YOR072W_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR072W / YOR072W

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:6.15|P-value:1.42E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:4.39|P-value:4.26E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:6.72|P-value:1.59E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:9.10|P-value:2.13E-12 ID:SGTC_136|Compound:0097-0015|FD-Score:7.14|P-value:2.77E-8 ID:SGTC_191|Compound:3914-0123|FD-Score:5.77|P-value:5.74E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:6.46|P-value:4.34E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.06|P-value:5.63E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:4.57|P-value:2.56E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-5.58|P-value:1.03E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.43|P-value:3.73E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:5.21|P-value:3.67E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:4.28|P-value:5.71E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.98|P-value:7.53E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.71|P-value:1.72E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:4.22|P-value:6.71E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.24|P-value:6.34E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:5.09|P-value:5.43E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:4.36|P-value:4.53E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.38|P-value:2.14E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:6.82|P-value:1.06E-7 ID:SGTC_810|Compound:3825-7150|FD-Score:6.78|P-value:1.23E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:5.89|P-value:3.68E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:-6.12|P-value:1.52E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:5.26|P-value:3.16E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:8.68|P-value:1.99E-11 ID:SGTC_948|Compound:3448-0295|FD-Score:6.22|P-value:1.12E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:7.72|P-value:2.08E-9 ID:SGTC_982|Compound:1491-0518|FD-Score:4.20|P-value:7.04E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.29|P-value:5.60E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.88|P-value:1.03E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.28|P-value:5.62E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.65|P-value:2.02E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.06|P-value:1.98E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:8.53|P-value:4.12E-11 ID:SGTC_1191|Compound:1487-1166|FD-Score:-4.28|P-value:5.38E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-4.18|P-value:7.04E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:6.08|P-value:1.89E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.94|P-value:8.18E-5 ID:SGTC_1657|Compound:st012939|FD-Score:-4.18|P-value:6.99E-4 ID:SGTC_1663|Compound:st014140|FD-Score:7.87|P-value:1.04E-9 ID:SGTC_1664|Compound:st014217|FD-Score:7.40|P-value:8.75E-9 ID:SGTC_1666|Compound:st014829|FD-Score:-4.23|P-value:6.22E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.57|P-value:2.53E-4 ID:SGTC_1676|Compound:st018489|FD-Score:7.57|P-value:4.15E-9 ID:SGTC_1786|Compound:berberine|FD-Score:7.16|P-value:2.57E-8 ID:SGTC_1909|Compound:st060837|FD-Score:11.70|P-value:3.19E-19 ID:SGTC_1910|Compound:st062352|FD-Score:9.19|P-value:1.29E-12 ID:SGTC_1911|Compound:st060208|FD-Score:5.52|P-value:1.35E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-4.63|P-value:2.03E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.29|P-value:5.57E-4 ID:SGTC_2016|Compound:5121758|FD-Score:8.81|P-value:9.78E-12 ID:SGTC_2038|Compound:4100038|FD-Score:4.67|P-value:1.94E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.71|P-value:1.72E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-4.43|P-value:3.59E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-4.55|P-value:2.55E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.10|P-value:8.78E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-4.46|P-value:3.26E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.78|P-value:1.38E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.56|P-value:2.60E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.74|P-value:1.57E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:4.37|P-value:4.47E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.12|P-value:8.64E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.12|P-value:8.62E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.14|P-value:8.27E-4 ID:SGTC_2809|Compound:7964133|FD-Score:5.77|P-value:5.58E-6 ID:SGTC_2911|Compound:7942208|FD-Score:4.28|P-value:5.65E-4 ID:SGTC_2913|Compound:7966556|FD-Score:5.66|P-value:8.37E-6 ID:SGTC_3093|Compound:9117344|FD-Score:5.32|P-value:2.56E-5 ID:SGTC_3126|Compound:9127922|FD-Score:8.53|P-value:4.14E-11 ID:SGTC_3135|Compound:9127742|FD-Score:4.50|P-value:3.13E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.10|P-value:8.69E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.23|P-value:6.52E-4 ID:SGTC_3145|Compound:9085516|FD-Score:5.32|P-value:2.57E-5 ID:SGTC_3170|Compound:9103054|FD-Score:5.34|P-value:2.40E-5 ID:SGTC_3185|Compound:9108267|FD-Score:5.17|P-value:4.13E-5 ID:SGTC_3213|Compound:9129884|FD-Score:4.42|P-value:3.83E-4 ID:SGTC_3222|Compound:9128301|FD-Score:6.06|P-value:1.97E-6 ID:SGTC_13|Compound:0199-0087|FD-Score:6.15|P-value:1.42E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:4.39|P-value:4.26E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:6.72|P-value:1.59E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:9.10|P-value:2.13E-12 ID:SGTC_136|Compound:0097-0015|FD-Score:7.14|P-value:2.77E-8 ID:SGTC_191|Compound:3914-0123|FD-Score:5.77|P-value:5.74E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:6.46|P-value:4.34E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.06|P-value:5.63E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:4.57|P-value:2.56E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-5.58|P-value:1.03E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.43|P-value:3.73E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:5.21|P-value:3.67E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:4.28|P-value:5.71E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.98|P-value:7.53E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.71|P-value:1.72E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:4.22|P-value:6.71E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.24|P-value:6.34E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:5.09|P-value:5.43E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:4.36|P-value:4.53E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.38|P-value:2.14E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:6.82|P-value:1.06E-7 ID:SGTC_810|Compound:3825-7150|FD-Score:6.78|P-value:1.23E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:5.89|P-value:3.68E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:-6.12|P-value:1.52E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:5.26|P-value:3.16E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:8.68|P-value:1.99E-11 ID:SGTC_948|Compound:3448-0295|FD-Score:6.22|P-value:1.12E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:7.72|P-value:2.08E-9 ID:SGTC_982|Compound:1491-0518|FD-Score:4.20|P-value:7.04E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.29|P-value:5.60E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.88|P-value:1.03E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.28|P-value:5.62E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.65|P-value:2.02E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.06|P-value:1.98E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:8.53|P-value:4.12E-11 ID:SGTC_1191|Compound:1487-1166|FD-Score:-4.28|P-value:5.38E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-4.18|P-value:7.04E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:6.08|P-value:1.89E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.94|P-value:8.18E-5 ID:SGTC_1657|Compound:st012939|FD-Score:-4.18|P-value:6.99E-4 ID:SGTC_1663|Compound:st014140|FD-Score:7.87|P-value:1.04E-9 ID:SGTC_1664|Compound:st014217|FD-Score:7.40|P-value:8.75E-9 ID:SGTC_1666|Compound:st014829|FD-Score:-4.23|P-value:6.22E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.57|P-value:2.53E-4 ID:SGTC_1676|Compound:st018489|FD-Score:7.57|P-value:4.15E-9 ID:SGTC_1786|Compound:berberine|FD-Score:7.16|P-value:2.57E-8 ID:SGTC_1909|Compound:st060837|FD-Score:11.70|P-value:3.19E-19 ID:SGTC_1910|Compound:st062352|FD-Score:9.19|P-value:1.29E-12 ID:SGTC_1911|Compound:st060208|FD-Score:5.52|P-value:1.35E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-4.63|P-value:2.03E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.29|P-value:5.57E-4 ID:SGTC_2016|Compound:5121758|FD-Score:8.81|P-value:9.78E-12 ID:SGTC_2038|Compound:4100038|FD-Score:4.67|P-value:1.94E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.71|P-value:1.72E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-4.43|P-value:3.59E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-4.55|P-value:2.55E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.10|P-value:8.78E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-4.46|P-value:3.26E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.78|P-value:1.38E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.56|P-value:2.60E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.74|P-value:1.57E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:4.37|P-value:4.47E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.12|P-value:8.64E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.12|P-value:8.62E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.14|P-value:8.27E-4 ID:SGTC_2809|Compound:7964133|FD-Score:5.77|P-value:5.58E-6 ID:SGTC_2911|Compound:7942208|FD-Score:4.28|P-value:5.65E-4 ID:SGTC_2913|Compound:7966556|FD-Score:5.66|P-value:8.37E-6 ID:SGTC_3093|Compound:9117344|FD-Score:5.32|P-value:2.56E-5 ID:SGTC_3126|Compound:9127922|FD-Score:8.53|P-value:4.14E-11 ID:SGTC_3135|Compound:9127742|FD-Score:4.50|P-value:3.13E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.10|P-value:8.69E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.23|P-value:6.52E-4 ID:SGTC_3145|Compound:9085516|FD-Score:5.32|P-value:2.57E-5 ID:SGTC_3170|Compound:9103054|FD-Score:5.34|P-value:2.40E-5 ID:SGTC_3185|Compound:9108267|FD-Score:5.17|P-value:4.13E-5 ID:SGTC_3213|Compound:9129884|FD-Score:4.42|P-value:3.83E-4 ID:SGTC_3222|Compound:9128301|FD-Score:6.06|P-value:1.97E-6

Top fitness defect scores for YOR072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1909 st060837 11.70 51.5 µM 3.19E-19 4 9.27E-32
2 SGTC_1910 st062352 9.19 60.4 µM 1.29E-12 2 1.90E-20
3 SGTC_63 0099-0242 9.10 26.7 µM 2.13E-12 mitochondrial stress 2 4.49E-20
4 SGTC_2016 5121758 8.81 140.0 µM 9.78E-12 redox potentiating 3 6.09E-19
5 SGTC_866 0495-0101 8.68 262.0 µM 1.99E-11 60S ribosome export 1 2.06E-18
6 SGTC_1186 1319-0216 8.53 26.0 µM 4.12E-11 1 7.11E-18
7 SGTC_3126 9127922 8.53 49.5 µM 4.14E-11 fatty acid desaturase (OLE1) 8 7.16E-18
8 SGTC_1663 st014140 7.87 55.4 µM 1.04E-9 60S ribosome export 1 1.76E-15
9 SGTC_972 1319-0219 7.72 195.0 µM 2.08E-9 3 5.75E-15
10 SGTC_1676 st018489 7.57 23.4 µM 4.15E-9 60S ribosome export 2 1.86E-14
11 SGTC_1664 st014217 7.40 9.0 µM 8.75E-9 60S ribosome export 1 6.64E-14
12 SGTC_1786 berberine 7.16 21.6 µM 2.57E-8 60S ribosome export 6 4.15E-13
13 SGTC_136 0097-0015 7.14 404.5 µM 2.77E-8 60S ribosome export 1 4.72E-13
14 SGTC_782 0083-0095 6.82 30.5 µM 1.06E-7 1 4.64E-12
15 SGTC_810 3825-7150 6.78 143.0 µM 1.23E-7 60S ribosome export 1 5.94E-12
16 SGTC_55 0767-0285 6.72 6.6 µM 1.59E-7 14 9.19E-12
17 SGTC_198 3454-2873 6.46 16.2 µM 4.34E-7 60S ribosome export 1 5.08E-11
18 SGTC_948 3448-0295 6.22 75.3 µM 1.12E-6 4 2.54E-10
19 SGTC_13 0199-0087 6.15 65.0 µM 1.42E-6 ERG2 4 3.79E-10
20 SGTC_1334 1486-0610 6.08 236.0 µM 1.89E-6 60S ribosome export 3 6.15E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.318 1.61E-79 YHR170W NMD3 het Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.303 3.60E-72 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.185 2.38E-27 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.172 1.01E-23 YOL068C HST1 hom NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance
0.142 1.18E-16 YOR279C RFM1 hom DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
0.136 2.09E-15 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.102 3.07E-9 YPL093W NOG1 het Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
0.099 8.39E-9 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.081 2.88E-6 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.077 8.10E-6 YPR016C TIF6 het Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
0.075 1.47E-5 YPL037C EGD1 hom Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
0.074 1.56E-5 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.074 1.88E-5 YPR015C_p YPR015C_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.073 2.60E-5 YLR347C KAP95 het Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
0.072 3.26E-5 YDR083W RRP8 hom Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1