YOR065W / CYT1

Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR065W / CYT1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:4.73|P-value:2.34E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:4.25|P-value:2.98E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:4.51|P-value:7.57E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.91|P-value:1.51E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:20.90|P-value:7.26E-110 ID:SGTC_291|Compound:4130-1278|FD-Score:3.07|P-value:5.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.37|P-value:1.61E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:9.23|P-value:4.42E-23 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.16|P-value:4.23E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.25|P-value:2.96E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.89|P-value:1.94E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.76|P-value:3.10E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:-2.94|P-value:9.37E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.45|P-value:1.33E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.24|P-value:3.05E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.61|P-value:4.38E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.23|P-value:3.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.03|P-value:6.14E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.43|P-value:1.42E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.43|P-value:1.40E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.09|P-value:4.86E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.44|P-value:1.22E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.20|P-value:6.72E-33 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.42|P-value:1.46E-4 ID:SGTC_1817|Compound:st052116|FD-Score:5.21|P-value:1.41E-8 ID:SGTC_1818|Compound:st052136|FD-Score:-3.25|P-value:2.97E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.03|P-value:6.18E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-4.79|P-value:1.94E-7 ID:SGTC_1952|Compound:st077036|FD-Score:-3.04|P-value:6.57E-4 ID:SGTC_1987|Compound:st072290|FD-Score:2.98|P-value:7.21E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.94|P-value:1.30E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.38|P-value:1.73E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.09|P-value:4.82E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.50|P-value:8.14E-7 ID:SGTC_2376|Compound:9072922|FD-Score:4.33|P-value:1.98E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.01|P-value:7.32E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.19|P-value:3.74E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.01|P-value:6.53E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.04|P-value:5.96E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.88|P-value:2.02E-5 ID:SGTC_2917|Compound:7979103|FD-Score:5.05|P-value:3.72E-8 ID:SGTC_2925|Compound:9010536|FD-Score:4.06|P-value:7.53E-6 ID:SGTC_3091|Compound:9116372|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-4.14|P-value:5.99E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-3.70|P-value:4.48E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.98|P-value:7.32E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.73|P-value:2.34E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:4.25|P-value:2.98E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:4.51|P-value:7.57E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.91|P-value:1.51E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:20.90|P-value:7.26E-110 ID:SGTC_291|Compound:4130-1278|FD-Score:3.07|P-value:5.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.37|P-value:1.61E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:9.23|P-value:4.42E-23 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.16|P-value:4.23E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.25|P-value:2.96E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.89|P-value:1.94E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.76|P-value:3.10E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:-2.94|P-value:9.37E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.45|P-value:1.33E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.24|P-value:3.05E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.61|P-value:4.38E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.23|P-value:3.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.03|P-value:6.14E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.43|P-value:1.42E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.43|P-value:1.40E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.09|P-value:4.86E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.44|P-value:1.22E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.20|P-value:6.72E-33 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.42|P-value:1.46E-4 ID:SGTC_1817|Compound:st052116|FD-Score:5.21|P-value:1.41E-8 ID:SGTC_1818|Compound:st052136|FD-Score:-3.25|P-value:2.97E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.03|P-value:6.18E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-4.79|P-value:1.94E-7 ID:SGTC_1952|Compound:st077036|FD-Score:-3.04|P-value:6.57E-4 ID:SGTC_1987|Compound:st072290|FD-Score:2.98|P-value:7.21E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.94|P-value:1.30E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.38|P-value:1.73E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.09|P-value:4.82E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.50|P-value:8.14E-7 ID:SGTC_2376|Compound:9072922|FD-Score:4.33|P-value:1.98E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.01|P-value:7.32E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.19|P-value:3.74E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.01|P-value:6.53E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.04|P-value:5.96E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.88|P-value:2.02E-5 ID:SGTC_2917|Compound:7979103|FD-Score:5.05|P-value:3.72E-8 ID:SGTC_2925|Compound:9010536|FD-Score:4.06|P-value:7.53E-6 ID:SGTC_3091|Compound:9116372|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-4.14|P-value:5.99E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-3.70|P-value:4.48E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.98|P-value:7.32E-4

Top fitness defect scores for YOR065W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 20.90 5.3 µM 7.26E-110 46 1.80E-97
2 SGTC_1635 st007035 11.20 42.4 µM 6.72E-33 67 2.64E-29
3 SGTC_386 1509-0011 9.23 3.1 µM 4.42E-23 51 1.31E-20
4 SGTC_1817 st052116 5.21 64.4 µM 1.41E-8 RNA processing & uracil transport 3 9.35E-8
5 SGTC_2917 7979103 5.05 53.8 µM 3.72E-8 10 2.21E-7
6 SGTC_70 0141-0289 4.73 43.3 µM 2.34E-7 mitochondrial stress 122 1.13E-6
7 SGTC_1383 3049-0032 4.61 20.7 µM 4.38E-7 60S ribosome export 12 1.97E-6
8 SGTC_134 0269-0018 4.51 6.9 µM 7.57E-7 112 3.21E-6
9 SGTC_2375 9072683 4.50 200.0 µM 8.14E-7 mitochondrial processes 10 3.42E-6
10 SGTC_310 1273-0058 4.37 1.1 µM 1.61E-6 mitochondrial stress 220 6.27E-6
11 SGTC_2376 9072922 4.33 81.3 µM 1.98E-6 16 7.51E-6
12 SGTC_87 0100-0052 4.25 35.5 µM 2.98E-6 89 1.08E-5
13 SGTC_2925 9010536 4.06 32.5 µM 7.53E-6 azole & statin 42 2.46E-5
14 SGTC_2054 5233173 3.94 129.0 µM 1.30E-5 mitochondrial response to ROS 53 4.01E-5
15 SGTC_214 4373-3496 3.91 70.0 µM 1.51E-5 56 4.56E-5
16 SGTC_1007 4101-0031 3.76 70.0 µM 3.10E-5 23 8.66E-5
17 SGTC_1625 st003711 3.44 30.1 µM 1.22E-4 calcium & mitochondrial duress 56 2.93E-4
18 SGTC_3091 9116372 3.33 49.5 µM 1.90E-4 37 4.35E-4
19 SGTC_2344 7990960 3.09 77.0 µM 4.82E-4 61 9.94E-4
20 SGTC_1622 st003707 3.09 19.4 µM 4.86E-4 calcium & mitochondrial duress 86 0.00100

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.722 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.715 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.673 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.661 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.659 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.654 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.653 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.650 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.644 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.640 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.640 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.638 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.625 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.608 0 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.607 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies