YOR042W / CUE5

Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR042W / CUE5

Click on Significant Values for Screen Details ID:SGTC_337|Compound:1315-0038|FD-Score:3.40|P-value:6.07E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:4.27|P-value:2.51E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-5.46|P-value:1.27E-7 ID:SGTC_753|Compound:1322-0200|FD-Score:3.91|P-value:1.04E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.53|P-value:8.39E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.30|P-value:8.48E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.48|P-value:5.25E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.70|P-value:1.05E-10 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.36|P-value:1.73E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-4.29|P-value:2.63E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:4.11|P-value:4.70E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:5.48|P-value:9.90E-8 ID:SGTC_1634|Compound:st006576|FD-Score:5.11|P-value:6.04E-7 ID:SGTC_1635|Compound:st007035|FD-Score:3.83|P-value:1.37E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.50|P-value:9.73E-6 ID:SGTC_1804|Compound:st050076|FD-Score:-4.46|P-value:1.29E-5 ID:SGTC_1817|Compound:st052116|FD-Score:-3.47|P-value:5.49E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.28|P-value:9.23E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-4.22|P-value:3.42E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-3.74|P-value:2.12E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.74|P-value:3.35E-6 ID:SGTC_2105|Compound:5350118|FD-Score:5.08|P-value:7.25E-7 ID:SGTC_2113|Compound:5491891|FD-Score:3.68|P-value:2.39E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.71|P-value:2.13E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.80|P-value:1.53E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.37|P-value:6.73E-4 ID:SGTC_2348|Compound:9022543|FD-Score:5.58|P-value:6.06E-8 ID:SGTC_2350|Compound:9023895|FD-Score:3.56|P-value:3.58E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.33|P-value:7.82E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.57|P-value:3.49E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.74|P-value:2.16E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:4.90|P-value:1.67E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:6.75|P-value:7.50E-11 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:6.09|P-value:3.70E-9 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.32|P-value:7.96E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.31|P-value:8.16E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-4.02|P-value:7.64E-5 ID:SGTC_2928|Compound:9011484|FD-Score:6.35|P-value:8.69E-10 ID:SGTC_2937|Compound:9044753|FD-Score:6.97|P-value:1.97E-11 ID:SGTC_2952|Compound:9073731|FD-Score:4.26|P-value:2.55E-5 ID:SGTC_2982|Compound:9019404|FD-Score:3.62|P-value:2.86E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.73|P-value:1.99E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.77|P-value:1.67E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.46|P-value:5.05E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.40|P-value:6.07E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:4.27|P-value:2.51E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-5.46|P-value:1.27E-7 ID:SGTC_753|Compound:1322-0200|FD-Score:3.91|P-value:1.04E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.53|P-value:8.39E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.30|P-value:8.48E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.48|P-value:5.25E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.70|P-value:1.05E-10 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.36|P-value:1.73E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-4.29|P-value:2.63E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:4.11|P-value:4.70E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:5.48|P-value:9.90E-8 ID:SGTC_1634|Compound:st006576|FD-Score:5.11|P-value:6.04E-7 ID:SGTC_1635|Compound:st007035|FD-Score:3.83|P-value:1.37E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.50|P-value:9.73E-6 ID:SGTC_1804|Compound:st050076|FD-Score:-4.46|P-value:1.29E-5 ID:SGTC_1817|Compound:st052116|FD-Score:-3.47|P-value:5.49E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.28|P-value:9.23E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-4.22|P-value:3.42E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-3.74|P-value:2.12E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.74|P-value:3.35E-6 ID:SGTC_2105|Compound:5350118|FD-Score:5.08|P-value:7.25E-7 ID:SGTC_2113|Compound:5491891|FD-Score:3.68|P-value:2.39E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.71|P-value:2.13E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.80|P-value:1.53E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.37|P-value:6.73E-4 ID:SGTC_2348|Compound:9022543|FD-Score:5.58|P-value:6.06E-8 ID:SGTC_2350|Compound:9023895|FD-Score:3.56|P-value:3.58E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.33|P-value:7.82E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.57|P-value:3.49E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.74|P-value:2.16E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:4.90|P-value:1.67E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:6.75|P-value:7.50E-11 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:6.09|P-value:3.70E-9 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.32|P-value:7.96E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.31|P-value:8.16E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-4.02|P-value:7.64E-5 ID:SGTC_2928|Compound:9011484|FD-Score:6.35|P-value:8.69E-10 ID:SGTC_2937|Compound:9044753|FD-Score:6.97|P-value:1.97E-11 ID:SGTC_2952|Compound:9073731|FD-Score:4.26|P-value:2.55E-5 ID:SGTC_2982|Compound:9019404|FD-Score:3.62|P-value:2.86E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.73|P-value:1.99E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.77|P-value:1.67E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.46|P-value:5.05E-4

