YOR039W / CKB2

Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR039W / CKB2

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.26|P-value:1.19E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.68|P-value:7.62E-18 ID:SGTC_64|Compound:000l-0018|FD-Score:5.90|P-value:2.61E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:6.21|P-value:4.07E-10 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.21|P-value:8.47E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:15.90|P-value:1.07E-55 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.62|P-value:2.02E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:19.00|P-value:1.62E-78 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.09|P-value:3.12E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.19|P-value:1.65E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:6.22|P-value:3.77E-10 ID:SGTC_146|Compound:3448-8650|FD-Score:9.47|P-value:4.17E-21 ID:SGTC_158|Compound:k038-0087|FD-Score:5.32|P-value:6.85E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:5.60|P-value:1.50E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:6.08|P-value:9.00E-10 ID:SGTC_178|Compound:4092-0806|FD-Score:3.28|P-value:5.70E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:10.30|P-value:1.57E-24 ID:SGTC_201|Compound:4262-0159|FD-Score:6.00|P-value:1.49E-9 ID:SGTC_206|Compound:4546-0025|FD-Score:5.58|P-value:1.73E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:24.20|P-value:1.49E-126 ID:SGTC_232|Compound:clozapine|FD-Score:16.30|P-value:3.36E-58 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.54|P-value:3.53E-6 ID:SGTC_254|Compound:nsc-64875|FD-Score:16.30|P-value:9.82E-59 ID:SGTC_262|Compound:fenpropimorph|FD-Score:10.80|P-value:9.41E-27 ID:SGTC_268|Compound:camptothecin|FD-Score:4.11|P-value:2.33E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:19.20|P-value:1.34E-80 ID:SGTC_294|Compound:k038-0071|FD-Score:3.93|P-value:4.90E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.23|P-value:1.47E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:12.10|P-value:6.12E-33 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.41|P-value:7.33E-17 ID:SGTC_312|Compound:4092-0653|FD-Score:5.23|P-value:1.15E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:8.65|P-value:6.40E-18 ID:SGTC_320|Compound:4092-0846|FD-Score:3.14|P-value:8.97E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.24|P-value:6.56E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.67|P-value:1.86E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:5.21|P-value:1.28E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:4.83|P-value:8.58E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.76|P-value:1.20E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.36|P-value:7.95E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:5.06|P-value:2.80E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.22|P-value:8.39E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:10.30|P-value:1.44E-24 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.95|P-value:4.82E-7 ID:SGTC_447|Compound:ml7|FD-Score:3.33|P-value:4.82E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.91|P-value:5.81E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-9.17|P-value:1.10E-19 ID:SGTC_535|Compound:2293-4129|FD-Score:16.20|P-value:8.95E-58 ID:SGTC_568|Compound:1193-0097|FD-Score:7.27|P-value:3.47E-13 ID:SGTC_637|Compound:1181-0519|FD-Score:7.50|P-value:6.31E-14 ID:SGTC_642|Compound:0335-0876|FD-Score:4.70|P-value:1.61E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:16.00|P-value:3.20E-56 ID:SGTC_768|Compound:0384-0033|FD-Score:3.12|P-value:9.79E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:12.00|P-value:1.40E-32 ID:SGTC_794|Compound:k038-0031|FD-Score:8.07|P-value:7.59E-16 ID:SGTC_797|Compound:k781-0471|FD-Score:3.21|P-value:7.24E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.97|P-value:4.19E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:4.41|P-value:6.16E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:10.40|P-value:4.64E-25 ID:SGTC_888|Compound:0916-0002|FD-Score:17.50|P-value:7.02E-67 ID:SGTC_900|Compound:1112-0045|FD-Score:7.39|P-value:1.37E-13 ID:SGTC_902|Compound:1120-0002|FD-Score:5.72|P-value:7.67E-9 ID:SGTC_940|Compound:3232-1287|FD-Score:7.55|P-value:4.27E-14 ID:SGTC_945|Compound:3381-0768|FD-Score:4.54|P-value:3.44E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:4.99|P-value:3.96E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:3.51|P-value:2.49E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:6.06|P-value:1.04E-9 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.31|P-value:6.12E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:5.41|P-value:4.40E-8 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.58|P-value:2.33E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.23|P-value:1.39E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.49|P-value:4.32E-6 ID:SGTC_1092|Compound:toremifene|FD-Score:5.61|P-value:1.45E-8 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.64|P-value:1.55E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.02|P-value:3.44E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.14|P-value:2.08E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-4.60|P-value:3.41E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.44|P-value:6.83E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.14|P-value:8.98E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:20.10|P-value:1.77E-87 