YOR068C / VAM10

Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR068C / VAM10

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.88|P-value:9.45E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:5.45|P-value:7.32E-8 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.21|P-value:2.45E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:7.36|P-value:6.17E-13 ID:SGTC_124|Compound:0136-0217|FD-Score:3.48|P-value:3.98E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.24|P-value:8.86E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.45|P-value:4.32E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.32|P-value:6.86E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.31|P-value:7.20E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.22|P-value:9.45E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.43|P-value:4.68E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:8.45|P-value:1.85E-16 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.01|P-value:6.98E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:4.47|P-value:8.23E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:11.40|P-value:1.41E-28 ID:SGTC_684|Compound:1140-0066|FD-Score:3.22|P-value:9.55E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.73|P-value:1.59E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.27|P-value:8.08E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.29|P-value:7.55E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.21|P-value:9.63E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.28|P-value:7.79E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.78|P-value:2.02E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:4.48|P-value:7.75E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.88|P-value:1.23E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.69|P-value:1.84E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.88|P-value:9.16E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.39|P-value:5.30E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.42|P-value:4.82E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.52|P-value:3.45E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.85|P-value:1.05E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.11|P-value:3.64E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.67|P-value:1.99E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.49|P-value:7.37E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.33|P-value:6.60E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.27|P-value:7.93E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.44|P-value:4.58E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.76|P-value:1.39E-8 ID:SGTC_2094|Compound:5332512|FD-Score:3.73|P-value:1.62E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.32|P-value:6.88E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.76|P-value:1.46E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.52|P-value:3.46E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.13|P-value:3.75E-7 ID:SGTC_2362|Compound:9071156|FD-Score:3.47|P-value:4.07E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.58|P-value:2.81E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.46|P-value:4.22E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.23|P-value:9.20E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.34|P-value:6.44E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.71|P-value:1.73E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.50|P-value:3.65E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.55|P-value:3.10E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.11|P-value:3.74E-5 ID:SGTC_2696|Compound:st077691|FD-Score:4.08|P-value:4.22E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-3.87|P-value:9.61E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.21|P-value:2.40E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.34|P-value:6.31E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.40|P-value:5.20E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.89|P-value:8.64E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.38|P-value:5.60E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.47|P-value:2.20E-10 ID:SGTC_3039|Compound:9090270|FD-Score:3.43|P-value:4.66E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.33|P-value:6.48E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.44|P-value:4.58E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.52|P-value:3.37E-4 ID:SGTC_3232|Compound:9132874|FD-Score:6.72|P-value:4.66E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.88|P-value:9.45E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:5.45|P-value:7.32E-8 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.21|P-value:2.45E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:7.36|P-value:6.17E-13 ID:SGTC_124|Compound:0136-0217|FD-Score:3.48|P-value:3.98E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.24|P-value:8.86E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.45|P-value:4.32E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.32|P-value:6.86E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.31|P-value:7.20E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.22|P-value:9.45E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.43|P-value:4.68E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:8.45|P-value:1.85E-16 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.01|P-value:6.98E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:4.47|P-value:8.23E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:11.40|P-value:1.41E-28 ID:SGTC_684|Compound:1140-0066|FD-Score:3.22|P-value:9.55E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.73|P-value:1.59E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.27|P-value:8.08E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.29|P-value:7.55E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.21|P-value:9.63E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.28|P-value:7.79E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.78|P-value:2.02E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:4.48|P-value:7.75E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.88|P-value:1.23E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.69|P-value:1.84E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.88|P-value:9.16E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.39|P-value:5.30E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.42|P-value:4.82E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.52|P-value:3.45E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.85|P-value:1.05E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.11|P-value:3.64E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.67|P-value:1.99E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.49|P-value:7.37E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.33|P-value:6.60E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.27|P-value:7.93E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.44|P-value:4.58E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.76|P-value:1.39E-8 ID:SGTC_2094|Compound:5332512|FD-Score:3.73|P-value:1.62E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.32|P-value:6.88E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.76|P-value:1.46E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.52|P-value:3.46E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.13|P-value:3.75E-7 ID:SGTC_2362|Compound:9071156|FD-Score:3.47|P-value:4.07E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.58|P-value:2.81E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.46|P-value:4.22E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.23|P-value:9.20E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.34|P-value:6.44E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.71|P-value:1.73E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.50|P-value:3.65E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.55|P-value:3.10E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.11|P-value:3.74E-5 ID:SGTC_2696|Compound:st077691|FD-Score:4.08|P-value:4.22E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-3.87|P-value:9.61E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.21|P-value:2.40E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.34|P-value:6.31E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.40|P-value:5.20E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.89|P-value:8.64E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.38|P-value:5.60E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.47|P-value:2.20E-10 ID:SGTC_3039|Compound:9090270|FD-Score:3.43|P-value:4.66E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.33|P-value:6.48E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.44|P-value:4.58E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.52|P-value:3.37E-4 ID:SGTC_3232|Compound:9132874|FD-Score:6.72|P-value:4.66E-11

Top fitness defect scores for YOR068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 11.40 172.0 µM 1.41E-28 calcium & mitochondrial duress 34 1.39E-30
2 SGTC_431 k089-0097 8.45 107.0 µM 1.85E-16 iron homeostasis 2 1.47E-17
3 SGTC_117 lucigenin 7.36 22.1 µM 6.17E-13 redox potentiating 26 8.97E-14
4 SGTC_3232 9132874 6.72 49.5 µM 4.66E-11 RPP1 & pyrimidine depletion 2 9.33E-12
5 SGTC_3037 9091026 6.47 49.5 µM 2.20E-10 NEO1-PIK1 38 4.94E-11
6 SGTC_2021 4019055 5.76 173.0 µM 1.39E-8 endomembrane recycling 43 4.23E-9
7 SGTC_70 0141-0289 5.45 43.3 µM 7.32E-8 mitochondrial stress 99 2.52E-8
8 SGTC_2322 7413319 5.13 38.2 µM 3.75E-7 ERAD & cell cycle 88 1.45E-7
9 SGTC_1000 4048-0884 4.88 8.7 µM 1.23E-6 copper-dependent oxidative stress 18 5.18E-7
10 SGTC_905 2-aminofluorene 4.78 215.0 µM 2.02E-6 cell wall signaling 15 8.82E-7
11 SGTC_1952 st077036 4.49 64.1 µM 7.37E-6 20 3.54E-6
12 SGTC_997 3996-0078 4.48 137.0 µM 7.75E-6 11 3.74E-6
13 SGTC_526 4469-0568 4.47 170.0 µM 8.23E-6 azole & statin 27 3.99E-6
14 SGTC_2752 diclazuril 4.21 33.1 µM 2.40E-5 104 1.25E-5
15 SGTC_102 gallobenzophenone 4.21 83.6 µM 2.45E-5 redox potentiating 39 1.28E-5
16 SGTC_1844 rapamycin 4.11 4.0 nM 3.64E-5 151 1.96E-5
17 SGTC_2679 rapamycin 4.11 1.0 nM 3.74E-5 133 2.02E-5
18 SGTC_2696 st077691 4.08 74.3 µM 4.22E-5 29 2.30E-5
19 SGTC_2873 9040596 3.89 71.4 µM 8.64E-5 52 4.95E-5
20 SGTC_1268 0828-0275 3.88 2.5 µM 9.16E-5 22 5.28E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.283 5.43E-63 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.260 8.25E-53 YOR069W VPS5 hom Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes
0.256 2.28E-51 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.244 1.57E-46 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.243 2.96E-46 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.235 1.85E-43 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.230 1.31E-41 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.228 7.24E-41 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.226 3.48E-40 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.213 6.69E-36 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.212 2.47E-35 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.209 2.11E-34 YDR486C VPS60 hom Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
0.205 4.17E-33 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.204 6.24E-33 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.199 2.52E-31 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes