YOR064C / YNG1

Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR064C / YNG1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.29|P-value:1.38E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.44|P-value:7.29E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:3.47|P-value:3.54E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:6.62|P-value:4.84E-11 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.45|P-value:3.77E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.80|P-value:1.02E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.61|P-value:2.09E-4 ID:SGTC_264|Compound:promethazine|FD-Score:6.76|P-value:2.02E-11 ID:SGTC_345|Compound:1362-0200|FD-Score:4.59|P-value:3.74E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:3.49|P-value:3.29E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.44|P-value:3.90E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-6.57|P-value:6.66E-11 ID:SGTC_684|Compound:1140-0066|FD-Score:3.48|P-value:3.37E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.41|P-value:4.28E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-5.47|P-value:4.39E-8 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.68|P-value:1.60E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.38|P-value:9.45E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.49|P-value:3.20E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.01|P-value:4.49E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.21|P-value:8.43E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.47|P-value:3.51E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.42|P-value:4.24E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.33|P-value:5.69E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.83|P-value:1.21E-6 ID:SGTC_1193|Compound:1488-0126|FD-Score:-4.39|P-value:8.91E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.21|P-value:8.53E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:-3.33|P-value:5.74E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.54|P-value:2.68E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.95|P-value:5.64E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.62|P-value:2.04E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.38|P-value:4.81E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.27|P-value:1.49E-5 ID:SGTC_1554|Compound:st069299|FD-Score:4.78|P-value:1.54E-6 ID:SGTC_1578|Compound:josamycin|FD-Score:3.28|P-value:6.69E-4 ID:SGTC_1624|Compound:st003710|FD-Score:-3.74|P-value:1.26E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.04|P-value:4.01E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.67|P-value:1.68E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.29|P-value:1.36E-5 ID:SGTC_2324|Compound:6149169|FD-Score:4.96|P-value:6.27E-7 ID:SGTC_2484|Compound:5809818|FD-Score:-3.25|P-value:7.33E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.19|P-value:9.21E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.31|P-value:1.28E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.29|P-value:6.42E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.49|P-value:3.31E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.29|P-value:6.65E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.46|P-value:6.48E-6 ID:SGTC_2940|Compound:9060638|FD-Score:-11.40|P-value:5.12E-29 ID:SGTC_3166|Compound:9102297|FD-Score:4.58|P-value:3.90E-6 ID:SGTC_3274|Compound:9138298|FD-Score:-3.37|P-value:4.93E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.75|P-value:1.27E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.26|P-value:7.35E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.29|P-value:1.38E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.44|P-value:7.29E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:3.47|P-value:3.54E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:6.62|P-value:4.84E-11 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.45|P-value:3.77E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.80|P-value:1.02E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.61|P-value:2.09E-4 ID:SGTC_264|Compound:promethazine|FD-Score:6.76|P-value:2.02E-11 ID:SGTC_345|Compound:1362-0200|FD-Score:4.59|P-value:3.74E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:3.49|P-value:3.29E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.44|P-value:3.90E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-6.57|P-value:6.66E-11 ID:SGTC_684|Compound:1140-0066|FD-Score:3.48|P-value:3.37E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.41|P-value:4.28E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-5.47|P-value:4.39E-8 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.68|P-value:1.60E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.38|P-value:9.45E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.49|P-value:3.20E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.01|P-value:4.49E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.21|P-value:8.43E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.47|P-value:3.51E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.42|P-value:4.24E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.33|P-value:5.69E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.83|P-value:1.21E-6 ID:SGTC_1193|Compound:1488-0126|FD-Score:-4.39|P-value:8.91E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.21|P-value:8.53E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:-3.33|P-value:5.74E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.54|P-value:2.68E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.95|P-value:5.64E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.62|P-value:2.04E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.38|P-value:4.81E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.27|P-value:1.49E-5 ID:SGTC_1554|Compound:st069299|FD-Score:4.78|P-value:1.54E-6 ID:SGTC_1578|Compound:josamycin|FD-Score:3.28|P-value:6.69E-4 ID:SGTC_1624|Compound:st003710|FD-Score:-3.74|P-value:1.26E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.04|P-value:4.01E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.67|P-value:1.68E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.29|P-value:1.36E-5 ID:SGTC_2324|Compound:6149169|FD-Score:4.96|P-value:6.27E-7 ID:SGTC_2484|Compound:5809818|FD-Score:-3.25|P-value:7.33E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.19|P-value:9.21E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.31|P-value:1.28E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.29|P-value:6.42E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.49|P-value:3.31E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.29|P-value:6.65E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.46|P-value:6.48E-6 ID:SGTC_2940|Compound:9060638|FD-Score:-11.40|P-value:5.12E-29 ID:SGTC_3166|Compound:9102297|FD-Score:4.58|P-value:3.90E-6 ID:SGTC_3274|Compound:9138298|FD-Score:-3.37|P-value:4.93E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.75|P-value:1.27E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.26|P-value:7.35E-4

Top fitness defect scores for YOR064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 6.76 12.5 mM 2.02E-11 DNA intercalators 15 6.98E-12
2 SGTC_145 3737-0113 6.62 38.4 µM 4.84E-11 DNA intercalators 19 1.74E-11
3 SGTC_2324 6149169 4.96 200.0 µM 6.27E-7 8 3.49E-7
4 SGTC_1186 1319-0216 4.83 26.0 µM 1.21E-6 6 6.93E-7
5 SGTC_1554 st069299 4.78 38.7 µM 1.54E-6 8 8.96E-7
6 SGTC_345 1362-0200 4.59 395.0 µM 3.74E-6 6 2.26E-6
7 SGTC_3166 9102297 4.58 49.5 µM 3.90E-6 Golgi 24 2.36E-6
8 SGTC_2930 9013230 4.46 14.9 µM 6.48E-6 heme biosynthesis & mitochondrial translocase 20 4.02E-6
9 SGTC_77 0828-0286 4.44 12.5 µM 7.29E-6 TSC3-RPN4 23 4.54E-6
10 SGTC_17 0960-0276 4.29 49.8 µM 1.38E-5 22 8.82E-6
11 SGTC_1484 3473-2379 4.27 286.0 µM 1.49E-5 11 9.60E-6
12 SGTC_1754 st042065 4.04 16.1 µM 4.01E-5 NEO1-PIK1 172 2.70E-5
13 SGTC_725 1497-0963 4.01 19.0 µM 4.49E-5 copper-dependent oxidative stress 17 3.04E-5
14 SGTC_255 tunicamycin 3.80 200.5 nM 1.02E-4 unfolded protein response 82 7.13E-5
15 SGTC_3304 9125678 3.75 46.1 µM 1.27E-4 60 8.99E-5
16 SGTC_1970 st070122 3.67 35.8 µM 1.68E-4 TSC3-RPN4 33 1.20E-4
17 SGTC_1353 1498-1206 3.62 8.1 µM 2.04E-4 mitochondrial response to ROS 64 1.48E-4
18 SGTC_257 daunorubicin 3.61 18.5 µM 2.09E-4 anthracycline transcription coupled DNA repair 28 1.52E-4
19 SGTC_1212 0520-0165 3.54 585.0 µM 2.68E-4 47 1.96E-4
20 SGTC_439 amiodarone 3.49 34.4 µM 3.29E-4 NEO1-PIK1 112 2.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.253 7.64E-50 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.252 9.31E-50 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.228 1.06E-40 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.226 5.07E-40 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.213 1.49E-35 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.209 2.39E-34 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.188 3.75E-28 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.170 4.86E-23 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.169 5.66E-23 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.163 2.89E-21 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.157 5.33E-20 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.153 5.01E-19 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.144 4.53E-17 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.142 1.55E-16 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.138 1.34E-15 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data