YOR049C / RSB1

Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR049C / RSB1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.26|P-value:4.62E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.25|P-value:4.91E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.26|P-value:4.70E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.14|P-value:7.16E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.84|P-value:4.37E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.06|P-value:9.34E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.35|P-value:3.41E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.35|P-value:3.33E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.64|P-value:1.23E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:4.15|P-value:1.29E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:4.12|P-value:1.42E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.25|P-value:4.86E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.41|P-value:2.68E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.45|P-value:2.31E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.59|P-value:1.56E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.60|P-value:1.30E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.32|P-value:3.69E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.13|P-value:7.37E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.11|P-value:7.90E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.55|P-value:1.58E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.21|P-value:9.47E-6 ID:SGTC_1775|Compound:st081588|FD-Score:4.43|P-value:3.43E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.28|P-value:4.34E-4 ID:SGTC_1778|Compound:st046819|FD-Score:5.90|P-value:1.06E-9 ID:SGTC_1835|Compound:st008666|FD-Score:3.11|P-value:8.08E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.89|P-value:3.92E-5 ID:SGTC_1982|Compound:st072467|FD-Score:-3.68|P-value:9.25E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.40|P-value:2.79E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.31|P-value:3.95E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.11|P-value:7.87E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.05|P-value:9.79E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.06|P-value:9.32E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.72|P-value:7.85E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.70|P-value:7.81E-58 ID:SGTC_2789|Compound:5281112|FD-Score:-3.34|P-value:3.51E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.41|P-value:2.64E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.65|P-value:1.05E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.26|P-value:4.62E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.25|P-value:4.91E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.26|P-value:4.70E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.14|P-value:7.16E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.84|P-value:4.37E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.06|P-value:9.34E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.35|P-value:3.41E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.35|P-value:3.33E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.64|P-value:1.23E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:4.15|P-value:1.29E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:4.12|P-value:1.42E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.25|P-value:4.86E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.41|P-value:2.68E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.45|P-value:2.31E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.59|P-value:1.56E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.60|P-value:1.30E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.32|P-value:3.69E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.13|P-value:7.37E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.11|P-value:7.90E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.55|P-value:1.58E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.21|P-value:9.47E-6 ID:SGTC_1775|Compound:st081588|FD-Score:4.43|P-value:3.43E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.28|P-value:4.34E-4 ID:SGTC_1778|Compound:st046819|FD-Score:5.90|P-value:1.06E-9 ID:SGTC_1835|Compound:st008666|FD-Score:3.11|P-value:8.08E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.89|P-value:3.92E-5 ID:SGTC_1982|Compound:st072467|FD-Score:-3.68|P-value:9.25E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.40|P-value:2.79E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.31|P-value:3.95E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.11|P-value:7.87E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.05|P-value:9.79E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.06|P-value:9.32E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.72|P-value:7.85E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.70|P-value:7.81E-58 ID:SGTC_2789|Compound:5281112|FD-Score:-3.34|P-value:3.51E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.41|P-value:2.64E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.65|P-value:1.05E-4

Top fitness defect scores for YOR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 15.70 100.0 µM 7.81E-58 redox potentiating 9 3.50E-56
2 SGTC_1778 st046819 5.90 58.9 µM 1.06E-9 7 1.82E-9
3 SGTC_453 enantio-paf c16 4.84 10.0 µM 4.37E-7 93 6.34E-7
4 SGTC_905 2-aminofluorene 4.64 215.0 µM 1.23E-6 cell wall signaling 16 1.73E-6
5 SGTC_1053 3366-3204 4.59 134.0 µM 1.56E-6 cell wall 19 2.18E-6
6 SGTC_1775 st081588 4.43 35.2 µM 3.43E-6 60S ribosome export 17 4.70E-6
7 SGTC_1771 st048882 4.21 4.2 µM 9.47E-6 RPP1 & pyrimidine depletion 13 1.26E-5
8 SGTC_922 1866-0035 4.15 480.0 µM 1.29E-5 excess fatty acid 50 1.70E-5
9 SGTC_971 1315-0384 4.12 26.7 µM 1.42E-5 cell wall signaling 18 1.87E-5
10 SGTC_1950 st077106 3.89 7.2 µM 3.92E-5 RNA processing & uracil transport 32 5.01E-5
11 SGTC_2340 7987427 3.72 183.4 µM 7.85E-5 43 9.83E-5
12 SGTC_3071 9117417 3.65 49.5 µM 1.05E-4 fatty acid desaturase (OLE1) 25 1.30E-4
13 SGTC_1318 1280-3875 3.65 124.0 µM 1.06E-4 34 1.32E-4
14 SGTC_1139 k015-0024 3.60 46.9 µM 1.30E-4 PDR1 17 1.60E-4
15 SGTC_1721 st082152 3.55 9.3 µM 1.58E-4 60S ribosome export 30 1.94E-4
16 SGTC_2923 7992654 3.41 58.1 µM 2.64E-4 Golgi 47 3.19E-4
17 SGTC_2053 5265679 3.40 138.0 µM 2.79E-4 43 3.37E-4
18 SGTC_671 0560-0003 3.35 407.0 µM 3.33E-4 27 4.00E-4
19 SGTC_1487 3970-0795 3.32 2.8 µM 3.69E-4 DNA intercalators 28 4.42E-4
20 SGTC_2130 NSC 7 3.31 2.5 µM 3.95E-4 copper-dependent oxidative stress 64 4.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.370 1.07E-109 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.364 1.81E-105 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.361 4.45E-104 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.358 3.86E-102 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.354 7.35E-100 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.323 1.45E-82 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.309 3.74E-75 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.305 1.98E-73 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.305 2.60E-73 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.293 1.50E-67 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.287 9.71E-65 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.286 1.95E-64 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.280 1.11E-61 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.275 4.40E-59 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.245 6.05E-47 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication