YOR061W / CKA2

Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR061W / CKA2

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.79|P-value:2.56E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.43|P-value:8.43E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:11.20|P-value:4.79E-25 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.94|P-value:1.50E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.47|P-value:7.49E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.39|P-value:2.85E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.23|P-value:5.37E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:7.13|P-value:3.18E-11 ID:SGTC_178|Compound:4092-0806|FD-Score:-5.02|P-value:1.97E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:4.91|P-value:3.39E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:6.73|P-value:3.48E-10 ID:SGTC_266|Compound:formosanin C|FD-Score:6.35|P-value:2.89E-9 ID:SGTC_271|Compound:rotenone|FD-Score:3.68|P-value:3.68E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.61|P-value:1.34E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:6.91|P-value:1.16E-10 ID:SGTC_315|Compound:k915-0449|FD-Score:4.42|P-value:2.60E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:4.35|P-value:3.36E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:4.12|P-value:7.88E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:6.51|P-value:1.19E-9 ID:SGTC_356|Compound:1634-0012|FD-Score:5.57|P-value:1.67E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.88|P-value:1.80E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.82|P-value:2.23E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.92|P-value:1.64E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:4.05|P-value:1.04E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.68|P-value:3.68E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.50|P-value:6.77E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.48|P-value:2.00E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:6.37E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.92|P-value:2.91E-8 ID:SGTC_470|Compound:aa-861|FD-Score:7.69|P-value:8.65E-13 ID:SGTC_502|Compound:l-744,832|FD-Score:4.76|P-value:6.40E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:4.74|P-value:7.11E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.47|P-value:7.19E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:11.30|P-value:1.61E-25 ID:SGTC_528|Compound:3492-0019|FD-Score:5.48|P-value:2.53E-7 ID:SGTC_548|Compound:1436-0017|FD-Score:4.67|P-value:9.23E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:6.64|P-value:5.73E-10 ID:SGTC_662|Compound:k832-1615|FD-Score:3.69|P-value:3.60E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.45|P-value:7.94E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.34|P-value:3.42E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:4.19|P-value:6.12E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.31|P-value:3.86E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:-4.23|P-value:5.11E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:4.35|P-value:3.36E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:4.12|P-value:8.08E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.57|P-value:5.19E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-5.18|P-value:9.52E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:4.08|P-value:9.25E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:13.20|P-value:5.64E-34 ID:SGTC_994|Compound:3910-0338|FD-Score:6.40|P-value:2.25E-9 ID:SGTC_1054|Compound:3429-0080|FD-Score:6.47|P-value:1.50E-9 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.51|P-value:6.51E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.06|P-value:9.78E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.99|P-value:2.42E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.05|P-value:1.03E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.81|P-value:4.87E-8 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.23|P-value:5.28E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:13.20|P-value:4.89E-34 ID:SGTC_1687|Compound:st020778|FD-Score:9.42|P-value:2.77E-18 ID:SGTC_1750|Compound:st081859|FD-Score:4.97|P-value:2.56E-6 ID:SGTC_1762|Compound:st045503|FD-Score:4.15|P-value:7.19E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.96|P-value:1.42E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.52|P-value:1.74E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.40|P-value:2.25E-9 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.33|P-value:3.29E-9 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.73|P-value:3.29E-10 ID:SGTC_1885|Compound:st057546|FD-Score:3.38|P-value:9.69E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.54|P-value:1.57E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.25|P-value:4.85E-5 ID:SGTC_1982|Compound:st072467|FD-Score:7.84|P-value:3.23E-13 ID:SGTC_2045|Compound:5106652|FD-Score:4.31|P-value:3.97E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.15|P-value:7.13E-5 ID:SGTC_2200|Compound:6600604|FD-Score:4.42|P-value:2.60E-5 ID:SGTC_2242|Compound:6630449|FD-Score:4.23|P-value:5.27E-5 ID:SGTC_2248|Compound:tofa|FD-Score:8.15|P-value:4.00E-14 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.17|P-value:6.31E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.46|P-value:2.05E-5 ID:SGTC_2322|Compound:7413319|FD-Score:6.00|P-value:1.90E-8 ID:SGTC_2482|Compound:5981709|FD-Score:3.39|P-value:9.46E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.95|P-value:1.50E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:19.40|P-value:3.90E-71 ID:SGTC_2524|Compound:avocatin b|FD-Score:11.60|P-value:9.08E-27 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:13.90|P-value:9.85E-38 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.56|P-value:5.55E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.83|P-value:2.27E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:10.90|P-value:7.07E-24 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.13|P-value:7.58E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:23.40|P-value:3.74E-102 ID:SGTC_2620|Compound:irigenin|FD-Score:3.97|P-value:1.38E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.54|P-value:1.92E-7 ID:SGTC_2710|Compound:st078562|FD-Score:3.56|P-value:5.51E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:7.48|P-value:3.45E-12 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.48|P-value:1.98E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.62|P-value:1.20E-7 ID:SGTC_2915|Compound:7971052|FD-Score:4.05|P-value:1.04E-4 ID:SGTC_3086|Compound:9117350|FD-Score:3.62|P-value:4.60E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.04|P-value:1.06E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.72|P-value:3.15E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.69|P-value:3.64E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.66|P-value:1.04E-12 ID:SGTC_3331|Compound:9141060|FD-Score:8.28|P-value:1.56E-14 ID:SGTC_64|Compound:000l-0018|FD-Score:3.79|P-value:2.56E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.43|P-value:8.43E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:11.20|P-value:4.79E-25 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.94|P-value:1.50E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.47|P-value:7.49E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.39|P-value:2.85E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.23|P-value:5.37E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:7.13|P-value:3.18E-11 ID:SGTC_178|Compound:4092-0806|FD-Score:-5.02|P-value:1.97E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:4.91|P-value:3.39E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:6.73|P-value:3.48E-10 ID:SGTC_266|Compound:formosanin C|FD-Score:6.35|P-value:2.89E-9 ID:SGTC_271|Compound:rotenone|FD-Score:3.68|P-value:3.68E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.61|P-value:1.34E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:6.91|P-value:1.16E-10 ID:SGTC_315|Compound:k915-0449|FD-Score:4.42|P-value:2.60E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:4.35|P-value:3.36E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:4.12|P-value:7.88E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:6.51|P-value:1.19E-9 ID:SGTC_356|Compound:1634-0012|FD-Score:5.57|P-value:1.67E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.88|P-value:1.80E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.82|P-value:2.23E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.92|P-value:1.64E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:4.05|P-value:1.04E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.68|P-value:3.68E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.50|P-value:6.77E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.48|P-value:2.00E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:6.37E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.92|P-value:2.91E-8 ID:SGTC_470|Compound:aa-861|FD-Score:7.69|P-value:8.65E-13 ID:SGTC_502|Compound:l-744,832|FD-Score:4.76|P-value:6.40E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:4.74|P-value:7.11E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.47|P-value:7.19E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:11.30|P-value:1.61E-25 ID:SGTC_528|Compound:3492-0019|FD-Score:5.48|P-value:2.53E-7 ID:SGTC_548|Compound:1436-0017|FD-Score:4.67|P-value:9.23E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:6.64|P-value:5.73E-10 ID:SGTC_662|Compound:k832-1615|FD-Score:3.69|P-value:3.60E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.45|P-value:7.94E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.34|P-value:3.42E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:4.19|P-value:6.12E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.31|P-value:3.86E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:-4.23|P-value:5.11E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:4.35|P-value:3.36E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:4.12|P-value:8.08E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.57|P-value:5.19E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-5.18|P-value:9.52E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:4.08|P-value:9.25E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:13.20|P-value:5.64E-34 ID:SGTC_994|Compound:3910-0338|FD-Score:6.40|P-value:2.25E-9 ID:SGTC_1054|Compound:3429-0080|FD-Score:6.47|P-value:1.50E-9 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.51|P-value:6.51E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.06|P-value:9.78E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.99|P-value:2.42E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.05|P-value:1.03E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.81|P-value:4.87E-8 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.23|P-value:5.28E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:13.20|P-value:4.89E-34 ID:SGTC_1687|Compound:st020778|FD-Score:9.42|P-value:2.77E-18 ID:SGTC_1750|Compound:st081859|FD-Score:4.97|P-value:2.56E-6 ID:SGTC_1762|Compound:st045503|FD-Score:4.15|P-value:7.19E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.96|P-value:1.42E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.52|P-value:1.74E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.40|P-value:2.25E-9 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.33|P-value:3.29E-9 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.73|P-value:3.29E-10 ID:SGTC_1885|Compound:st057546|FD-Score:3.38|P-value:9.69E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.54|P-value:1.57E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.25|P-value:4.85E-5 ID:SGTC_1982|Compound:st072467|FD-Score:7.84|P-value:3.23E-13 ID:SGTC_2045|Compound:5106652|FD-Score:4.31|P-value:3.97E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.15|P-value:7.13E-5 ID:SGTC_2200|Compound:6600604|FD-Score:4.42|P-value:2.60E-5 ID:SGTC_2242|Compound:6630449|FD-Score:4.23|P-value:5.27E-5 ID:SGTC_2248|Compound:tofa|FD-Score:8.15|P-value:4.00E-14 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.17|P-value:6.31E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.46|P-value:2.05E-5 ID:SGTC_2322|Compound:7413319|FD-Score:6.00|P-value:1.90E-8 ID:SGTC_2482|Compound:5981709|FD-Score:3.39|P-value:9.46E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.95|P-value:1.50E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:19.40|P-value:3.90E-71 ID:SGTC_2524|Compound:avocatin b|FD-Score:11.60|P-value:9.08E-27 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:13.90|P-value:9.85E-38 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.56|P-value:5.55E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.83|P-value:2.27E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:10.90|P-value:7.07E-24 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.13|P-value:7.58E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:23.40|P-value:3.74E-102 ID:SGTC_2620|Compound:irigenin|FD-Score:3.97|P-value:1.38E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.54|P-value:1.92E-7 ID:SGTC_2710|Compound:st078562|FD-Score:3.56|P-value:5.51E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:7.48|P-value:3.45E-12 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.48|P-value:1.98E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.62|P-value:1.20E-7 ID:SGTC_2915|Compound:7971052|FD-Score:4.05|P-value:1.04E-4 ID:SGTC_3086|Compound:9117350|FD-Score:3.62|P-value:4.60E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.04|P-value:1.06E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.72|P-value:3.15E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.69|P-value:3.64E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.66|P-value:1.04E-12 ID:SGTC_3331|Compound:9141060|FD-Score:8.28|P-value:1.56E-14

Top fitness defect scores for YOR061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2618 avocadyne 23.40 43.4 µM 3.74E-102 4 6.57E-121
2 SGTC_2502 avocadyne acetate 19.40 18.6 µM 3.90E-71 1 4.32E-84
3 SGTC_2567 aureobasidin a 13.90 60.0 nM 9.85E-38 5 1.89E-44
4 SGTC_1568 digitonin 13.20 820.0 nM 4.89E-34 sphingolipid biosynthesis & PDR1 5 4.60E-40
5 SGTC_955 1216-0110 13.20 33.0 µM 5.64E-34 sphingolipid biosynthesis & PDR1 9 5.44E-40
6 SGTC_2524 avocatin b 11.60 10.6 µM 9.08E-27 3 1.93E-31
7 SGTC_527 4476-4215 11.30 268.0 µM 1.61E-25 PDR1 3 5.85E-30
8 SGTC_103 0844-0104 11.20 51.8 µM 4.79E-25 ERAD & cell cycle 25 2.13E-29
9 SGTC_2581 avocatin a 10.90 64.0 µM 7.07E-24 sphingolipid biosynthesis & PDR1 2 5.18E-28
10 SGTC_1687 st020778 9.42 55.4 µM 2.77E-18 54 2.23E-21
11 SGTC_3331 9141060 8.28 2.0 µM 1.56E-14 cell wall 4 6.20E-17
12 SGTC_2248 tofa 8.15 1.1 µM 4.00E-14 sphingolipid biosynthesis & PDR1 11 1.89E-16
13 SGTC_1982 st072467 7.84 71.9 µM 3.23E-13 6 2.25E-15
14 SGTC_470 aa-861 7.69 153.0 µM 8.65E-13 sphingolipid biosynthesis & PDR1 16 7.23E-15
15 SGTC_3311 9131146 7.66 2.9 µM 1.04E-12 cell wall 37 8.99E-15
16 SGTC_2740 felodipine 7.48 17.1 µM 3.45E-12 5 3.72E-14
17 SGTC_146 3448-8650 7.13 53.1 µM 3.18E-11 NEO1-PIK1 35 5.16E-13
18 SGTC_309 k408-0051 6.91 1.5 µM 1.16E-10 9 2.38E-12
19 SGTC_1877 wortmannin 6.73 25.0 µM 3.29E-10 37 8.22E-12
20 SGTC_181 1447-1644 6.73 8.1 µM 3.48E-10 endomembrane recycling 10 8.77E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.353 4.22E-99 YDR297W SUR2 hom Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
0.308 1.43E-74 YLR372W SUR4 hom Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.304 1.26E-72 YKL126W YPK1 hom Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
0.296 6.55E-69 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.256 2.27E-51 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.248 2.15E-48 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.245 2.95E-47 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.238 1.90E-44 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.234 5.16E-43 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.230 1.14E-41 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.227 1.54E-40 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.224 2.52E-39 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.218 1.60E-37 YIL036W CST6 hom Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication
0.217 3.14E-37 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.209 2.55E-34 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress