YOR057W / SGT1

Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR057W / SGT1

Click on Significant Values for Screen Details ID:SGTC_304|Compound:1310-0298|FD-Score:-3.26|P-value:3.84E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.25|P-value:4.32E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.48|P-value:1.74E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.52|P-value:1.76E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.58|P-value:1.12E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.59|P-value:1.14E-6 ID:SGTC_2022|Compound:5136654|FD-Score:4.15|P-value:1.00E-5 ID:SGTC_2035|Compound:5154463|FD-Score:4.63|P-value:1.00E-6 ID:SGTC_2043|Compound:5101342|FD-Score:3.43|P-value:2.16E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-5.64|P-value:3.09E-9 ID:SGTC_2055|Compound:5235184|FD-Score:-3.41|P-value:2.24E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.22|P-value:6.82E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.34|P-value:3.01E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.11|P-value:7.11E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.28|P-value:5.26E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.92|P-value:2.69E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.02|P-value:9.78E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.57|P-value:1.15E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.93|P-value:2.54E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.22|P-value:7.26E-6 ID:SGTC_2835|Compound:9006588|FD-Score:4.54|P-value:1.59E-6 ID:SGTC_2838|Compound:9002687|FD-Score:3.09|P-value:7.64E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.22|P-value:4.73E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.26|P-value:4.13E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.02|P-value:9.39E-4 ID:SGTC_3026|Compound:9090633|FD-Score:4.65|P-value:9.13E-7 ID:SGTC_3085|Compound:9117376|FD-Score:3.82|P-value:4.35E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.23|P-value:4.64E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.26|P-value:3.84E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.25|P-value:4.32E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.48|P-value:1.74E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.52|P-value:1.76E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.58|P-value:1.12E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.59|P-value:1.14E-6 ID:SGTC_2022|Compound:5136654|FD-Score:4.15|P-value:1.00E-5 ID:SGTC_2035|Compound:5154463|FD-Score:4.63|P-value:1.00E-6 ID:SGTC_2043|Compound:5101342|FD-Score:3.43|P-value:2.16E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-5.64|P-value:3.09E-9 ID:SGTC_2055|Compound:5235184|FD-Score:-3.41|P-value:2.24E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.22|P-value:6.82E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.34|P-value:3.01E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.11|P-value:7.11E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.28|P-value:5.26E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.92|P-value:2.69E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.02|P-value:9.78E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.57|P-value:1.15E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.93|P-value:2.54E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.22|P-value:7.26E-6 ID:SGTC_2835|Compound:9006588|FD-Score:4.54|P-value:1.59E-6 ID:SGTC_2838|Compound:9002687|FD-Score:3.09|P-value:7.64E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.22|P-value:4.73E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.26|P-value:4.13E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.02|P-value:9.39E-4 ID:SGTC_3026|Compound:9090633|FD-Score:4.65|P-value:9.13E-7 ID:SGTC_3085|Compound:9117376|FD-Score:3.82|P-value:4.35E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.23|P-value:4.64E-4

Top fitness defect scores for YOR057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3026 9090633 4.65 49.5 µM 9.13E-7 4 1.69E-6 0.54
2 SGTC_2035 5154463 4.63 94.6 µM 1.00E-6 6 1.85E-6 0.17
3 SGTC_2835 9006588 4.54 71.4 µM 1.59E-6 7 2.86E-6 0.15
4 SGTC_1061 3448-9325 4.52 110.0 µM 1.76E-6 4 3.15E-6 0.66
5 SGTC_2816 7982706 4.22 58.4 µM 7.26E-6 azole & statin 6 1.21E-5 0.00
6 SGTC_2022 5136654 4.15 200.0 µM 1.00E-5 4 1.64E-5 0.05
7 SGTC_3085 9117376 3.82 49.5 µM 4.35E-5 9 6.61E-5 0.12
8 SGTC_381 3461-2219 3.48 42.7 µM 1.74E-4 copper-dependent oxidative stress 5 2.47E-4 0.00
9 SGTC_2796 7949634 3.44 45.5 µM 2.05E-4 13 2.88E-4 0.15
10 SGTC_2043 5101342 3.43 149.0 µM 2.16E-4 SWF1 & branched chain AA biosynthesis 7 3.03E-4 0.06
11 SGTC_2255 7941087 3.34 197.4 µM 3.01E-4 11 4.15E-4 0.18
12 SGTC_2913 7966556 3.26 36.6 µM 4.13E-4 60S ribosome export 12 5.61E-4 0.08
13 SGTC_314 1671-0008 3.25 2.7 µM 4.32E-4 19 5.85E-4 0.04
14 SGTC_3193 9111931 3.23 49.5 µM 4.64E-4 16 6.26E-4 0.20
15 SGTC_2852 9023854 3.22 52.0 µM 4.73E-4 15 6.38E-4 0.01
16 SGTC_2262 9014885 3.11 67.5 µM 7.11E-4 2 9.40E-4 0.43
17 SGTC_2838 9002687 3.09 71.4 µM 7.64E-4 fatty acid desaturase (OLE1) 27 0.00101 0.01
18 SGTC_2563 tomatine 3.02 8.5 µM 9.78E-4 25 0.00127 0.02
19 SGTC_426 0988-0037 3.00 14.6 µM 0.00103 ERAD & cell cycle 23 0.00134 0.03
20 SGTC_417 st075190 2.99 100.0 µM 0.00107 9 0.00139 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.86E-13 YLR072W_p YLR072W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.112 8.90E-11 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.110 1.68E-10 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.106 7.07E-10 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.105 1.23E-9 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene
0.102 3.43E-9 YLR104W_p LCL2_p hom Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.100 6.28E-9 YGL091C NBP35 het Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
0.092 9.03E-8 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.092 9.79E-8 YOL100W PKH2 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
0.092 1.01E-7 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.091 1.35E-7 YMR172W HOT1 hom Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
0.090 1.64E-7 YHL026C_p YHL026C_p hom Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
0.090 1.96E-7 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.090 2.00E-7 YLR389C STE23 hom Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family
0.089 2.59E-7 YKR053C YSR3 hom Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication