YOR058C / ASE1

Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR058C / ASE1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.13|P-value:1.88E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:-2.84|P-value:7.29E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.62|P-value:2.01E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:2.84|P-value:6.38E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:2.79|P-value:7.56E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.92|P-value:1.28E-8 ID:SGTC_759|Compound:3486-0358|FD-Score:3.27|P-value:1.05E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:4.47|P-value:2.09E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:2.98|P-value:3.64E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:2.78|P-value:8.06E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.84|P-value:6.35E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.88|P-value:5.47E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.96|P-value:3.86E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.89|P-value:5.13E-6 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.27|P-value:1.03E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-3.30|P-value:1.10E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.83|P-value:7.13E-6 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.90|P-value:6.16E-6 ID:SGTC_1613|Compound:st002381|FD-Score:2.75|P-value:9.07E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.69|P-value:1.47E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.22|P-value:1.32E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.57|P-value:3.17E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.98|P-value:3.16E-6 ID:SGTC_1859|Compound:st055998|FD-Score:3.27|P-value:1.06E-4 ID:SGTC_2005|Compound:4024620|FD-Score:2.95|P-value:4.06E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:2.77|P-value:8.26E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.48|P-value:3.93E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-2.96|P-value:4.66E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.77|P-value:9.44E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.02|P-value:3.09E-4 ID:SGTC_2444|Compound:5485484|FD-Score:5.43|P-value:3.98E-10 ID:SGTC_2447|Compound:5741742|FD-Score:3.69|P-value:1.42E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.25|P-value:1.36E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.99|P-value:3.08E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.41|P-value:5.50E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.92|P-value:4.48E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.07|P-value:2.50E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.79|P-value:2.84E-8 ID:SGTC_2907|Compound:7721985|FD-Score:4.63|P-value:7.97E-8 ID:SGTC_2923|Compound:7992654|FD-Score:-3.13|P-value:2.27E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-2.90|P-value:5.85E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.75|P-value:1.08E-5 ID:SGTC_3030|Compound:9087619|FD-Score:-3.33|P-value:9.64E-5 ID:SGTC_3251|Compound:9135047|FD-Score:3.96|P-value:3.54E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.13|P-value:1.88E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:-2.84|P-value:7.29E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.62|P-value:2.01E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:2.84|P-value:6.38E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:2.79|P-value:7.56E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.92|P-value:1.28E-8 ID:SGTC_759|Compound:3486-0358|FD-Score:3.27|P-value:1.05E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:4.47|P-value:2.09E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:2.98|P-value:3.64E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:2.78|P-value:8.06E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.84|P-value:6.35E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.88|P-value:5.47E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.96|P-value:3.86E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.89|P-value:5.13E-6 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.27|P-value:1.03E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-3.30|P-value:1.10E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.83|P-value:7.13E-6 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.90|P-value:6.16E-6 ID:SGTC_1613|Compound:st002381|FD-Score:2.75|P-value:9.07E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.69|P-value:1.47E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.22|P-value:1.32E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.57|P-value:3.17E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.98|P-value:3.16E-6 ID:SGTC_1859|Compound:st055998|FD-Score:3.27|P-value:1.06E-4 ID:SGTC_2005|Compound:4024620|FD-Score:2.95|P-value:4.06E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:2.77|P-value:8.26E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.48|P-value:3.93E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-2.96|P-value:4.66E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.77|P-value:9.44E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.02|P-value:3.09E-4 ID:SGTC_2444|Compound:5485484|FD-Score:5.43|P-value:3.98E-10 ID:SGTC_2447|Compound:5741742|FD-Score:3.69|P-value:1.42E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.25|P-value:1.36E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.99|P-value:3.08E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.41|P-value:5.50E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.92|P-value:4.48E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.07|P-value:2.50E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.79|P-value:2.84E-8 ID:SGTC_2907|Compound:7721985|FD-Score:4.63|P-value:7.97E-8 ID:SGTC_2923|Compound:7992654|FD-Score:-3.13|P-value:2.27E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-2.90|P-value:5.85E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.75|P-value:1.08E-5 ID:SGTC_3030|Compound:9087619|FD-Score:-3.33|P-value:9.64E-5 ID:SGTC_3251|Compound:9135047|FD-Score:3.96|P-value:3.54E-6

Top fitness defect scores for YOR058C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2444 5485484 5.43 36.4 µM 3.98E-10 9 2.81E-8
2 SGTC_619 1652-1634 4.92 108.0 µM 1.28E-8 PDR1 8 4.35E-7
3 SGTC_2844 9010103 4.79 26.0 µM 2.84E-8 13 8.14E-7
4 SGTC_2907 7721985 4.63 69.9 µM 7.97E-8 9 1.84E-6
5 SGTC_856 0433-0016 4.47 11.3 µM 2.09E-7 9 3.94E-6
6 SGTC_2790 5423970 3.99 71.4 µM 3.08E-6 endomembrane recycling 70 3.31E-5
7 SGTC_1846 st056244 3.98 14.8 µM 3.16E-6 24 3.38E-5
8 SGTC_3251 9135047 3.96 49.5 µM 3.54E-6 60S ribosome export 3 3.69E-5
9 SGTC_2837 9008476 3.92 45.5 µM 4.48E-6 37 4.44E-5
10 SGTC_1308 1187-1617 3.89 41.4 µM 5.13E-6 fatty acid desaturase (OLE1) 44 4.95E-5
11 SGTC_1583 clindamycin 3.83 39.6 µM 7.13E-6 mitochondrial processes 16 6.42E-5
12 SGTC_2160 5660466 3.77 132.9 µM 9.44E-6 60S ribosome export 23 8.02E-5
13 SGTC_3026 9090633 3.75 49.5 µM 1.08E-5 25 8.94E-5
14 SGTC_2447 5741742 3.69 33.8 µM 1.42E-5 29 1.11E-4
15 SGTC_1780 st038448 3.69 24.5 µM 1.47E-5 iron homeostasis 29 1.14E-4
16 SGTC_345 1362-0200 3.62 395.0 µM 2.01E-5 24 1.46E-4
17 SGTC_2042 p-Dimethylaminoacetophenone 3.48 200.0 µM 3.93E-5 35 2.48E-4
18 SGTC_2833 9001315 3.41 45.5 µM 5.50E-5 amide catabolism 78 3.25E-4
19 SGTC_35 0133-0054 3.28 64.1 µM 1.00E-4 55 5.22E-4
20 SGTC_1342 1486-1464 3.27 234.0 µM 1.03E-4 40 5.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.10E-14 YJL041W NSP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
0.105 9.15E-10 YOR228C YOR228C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.103 2.00E-9 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.102 2.86E-9 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.097 1.90E-8 YEL014C_d YEL014C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.49E-6 YBR059C AKL1 hom Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
0.077 7.63E-6 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.077 7.89E-6 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 9.17E-6 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.075 1.21E-5 YJL215C_d YJL215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.32E-5 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.075 1.55E-5 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.074 1.70E-5 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.073 2.12E-5 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.072 3.03E-5 YDR355C_d YDR355C_d het Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W