YOR075W / UFE1

t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR075W / UFE1

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-6.41|P-value:4.84E-10 ID:SGTC_129|Compound:0088-0017|FD-Score:3.35|P-value:6.08E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:4.78|P-value:2.13E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:4.26|P-value:2.08E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.22|P-value:9.59E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.58|P-value:2.76E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.16|P-value:3.06E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:4.30|P-value:1.71E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.28|P-value:7.71E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.03|P-value:5.21E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.40|P-value:5.20E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.56|P-value:2.98E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.30|P-value:8.58E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.29|P-value:8.85E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.12|P-value:3.62E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.26|P-value:8.34E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.39|P-value:1.19E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.89|P-value:1.24E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.93|P-value:7.75E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-5.82|P-value:1.43E-8 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.12|P-value:3.67E-5 ID:SGTC_1605|Compound:st000082|FD-Score:3.48|P-value:3.94E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.42|P-value:4.81E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.14|P-value:3.99E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.22|P-value:2.37E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.31|P-value:7.05E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-3.45|P-value:5.10E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.53|P-value:3.29E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.31|P-value:6.95E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:5.35|P-value:1.30E-7 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.52|P-value:4.09E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.99|P-value:7.15E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.87|P-value:9.54E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.01|P-value:5.66E-5 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.58|P-value:2.78E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.25|P-value:8.45E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-5.51|P-value:7.18E-8 ID:SGTC_2953|Compound:9074162|FD-Score:-6.46|P-value:3.44E-10 ID:SGTC_3124|Compound:9127567|FD-Score:-3.42|P-value:5.72E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.03|P-value:5.18E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-5.40|P-value:1.29E-7 ID:SGTC_3221|Compound:9128209|FD-Score:-3.81|P-value:1.45E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.45|P-value:5.08E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.26|P-value:9.63E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.41|P-value:4.84E-10 ID:SGTC_129|Compound:0088-0017|FD-Score:3.35|P-value:6.08E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:4.78|P-value:2.13E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:4.26|P-value:2.08E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.22|P-value:9.59E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.58|P-value:2.76E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.16|P-value:3.06E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:4.30|P-value:1.71E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.28|P-value:7.71E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.03|P-value:5.21E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.40|P-value:5.20E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.56|P-value:2.98E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.30|P-value:8.58E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.29|P-value:8.85E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.12|P-value:3.62E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.26|P-value:8.34E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.39|P-value:1.19E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.89|P-value:1.24E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.93|P-value:7.75E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-5.82|P-value:1.43E-8 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.12|P-value:3.67E-5 ID:SGTC_1605|Compound:st000082|FD-Score:3.48|P-value:3.94E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.42|P-value:4.81E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.14|P-value:3.99E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.22|P-value:2.37E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.31|P-value:7.05E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-3.45|P-value:5.10E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.53|P-value:3.29E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.31|P-value:6.95E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:5.35|P-value:1.30E-7 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.52|P-value:4.09E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.99|P-value:7.15E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.87|P-value:9.54E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.01|P-value:5.66E-5 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.58|P-value:2.78E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.25|P-value:8.45E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-5.51|P-value:7.18E-8 ID:SGTC_2953|Compound:9074162|FD-Score:-6.46|P-value:3.44E-10 ID:SGTC_3124|Compound:9127567|FD-Score:-3.42|P-value:5.72E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.03|P-value:5.18E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-5.40|P-value:1.29E-7 ID:SGTC_3221|Compound:9128209|FD-Score:-3.81|P-value:1.45E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.45|P-value:5.08E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.26|P-value:9.63E-4

Top fitness defect scores for YOR075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2560 caryophyllene 5.35 100.0 µM 1.30E-7 2 4.31E-8 0.43
2 SGTC_1579 chlormadinone acetate 4.89 49.4 µM 1.24E-6 3 4.96E-7 0.50
3 SGTC_192 3455-0609 4.78 60.9 µM 2.13E-6 4 8.89E-7 0.79
4 SGTC_1466 k213-0079 4.39 57.5 µM 1.19E-5 7 5.69E-6 0.01
5 SGTC_656 4090-1979 4.30 187.0 µM 1.71E-5 2 8.48E-6 0.75
6 SGTC_370 0180-0345 4.26 38.7 µM 2.08E-5 DNA intercalators 6 1.04E-5 0.06
7 SGTC_1756 st041558 4.22 35.5 µM 2.37E-5 2 1.20E-5 0.41
8 SGTC_473 2-arachidonoylglycerol 4.16 10.0 µM 3.06E-5 2 1.58E-5 0.14
9 SGTC_1222 0366-0074 4.12 1.2 µM 3.62E-5 TSC3-RPN4 3 1.90E-5 0.02
10 SGTC_1601 4'-hydroxyflavanone 4.12 55.5 µM 3.67E-5 RPP1 & pyrimidine depletion 4 1.93E-5 0.13
11 SGTC_3202 9113761 4.03 49.5 µM 5.18E-5 11 2.80E-5 0.32
12 SGTC_924 2046-0044 4.03 21.3 µM 5.21E-5 7 2.81E-5 0.25
13 SGTC_2664 lyso-paf C-16 4.01 73.5 µM 5.66E-5 4 3.08E-5 0.60
14 SGTC_1592 4',5'-dihydroxyflavone 3.93 8.8 µM 7.75E-5 60S ribosome export 7 4.32E-5 0.14
15 SGTC_2662 daunorubicin 3.87 22.4 µM 9.54E-5 anthracycline transcription coupled DNA repair 17 5.41E-5 0.04
16 SGTC_1728 st035614 3.62 33.8 µM 2.45E-4 9 1.50E-4 0.10
17 SGTC_387 norethindrone acetate 3.58 66.7 µM 2.76E-4 6 1.70E-4 0.18
18 SGTC_2723 salbutamol 3.58 83.6 µM 2.78E-4 1 1.71E-4 0.37
19 SGTC_1056 3448-1962 3.56 115.0 µM 2.98E-4 amide catabolism 10 1.85E-4 0.33
20 SGTC_2431 5490079 3.53 200.0 µM 3.29E-4 9 2.06E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.37E-10 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.110 1.47E-10 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.104 1.72E-9 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.093 6.19E-8 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.088 2.96E-7 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.087 5.20E-7 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.086 5.37E-7 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.086 6.27E-7 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.084 1.10E-6 YPL155C KIP2 hom Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
0.082 1.88E-6 YCR014C POL4 hom DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
0.079 4.32E-6 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.077 7.23E-6 YBL084C CDC27 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.074 1.75E-5 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.072 3.01E-5 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.070 5.40E-5 YHL047C ARN2 hom Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C