YOR041C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR041C / YOR041C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:2.94|P-value:6.26E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.18|P-value:2.44E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.37|P-value:1.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.86|P-value:1.22E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.11|P-value:3.49E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.96|P-value:9.88E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:4.06|P-value:4.34E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:3.16|P-value:2.63E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.55|P-value:5.05E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.60|P-value:5.21E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.19|P-value:3.01E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.12|P-value:3.14E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.98|P-value:6.52E-6 ID:SGTC_1022|Compound:4477-0945|FD-Score:2.86|P-value:8.29E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.10|P-value:3.32E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:-2.93|P-value:8.21E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.91|P-value:7.14E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-2.93|P-value:8.32E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.51|P-value:6.06E-5 ID:SGTC_1526|Compound:st051518|FD-Score:2.93|P-value:6.62E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-4.10|P-value:4.92E-6 ID:SGTC_1540|Compound:guanosine|FD-Score:2.84|P-value:8.96E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.48|P-value:1.08E-9 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.67|P-value:2.87E-5 ID:SGTC_1554|Compound:st069299|FD-Score:5.47|P-value:1.13E-9 ID:SGTC_1555|Compound:citronellol|FD-Score:3.58|P-value:4.41E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:2.90|P-value:7.18E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.55|P-value:6.54E-5 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:6.44|P-value:1.04E-12 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.17|P-value:2.55E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.19|P-value:2.96E-4 ID:SGTC_1985|Compound:st071382|FD-Score:4.08|P-value:4.10E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-2.96|P-value:7.21E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.14|P-value:2.97E-6 ID:SGTC_2025|Compound:5147754|FD-Score:3.24|P-value:1.88E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.59|P-value:4.28E-5 ID:SGTC_2281|Compound:7943571|FD-Score:-3.41|P-value:1.21E-4 ID:SGTC_2391|Compound:6285546|FD-Score:2.85|P-value:8.64E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.26|P-value:1.79E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.40|P-value:9.76E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.61|P-value:4.97E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:2.83|P-value:9.50E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.52|P-value:3.95E-7 ID:SGTC_2694|Compound:st077685|FD-Score:-5.07|P-value:2.25E-8 ID:SGTC_2695|Compound:st077686|FD-Score:-3.20|P-value:2.86E-4 ID:SGTC_2786|Compound:7743617|FD-Score:2.88|P-value:7.93E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.34|P-value:1.23E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.88|P-value:6.87E-8 ID:SGTC_2891|Compound:9063876|FD-Score:3.13|P-value:2.98E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.07|P-value:4.80E-4 ID:SGTC_3150|Compound:9097574|FD-Score:2.91|P-value:7.03E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-6.28|P-value:5.84E-12 ID:SGTC_3304|Compound:9125678|FD-Score:-5.03|P-value:2.76E-8 ID:SGTC_3309|Compound:9129340|FD-Score:3.24|P-value:1.94E-4 ID:SGTC_3320|Compound:9137005|FD-Score:4.51|P-value:4.03E-7 ID:SGTC_3322|Compound:9139058|FD-Score:3.74|P-value:2.10E-5 ID:SGTC_3328|Compound:9140624|FD-Score:-3.95|P-value:1.06E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:2.94|P-value:6.26E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.18|P-value:2.44E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.37|P-value:1.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.86|P-value:1.22E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.11|P-value:3.49E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.96|P-value:9.88E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:4.06|P-value:4.34E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:3.16|P-value:2.63E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.55|P-value:5.05E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.60|P-value:5.21E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.19|P-value:3.01E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.12|P-value:3.14E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.98|P-value:6.52E-6 ID:SGTC_1022|Compound:4477-0945|FD-Score:2.86|P-value:8.29E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.10|P-value:3.32E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:-2.93|P-value:8.21E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.91|P-value:7.14E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-2.93|P-value:8.32E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.51|P-value:6.06E-5 ID:SGTC_1526|Compound:st051518|FD-Score:2.93|P-value:6.62E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-4.10|P-value:4.92E-6 ID:SGTC_1540|Compound:guanosine|FD-Score:2.84|P-value:8.96E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.48|P-value:1.08E-9 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.67|P-value:2.87E-5 ID:SGTC_1554|Compound:st069299|FD-Score:5.47|P-value:1.13E-9 ID:SGTC_1555|Compound:citronellol|FD-Score:3.58|P-value:4.41E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:2.90|P-value:7.18E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.55|P-value:6.54E-5 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:6.44|P-value:1.04E-12 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.17|P-value:2.55E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.19|P-value:2.96E-4 ID:SGTC_1985|Compound:st071382|FD-Score:4.08|P-value:4.10E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-2.96|P-value:7.21E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.14|P-value:2.97E-6 ID:SGTC_2025|Compound:5147754|FD-Score:3.24|P-value:1.88E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.59|P-value:4.28E-5 ID:SGTC_2281|Compound:7943571|FD-Score:-3.41|P-value:1.21E-4 ID:SGTC_2391|Compound:6285546|FD-Score:2.85|P-value:8.64E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.26|P-value:1.79E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.40|P-value:9.76E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.61|P-value:4.97E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:2.83|P-value:9.50E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.52|P-value:3.95E-7 ID:SGTC_2694|Compound:st077685|FD-Score:-5.07|P-value:2.25E-8 ID:SGTC_2695|Compound:st077686|FD-Score:-3.20|P-value:2.86E-4 ID:SGTC_2786|Compound:7743617|FD-Score:2.88|P-value:7.93E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.34|P-value:1.23E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.88|P-value:6.87E-8 ID:SGTC_2891|Compound:9063876|FD-Score:3.13|P-value:2.98E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.07|P-value:4.80E-4 ID:SGTC_3150|Compound:9097574|FD-Score:2.91|P-value:7.03E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-6.28|P-value:5.84E-12 ID:SGTC_3304|Compound:9125678|FD-Score:-5.03|P-value:2.76E-8 ID:SGTC_3309|Compound:9129340|FD-Score:3.24|P-value:1.94E-4 ID:SGTC_3320|Compound:9137005|FD-Score:4.51|P-value:4.03E-7 ID:SGTC_3322|Compound:9139058|FD-Score:3.74|P-value:2.10E-5 ID:SGTC_3328|Compound:9140624|FD-Score:-3.95|P-value:1.06E-5

Top fitness defect scores for YOR041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1560 lithocholic acid 6.44 53.1 µM 1.04E-12 1 5.96E-11
2 SGTC_1544 7-methoxy-4-methylcoumarin 5.48 105.0 µM 1.08E-9 5 2.13E-8
3 SGTC_1554 st069299 5.47 38.7 µM 1.13E-9 4 2.21E-8
4 SGTC_2615 purpurogallin-4-carboxylic acid 4.52 100.0 µM 3.95E-7 redox potentiating 48 3.16E-6
5 SGTC_3320 9137005 4.51 35.1 µM 4.03E-7 endomembrane recycling 7 3.21E-6
6 SGTC_2017 5132927 4.14 60.6 µM 2.97E-6 27 1.75E-5
7 SGTC_358 0075-0058 4.11 9.4 µM 3.49E-6 55 2.00E-5
8 SGTC_1985 st071382 4.08 65.5 µM 4.10E-6 15 2.30E-5
9 SGTC_504 lovastatin 4.06 124.0 µM 4.34E-6 10 2.41E-5
10 SGTC_973 1325-0077 3.98 65.9 µM 6.52E-6 6 3.41E-5
11 SGTC_95 0471-0001 3.86 561.1 µM 1.22E-5 28 5.78E-5
12 SGTC_3322 9139058 3.74 2.1 µM 2.10E-5 cell wall 35 9.18E-5
13 SGTC_1551 6-bromo-3'-methylflavone 3.67 63.5 µM 2.87E-5 26 1.20E-4
14 SGTC_2042 p-Dimethylaminoacetophenone 3.59 200.0 µM 4.28E-5 29 1.68E-4
15 SGTC_1555 citronellol 3.58 128.0 µM 4.41E-5 9 1.73E-4
16 SGTC_544 k015-0020 3.55 52.4 µM 5.05E-5 18 1.94E-4
17 SGTC_1514 1189-1591 3.51 158.0 µM 6.06E-5 55 2.26E-4
18 SGTC_2584 androsterone 3.40 48.7 µM 9.76E-5 cell wall 167 3.39E-4
19 SGTC_73 0327-0325 3.37 16.2 µM 1.12E-4 DNA damage response 73 3.80E-4
20 SGTC_2834 9001755 3.34 58.4 µM 1.23E-4 58 4.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.57E-13 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.116 1.91E-11 YJR150C DAN1 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
0.112 7.80E-11 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.108 3.79E-10 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.105 9.66E-10 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.098 1.28E-8 YNR021W_p YNR021W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
0.092 8.16E-8 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.082 2.01E-6 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.27E-6 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.081 2.94E-6 YNL072W RNH201 hom Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome
0.081 2.96E-6 YPL124W SPC29 het Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication
0.079 4.13E-6 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.079 4.92E-6 YKR044W UIP5 hom Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
0.079 5.24E-6 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.074 1.61E-5 YGR059W SPR3 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI