YOR052C

Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR052C / YOR052C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.07|P-value:8.94E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.38|P-value:2.62E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.61|P-value:1.17E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.34|P-value:3.02E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.31|P-value:3.66E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.21|P-value:5.26E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.02|P-value:9.56E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.09|P-value:8.14E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.25|P-value:4.27E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.58|P-value:1.33E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.73|P-value:6.29E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.24|P-value:4.41E-8 ID:SGTC_598|Compound:3937-0236|FD-Score:-4.07|P-value:1.51E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:5.05|P-value:1.29E-7 ID:SGTC_615|Compound:k087-0205|FD-Score:-5.09|P-value:8.80E-8 ID:SGTC_728|Compound:3030-5151|FD-Score:3.16|P-value:6.50E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.17|P-value:1.05E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.38|P-value:2.84E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.43|P-value:2.38E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.73|P-value:6.31E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.06|P-value:8.99E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.33|P-value:3.40E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:8.48|P-value:2.22E-18 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.17|P-value:1.03E-5 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.05|P-value:9.32E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.19|P-value:5.69E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.62|P-value:1.00E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.97|P-value:2.54E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.20|P-value:5.60E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.05|P-value:9.38E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.88|P-value:3.73E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.73|P-value:2.38E-9 ID:SGTC_1941|Compound:st076221|FD-Score:3.04|P-value:9.79E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.15|P-value:6.16E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.13|P-value:7.21E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.40|P-value:2.61E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.97|P-value:1.94E-7 ID:SGTC_2311|Compound:7694451|FD-Score:3.44|P-value:2.31E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.19|P-value:5.82E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.12|P-value:6.70E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.38|P-value:2.82E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.08|P-value:7.68E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-6.69|P-value:3.46E-12 ID:SGTC_2933|Compound:9026794|FD-Score:-3.96|P-value:2.42E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-4.07|P-value:1.48E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.41|P-value:2.33E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.03|P-value:9.35E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.73|P-value:7.01E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.46|P-value:2.10E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.07|P-value:8.94E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.38|P-value:2.62E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.61|P-value:1.17E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.34|P-value:3.02E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.31|P-value:3.66E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.21|P-value:5.26E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.02|P-value:9.56E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.09|P-value:8.14E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.25|P-value:4.27E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.58|P-value:1.33E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.73|P-value:6.29E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.24|P-value:4.41E-8 ID:SGTC_598|Compound:3937-0236|FD-Score:-4.07|P-value:1.51E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:5.05|P-value:1.29E-7 ID:SGTC_615|Compound:k087-0205|FD-Score:-5.09|P-value:8.80E-8 ID:SGTC_728|Compound:3030-5151|FD-Score:3.16|P-value:6.50E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.17|P-value:1.05E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.38|P-value:2.84E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.43|P-value:2.38E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.73|P-value:6.31E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.06|P-value:8.99E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.33|P-value:3.40E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:8.48|P-value:2.22E-18 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.17|P-value:1.03E-5 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.05|P-value:9.32E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.19|P-value:5.69E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.62|P-value:1.00E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.97|P-value:2.54E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.20|P-value:5.60E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.05|P-value:9.38E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.88|P-value:3.73E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.73|P-value:2.38E-9 ID:SGTC_1941|Compound:st076221|FD-Score:3.04|P-value:9.79E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.15|P-value:6.16E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.13|P-value:7.21E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.40|P-value:2.61E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.97|P-value:1.94E-7 ID:SGTC_2311|Compound:7694451|FD-Score:3.44|P-value:2.31E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.19|P-value:5.82E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.12|P-value:6.70E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.38|P-value:2.82E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.08|P-value:7.68E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-6.69|P-value:3.46E-12 ID:SGTC_2933|Compound:9026794|FD-Score:-3.96|P-value:2.42E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-4.07|P-value:1.48E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.41|P-value:2.33E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.03|P-value:9.35E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.73|P-value:7.01E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.46|P-value:2.10E-4

Top fitness defect scores for YOR052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1206 3978-0017 8.48 132.0 µM 2.22E-18 ERG2 3 1.10E-17
2 SGTC_1872 amphotericin b 5.73 148.0 nM 2.38E-9 RNA pol III & RNase P/MRP 12 4.88E-9
3 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 5.24 150.0 µM 4.41E-8 Golgi 22 7.99E-8
4 SGTC_611 3453-1652 5.05 23.7 µM 1.29E-7 7 2.24E-7
5 SGTC_2309 7664088 4.97 163.9 µM 1.94E-7 9 3.30E-7
6 SGTC_1334 1486-0610 4.17 236.0 µM 1.03E-5 60S ribosome export 12 1.50E-5
7 SGTC_866 0495-0101 4.17 262.0 µM 1.05E-5 60S ribosome export 12 1.52E-5
8 SGTC_1571 st070080 3.97 73.4 µM 2.54E-5 17 3.55E-5
9 SGTC_1755 st041960 3.88 45.2 µM 3.73E-5 27 5.14E-5
10 SGTC_3076 9116187 3.73 49.5 µM 7.01E-5 21 9.42E-5
11 SGTC_265 mycophenolic acid 3.61 32.9 µM 1.17E-4 RPP1 & pyrimidine depletion 32 1.54E-4
12 SGTC_431 k089-0097 3.58 107.0 µM 1.33E-4 iron homeostasis 61 1.74E-4
13 SGTC_368 fentichlor 3.50 4.6 µM 1.79E-4 32 2.32E-4
14 SGTC_2742 clothiapine 3.49 36.3 µM 1.89E-4 NEO1 24 2.44E-4
15 SGTC_3305 9127027 3.46 53.8 µM 2.10E-4 33 2.71E-4
16 SGTC_2311 7694451 3.44 200.0 µM 2.31E-4 39 2.96E-4
17 SGTC_936 3005-4620 3.43 401.0 µM 2.38E-4 45 3.04E-4
18 SGTC_2196 6573537 3.40 42.7 µM 2.61E-4 copper-dependent oxidative stress 20 3.33E-4
19 SGTC_2585 alliin 3.38 100.0 µM 2.82E-4 47 3.59E-4
20 SGTC_874 0599-0792 3.38 117.0 µM 2.84E-4 50 3.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.14E-12 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.110 1.58E-10 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.098 1.44E-8 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.096 2.36E-8 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.094 5.01E-8 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.092 9.19E-8 YPL218W SAR1 het GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
0.088 3.22E-7 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.088 3.72E-7 YJL077C ICS3 hom Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2
0.084 9.99E-7 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.082 1.96E-6 YGR243W FMP43 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress
0.080 3.71E-6 YJR080C AIM24 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
0.076 9.30E-6 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.076 1.04E-5 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.076 1.14E-5 YDL144C YDL144C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress
0.075 1.25E-5 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1