YOR062C_p

Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR062C / YOR062C

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-4.20|P-value:4.98E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:2.98|P-value:7.26E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.49|P-value:1.22E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.29|P-value:2.25E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:2.90|P-value:9.87E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.56|P-value:7.38E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.69|P-value:4.22E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.80|P-value:3.24E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-5.00|P-value:7.07E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.89|P-value:1.32E-7 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.05|P-value:6.77E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:2.97|P-value:7.42E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.35|P-value:1.78E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.84|P-value:2.65E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.20|P-value:3.89E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.06|P-value:5.36E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:2.95|P-value:8.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.05|P-value:1.02E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.21|P-value:3.61E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.68|P-value:7.71E-10 ID:SGTC_1260|Compound:0700-1617|FD-Score:-4.13|P-value:7.08E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:8.89|P-value:1.77E-21 ID:SGTC_1263|Compound:0774-1208|FD-Score:8.55|P-value:5.29E-20 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.82|P-value:2.96E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:2.91|P-value:9.38E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.51|P-value:7.77E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.20|P-value:3.80E-6 ID:SGTC_1590|Compound:st077108|FD-Score:3.20|P-value:3.21E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.03|P-value:6.09E-4 ID:SGTC_2399|Compound:5884133|FD-Score:6.92|P-value:9.24E-14 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.16|P-value:3.75E-4 ID:SGTC_2415|Compound:st077333|FD-Score:7.66|P-value:1.93E-16 ID:SGTC_2487|Compound:5918373|FD-Score:3.10|P-value:4.65E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.29|P-value:2.18E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.92|P-value:8.92E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.24|P-value:3.11E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.99|P-value:1.35E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.55|P-value:9.48E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.18|P-value:4.23E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.40|P-value:1.75E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.20|P-value:4.98E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:2.98|P-value:7.26E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.49|P-value:1.22E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.29|P-value:2.25E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:2.90|P-value:9.87E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.56|P-value:7.38E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.69|P-value:4.22E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.80|P-value:3.24E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-5.00|P-value:7.07E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.89|P-value:1.32E-7 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.05|P-value:6.77E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:2.97|P-value:7.42E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.35|P-value:1.78E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.84|P-value:2.65E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.20|P-value:3.89E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.06|P-value:5.36E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:2.95|P-value:8.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.05|P-value:1.02E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.21|P-value:3.61E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.68|P-value:7.71E-10 ID:SGTC_1260|Compound:0700-1617|FD-Score:-4.13|P-value:7.08E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:8.89|P-value:1.77E-21 ID:SGTC_1263|Compound:0774-1208|FD-Score:8.55|P-value:5.29E-20 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.82|P-value:2.96E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:2.91|P-value:9.38E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.51|P-value:7.77E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.20|P-value:3.80E-6 ID:SGTC_1590|Compound:st077108|FD-Score:3.20|P-value:3.21E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.03|P-value:6.09E-4 ID:SGTC_2399|Compound:5884133|FD-Score:6.92|P-value:9.24E-14 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.16|P-value:3.75E-4 ID:SGTC_2415|Compound:st077333|FD-Score:7.66|P-value:1.93E-16 ID:SGTC_2487|Compound:5918373|FD-Score:3.10|P-value:4.65E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.29|P-value:2.18E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.92|P-value:8.92E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.24|P-value:3.11E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.99|P-value:1.35E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.55|P-value:9.48E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.18|P-value:4.23E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.40|P-value:1.75E-4

Top fitness defect scores for YOR062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1262 0737-0114 8.89 49.6 µM 1.77E-21 1 3.00E-19
2 SGTC_1263 0774-1208 8.55 64.8 µM 5.29E-20 1 6.15E-18
3 SGTC_2415 st077333 7.66 57.7 µM 1.93E-16 4 9.10E-15
4 SGTC_2399 5884133 6.92 200.0 µM 9.24E-14 cell wall signaling 22 2.22E-12
5 SGTC_1255 0566-0045 5.68 221.0 µM 7.71E-10 excess fatty acid 6 6.87E-9
6 SGTC_1584 6-fluoro-dl-tryptophan 4.51 90.0 µM 7.77E-7 mitochondrial processes 6 3.24E-6
7 SGTC_649 1123-0311 4.35 367.0 µM 1.78E-6 endomembrane recycling 55 6.78E-6
8 SGTC_2576 guaiol 4.24 23.1 µM 3.11E-6 14 1.12E-5
9 SGTC_1125 tnp00248 4.21 1.3 µM 3.61E-6 19 1.28E-5
10 SGTC_1586 deoxycorticosterone acetate 4.20 53.7 µM 3.80E-6 5 1.33E-5
11 SGTC_431 k089-0097 3.69 107.0 µM 4.22E-5 iron homeostasis 55 1.14E-4
12 SGTC_297 0986-0032 3.56 24.0 µM 7.38E-5 60S ribosome export 11 1.88E-4
13 SGTC_2568 diosmetin 3.29 100.0 µM 2.18E-4 49 4.93E-4
14 SGTC_281 1672-3440 3.29 14.9 µM 2.25E-4 Golgi 18 5.07E-4
15 SGTC_1590 st077108 3.20 57.8 µM 3.21E-4 21 6.97E-4
16 SGTC_2410 aloe-emodin-8-o-glycoside 3.16 46.3 µM 3.75E-4 mitochondrial processes 74 8.00E-4
17 SGTC_2487 5918373 3.10 44.0 µM 4.65E-4 48 9.69E-4
18 SGTC_915 methyl methanesulfonate (MMS) 3.06 110.0 mM 5.36E-4 DNA damage response 78 0.00110
19 SGTC_1630 st005209 3.03 31.3 µM 6.09E-4 70 0.00123
20 SGTC_130 0136-0219 2.98 337.7 µM 7.26E-4 68 0.00144

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.35E-41 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.208 4.87E-34 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.206 1.45E-33 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.199 2.16E-31 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.193 1.34E-29 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.185 2.77E-27 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.185 3.25E-27 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.182 2.46E-26 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.179 1.77E-25 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.178 2.48E-25 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.176 1.17E-24 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.174 2.57E-24 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.170 3.62E-23 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.163 2.27E-21 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.155 1.45E-19 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases