YOR043W / WHI2

Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR043W / WHI2

Click on Significant Values for Screen Details ID:SGTC_108|Compound:0509-0257|FD-Score:4.20|P-value:4.30E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:7.05|P-value:5.31E-14 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.09|P-value:7.56E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.55|P-value:8.21E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.77|P-value:3.15E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.35|P-value:1.82E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.65|P-value:2.71E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:6.33|P-value:1.25E-11 ID:SGTC_547|Compound:1120-0019|FD-Score:3.74|P-value:3.57E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:2.96|P-value:7.97E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.42|P-value:1.38E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.08|P-value:7.50E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.44|P-value:2.07E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.50|P-value:9.81E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.34|P-value:1.88E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.15|P-value:5.37E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.67|P-value:7.86E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.28|P-value:2.39E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:2.95|P-value:8.23E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.34|P-value:1.91E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.44|P-value:1.27E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.59|P-value:6.92E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.65|P-value:3.94E-16 ID:SGTC_1686|Compound:st019653|FD-Score:4.15|P-value:5.38E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.05|P-value:5.76E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.49|P-value:6.85E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.51|P-value:1.54E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.63|P-value:5.91E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.57|P-value:7.45E-5 ID:SGTC_2121|Compound:5257820|FD-Score:2.93|P-value:8.89E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-3.15|P-value:6.17E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-4.27|P-value:5.45E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.63|P-value:5.73E-5 ID:SGTC_2414|Compound:st077232|FD-Score:-3.32|P-value:3.26E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.15|P-value:4.06E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.20|P-value:3.35E-4 ID:SGTC_2462|Compound:5162487|FD-Score:2.92|P-value:9.29E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.69|P-value:4.51E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.45|P-value:2.00E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.61|P-value:6.23E-5 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.58|P-value:7.03E-5 ID:SGTC_2693|Compound:st077581|FD-Score:4.00|P-value:1.13E-5 ID:SGTC_2791|Compound:5663188|FD-Score:4.48|P-value:1.06E-6 ID:SGTC_2805|Compound:7950783|FD-Score:-3.45|P-value:1.94E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.71|P-value:4.07E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:4.20|P-value:4.30E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:7.05|P-value:5.31E-14 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.09|P-value:7.56E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.55|P-value:8.21E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.77|P-value:3.15E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.35|P-value:1.82E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.65|P-value:2.71E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:6.33|P-value:1.25E-11 ID:SGTC_547|Compound:1120-0019|FD-Score:3.74|P-value:3.57E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:2.96|P-value:7.97E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.42|P-value:1.38E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.08|P-value:7.50E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.44|P-value:2.07E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.50|P-value:9.81E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.34|P-value:1.88E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.15|P-value:5.37E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.67|P-value:7.86E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.28|P-value:2.39E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:2.95|P-value:8.23E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.34|P-value:1.91E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.44|P-value:1.27E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.59|P-value:6.92E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.65|P-value:3.94E-16 ID:SGTC_1686|Compound:st019653|FD-Score:4.15|P-value:5.38E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.05|P-value:5.76E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.49|P-value:6.85E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.51|P-value:1.54E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.63|P-value:5.91E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.57|P-value:7.45E-5 ID:SGTC_2121|Compound:5257820|FD-Score:2.93|P-value:8.89E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-3.15|P-value:6.17E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-4.27|P-value:5.45E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.63|P-value:5.73E-5 ID:SGTC_2414|Compound:st077232|FD-Score:-3.32|P-value:3.26E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.15|P-value:4.06E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.20|P-value:3.35E-4 ID:SGTC_2462|Compound:5162487|FD-Score:2.92|P-value:9.29E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.69|P-value:4.51E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.45|P-value:2.00E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.61|P-value:6.23E-5 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.58|P-value:7.03E-5 ID:SGTC_2693|Compound:st077581|FD-Score:4.00|P-value:1.13E-5 ID:SGTC_2791|Compound:5663188|FD-Score:4.48|P-value:1.06E-6 ID:SGTC_2805|Compound:7950783|FD-Score:-3.45|P-value:1.94E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.71|P-value:4.07E-5

Top fitness defect scores for YOR043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 7.65 42.4 µM 3.94E-16 100 1.01E-14
2 SGTC_168 3970-0862 7.05 530.5 µM 5.31E-14 29 8.72E-13
3 SGTC_528 3492-0019 6.33 172.0 µM 1.25E-11 calcium & mitochondrial duress 114 1.25E-10
4 SGTC_2791 5663188 4.48 71.4 µM 1.06E-6 RPP1 & pyrimidine depletion 13 3.75E-6
5 SGTC_108 0509-0257 4.20 621.1 µM 4.30E-6 42 1.34E-5
6 SGTC_1097 itavastatin 4.15 7.2 µM 5.37E-6 azole & statin 17 1.64E-5
7 SGTC_1686 st019653 4.15 115.5 µM 5.38E-6 mitochondrial processes 9 1.64E-5
8 SGTC_940 3232-1287 4.08 54.8 µM 7.50E-6 NEO1 33 2.22E-5
9 SGTC_2693 st077581 4.00 40.7 µM 1.13E-5 33 3.21E-5
10 SGTC_396 dithiazanine 3.77 1.2 µM 3.15E-5 8 8.17E-5
11 SGTC_547 1120-0019 3.74 610.0 nM 3.57E-5 azole & statin 37 9.13E-5
12 SGTC_2829 7992743 3.71 58.4 µM 4.07E-5 47 1.03E-4
13 SGTC_2566 crystal violet carbinol 3.69 226.0 nM 4.51E-5 49 1.13E-4
14 SGTC_2329 6138490 3.63 200.0 µM 5.73E-5 43 1.40E-4
15 SGTC_1800 st050079 3.63 29.1 µM 5.91E-5 NEO1-PIK1 146 1.44E-4
16 SGTC_2576 guaiol 3.61 23.1 µM 6.23E-5 37 1.52E-4
17 SGTC_1603 st002045 3.59 67.8 µM 6.92E-5 TSC3-RPN4 21 1.67E-4
18 SGTC_2670 beta-carotene 3.58 100.0 µM 7.03E-5 3 1.69E-4
19 SGTC_2021 4019055 3.57 173.0 µM 7.45E-5 endomembrane recycling 146 1.78E-4
20 SGTC_377 3970-0964 3.55 33.1 µM 8.21E-5 61 1.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 2.85E-57 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.260 7.29E-53 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.237 3.89E-44 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.233 1.99E-42 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.227 1.89E-40 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.217 3.33E-37 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.215 2.04E-36 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.214 5.24E-36 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.203 1.13E-32 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.190 1.09E-28 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.183 1.50E-26 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.180 9.77E-26 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.178 2.20E-25 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.177 4.72E-25 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.176 9.02E-25 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes