.13|P-value:1.51E-7 ID:SGTC_2257|Compound:7960413|FD-Score:5.43|P-value:2.92E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.81|P-value:7.26E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.12|P-value:2.88E-4 ID:SGTC_2381|Compound:9035592|FD-Score:5.69|P-value:1.00E-6 ID:SGTC_2398|Compound:5228213|FD-Score:5.36|P-value:3.71E-6 ID:SGTC_2430|Compound:5571206|FD-Score:3.73|P-value:9.10E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.37|P-value:1.30E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:7.02|P-value:2.21E-9 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.33|P-value:1.49E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-4.08|P-value:3.23E-4 ID:SGTC_2526|Compound:patulin|FD-Score:15.20|P-value:2.88E-37 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.82|P-value:3.23E-11 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.14|P-value:8.69E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.12|P-value:9.37E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.17|P-value:7.81E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:4.40|P-value:1.18E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.80|P-value:7.51E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.72|P-value:9.20E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.86|P-value:6.30E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.85|P-value:6.47E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.94|P-value:5.06E-4 ID:SGTC_2914|Compound:7968218|FD-Score:6.23|P-value:9.54E-8 ID:SGTC_2924|Compound:9010168|FD-Score:-5.30|P-value:4.59E-6 ID:SGTC_2926|Compound:9010726|FD-Score:5.89|P-value:4.34E-7 ID:SGTC_2932|Compound:9016711|FD-Score:4.16|P-value:2.58E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.45|P-value:1.01E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-5.15|P-value:8.34E-6 ID:SGTC_3178|Compound:9107506|FD-Score:4.35|P-value:1.42E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.77|P-value:8.04E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-6.42|P-value:3.89E-8 ID:SGTC_3211|Compound:9128781|FD-Score:-3.80|P-value:7.46E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.58|P-value:6.60E-5 ID:SGTC_3317|Compound:9138495|FD-Score:4.27|P-value:1.80E-4

Top fitness defect scores for YOR036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 21.00 55.4 µM 1.45E-69 8 1.16E-98
2 SGTC_748 0136-0228 17.20 77.9 µM 2.25E-47 redox potentiating 1 6.30E-67
3 SGTC_2526 patulin 15.20 37.6 µM 2.88E-37 4 1.76E-52
4 SGTC_1760 st045453 13.20 10.4 µM 2.00E-28 NEO1-PIK1 17 7.56E-40
5 SGTC_670 4204-0025 12.20 119.0 µM 1.11E-24 copper-dependent oxidative stress 2 1.68E-34
6 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 9.93 54.9 µM 5.35E-17 redox potentiating 12 1.55E-23
7 SGTC_221 trifluoperazine 9.60 10.3 µM 5.19E-16 NEO1-PIK1 64 3.95E-22
8 SGTC_1801 st050089 9.32 28.4 µM 3.33E-15 NEO1-PIK1 16 5.60E-21
9 SGTC_124 0136-0217 9.16 7.1 µM 9.51E-15 mitochondrial stress 6 2.50E-20
10 SGTC_2077 5212015 8.61 200.0 µM 3.14E-13 9 3.65E-18
11 SGTC_119 0121-0043 8.18 24.8 µM 4.14E-12 mitochondrial stress 9 1.43E-16
12 SGTC_2567 aureobasidin a 7.82 60.0 nM 3.23E-11 22 2.67E-15
13 SGTC_117 lucigenin 7.59 22.1 µM 1.11E-10 redox potentiating 23 1.55E-14
14 SGTC_528 3492-0019 7.56 172.0 µM 1.37E-10 calcium & mitochondrial duress 86 2.08E-14
15 SGTC_1677 st019204 7.54 53.9 µM 1.49E-10 1 2.34E-14
16 SGTC_52 0329-0193 7.32 875.0 nM 4.85E-10 TSC3-RPN4 4 1.26E-13
17 SGTC_1495 4469-0029 7.32 237.0 µM 4.93E-10 34 1.29E-13
18 SGTC_836 0330-0104 7.21 1.4 µM 8.52E-10 2 2.80E-13
19 SGTC_365 0121-0052 7.20 13.6 µM 8.77E-10 mitochondrial response to ROS 10 2.91E-13
20 SGTC_2514 salinomycin 7.02 42.7 µM 2.21E-9 11 1.08E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.609 0 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.523 1.99E-235 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.432 1.00E-152 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.406 1.46E-133 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.392 1.62E-123 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.377 9.21E-114 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.366 1.62E-106 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.362 1.52E-104 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.355 3.06E-100 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.351 6.39E-98 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.350 3.38E-97 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.347 2.16E-95 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.342 1.42E-92 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.336 3.49E-89 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.333 7.23E-88 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism