YOR046C / DBP5

Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR046C / DBP5

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.54|P-value:9.76E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.11|P-value:5.28E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:4.19|P-value:5.12E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.03|P-value:8.17E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.61|P-value:8.54E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.01|P-value:8.66E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.18|P-value:3.98E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.11|P-value:5.28E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.13|P-value:5.69E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-2.99|P-value:9.21E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:2.95|P-value:9.33E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.64|P-value:6.37E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.33|P-value:2.27E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:4.50|P-value:1.12E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.43|P-value:1.62E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.97|P-value:1.77E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:2.98|P-value:8.25E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.07|P-value:7.06E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.72|P-value:4.47E-5 ID:SGTC_1799|Compound:st045822|FD-Score:3.07|P-value:6.10E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.21|P-value:3.59E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.03|P-value:7.96E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.35|P-value:2.41E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.10|P-value:5.50E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.02|P-value:8.26E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.33|P-value:2.60E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.10|P-value:6.33E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-4.05|P-value:1.25E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.06|P-value:6.30E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.37|P-value:1.94E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.03|P-value:8.10E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.26|P-value:2.93E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.20|P-value:4.31E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.33|P-value:2.28E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-4.91|P-value:1.55E-7 ID:SGTC_3147|Compound:9097027|FD-Score:-3.40|P-value:1.97E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.93|P-value:1.77E-5 ID:SGTC_3199|Compound:9111318|FD-Score:4.19|P-value:5.15E-6 ID:SGTC_3268|Compound:9137683|FD-Score:-3.46|P-value:1.57E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-6.56|P-value:3.77E-12 ID:SGTC_1|Compound:0258-0098|FD-Score:3.54|P-value:9.76E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.11|P-value:5.28E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:4.19|P-value:5.12E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.03|P-value:8.17E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.61|P-value:8.54E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.01|P-value:8.66E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.18|P-value:3.98E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.11|P-value:5.28E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.13|P-value:5.69E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-2.99|P-value:9.21E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:2.95|P-value:9.33E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.64|P-value:6.37E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.33|P-value:2.27E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:4.50|P-value:1.12E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.43|P-value:1.62E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.97|P-value:1.77E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:2.98|P-value:8.25E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.07|P-value:7.06E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.72|P-value:4.47E-5 ID:SGTC_1799|Compound:st045822|FD-Score:3.07|P-value:6.10E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.21|P-value:3.59E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.03|P-value:7.96E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.35|P-value:2.41E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.10|P-value:5.50E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.02|P-value:8.26E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.33|P-value:2.60E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.10|P-value:6.33E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-4.05|P-value:1.25E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.06|P-value:6.30E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.37|P-value:1.94E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.03|P-value:8.10E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.26|P-value:2.93E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.20|P-value:4.31E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.33|P-value:2.28E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-4.91|P-value:1.55E-7 ID:SGTC_3147|Compound:9097027|FD-Score:-3.40|P-value:1.97E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.93|P-value:1.77E-5 ID:SGTC_3199|Compound:9111318|FD-Score:4.19|P-value:5.15E-6 ID:SGTC_3268|Compound:9137683|FD-Score:-3.46|P-value:1.57E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-6.56|P-value:3.77E-12

Top fitness defect scores for YOR046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_867 0518-0118 4.50 155.0 µM 1.12E-6 DNA intercalators 11 3.45E-6 0.68
2 SGTC_1075 aripiprazole 4.43 15.2 µM 1.62E-6 3 4.82E-6 0.10
3 SGTC_2445 5742597 4.33 35.6 µM 2.60E-6 3 7.44E-6 0.01
4 SGTC_24 0417-1663 4.19 219.0 µM 5.12E-6 1 1.38E-5 0.68
5 SGTC_3199 9111318 4.19 49.5 µM 5.15E-6 10 1.39E-5 0.53
6 SGTC_3190 9110366 3.93 49.5 µM 1.77E-5 3 4.27E-5 0.05
7 SGTC_1755 st041960 3.72 45.2 µM 4.47E-5 10 9.93E-5 0.20
8 SGTC_716 1683-5115 3.64 658.0 µM 6.37E-5 5 1.37E-4 0.13
9 SGTC_1 0258-0098 3.54 57.4 µM 9.76E-5 heme biosynthesis & mitochondrial translocase 22 2.02E-4 0.17
10 SGTC_2576 guaiol 3.37 23.1 µM 1.94E-4 16 3.79E-4 0.03
11 SGTC_717 1532-0246 3.33 73.2 µM 2.27E-4 Golgi 13 4.38E-4 0.06
12 SGTC_3058 9093861 3.33 49.5 µM 2.28E-4 7 4.39E-4 0.08
13 SGTC_2873 9040596 3.26 71.4 µM 2.93E-4 15 5.52E-4 0.07
14 SGTC_1841 st054148 3.21 70.0 µM 3.59E-4 9 6.65E-4 0.03
15 SGTC_234 nsc-17383 3.18 10.7 µM 3.98E-4 ERG2 13 7.29E-4 0.04
16 SGTC_314 1671-0008 3.11 2.7 µM 5.28E-4 23 9.44E-4 0.02
17 SGTC_19 0279-0214 3.11 38.4 µM 5.28E-4 TRP & mitochondrial translation 9 9.45E-4 0.03
18 SGTC_2407 paclitaxel 3.10 400.0 µM 5.50E-4 15 9.80E-4 0.07
19 SGTC_1799 st045822 3.07 46.1 µM 6.10E-4 8 0.00108 0.24
20 SGTC_2573 2',4'-dihydroxychalcone 3.06 15.0 µM 6.30E-4 21 0.00111 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.14E-12 YFL050C ALR2 hom Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
0.115 2.99E-11 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
0.111 1.37E-10 YLR079W SIC1 hom Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.092 8.10E-8 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.086 5.98E-7 YHR074W QNS1 het Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
0.081 2.55E-6 YDL211C_p YDL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.080 3.64E-6 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.078 6.58E-6 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.077 8.16E-6 YJL011C RPC17 het RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress
0.077 8.63E-6 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.076 1.15E-5 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.076 1.19E-5 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.074 1.62E-5 YOR303W CPA1 hom Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
0.074 1.69E-5 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.073 2.14E-5 YHR057C CPR2 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway