YOR045W / TOM6

Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR045W / TOM6

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.43|P-value:2.16E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.60|P-value:1.08E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.68|P-value:7.98E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.53|P-value:1.47E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.04|P-value:8.59E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.76|P-value:5.64E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.02|P-value:9.09E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.56|P-value:1.22E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.03|P-value:8.89E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.63|P-value:9.86E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.84|P-value:4.17E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.22|P-value:4.77E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.50|P-value:1.65E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.54|P-value:1.41E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.08|P-value:8.08E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.36|P-value:2.59E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.30|P-value:3.55E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.80|P-value:4.46E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.33|P-value:3.17E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.18|P-value:5.22E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.68|P-value:7.77E-7 ID:SGTC_1782|Compound:st039423|FD-Score:-3.01|P-value:9.36E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.47|P-value:1.72E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.61|P-value:1.08E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.06|P-value:8.56E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.94|P-value:2.70E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-5.57|P-value:4.77E-9 ID:SGTC_2070|Compound:5230947|FD-Score:-3.11|P-value:6.68E-4 ID:SGTC_2166|Compound:5933061|FD-Score:7.17|P-value:9.16E-14 ID:SGTC_2202|Compound:7226349|FD-Score:3.02|P-value:9.92E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.29|P-value:3.78E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.40|P-value:2.49E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.09|P-value:7.21E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.69|P-value:7.14E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.02|P-value:9.82E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.02|P-value:9.77E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.19|P-value:8.41E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.10|P-value:6.98E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.35|P-value:2.78E-4 ID:SGTC_2940|Compound:9060638|FD-Score:5.06|P-value:1.05E-7 ID:SGTC_3054|Compound:9094397|FD-Score:3.05|P-value:8.86E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.14|P-value:6.38E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.45|P-value:1.99E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.07|P-value:8.17E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.77|P-value:5.45E-5 ID:SGTC_3315|Compound:9136395|FD-Score:-3.00|P-value:9.94E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.43|P-value:2.16E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.60|P-value:1.08E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.68|P-value:7.98E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.53|P-value:1.47E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.04|P-value:8.59E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.76|P-value:5.64E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.02|P-value:9.09E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.56|P-value:1.22E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.03|P-value:8.89E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.63|P-value:9.86E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.84|P-value:4.17E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.22|P-value:4.77E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.50|P-value:1.65E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.54|P-value:1.41E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.08|P-value:8.08E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.36|P-value:2.59E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.30|P-value:3.55E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.80|P-value:4.46E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.33|P-value:3.17E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.18|P-value:5.22E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.68|P-value:7.77E-7 ID:SGTC_1782|Compound:st039423|FD-Score:-3.01|P-value:9.36E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.47|P-value:1.72E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.61|P-value:1.08E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.06|P-value:8.56E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.94|P-value:2.70E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-5.57|P-value:4.77E-9 ID:SGTC_2070|Compound:5230947|FD-Score:-3.11|P-value:6.68E-4 ID:SGTC_2166|Compound:5933061|FD-Score:7.17|P-value:9.16E-14 ID:SGTC_2202|Compound:7226349|FD-Score:3.02|P-value:9.92E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.29|P-value:3.78E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.40|P-value:2.49E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.09|P-value:7.21E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.69|P-value:7.14E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.02|P-value:9.82E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.02|P-value:9.77E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.19|P-value:8.41E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.10|P-value:6.98E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.35|P-value:2.78E-4 ID:SGTC_2940|Compound:9060638|FD-Score:5.06|P-value:1.05E-7 ID:SGTC_3054|Compound:9094397|FD-Score:3.05|P-value:8.86E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.14|P-value:6.38E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.45|P-value:1.99E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.07|P-value:8.17E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.77|P-value:5.45E-5 ID:SGTC_3315|Compound:9136395|FD-Score:-3.00|P-value:9.94E-4

Top fitness defect scores for YOR045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2166 5933061 7.17 31.5 µM 9.16E-14 tubulin folding & SWR complex 7 3.85E-13
2 SGTC_2940 9060638 5.06 45.9 µM 1.05E-7 amide catabolism 7 2.13E-7
3 SGTC_1510 1123-0200 4.68 71.5 µM 7.77E-7 28 1.43E-6
4 SGTC_2660 2',4'-dihydroxychalcone 4.19 17.1 µM 8.41E-6 13 1.37E-5
5 SGTC_2066 5222451 3.94 176.0 µM 2.70E-5 heme biosynthesis & mitochondrial translocase 30 4.14E-5
6 SGTC_693 4161-2696 3.84 114.0 µM 4.17E-5 12 6.26E-5
7 SGTC_3304 9125678 3.77 46.1 µM 5.45E-5 58 8.08E-5
8 SGTC_451 chloral hydrate 3.76 100.0 µM 5.64E-5 62 8.35E-5
9 SGTC_63 0099-0242 3.68 26.7 µM 7.98E-5 mitochondrial stress 101 1.16E-4
10 SGTC_685 1278-0033 3.63 54.9 µM 9.86E-5 60S ribosome export 32 1.42E-4
11 SGTC_2045 5106652 3.61 78.0 µM 1.08E-4 21 1.55E-4
12 SGTC_711 k292-0785 3.54 179.0 µM 1.41E-4 DNA intercalators 34 1.99E-4
13 SGTC_178 4092-0806 3.53 87.5 µM 1.47E-4 ergosterol depletion effects on membrane 119 2.07E-4
14 SGTC_167 3672-0051 3.52 66.2 µM 1.53E-4 54 2.16E-4
15 SGTC_706 4262-0057 3.50 46.9 µM 1.65E-4 fatty acid desaturase (OLE1) 53 2.32E-4
16 SGTC_3114 9122766 3.45 49.5 µM 1.99E-4 33 2.77E-4
17 SGTC_14 0354-0009 3.43 295.0 µM 2.16E-4 43 2.99E-4
18 SGTC_2383 9036125 3.40 200.0 µM 2.49E-4 14 3.42E-4
19 SGTC_1363 1636-0063 3.33 10.4 µM 3.17E-4 Golgi 51 4.31E-4
20 SGTC_1255 0566-0045 3.30 221.0 µM 3.55E-4 excess fatty acid 51 4.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.29E-29 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.149 4.12E-18 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.120 3.67E-12 YNR034W SOL1 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.117 9.70E-12 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.112 9.37E-11 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.110 1.60E-10 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.106 8.39E-10 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.105 1.26E-9 YDR438W THI74 hom Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
0.102 2.82E-9 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.101 4.97E-9 YFR011C AIM13 hom Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.100 6.94E-9 YLR109W AHP1 hom Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
0.098 1.45E-8 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.098 1.46E-8 YDR156W RPA14 hom RNA polymerase I subunit A14
0.088 3.06E-7 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.087 4.32E-7 YER060W FCY21 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function