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.12|P-value:9.61E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.48|P-value:7.26E-14 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.56|P-value:2.04E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.40|P-value:3.65E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:8.14|P-value:4.53E-16 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.22|P-value:6.98E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.59|P-value:1.87E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.32|P-value:4.88E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.28|P-value:6.75E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.49|P-value:2.72E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.07|P-value:2.79E-5 ID:SGTC_1697|Compound:st025554|FD-Score:3.75|P-value:1.00E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.86|P-value:6.57E-5 ID:SGTC_1712|Compound:st032288|FD-Score:8.15|P-value:3.98E-16 ID:SGTC_1718|Compound:roemerine|FD-Score:3.61|P-value:1.72E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.50|P-value:4.18E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-5.72|P-value:1.06E-8 ID:SGTC_1750|Compound:st081859|FD-Score:7.78|P-value:7.69E-15 ID:SGTC_1754|Compound:st042065|FD-Score:10.30|P-value:9.02E-25 ID:SGTC_1760|Compound:st045453|FD-Score:20.90|P-value:1.97E-94 ID:SGTC_1781|Compound:st038725|FD-Score:21.70|P-value:1.91E-101 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.86|P-value:7.43E-7 ID:SGTC_1797|Compound:st048695|FD-Score:14.10|P-value:2.09E-44 ID:SGTC_1801|Compound:st050089|FD-Score:7.24|P-value:4.05E-13 ID:SGTC_1803|Compound:st050068|FD-Score:6.32|P-value:2.00E-10 ID:SGTC_1804|Compound:st050076|FD-Score:3.18|P-value:8.09E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.38|P-value:7.14E-6 ID:SGTC_1932|Compound:st074806|FD-Score:3.12|P-value:9.77E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.35|P-value:4.51E-4 ID:SGTC_1991|Compound:st073000|FD-Score:16.90|P-value:1.13E-62 ID:SGTC_2006|Compound:4011487|FD-Score:9.17|P-value:6.73E-20 ID:SGTC_2027|Compound:5150920|FD-Score:4.06|P-value:2.90E-5 ID:SGTC_2036|Compound:5160441|FD-Score:7.00|P-value:2.25E-12 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.39|P-value:1.35E-10 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.30|P-value:1.55E-24 ID:SGTC_2257|Compound:7960413|FD-Score:6.12|P-value:7.13E-10 ID:SGTC_2350|Compound:9023895|FD-Score:4.86|P-value:7.62E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.42|P-value:3.50E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.53|P-value:2.32E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.19|P-value:7.67E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.50|P-value:2.59E-8 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:14.40|P-value:8.08E-46 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.12|P-value:9.66E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.15|P-value:8.67E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.21|P-value:8.57E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.41|P-value:3.56E-4 ID:SGTC_2790|Compound:5423970|FD-Score:7.76|P-value:8.66E-15 ID:SGTC_2812|Compound:7970281|FD-Score:3.45|P-value:3.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.12|P-value:2.05E-7 ID:SGTC_2925|Compound:9010536|FD-Score:3.89|P-value:5.72E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.53|P-value:3.69E-6 ID:SGTC_3018|Compound:9082602|FD-Score:5.93|P-value:2.28E-9 ID:SGTC_3037|Compound:9091026|FD-Score:4.45|P-value:5.14E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.56|P-value:2.04E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.37|P-value:1.49E-10 ID:SGTC_3207|Compound:9114163|FD-Score:-4.13|P-value:2.72E-5 ID:SGTC_3218|Compound:9131285|FD-Score:7.40|P-value:1.27E-13 ID:SGTC_36|Compound:0335-0881|FD-Score:4.26|P-value:1.19E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.68|P-value:7.62E-18 ID:SGTC_64|Compound:000l-0018|FD-Score:5.90|P-value:2.61E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:6.21|P-value:4.07E-10 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.21|P-value:8.47E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:15.90|P-value:1.07E-55 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.62|P-value:2.02E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:19.00|P-value:1.62E-78 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.09|P-value:3.12E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.19|P-value:1.65E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:6.22|P-value:3.77E-10 ID:SGTC_146|Compound:3448-8650|FD-Score:9.47|P-value:4.17E-21 ID:SGTC_158|Compound:k038-0087|FD-Score:5.32|P-value:6.85E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:5.60|P-value:1.50E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:6.08|P-value:9.00E-10 ID:SGTC_178|Compound:4092-0806|FD-Score:3.28|P-value:5.70E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:10.30|P-value:1.57E-24 ID:SGTC_201|Compound:4262-0159|FD-Score:6.00|P-value:1.49E-9 ID:SGTC_206|Compound:4546-0025|FD-Score:5.58|P-value:1.73E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:24.20|P-value:1.49E-126 ID:SGTC_232|Compound:clozapine|FD-Score:16.30|P-value:3.36E-58 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.54|P-value:3.53E-6 ID:SGTC_254|Compound:nsc-64875|FD-Score:16.30|P-value:9.82E-59 ID:SGTC_262|Compound:fenpropimorph|FD-Score:10.80|P-value:9.41E-27 ID:SGTC_268|Compound:camptothecin|FD-Score:4.11|P-value:2.33E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:19.20|P-value:1.34E-80 ID:SGTC_294|Compound:k038-0071|FD-Score:3.93|P-value:4.90E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.23|P-value:1.47E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:12.10|P-value:6.12E-33 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.41|P-value:7.33E-17 ID:SGTC_312|Compound:4092-0653|FD-Score:5.23|P-value:1.15E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:8.65|P-value:6.40E-18 ID:SGTC_320|Compound:4092-0846|FD-Score:3.14|P-value:8.97E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.24|P-value:6.56E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.67|P-value:1.86E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:5.21|P-value:1.28E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:4.83|P-value:8.58E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.76|P-value:1.20E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.36|P-value:7.95E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:5.06|P-value:2.80E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.22|P-value:8.39E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:10.30|P-value:1.44E-24 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.95|P-value:4.82E-7 ID:SGTC_447|Compound:ml7|FD-Score:3.33|P-value:4.82E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.91|P-value:5.81E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-9.17|P-value:1.10E-19 ID:SGTC_535|Compound:2293-4129|FD-Score:16.20|P-value:8.95E-58 ID:SGTC_568|Compound:1193-0097|FD-Score:7.27|P-value:3.47E-13 ID:SGTC_637|Compound:1181-0519|FD-Score:7.50|P-value:6.31E-14 ID:SGTC_642|Compound:0335-0876|FD-Score:4.70|P-value:1.61E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:16.00|P-value:3.20E-56 ID:SGTC_768|Compound:0384-0033|FD-Score:3.12|P-value:9.79E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:12.00|P-value:1.40E-32 ID:SGTC_794|Compound:k038-0031|FD-Score:8.07|P-value:7.59E-16 ID:SGTC_797|Compound:k781-0471|FD-Score:3.21|P-value:7.24E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.97|P-value:4.19E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:4.41|P-value:6.16E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:10.40|P-value:4.64E-25 ID:SGTC_888|Compound:0916-0002|FD-Score:17.50|P-value:7.02E-67 ID:SGTC_900|Compound:1112-0045|FD-Score:7.39|P-value:1.37E-13 ID:SGTC_902|Compound:1120-0002|FD-Score:5.72|P-value:7.67E-9 ID:SGTC_940|Compound:3232-1287|FD-Score:7.55|P-value:4.27E-14 ID:SGTC_945|Compound:3381-0768|FD-Score:4.54|P-value:3.44E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:4.99|P-value:3.96E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:3.51|P-value:2.49E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:6.06|P-value:1.04E-9 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.31|P-value:6.12E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:5.41|P-value:4.40E-8 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.58|P-value:2.33E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.23|P-value:1.39E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.49|P-value:4.32E-6 ID:SGTC_1092|Compound:toremifene|FD-Score:5.61|P-value:1.45E-8 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.64|P-value:1.55E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.02|P-value:3.44E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.14|P-value:2.08E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-4.60|P-value:3.41E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.44|P-value:6.83E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.14|P-value:8.98E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:20.10|P-value:1.77E-87 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.12|P-value:9.61E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.48|P-value:7.26E-14 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.56|P-value:2.04E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.40|P-value:3.65E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:8.14|P-value:4.53E-16 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.22|P-value:6.98E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.59|P-value:1.87E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.32|P-value:4.88E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.28|P-value:6.75E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.49|P-value:2.72E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.07|P-value:2.79E-5 ID:SGTC_1697|Compound:st025554|FD-Score:3.75|P-value:1.00E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.86|P-value:6.57E-5 ID:SGTC_1712|Compound:st032288|FD-Score:8.15|P-value:3.98E-16 ID:SGTC_1718|Compound:roemerine|FD-Score:3.61|P-value:1.72E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.50|P-value:4.18E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-5.72|P-value:1.06E-8 ID:SGTC_1750|Compound:st081859|FD-Score:7.78|P-value:7.69E-15 ID:SGTC_1754|Compound:st042065|FD-Score:10.30|P-value:9.02E-25 ID:SGTC_1760|Compound:st045453|FD-Score:20.90|P-value:1.97E-94 ID:SGTC_1781|Compound:st038725|FD-Score:21.70|P-value:1.91E-101 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.86|P-value:7.43E-7 ID:SGTC_1797|Compound:st048695|FD-Score:14.10|P-value:2.09E-44 ID:SGTC_1801|Compound:st050089|FD-Score:7.24|P-value:4.05E-13 ID:SGTC_1803|Compound:st050068|FD-Score:6.32|P-value:2.00E-10 ID:SGTC_1804|Compound:st050076|FD-Score:3.18|P-value:8.09E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.38|P-value:7.14E-6 ID:SGTC_1932|Compound:st074806|FD-Score:3.12|P-value:9.77E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.35|P-value:4.51E-4 ID:SGTC_1991|Compound:st073000|FD-Score:16.90|P-value:1.13E-62 ID:SGTC_2006|Compound:4011487|FD-Score:9.17|P-value:6.73E-20 ID:SGTC_2027|Compound:5150920|FD-Score:4.06|P-value:2.90E-5 ID:SGTC_2036|Compound:5160441|FD-Score:7.00|P-value:2.25E-12 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.39|P-value:1.35E-10 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.30|P-value:1.55E-24 ID:SGTC_2257|Compound:7960413|FD-Score:6.12|P-value:7.13E-10 ID:SGTC_2350|Compound:9023895|FD-Score:4.86|P-value:7.62E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.42|P-value:3.50E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.53|P-value:2.32E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.19|P-value:7.67E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.50|P-value:2.59E-8 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:14.40|P-value:8.08E-46 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.12|P-value:9.66E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.15|P-value:8.67E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.21|P-value:8.57E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.41|P-value:3.56E-4 ID:SGTC_2790|Compound:5423970|FD-Score:7.76|P-value:8.66E-15 ID:SGTC_2812|Compound:7970281|FD-Score:3.45|P-value:3.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.12|P-value:2.05E-7 ID:SGTC_2925|Compound:9010536|FD-Score:3.89|P-value:5.72E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.53|P-value:3.69E-6 ID:SGTC_3018|Compound:9082602|FD-Score:5.93|P-value:2.28E-9 ID:SGTC_3037|Compound:9091026|FD-Score:4.45|P-value:5.14E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.56|P-value:2.04E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.37|P-value:1.49E-10 ID:SGTC_3207|Compound:9114163|FD-Score:-4.13|P-value:2.72E-5 ID:SGTC_3218|Compound:9131285|FD-Score:7.40|P-value:1.27E-13

Top fitness defect scores for YOR039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 24.20 10.3 µM 1.49E-126 NEO1-PIK1 6 3.53E-130
2 SGTC_1781 st038725 21.70 66.3 µM 1.91E-101 NEO1 4 2.58E-104
3 SGTC_1760 st045453 20.90 10.4 µM 1.97E-94 NEO1-PIK1 7 4.34E-97
4 SGTC_1130 3454-2858 20.10 15.9 µM 1.77E-87 NEO1 5 6.30E-90
5 SGTC_270 tamoxifen 19.20 5.5 µM 1.34E-80 NEO1 1 7.67E-83
6 SGTC_103 0844-0104 19.00 51.8 µM 1.62E-78 ERAD & cell cycle 5 1.07E-80
7 SGTC_888 0916-0002 17.50 7.0 µM 7.02E-67 NEO1 2 1.03E-68
8 SGTC_1991 st073000 16.90 8.9 µM 1.13E-62 NEO1 4 2.21E-64
9 SGTC_254 nsc-64875 16.30 3.8 µM 9.82E-59 ergosterol depletion effects on membrane 3 2.52E-60
10 SGTC_232 clozapine 16.30 119.0 µM 3.36E-58 NEO1 8 8.93E-60
11 SGTC_535 2293-4129 16.20 48.2 µM 8.95E-58 NEO1 3 2.45E-59
12 SGTC_649 1123-0311 16.00 367.0 µM 3.20E-56 endomembrane recycling 2 9.74E-58
13 SGTC_86 0417-1630 15.90 471.9 µM 1.07E-55 ubiquinone biosynthesis & proteasome 16 3.38E-57
14 SGTC_2697 mebhydrolin 14.40 72.4 µM 8.08E-46 NEO1 9 4.98E-47
15 SGTC_1797 st048695 14.10 56.8 µM 2.09E-44 NEO1 8 1.42E-45
16 SGTC_301 4119-0100 12.10 24.5 µM 6.12E-33 NEO1 10 8.98E-34
17 SGTC_788 1182-0090 12.00 188.0 µM 1.40E-32 endomembrane recycling 8 2.10E-33
18 SGTC_262 fenpropimorph 10.80 62.5 µM 9.41E-27 ergosterol depletion effects on membrane 3 2.08E-27
19 SGTC_887 0885-0007 10.40 9.6 µM 4.64E-25 endomembrane recycling 8 1.15E-25
20 SGTC_1754 st042065 10.30 16.1 µM 9.02E-25 NEO1-PIK1 22 2.27E-25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.733 0 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.685 0 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.574 1.78E-293 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.564 1.03E-280 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.518 1.18E-227 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.508 2.49E-219 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.506 7.89E-218 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.503 4.68E-214 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.494 8.54E-206 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.488 3.12E-200 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.476 4.62E-189 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.472 4.96E-185 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.470 1.44E-183 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.467 2.86E-181 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.457 6.47E-172 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication