HIPHOP chemogenomics database

YOR048C / RAT1

Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination

Zygosity: Heterozygous strain

fixedexpanded
Profile for YOR048C / RAT1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR048C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1019	4262-0212	8.11	3.4 µM	4.94E-14	ergosterol depletion effects on membrane	2	2.44E-16	1.96
2	SGTC_178	4092-0806	8.00	87.5 µM	1.10E-13	ergosterol depletion effects on membrane	5	6.35E-16	0.05
3	SGTC_201	4262-0159	7.26	12.8 µM	1.34E-11	ergosterol depletion effects on membrane	3	1.95E-13	0.37
4	SGTC_312	4092-0653	6.40	6.8 µM	2.09E-9	ergosterol depletion effects on membrane	12	7.98E-11	0.21
5	SGTC_2147	5545932	5.96	89.7 µM	2.15E-8	ergosterol biosynthesis	4	1.28E-9	0.75
6	SGTC_2250	alverine citrate	5.95	130.0 µM	2.21E-8		18	1.32E-9	0.26
7	SGTC_262	fenpropimorph	5.94	62.5 µM	2.41E-8	ergosterol depletion effects on membrane	7	1.46E-9	0.07
8	SGTC_320	4092-0846	5.90	5.3 µM	2.87E-8	ergosterol depletion effects on membrane	10	1.80E-9	0.07
9	SGTC_3047	9092122	5.69	49.5 µM	8.28E-8		2	6.34E-9	0.68
10	SGTC_1899	st063254	5.54	59.6 µM	1.76E-7		2	1.55E-8	1.55
11	SGTC_36	0335-0881	4.86	14.2 µM	3.69E-6	ubiquinone biosynthesis & proteasome	24	5.73E-7	0.05
12	SGTC_2760	etidronate	4.70	98.0 µM	7.40E-6		2	1.30E-6	0.11
13	SGTC_353	1988-1175	4.40	58.3 µM	2.44E-5	unfolded protein response	6	5.35E-6	0.01
14	SGTC_2233	sulbentine	4.39	40.4 µM	2.57E-5		31	5.70E-6	0.01
15	SGTC_2733	amorolfine	4.32	100.0 µM	3.32E-5	plasma membrane duress	5	7.70E-6	0.16
16	SGTC_1473	k844-0725	4.30	134.0 µM	3.58E-5		4	8.41E-6	0.38
17	SGTC_2125	5246583	4.28	200.0 µM	3.92E-5	tubulin folding & SWR complex	5	9.35E-6	0.60
18	SGTC_2263	7948595	4.26	193.3 µM	4.26E-5		3	1.03E-5	0.00
19	SGTC_1595	6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin	4.25	67.5 µM	4.35E-5		6	1.06E-5	0.03
20	SGTC_3057	9095946	4.24	49.5 µM	4.55E-5	Golgi	3	1.12E-5	0.17

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.174	3.89E-24	YBR103W	SIF2	hom	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.151	1.86E-18	YML031W	NDC1	het	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.146	2.27E-17	YDR407C	TRS120	het	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.144	6.56E-17	YIL112W	HOS4	hom	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.139	7.91E-16	YDR213W	UPC2	hom	Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.135	4.99E-15	YIL068C	SEC6	het	Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.132	1.43E-14	YIL052C	RPL34B	hom	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.128	1.19E-13	YGL116W	CDC20	het	Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.127	1.72E-13	YML092C	PRE8	het	Alpha 2 subunit of the 20S proteasome
0.125	3.42E-13	YDR144C	MKC7	hom	GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.124	5.79E-13	YDR145W	TAF12	het	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
0.123	9.63E-13	YGL011C	SCL1	het	Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.121	2.32E-12	YLR083C	EMP70	hom	Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments
0.119	5.81E-12	YCR033W	SNT1	hom	Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.117	9.40E-12	YJL001W	PRE3	het	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides