HIPHOP chemogenomics database
YOR041C_d 
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR041C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.127 | 1.57E-13 | YDL234C | GYP7 | hom | GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking |
| 0.116 | 1.91E-11 | YJR150C | DAN1 | hom | Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth |
| 0.112 | 7.80E-11 | YKL004W | AUR1 | het | Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance |
| 0.108 | 3.79E-10 | YLR212C | TUB4 | het | Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress |
| 0.105 | 9.66E-10 | YGL067W | NPY1 | hom | NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member |
| 0.098 | 1.28E-8 | YNR021W_p | YNR021W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene |
| 0.092 | 8.16E-8 | YJR011C_p | YJR011C_p | hom | Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS |
| 0.082 | 2.01E-6 | YBR134W_d | YBR134W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.082 | 2.27E-6 | YGR197C | SNG1 | hom | Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance |
| 0.081 | 2.94E-6 | YNL072W | RNH201 | hom | Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome |
| 0.081 | 2.96E-6 | YPL124W | SPC29 | het | Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication |
| 0.079 | 4.13E-6 | YML119W_p | YML119W_p | hom | Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate |
| 0.079 | 4.92E-6 | YKR044W | UIP5 | hom | Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates |
| 0.079 | 5.24E-6 | YNL104C | LEU4 | hom | Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication |
| 0.074 | 1.61E-5 | YGR059W | SPR3 | hom | Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI |