YOR063W / RPL3

Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR063W / RPL3

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-5.50|P-value:1.56E-9 ID:SGTC_39|Compound:0986-0283|FD-Score:3.85|P-value:1.23E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.55|P-value:8.31E-13 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.93|P-value:8.39E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.43|P-value:1.19E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.33|P-value:1.32E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.57|P-value:6.49E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.17|P-value:2.57E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.15|P-value:2.79E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.08|P-value:3.57E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.68|P-value:2.73E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.73|P-value:2.17E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:3.36|P-value:1.17E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.24|P-value:2.56E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.92|P-value:6.72E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.82|P-value:6.92E-8 ID:SGTC_958|Compound:1222-0007|FD-Score:3.70|P-value:2.55E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:2.84|P-value:8.91E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.20|P-value:3.06E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.57|P-value:2.95E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.17|P-value:2.56E-6 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.01|P-value:5.68E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.58|P-value:4.34E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.20|P-value:2.24E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.34|P-value:1.25E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.09|P-value:3.50E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-2.91|P-value:9.12E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.99|P-value:3.96E-8 ID:SGTC_1734|Compound:st037168|FD-Score:-2.95|P-value:7.79E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.48|P-value:4.85E-7 ID:SGTC_2008|Compound:4012253|FD-Score:3.73|P-value:2.22E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.12|P-value:3.08E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.89|P-value:1.05E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-3.47|P-value:9.99E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.63|P-value:2.09E-7 ID:SGTC_2286|Compound:7945697|FD-Score:3.72|P-value:2.29E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.39|P-value:9.92E-5 ID:SGTC_2462|Compound:5162487|FD-Score:3.73|P-value:2.20E-5 ID:SGTC_2470|Compound:5664817|FD-Score:-3.41|P-value:1.26E-4 ID:SGTC_2781|Compound:5567276|FD-Score:6.06|P-value:1.83E-11 ID:SGTC_2807|Compound:7945238|FD-Score:3.23|P-value:1.99E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.14|P-value:3.89E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.67|P-value:4.03E-5 ID:SGTC_2961|Compound:9083290|FD-Score:2.98|P-value:5.35E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.85|P-value:8.84E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-4.01|P-value:8.11E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-5.06|P-value:2.58E-8 ID:SGTC_3000|Compound:9075062|FD-Score:3.17|P-value:2.56E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-2.94|P-value:8.13E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.28|P-value:2.10E-6 ID:SGTC_3081|Compound:9117243|FD-Score:2.88|P-value:7.89E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.41|P-value:9.22E-5 ID:SGTC_3199|Compound:9111318|FD-Score:5.22|P-value:6.14E-9 ID:SGTC_3328|Compound:9140624|FD-Score:-2.94|P-value:8.21E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.42|P-value:8.82E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:-5.50|P-value:1.56E-9 ID:SGTC_39|Compound:0986-0283|FD-Score:3.85|P-value:1.23E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.55|P-value:8.31E-13 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.93|P-value:8.39E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.43|P-value:1.19E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.33|P-value:1.32E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.57|P-value:6.49E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.17|P-value:2.57E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.15|P-value:2.79E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.08|P-value:3.57E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.68|P-value:2.73E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.73|P-value:2.17E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:3.36|P-value:1.17E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.24|P-value:2.56E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.92|P-value:6.72E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.82|P-value:6.92E-8 ID:SGTC_958|Compound:1222-0007|FD-Score:3.70|P-value:2.55E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:2.84|P-value:8.91E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.20|P-value:3.06E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.57|P-value:2.95E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.17|P-value:2.56E-6 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.01|P-value:5.68E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.58|P-value:4.34E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.20|P-value:2.24E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.34|P-value:1.25E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.09|P-value:3.50E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-2.91|P-value:9.12E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.99|P-value:3.96E-8 ID:SGTC_1734|Compound:st037168|FD-Score:-2.95|P-value:7.79E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.48|P-value:4.85E-7 ID:SGTC_2008|Compound:4012253|FD-Score:3.73|P-value:2.22E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.12|P-value:3.08E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.89|P-value:1.05E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-3.47|P-value:9.99E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.63|P-value:2.09E-7 ID:SGTC_2286|Compound:7945697|FD-Score:3.72|P-value:2.29E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.39|P-value:9.92E-5 ID:SGTC_2462|Compound:5162487|FD-Score:3.73|P-value:2.20E-5 ID:SGTC_2470|Compound:5664817|FD-Score:-3.41|P-value:1.26E-4 ID:SGTC_2781|Compound:5567276|FD-Score:6.06|P-value:1.83E-11 ID:SGTC_2807|Compound:7945238|FD-Score:3.23|P-value:1.99E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.14|P-value:3.89E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.67|P-value:4.03E-5 ID:SGTC_2961|Compound:9083290|FD-Score:2.98|P-value:5.35E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.85|P-value:8.84E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-4.01|P-value:8.11E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-5.06|P-value:2.58E-8 ID:SGTC_3000|Compound:9075062|FD-Score:3.17|P-value:2.56E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-2.94|P-value:8.13E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.28|P-value:2.10E-6 ID:SGTC_3081|Compound:9117243|FD-Score:2.88|P-value:7.89E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.41|P-value:9.22E-5 ID:SGTC_3199|Compound:9111318|FD-Score:5.22|P-value:6.14E-9 ID:SGTC_3328|Compound:9140624|FD-Score:-2.94|P-value:8.21E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.42|P-value:8.82E-5

Top fitness defect scores for YOR063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2781 5567276 6.06 71.4 µM 1.83E-11 1 6.61E-10 0.64
2 SGTC_3199 9111318 5.22 49.5 µM 6.14E-9 5 9.19E-8 0.01
3 SGTC_955 1216-0110 4.82 33.0 µM 6.92E-8 sphingolipid biosynthesis & PDR1 3 7.17E-7 0.54
4 SGTC_2285 7945142 4.63 200.0 µM 2.09E-7 6 1.83E-6 0.06
5 SGTC_1242 0402-0103 4.57 60.1 µM 2.95E-7 4 2.46E-6 0.07
6 SGTC_1976 st070609 4.48 63.5 µM 4.85E-7 1 3.75E-6 0.46
7 SGTC_1275 0867-0008 4.17 21.1 µM 2.56E-6 4 1.54E-5 0.30
8 SGTC_1314 1222-0010 4.01 41.1 µM 5.68E-6 1 3.03E-5 0.41
9 SGTC_2113 5491891 3.89 107.0 µM 1.05E-5 TSC3-RPN4 7 5.11E-5 0.10
10 SGTC_39 0986-0283 3.85 58.4 µM 1.23E-5 calcium & mitochondrial duress 9 5.83E-5 0.08
11 SGTC_891 0929-0073 3.73 133.0 µM 2.17E-5 3 9.46E-5 0.47
12 SGTC_2462 5162487 3.73 171.8 µM 2.20E-5 5 9.58E-5 0.12
13 SGTC_2008 4012253 3.73 172.0 µM 2.22E-5 15 9.64E-5 0.36
14 SGTC_2286 7945697 3.72 125.0 µM 2.29E-5 13 9.91E-5 0.01
15 SGTC_958 1222-0007 3.70 33.0 µM 2.55E-5 6 1.08E-4 0.01
16 SGTC_710 3448-4187 3.68 58.0 µM 2.73E-5 fatty acid desaturase (OLE1) 13 1.15E-4 0.41
17 SGTC_1318 1280-3875 3.58 124.0 µM 4.34E-5 8 1.70E-4 0.17
18 SGTC_3332 9141069 3.42 11.2 µM 8.82E-5 3 3.11E-4 0.06
19 SGTC_3101 9120531 3.41 49.5 µM 9.22E-5 8 3.23E-4 0.00
20 SGTC_2456 5770359 3.39 74.5 µM 9.92E-5 8 3.44E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 9.27E-26 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.125 3.18E-13 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.121 1.91E-12 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.108 3.26E-10 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.107 5.61E-10 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.104 1.77E-9 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.102 3.44E-9 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.101 4.19E-9 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.101 4.77E-9 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.099 9.58E-9 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.098 1.08E-8 YML054C-A_p YML054C-A_p hom Putative protein of unknown function
0.098 1.15E-8 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.096 2.66E-8 YCR068W ATG15 hom Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
0.094 4.45E-8 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.089 2.60E-7 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC