YOR044W / IRC23

Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR044W / IRC23

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:6.18|P-value:1.04E-10 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.90|P-value:3.42E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.13|P-value:6.25E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.13|P-value:6.30E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.18|P-value:5.30E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.20|P-value:4.97E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.27|P-value:4.24E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.38|P-value:2.73E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.06|P-value:8.03E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.06|P-value:8.89E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.37|P-value:2.93E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.01|P-value:9.55E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:5.17|P-value:5.39E-8 ID:SGTC_935|Compound:2996-0153|FD-Score:3.67|P-value:7.80E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:4.62|P-value:1.01E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.35|P-value:2.83E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:-3.38|P-value:2.72E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.64|P-value:9.16E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.16|P-value:6.25E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.18|P-value:5.76E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.64|P-value:8.88E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.02|P-value:1.25E-7 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.31|P-value:3.63E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:5.44|P-value:1.09E-8 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.00|P-value:1.93E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-3.71|P-value:7.55E-5 ID:SGTC_1737|Compound:st035557|FD-Score:3.25|P-value:4.03E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.27|P-value:4.13E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.53|P-value:1.38E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.90|P-value:2.97E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.34|P-value:2.96E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.19|P-value:5.15E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.26|P-value:3.28E-8 ID:SGTC_1981|Compound:st071826|FD-Score:-3.08|P-value:8.23E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.29|P-value:3.50E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.31|P-value:3.62E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.50|P-value:1.89E-6 ID:SGTC_2106|Compound:5357045|FD-Score:5.32|P-value:2.27E-8 ID:SGTC_2108|Compound:5365811|FD-Score:-3.14|P-value:6.81E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.33|P-value:3.36E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.09|P-value:8.10E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.10|P-value:6.95E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.01|P-value:9.60E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.12|P-value:7.19E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.23|P-value:6.65E-6 ID:SGTC_2977|Compound:9011197|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.30|P-value:3.39E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.44|P-value:2.18E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.10|P-value:7.61E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:6.18|P-value:1.04E-10 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.90|P-value:3.42E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.13|P-value:6.25E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.13|P-value:6.30E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.18|P-value:5.30E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.20|P-value:4.97E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.27|P-value:4.24E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.38|P-value:2.73E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.06|P-value:8.03E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.06|P-value:8.89E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.37|P-value:2.93E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.01|P-value:9.55E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:5.17|P-value:5.39E-8 ID:SGTC_935|Compound:2996-0153|FD-Score:3.67|P-value:7.80E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:4.62|P-value:1.01E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.35|P-value:2.83E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:-3.38|P-value:2.72E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.64|P-value:9.16E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.16|P-value:6.25E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.18|P-value:5.76E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.64|P-value:8.88E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.02|P-value:1.25E-7 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.31|P-value:3.63E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:5.44|P-value:1.09E-8 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.00|P-value:1.93E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-3.71|P-value:7.55E-5 ID:SGTC_1737|Compound:st035557|FD-Score:3.25|P-value:4.03E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.27|P-value:4.13E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.53|P-value:1.38E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.90|P-value:2.97E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.34|P-value:2.96E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.19|P-value:5.15E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.26|P-value:3.28E-8 ID:SGTC_1981|Compound:st071826|FD-Score:-3.08|P-value:8.23E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.29|P-value:3.50E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.31|P-value:3.62E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.50|P-value:1.89E-6 ID:SGTC_2106|Compound:5357045|FD-Score:5.32|P-value:2.27E-8 ID:SGTC_2108|Compound:5365811|FD-Score:-3.14|P-value:6.81E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.33|P-value:3.36E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.09|P-value:8.10E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.10|P-value:6.95E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.01|P-value:9.60E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.12|P-value:7.19E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.23|P-value:6.65E-6 ID:SGTC_2977|Compound:9011197|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.30|P-value:3.39E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.44|P-value:2.18E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.10|P-value:7.61E-4

Top fitness defect scores for YOR044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_74 000s-0487 6.18 160.3 µM 1.04E-10 6 3.11E-10
2 SGTC_1578 josamycin 5.44 24.2 µM 1.09E-8 3 2.59E-8
3 SGTC_2106 5357045 5.32 167.3 µM 2.27E-8 4 5.20E-8
4 SGTC_1908 st060353 5.26 56.5 µM 3.28E-8 RPP1 & pyrimidine depletion 17 7.38E-8
5 SGTC_749 1000-0129 5.17 128.0 µM 5.39E-8 amide catabolism 3 1.18E-7
6 SGTC_1258 0671-0043 5.02 57.1 µM 1.25E-7 7 2.62E-7
7 SGTC_965 1291-5240 4.62 308.0 µM 1.01E-6 17 1.92E-6
8 SGTC_2088 5278280 4.50 127.4 µM 1.89E-6 11 3.46E-6
9 SGTC_2960 9079389 4.23 6.0 µM 6.65E-6 22 1.15E-5
10 SGTC_1586 deoxycorticosterone acetate 4.00 53.7 µM 1.93E-5 8 3.16E-5
11 SGTC_1805 st050013 3.90 60.3 µM 2.97E-5 8 4.76E-5
12 SGTC_935 2996-0153 3.67 430.0 µM 7.80E-5 PDR1 26 1.19E-4
13 SGTC_1239 0337-0584 3.64 35.4 µM 8.88E-5 unfolded protein response 69 1.35E-4
14 SGTC_1080 nisoldipine 3.64 24.4 µM 9.16E-5 TSC3-RPN4 37 1.39E-4
15 SGTC_1792 st045773 3.53 43.6 µM 1.38E-4 44 2.06E-4
16 SGTC_1421 4029-0249 3.52 71.4 µM 1.44E-4 28 2.14E-4
17 SGTC_3333 9141820 3.44 12.1 µM 1.97E-4 26 2.88E-4
18 SGTC_1071 trifluoperazine 3.35 6.3 µM 2.83E-4 43 4.05E-4
19 SGTC_1806 st050005 3.34 60.3 µM 2.96E-4 37 4.24E-4
20 SGTC_3117 9124945 3.30 49.5 µM 3.39E-4 16 4.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.53E-11 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.103 1.93E-9 YDR156W RPA14 hom RNA polymerase I subunit A14
0.096 2.85E-8 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.095 3.11E-8 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.094 5.46E-8 YPR144C NOC4 het Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
0.090 1.88E-7 YAL048C GEM1 hom Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases
0.089 2.15E-7 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.080 3.82E-6 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.078 6.90E-6 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.077 7.62E-6 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.077 8.96E-6 YMR236W TAF9 het Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
0.074 1.61E-5 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.072 2.82E-5 YDR322C-A TIM11 hom Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
0.070 5.53E-5 YCL063W VAC17 hom Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p
0.069 6.28E-5 YOR244W ESA1 het Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy