YOR048C / RAT1

Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR048C / RAT1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.86|P-value:3.69E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:4.06|P-value:8.74E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.89|P-value:2.37E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.00|P-value:1.10E-13 ID:SGTC_201|Compound:4262-0159|FD-Score:7.26|P-value:1.34E-11 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.94|P-value:2.41E-8 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.67|P-value:3.49E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.40|P-value:2.09E-9 ID:SGTC_320|Compound:4092-0846|FD-Score:5.90|P-value:2.87E-8 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.62|P-value:5.84E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.40|P-value:2.44E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.61|P-value:5.96E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.99|P-value:1.68E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.70|P-value:4.48E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.74|P-value:3.90E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:-3.72|P-value:4.19E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.53|P-value:5.45E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.86|P-value:6.15E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:3.89|P-value:1.62E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.22|P-value:4.89E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.49|P-value:8.92E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-5.71|P-value:1.32E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.48|P-value:2.76E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.55|P-value:2.15E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.38|P-value:8.70E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.81|P-value:2.11E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.94|P-value:2.04E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.11|P-value:4.94E-14 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.72|P-value:2.92E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-5.57|P-value:2.54E-7 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.44|P-value:7.16E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.48|P-value:6.38E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.82|P-value:3.00E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.71|P-value:3.04E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.30|P-value:3.58E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.99|P-value:1.69E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.50|P-value:6.00E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.34|P-value:9.80E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.25|P-value:4.35E-5 ID:SGTC_1614|Compound:st002383|FD-Score:3.45|P-value:7.07E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.00|P-value:1.09E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.70|P-value:4.51E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.74|P-value:2.71E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-3.63|P-value:5.74E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.05|P-value:9.29E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-3.87|P-value:2.58E-4 ID:SGTC_1899|Compound:st063254|FD-Score:5.54|P-value:1.76E-7 ID:SGTC_1919|Compound:st067113|FD-Score:3.94|P-value:1.36E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.54|P-value:5.27E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.28|P-value:3.92E-5 ID:SGTC_2147|Compound:5545932|FD-Score:5.96|P-value:2.15E-8 ID:SGTC_2179|Compound:6298986|FD-Score:-3.65|P-value:5.29E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.41|P-value:7.93E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.39|P-value:2.57E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.22|P-value:4.88E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.95|P-value:2.21E-8 ID:SGTC_2263|Compound:7948595|FD-Score:4.26|P-value:4.26E-5 ID:SGTC_2272|Compound:7805186|FD-Score:-3.94|P-value:2.02E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.84|P-value:6.51E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-3.52|P-value:8.09E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-4.50|P-value:2.60E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.15|P-value:6.47E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.67|P-value:4.93E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:4.32|P-value:3.32E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.50|P-value:8.63E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.47|P-value:2.95E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.70|P-value:7.40E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.89|P-value:1.60E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-3.74|P-value:3.92E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.66|P-value:5.09E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.87|P-value:2.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.60|P-value:1.76E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.64|P-value:3.87E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.22|P-value:4.93E-5 ID:SGTC_3047|Compound:9092122|FD-Score:5.69|P-value:8.28E-8 ID:SGTC_3057|Compound:9095946|FD-Score:4.24|P-value:4.55E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-3.92|P-value:2.14E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.48|P-value:2.75E-5 ID:SGTC_3352|Compound:9151559|FD-Score:3.44|P-value:7.27E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.86|P-value:3.69E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:4.06|P-value:8.74E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.89|P-value:2.37E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.00|P-value:1.10E-13 ID:SGTC_201|Compound:4262-0159|FD-Score:7.26|P-value:1.34E-11 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.94|P-value:2.41E-8 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.67|P-value:3.49E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.40|P-value:2.09E-9 ID:SGTC_320|Compound:4092-0846|FD-Score:5.90|P-value:2.87E-8 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.62|P-value:5.84E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.40|P-value:2.44E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.61|P-value:5.96E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.99|P-value:1.68E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.70|P-value:4.48E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.74|P-value:3.90E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:-3.72|P-value:4.19E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.53|P-value:5.45E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.86|P-value:6.15E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:3.89|P-value:1.62E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.22|P-value:4.89E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.49|P-value:8.92E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-5.71|P-value:1.32E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.48|P-value:2.76E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.55|P-value:2.15E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.38|P-value:8.70E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.81|P-value:2.11E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.94|P-value:2.04E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.11|P-value:4.94E-14 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.72|P-value:2.92E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-5.57|P-value:2.54E-7 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.44|P-value:7.16E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.48|P-value:6.38E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.82|P-value:3.00E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.71|P-value:3.04E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.30|P-value:3.58E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.99|P-value:1.69E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.50|P-value:6.00E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.34|P-value:9.80E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.25|P-value:4.35E-5 ID:SGTC_1614|Compound:st002383|FD-Score:3.45|P-value:7.07E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.00|P-value:1.09E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.70|P-value:4.51E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.74|P-value:2.71E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-3.63|P-value:5.74E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.05|P-value:9.29E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-3.87|P-value:2.58E-4 ID:SGTC_1899|Compound:st063254|FD-Score:5.54|P-value:1.76E-7 ID:SGTC_1919|Compound:st067113|FD-Score:3.94|P-value:1.36E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.54|P-value:5.27E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.28|P-value:3.92E-5 ID:SGTC_2147|Compound:5545932|FD-Score:5.96|P-value:2.15E-8 ID:SGTC_2179|Compound:6298986|FD-Score:-3.65|P-value:5.29E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.41|P-value:7.93E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.39|P-value:2.57E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.22|P-value:4.88E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.95|P-value:2.21E-8 ID:SGTC_2263|Compound:7948595|FD-Score:4.26|P-value:4.26E-5 ID:SGTC_2272|Compound:7805186|FD-Score:-3.94|P-value:2.02E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.84|P-value:6.51E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-3.52|P-value:8.09E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-4.50|P-value:2.60E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.15|P-value:6.47E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.67|P-value:4.93E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:4.32|P-value:3.32E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.50|P-value:8.63E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.47|P-value:2.95E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.70|P-value:7.40E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.89|P-value:1.60E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-3.74|P-value:3.92E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.66|P-value:5.09E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.87|P-value:2.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.60|P-value:1.76E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.64|P-value:3.87E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.22|P-value:4.93E-5 ID:SGTC_3047|Compound:9092122|FD-Score:5.69|P-value:8.28E-8 ID:SGTC_3057|Compound:9095946|FD-Score:4.24|P-value:4.55E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-3.92|P-value:2.14E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.48|P-value:2.75E-5 ID:SGTC_3352|Compound:9151559|FD-Score:3.44|P-value:7.27E-4

Top fitness defect scores for YOR048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1019 4262-0212 8.11 3.4 µM 4.94E-14 ergosterol depletion effects on membrane 2 2.44E-16 1.96
2 SGTC_178 4092-0806 8.00 87.5 µM 1.10E-13 ergosterol depletion effects on membrane 5 6.35E-16 0.05
3 SGTC_201 4262-0159 7.26 12.8 µM 1.34E-11 ergosterol depletion effects on membrane 3 1.95E-13 0.37
4 SGTC_312 4092-0653 6.40 6.8 µM 2.09E-9 ergosterol depletion effects on membrane 12 7.98E-11 0.21
5 SGTC_2147 5545932 5.96 89.7 µM 2.15E-8 ergosterol biosynthesis 4 1.28E-9 0.75
6 SGTC_2250 alverine citrate 5.95 130.0 µM 2.21E-8 18 1.32E-9 0.26
7 SGTC_262 fenpropimorph 5.94 62.5 µM 2.41E-8 ergosterol depletion effects on membrane 7 1.46E-9 0.07
8 SGTC_320 4092-0846 5.90 5.3 µM 2.87E-8 ergosterol depletion effects on membrane 10 1.80E-9 0.07
9 SGTC_3047 9092122 5.69 49.5 µM 8.28E-8 2 6.34E-9 0.68
10 SGTC_1899 st063254 5.54 59.6 µM 1.76E-7 2 1.55E-8 1.55
11 SGTC_36 0335-0881 4.86 14.2 µM 3.69E-6 ubiquinone biosynthesis & proteasome 24 5.73E-7 0.05
12 SGTC_2760 etidronate 4.70 98.0 µM 7.40E-6 2 1.30E-6 0.11
13 SGTC_353 1988-1175 4.40 58.3 µM 2.44E-5 unfolded protein response 6 5.35E-6 0.01
14 SGTC_2233 sulbentine 4.39 40.4 µM 2.57E-5 31 5.70E-6 0.01
15 SGTC_2733 amorolfine 4.32 100.0 µM 3.32E-5 plasma membrane duress 5 7.70E-6 0.16
16 SGTC_1473 k844-0725 4.30 134.0 µM 3.58E-5 4 8.41E-6 0.38
17 SGTC_2125 5246583 4.28 200.0 µM 3.92E-5 tubulin folding & SWR complex 5 9.35E-6 0.60
18 SGTC_2263 7948595 4.26 193.3 µM 4.26E-5 3 1.03E-5 0.00
19 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 4.25 67.5 µM 4.35E-5 6 1.06E-5 0.03
20 SGTC_3057 9095946 4.24 49.5 µM 4.55E-5 Golgi 3 1.12E-5 0.17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 3.89E-24 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.151 1.86E-18 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.146 2.27E-17 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.144 6.56E-17 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.139 7.91E-16 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.135 4.99E-15 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.132 1.43E-14 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.128 1.19E-13 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.127 1.72E-13 YML092C PRE8 het Alpha 2 subunit of the 20S proteasome
0.125 3.42E-13 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.124 5.79E-13 YDR145W TAF12 het Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
0.123 9.63E-13 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.121 2.32E-12 YLR083C EMP70 hom Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments
0.119 5.81E-12 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.117 9.40E-12 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides