YOR070C / GYP1

Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR070C / GYP1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-6.49|P-value:4.16E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:16.30|P-value:7.03E-29 ID:SGTC_100|Compound:0086-0128|FD-Score:-4.75|P-value:5.44E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.74|P-value:6.41E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:7.10|P-value:6.70E-7 ID:SGTC_110|Compound:0850-0284|FD-Score:5.66|P-value:5.86E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:-7.85|P-value:3.60E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:22.20|P-value:2.75E-52 ID:SGTC_124|Compound:0136-0217|FD-Score:18.70|P-value:1.36E-37 ID:SGTC_126|Compound:0417-1624|FD-Score:6.08|P-value:1.75E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.26|P-value:3.80E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.56|P-value:9.74E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:6.48|P-value:5.16E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:16.60|P-value:6.77E-30 ID:SGTC_180|Compound:1486-1293|FD-Score:4.83|P-value:5.18E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:11.60|P-value:1.32E-15 ID:SGTC_206|Compound:4546-0025|FD-Score:7.89|P-value:3.81E-8 ID:SGTC_218|Compound:alverine citrate|FD-Score:8.07|P-value:1.92E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:17.50|P-value:3.85E-33 ID:SGTC_232|Compound:clozapine|FD-Score:14.00|P-value:7.37E-22 ID:SGTC_254|Compound:nsc-64875|FD-Score:13.10|P-value:1.69E-19 ID:SGTC_258|Compound:haloperidol|FD-Score:7.62|P-value:1.05E-7 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.98|P-value:2.76E-8 ID:SGTC_278|Compound:4092-0821|FD-Score:6.79|P-value:1.87E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.95|P-value:3.31E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:6.27|P-value:9.83E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:6.54|P-value:4.29E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.08|P-value:2.40E-10 ID:SGTC_312|Compound:4092-0653|FD-Score:6.61|P-value:3.44E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:6.48|P-value:5.23E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:7.50|P-value:1.62E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:8.04|P-value:2.14E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:6.72|P-value:2.36E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:10.10|P-value:3.06E-12 ID:SGTC_426|Compound:0988-0037|FD-Score:5.71|P-value:5.10E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.61|P-value:7.57E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-6.29|P-value:7.81E-6 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:5.58|P-value:7.38E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.31|P-value:8.66E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-12.40|P-value:1.17E-17 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.04|P-value:1.67E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.94|P-value:3.97E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-4.52|P-value:9.36E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.39|P-value:1.24E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:9.71|P-value:1.81E-11 ID:SGTC_577|Compound:r071-0003|FD-Score:11.60|P-value:1.10E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:11.10|P-value:2.29E-14 ID:SGTC_669|Compound:0108-0021|FD-Score:31.70|P-value:1.63E-104 ID:SGTC_689|Compound:0833-0039|FD-Score:7.14|P-value:5.90E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.61|P-value:5.83E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.98|P-value:3.58E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:5.96|P-value:2.50E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:7.51|P-value:1.57E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:24.70|P-value:2.82E-64 ID:SGTC_794|Compound:k038-0031|FD-Score:5.68|P-value:5.55E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:5.79|P-value:4.06E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:8.63|P-value:2.08E-9 ID:SGTC_875|Compound:0709-0210|FD-Score:5.73|P-value:4.82E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:9.48|P-value:5.17E-11 ID:SGTC_999|Compound:4022-0066|FD-Score:7.01|P-value:9.03E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:9.26|P-value:1.38E-10 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.70|P-value:5.35E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.43|P-value:1.10E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.70|P-value:7.06E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:5.16|P-value:2.25E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.70|P-value:6.95E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:7.74|P-value:6.67E-8 ID:SGTC_1104|Compound:tacrolimus|FD-Score:5.85|P-value:3.42E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:8.68|P-value:1.65E-9 ID:SGTC_1161|Compound:k007-0610|FD-Score:9.28|P-value:1.25E-10 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.19|P-value:2.09E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.31|P-value:1.53E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.65|P-value:6.04E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:9.83|P-value:1.03E-11 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.82|P-value:5.29E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.76|P-value:6.03E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:8.26|P-value:9.11E-9 ID:SGTC_1658|Compound:st012944|FD-Score:4.87|P-value:4.65E-4 ID:SGTC_1665|Compound:st014639|FD-Score:8.06|P-value:1.97E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.84|P-value:5.05E-4 ID:SGTC_1708|Compound:st033234|FD-Score:5.30|P-value:1.56E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.73|P-value:1.37E-9 ID:SGTC_1760|Compound:st045453|FD-Score:15.60|P-value:6.71E-27 ID:SGTC_1781|Compound:st038725|FD-Score:8.68|P-value:1.70E-9 ID:SGTC_1797|Compound:st048695|FD-Score:11.10|P-value:2.25E-14 ID:SGTC_1801|Compound:st050089|FD-Score:11.90|P-value:1.85E-16 ID:SGTC_1803|Compound:st050068|FD-Score:8.14|P-value:1.49E-8 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.99|P-value:3.45E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.95|P-value:3.86E-4 ID:SGTC_1917|Compound:st066507|FD-Score:6.22|P-value:1.14E-5 ID:SGTC_1923|Compound:st058458|FD-Score:8.39|P-value:5.53E-9 ID:SGTC_1945|Compound:st075991|FD-Score:5.92|P-value:2.83E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-6.58|P-value:3.11E-6 ID:SGTC_1952|Compound:st077036|FD-Score:6.00|P-value:2.21E-5 ID:SGTC_1991|Compound:st073000|FD-Score:17.80|P-value:3.50E-34 ID:SGTC_2006|Compound:4011487|FD-Score:9.97|P-value:5.36E-12 ID:SGTC_2036|Compound:5160441|FD-Score:19.90|P-value:3.67E-42 ID:SGTC_2055|Compound:5235184|FD-Score:4.87|P-value:4.64E-4 ID:SGTC_2127|Compound:5253358|FD-Score:5.43|P-value:1.10E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.98|P-value:3.60E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.55|P-value:8.01E-5 ID:SGTC_2231|Compound:micatex|FD-Score:5.89|P-value:3.05E-5 ID:SGTC_2242|Compound:6630449|FD-Score:8.13|P-value:1.53E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.56|P-value:1.31E-7 ID:SGTC_2297|Compound:7971671|FD-Score:7.45|P-value:1.99E-7 ID:SGTC_2300|Compound:7976697|FD-Score:11.00|P-value:3.10E-14 ID:SGTC_2322|Compound:7413319|FD-Score:8.71|P-value:1.47E-9 ID:SGTC_2332|Compound:7982454|FD-Score:5.30|P-value:1.57E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.15|P-value:2.30E-4 ID:SGTC_2413|Compound:inermin|FD-Score:7.30|P-value:3.33E-7 ID:SGTC_2424|Compound:5537928|FD-Score:4.84|P-value:4.98E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-5.46|P-value:8.91E-5 ID:SGTC_2436|Compound:5633522|FD-Score:10.20|P-value:1.55E-12 ID:SGTC_2460|Compound:5552655|FD-Score:6.26|P-value:1.01E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-4.75|P-value:5.43E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.16|P-value:1.18E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:6.12|P-value:1.58E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:10.70|P-value:1.64E-13 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.74|P-value:6.35E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.80|P-value:1.86E-6 ID:SGTC_2699|Compound:st077704|FD-Score:10.00|P-value:4.10E-12 ID:SGTC_2725|Compound:haloperidol|FD-Score:7.61|P-value:1.07E-7 ID:SGTC_2733|Compound:amorolfine|FD-Score:5.00|P-value:3.42E-4 ID:SGTC_2790|Compound:5423970|FD-Score:9.58|P-value:3.37E-11 ID:SGTC_2838|Compound:9002687|FD-Score:9.63|P-value:2.62E-11 ID:SGTC_2845|Compound:9003024|FD-Score:5.74|P-value:4.69E-5 ID:SGTC_2873|Compound:9040596|FD-Score:6.18|P-value:1.32E-5 ID:SGTC_2896|Compound:9052656|FD-Score:10.50|P-value:4.30E-13 ID:SGTC_2900|Compound:5328528|FD-Score:4.90|P-value:4.32E-4 ID:SGTC_2938|Compound:9059746|FD-Score:11.60|P-value:1.55E-15 ID:SGTC_2976|Compound:9009005|FD-Score:5.50|P-value:9.12E-5 ID:SGTC_3018|Compound:9082602|FD-Score:5.56|P-value:7.74E-5 