YOR060C / SLD7

Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR060C / SLD7

Click on Significant Values for Screen Details ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.77|P-value:9.44E-6 ID:SGTC_443|Compound:clozapine|FD-Score:3.72|P-value:1.25E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.00|P-value:3.07E-6 ID:SGTC_460|Compound:trequinsin|FD-Score:-2.98|P-value:3.84E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-2.94|P-value:4.39E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:4.19|P-value:1.03E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:2.92|P-value:4.52E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.77|P-value:9.48E-6 ID:SGTC_1163|Compound:k060-0048|FD-Score:-2.94|P-value:4.44E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.85|P-value:6.18E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.51|P-value:3.60E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.74|P-value:3.90E-8 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.17|P-value:1.58E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.09|P-value:2.25E-4 ID:SGTC_1677|Compound:st019204|FD-Score:2.82|P-value:6.72E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.28|P-value:1.05E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-2.79|P-value:8.20E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.39|P-value:6.30E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.06|P-value:2.57E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.06|P-value:2.54E-4 ID:SGTC_2691|Compound:st077356|FD-Score:2.74|P-value:9.25E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.22|P-value:1.37E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.15|P-value:2.68E-9 ID:SGTC_2843|Compound:9000894|FD-Score:2.95|P-value:4.10E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.14|P-value:1.86E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.77|P-value:9.44E-6 ID:SGTC_443|Compound:clozapine|FD-Score:3.72|P-value:1.25E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.00|P-value:3.07E-6 ID:SGTC_460|Compound:trequinsin|FD-Score:-2.98|P-value:3.84E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-2.94|P-value:4.39E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:4.19|P-value:1.03E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:2.92|P-value:4.52E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.77|P-value:9.48E-6 ID:SGTC_1163|Compound:k060-0048|FD-Score:-2.94|P-value:4.44E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.85|P-value:6.18E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.51|P-value:3.60E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.74|P-value:3.90E-8 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.17|P-value:1.58E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.09|P-value:2.25E-4 ID:SGTC_1677|Compound:st019204|FD-Score:2.82|P-value:6.72E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.28|P-value:1.05E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-2.79|P-value:8.20E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.39|P-value:6.30E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.06|P-value:2.57E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.06|P-value:2.54E-4 ID:SGTC_2691|Compound:st077356|FD-Score:2.74|P-value:9.25E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.22|P-value:1.37E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.15|P-value:2.68E-9 ID:SGTC_2843|Compound:9000894|FD-Score:2.95|P-value:4.10E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.14|P-value:1.86E-4

Top fitness defect scores for YOR060C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2814 7977482 5.15 43.0 µM 2.68E-9 4 1.33E-7 0.04
2 SGTC_1251 0490-5699 4.74 265.0 µM 3.90E-8 4 1.09E-6 0.35
3 SGTC_1138 3761-0006 4.19 1.0 µM 1.03E-6 2 1.42E-5 1.08
4 SGTC_416 estradiol valerate 3.77 100.0 µM 9.44E-6 6 8.15E-5 0.15
5 SGTC_1143 3454-2408 3.77 5.1 µM 9.48E-6 60S ribosome export 4 8.18E-5 0.26
6 SGTC_443 clozapine 3.72 122.0 µM 1.25E-5 NEO1-PIK1 3 1.02E-4 0.18
7 SGTC_1351 1496-0003 3.17 46.5 µM 1.58E-4 9 7.52E-4 0.07
8 SGTC_2847 9005661 3.14 71.4 µM 1.86E-4 4 8.55E-4 0.30
9 SGTC_1524 corynanthine 3.09 62.1 µM 2.25E-4 13 9.95E-4 0.00
10 SGTC_2625 euphol 3.06 100.0 µM 2.54E-4 15 0.00109 0.09
11 SGTC_2362 9071156 3.06 126.0 µM 2.57E-4 13 0.00111 0.02
12 SGTC_2843 9000894 2.95 45.5 µM 4.10E-4 7 0.00160 0.23
13 SGTC_1139 k015-0024 2.92 46.9 µM 4.52E-4 PDR1 10 0.00173 0.01
14 SGTC_1176 0848-0131 2.85 83.3 µM 6.18E-4 Golgi 14 0.00222 0.01
15 SGTC_1677 st019204 2.82 53.9 µM 6.72E-4 20 0.00237 0.05
16 SGTC_2691 st077356 2.74 60.2 µM 9.25E-4 25 0.00305 0.02
17 SGTC_2491 paeonol 2.71 100.0 µM 0.00105 7 0.00337 0.01
18 SGTC_716 1683-5115 2.67 658.0 µM 0.00122 18 0.00381 0.02
19 SGTC_2863 9028737 2.58 58.4 µM 0.00170 8 0.00495 0.01
20 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 2.57 61.8 µM 0.00178 ergosterol biosynthesis 12 0.00513 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 3.22E-44 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.175 2.22E-24 YDR421W ARO80 hom Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
0.170 3.40E-23 YMR171C EAR1 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p
0.156 8.31E-20 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.152 9.80E-19 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.147 1.34E-17 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.131 3.05E-14 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.128 8.74E-14 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.116 1.83E-11 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.116 1.85E-11 YNR056C BIO5 hom Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.114 3.85E-11 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.111 1.29E-10 YPL273W SAM4 hom S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.106 7.99E-10 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.106 8.68E-10 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.103 1.89E-9 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)