Top fitness defect scores for YOR042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2937 9044753 6.97 11.3 µM 1.97E-11 60S ribosome export 4 1.63E-12
2 SGTC_2552 juarezic acid 6.75 87.0 µM 7.50E-11 TSC3-RPN4 3 7.21E-12
3 SGTC_1134 3477-0009 6.70 42.5 µM 1.05E-10 6 1.05E-11
4 SGTC_2928 9011484 6.35 9.8 µM 8.69E-10 heme biosynthesis & mitochondrial translocase 6 1.10E-10
5 SGTC_2559 tetrahydrosappanone a trimethyl ether 6.09 100.0 µM 3.70E-9 1 5.49E-10
6 SGTC_2348 9022543 5.58 33.4 µM 6.06E-8 mitochondrial processes 8 1.23E-8
7 SGTC_1575 cyproterone acetate 5.48 48.0 µM 9.90E-8 4 2.12E-8
8 SGTC_1634 st006576 5.11 41.0 µM 6.04E-7 TSC3-RPN4 9 1.58E-7
9 SGTC_2105 5350118 5.08 200.0 µM 7.25E-7 10 1.93E-7
10 SGTC_2518 prenyletin 4.90 46.3 µM 1.67E-6 4 4.87E-7
11 SGTC_2005 4024620 4.74 188.0 µM 3.35E-6 9 1.05E-6
12 SGTC_881 0833-0569 4.53 170.0 µM 8.39E-6 13 2.91E-6
13 SGTC_1734 st037168 4.50 69.4 µM 9.73E-6 12 3.43E-6
14 SGTC_1282 0886-0010 4.36 32.4 µM 1.73E-5 endomembrane recycling 26 6.49E-6
15 SGTC_724 3910-0327 4.27 137.0 µM 2.51E-5 ERG2 14 9.80E-6
16 SGTC_2952 9073731 4.26 13.8 µM 2.55E-5 tubulin folding & SWR complex 34 1.00E-5
17 SGTC_1540 guanosine 4.11 70.6 µM 4.70E-5 7 1.96E-5
18 SGTC_753 1322-0200 3.91 289.0 µM 1.04E-4 22 4.71E-5
19 SGTC_1059 3448-6867 3.83 171.0 µM 1.35E-4 13 6.29E-5
20 SGTC_1635 st007035 3.83 42.4 µM 1.37E-4 220 6.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 8.48E-25 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.115 2.32E-11 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.098 1.29E-8 YGR005C TFG2 het TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
0.097 1.90E-8 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.092 8.11E-8 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.092 1.03E-7 YIL014W MNT3 hom Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
0.087 4.14E-7 YOR161C-C_p YOR161C-C_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.087 4.56E-7 YHR136C SPL2 hom Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm
0.085 7.92E-7 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.083 1.36E-6 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.083 1.60E-6 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.082 2.14E-6 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.081 2.40E-6 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.078 5.62E-6 YIL085C KTR7 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication
0.076 1.15E-5 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p