ID:SGTC_3021|Compound:9087658|FD-Score:-5.27|P-value:1.48E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.63|P-value:8.19E-4 ID:SGTC_3037|Compound:9091026|FD-Score:9.66|P-value:2.29E-11 ID:SGTC_3044|Compound:9093193|FD-Score:5.48|P-value:9.67E-5 ID:SGTC_3068|Compound:9116768|FD-Score:6.20|P-value:1.24E-5 ID:SGTC_3077|Compound:9117319|FD-Score:6.60|P-value:3.50E-6 ID:SGTC_3152|Compound:9099253|FD-Score:23.80|P-value:1.87E-59 ID:SGTC_3154|Compound:9100113|FD-Score:8.90|P-value:6.50E-10 ID:SGTC_3180|Compound:9109287|FD-Score:5.78|P-value:4.26E-5 ID:SGTC_3189|Compound:9110682|FD-Score:6.43|P-value:6.07E-6 ID:SGTC_3200|Compound:9114385|FD-Score:7.74|P-value:6.67E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-5.72|P-value:4.24E-5 ID:SGTC_3273|Compound:9137859|FD-Score:5.45|P-value:1.06E-4 ID:SGTC_3308|Compound:9128332|FD-Score:7.64|P-value:9.86E-8 ID:SGTC_3320|Compound:9137005|FD-Score:6.28|P-value:9.58E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.49|P-value:4.16E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:16.30|P-value:7.03E-29 ID:SGTC_100|Compound:0086-0128|FD-Score:-4.75|P-value:5.44E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.74|P-value:6.41E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:7.10|P-value:6.70E-7 ID:SGTC_110|Compound:0850-0284|FD-Score:5.66|P-value:5.86E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:-7.85|P-value:3.60E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:22.20|P-value:2.75E-52 ID:SGTC_124|Compound:0136-0217|FD-Score:18.70|P-value:1.36E-37 ID:SGTC_126|Compound:0417-1624|FD-Score:6.08|P-value:1.75E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.26|P-value:3.80E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.56|P-value:9.74E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:6.48|P-value:5.16E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:16.60|P-value:6.77E-30 ID:SGTC_180|Compound:1486-1293|FD-Score:4.83|P-value:5.18E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:11.60|P-value:1.32E-15 ID:SGTC_206|Compound:4546-0025|FD-Score:7.89|P-value:3.81E-8 ID:SGTC_218|Compound:alverine citrate|FD-Score:8.07|P-value:1.92E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:17.50|P-value:3.85E-33 ID:SGTC_232|Compound:clozapine|FD-Score:14.00|P-value:7.37E-22 ID:SGTC_254|Compound:nsc-64875|FD-Score:13.10|P-value:1.69E-19 ID:SGTC_258|Compound:haloperidol|FD-Score:7.62|P-value:1.05E-7 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.98|P-value:2.76E-8 ID:SGTC_278|Compound:4092-0821|FD-Score:6.79|P-value:1.87E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.95|P-value:3.31E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:6.27|P-value:9.83E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:6.54|P-value:4.29E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.08|P-value:2.40E-10 ID:SGTC_312|Compound:4092-0653|FD-Score:6.61|P-value:3.44E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:6.48|P-value:5.23E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:7.50|P-value:1.62E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:8.04|P-value:2.14E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:6.72|P-value:2.36E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:10.10|P-value:3.06E-12 ID:SGTC_426|Compound:0988-0037|FD-Score:5.71|P-value:5.10E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.61|P-value:7.57E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-6.29|P-value:7.81E-6 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:5.58|P-value:7.38E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.31|P-value:8.66E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-12.40|P-value:1.17E-17 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.04|P-value:1.67E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.94|P-value:3.97E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-4.52|P-value:9.36E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.39|P-value:1.24E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:9.71|P-value:1.81E-11 ID:SGTC_577|Compound:r071-0003|FD-Score:11.60|P-value:1.10E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:11.10|P-value:2.29E-14 ID:SGTC_669|Compound:0108-0021|FD-Score:31.70|P-value:1.63E-104 ID:SGTC_689|Compound:0833-0039|FD-Score:7.14|P-value:5.90E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.61|P-value:5.83E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.98|P-value:3.58E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:5.96|P-value:2.50E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:7.51|P-value:1.57E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:24.70|P-value:2.82E-64 ID:SGTC_794|Compound:k038-0031|FD-Score:5.68|P-value:5.55E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:5.79|P-value:4.06E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:8.63|P-value:2.08E-9 ID:SGTC_875|Compound:0709-0210|FD-Score:5.73|P-value:4.82E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:9.48|P-value:5.17E-11 ID:SGTC_999|Compound:4022-0066|FD-Score:7.01|P-value:9.03E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:9.26|P-value:1.38E-10 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.70|P-value:5.35E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.43|P-value:1.10E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.70|P-value:7.06E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:5.16|P-value:2.25E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.70|P-value:6.95E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:7.74|P-value:6.67E-8 ID:SGTC_1104|Compound:tacrolimus|FD-Score:5.85|P-value:3.42E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:8.68|P-value:1.65E-9 ID:SGTC_1161|Compound:k007-0610|FD-Score:9.28|P-value:1.25E-10 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.19|P-value:2.09E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.31|P-value:1.53E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.65|P-value:6.04E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:9.83|P-value:1.03E-11 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.82|P-value:5.29E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.76|P-value:6.03E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:8.26|P-value:9.11E-9 ID:SGTC_1658|Compound:st012944|FD-Score:4.87|P-value:4.65E-4 ID:SGTC_1665|Compound:st014639|FD-Score:8.06|P-value:1.97E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.84|P-value:5.05E-4 ID:SGTC_1708|Compound:st033234|FD-Score:5.30|P-value:1.56E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.73|P-value:1.37E-9 ID:SGTC_1760|Compound:st045453|FD-Score:15.60|P-value:6.71E-27 ID:SGTC_1781|Compound:st038725|FD-Score:8.68|P-value:1.70E-9 ID:SGTC_1797|Compound:st048695|FD-Score:11.10|P-value:2.25E-14 ID:SGTC_1801|Compound:st050089|FD-Score:11.90|P-value:1.85E-16 ID:SGTC_1803|Compound:st050068|FD-Score:8.14|P-value:1.49E-8 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.99|P-value:3.45E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.95|P-value:3.86E-4 ID:SGTC_1917|Compound:st066507|FD-Score:6.22|P-value:1.14E-5 ID:SGTC_1923|Compound:st058458|FD-Score:8.39|P-value:5.53E-9 ID:SGTC_1945|Compound:st075991|FD-Score:5.92|P-value:2.83E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-6.58|P-value:3.11E-6 ID:SGTC_1952|Compound:st077036|FD-Score:6.00|P-value:2.21E-5 ID:SGTC_1991|Compound:st073000|FD-Score:17.80|P-value:3.50E-34 ID:SGTC_2006|Compound:4011487|FD-Score:9.97|P-value:5.36E-12 ID:SGTC_2036|Compound:5160441|FD-Score:19.90|P-value:3.67E-42 ID:SGTC_2055|Compound:5235184|FD-Score:4.87|P-value:4.64E-4 ID:SGTC_2127|Compound:5253358|FD-Score:5.43|P-value:1.10E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.98|P-value:3.60E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.55|P-value:8.01E-5 ID:SGTC_2231|Compound:micatex|FD-Score:5.89|P-value:3.05E-5 ID:SGTC_2242|Compound:6630449|FD-Score:8.13|P-value:1.53E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.56|P-value:1.31E-7 ID:SGTC_2297|Compound:7971671|FD-Score:7.45|P-value:1.99E-7 ID:SGTC_2300|Compound:7976697|FD-Score:11.00|P-value:3.10E-14 ID:SGTC_2322|Compound:7413319|FD-Score:8.71|P-value:1.47E-9 ID:SGTC_2332|Compound:7982454|FD-Score:5.30|P-value:1.57E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.15|P-value:2.30E-4 ID:SGTC_2413|Compound:inermin|FD-Score:7.30|P-value:3.33E-7 ID:SGTC_2424|Compound:5537928|FD-Score:4.84|P-value:4.98E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-5.46|P-value:8.91E-5 ID:SGTC_2436|Compound:5633522|FD-Score:10.20|P-value:1.55E-12 ID:SGTC_2460|Compound:5552655|FD-Score:6.26|P-value:1.01E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-4.75|P-value:5.43E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.16|P-value:1.18E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:6.12|P-value:1.58E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:10.70|P-value:1.64E-13 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.74|P-value:6.35E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.80|P-value:1.86E-6 ID:SGTC_2699|Compound:st077704|FD-Score:10.00|P-value:4.10E-12 ID:SGTC_2725|Compound:haloperidol|FD-Score:7.61|P-value:1.07E-7 ID:SGTC_2733|Compound:amorolfine|FD-Score:5.00|P-value:3.42E-4 ID:SGTC_2790|Compound:5423970|FD-Score:9.58|P-value:3.37E-11 ID:SGTC_2838|Compound:9002687|FD-Score:9.63|P-value:2.62E-11 ID:SGTC_2845|Compound:9003024|FD-Score:5.74|P-value:4.69E-5 ID:SGTC_2873|Compound:9040596|FD-Score:6.18|P-value:1.32E-5 ID:SGTC_2896|Compound:9052656|FD-Score:10.50|P-value:4.30E-13 ID:SGTC_2900|Compound:5328528|FD-Score:4.90|P-value:4.32E-4 ID:SGTC_2938|Compound:9059746|FD-Score:11.60|P-value:1.55E-15 ID:SGTC_2976|Compound:9009005|FD-Score:5.50|P-value:9.12E-5 ID:SGTC_3018|Compound:9082602|FD-Score:5.56|P-value:7.74E-5 ID:SGTC_3021|Compound:9087658|FD-Score:-5.27|P-value:1.48E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.63|P-value:8.19E-4 ID:SGTC_3037|Compound:9091026|FD-Score:9.66|P-value:2.29E-11 ID:SGTC_3044|Compound:9093193|FD-Score:5.48|P-value:9.67E-5 ID:SGTC_3068|Compound:9116768|FD-Score:6.20|P-value:1.24E-5 ID:SGTC_3077|Compound:9117319|FD-Score:6.60|P-value:3.50E-6 ID:SGTC_3152|Compound:9099253|FD-Score:23.80|P-value:1.87E-59 ID:SGTC_3154|Compound:9100113|FD-Score:8.90|P-value:6.50E-10 ID:SGTC_3180|Compound:9109287|FD-Score:5.78|P-value:4.26E-5 ID:SGTC_3189|Compound:9110682|FD-Score:6.43|P-value:6.07E-6 ID:SGTC_3200|Compound:9114385|FD-Score:7.74|P-value:6.67E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-5.72|P-value:4.24E-5 ID:SGTC_3273|Compound:9137859|FD-Score:5.45|P-value:1.06E-4 ID:SGTC_3308|Compound:9128332|FD-Score:7.64|P-value:9.86E-8 ID:SGTC_3320|Compound:9137005|FD-Score:6.28|P-value:9.58E-6

Top fitness defect scores for YOR070C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_669 0108-0021 31.70 26.2 µM 1.63E-104 fatty acid desaturase (OLE1) 1 1.96E-221
2 SGTC_768 0384-0033 24.70 77.3 µM 2.82E-64 fatty acid desaturase (OLE1) 2 2.38E-135
3 SGTC_3152 9099253 23.80 49.5 µM 1.87E-59 NEO1-PIK1 2 4.88E-125
4 SGTC_119 0121-0043 22.20 24.8 µM 2.75E-52 mitochondrial stress 1 1.03E-109
5 SGTC_2036 5160441 19.90 105.0 µM 3.67E-42 NEO1 2 4.58E-88
6 SGTC_124 0136-0217 18.70 7.1 µM 1.36E-37 mitochondrial stress 1 2.64E-78
7 SGTC_1991 st073000 17.80 8.9 µM 3.50E-34 NEO1 3 5.13E-71
8 SGTC_221 trifluoperazine 17.50 10.3 µM 3.85E-33 NEO1-PIK1 16 8.59E-69
9 SGTC_178 4092-0806 16.60 87.5 µM 6.77E-30 ergosterol depletion effects on membrane 3 7.32E-62
10 SGTC_70 0141-0289 16.30 43.3 µM 7.03E-29 mitochondrial stress 8 1.08E-59
11 SGTC_1760 st045453 15.60 10.4 µM 6.71E-27 NEO1-PIK1 12 1.82E-55
12 SGTC_232 clozapine 14.00 119.0 µM 7.37E-22 NEO1 12 1.04E-44
13 SGTC_254 nsc-64875 13.10 3.8 µM 1.69E-19 ergosterol depletion effects on membrane 5 1.11E-39
14 SGTC_1801 st050089 11.90 28.4 µM 1.85E-16 NEO1-PIK1 8 3.34E-33
15 SGTC_577 r071-0003 11.60 38.6 µM 1.10E-15 fatty acid desaturase (OLE1) 2 1.49E-31
16 SGTC_201 4262-0159 11.60 12.8 µM 1.32E-15 ergosterol depletion effects on membrane 5 2.17E-31
17 SGTC_2938 9059746 11.60 27.3 µM 1.55E-15 fatty acid desaturase (OLE1) 4 3.06E-31
18 SGTC_1797 st048695 11.10 56.8 µM 2.25E-14 NEO1 15 9.08E-29
19 SGTC_637 1181-0519 11.10 7.3 µM 2.29E-14 fatty acid desaturase (OLE1) 17 9.45E-29
20 SGTC_2300 7976697 11.00 71.6 µM 3.10E-14 ERG2 3 1.80E-28

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.433 3.39E-153 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.415 1.36E-139 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.414 7.19E-139 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.408 9.13E-135 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.406 5.60E-133 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.400 9.59E-129 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.390 3.51E-122 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.374 3.96E-112 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.370 1.36E-109 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.368 5.39E-108 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.350 3.90E-97 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.346 4.97E-95 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.343 6.07E-93 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.340 2.99E-91 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.335 1.02E-88 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress