YOR077W / RTS2

Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR077W / RTS2

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:-2.87|P-value:3.74E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:2.95|P-value:1.89E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.02|P-value:6.78E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:7.20|P-value:3.55E-18 ID:SGTC_174|Compound:3553-0389|FD-Score:3.44|P-value:1.75E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.08|P-value:1.49E-4 ID:SGTC_276|Compound:colchicine|FD-Score:2.91|P-value:2.30E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.17|P-value:9.78E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.08|P-value:1.04E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.21|P-value:2.16E-7 ID:SGTC_732|Compound:3970-1727|FD-Score:2.78|P-value:4.04E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.63|P-value:6.40E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:2.70|P-value:5.53E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.34|P-value:4.26E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:-4.95|P-value:2.52E-9 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.09|P-value:9.76E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.64|P-value:7.19E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:-2.67|P-value:8.76E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:2.69|P-value:5.80E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.62|P-value:7.89E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.18|P-value:2.64E-7 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-2.76|P-value:6.04E-4 ID:SGTC_1704|Compound:st028805|FD-Score:2.70|P-value:5.66E-4 ID:SGTC_1737|Compound:st035557|FD-Score:2.94|P-value:1.95E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.15|P-value:7.29E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-4.35|P-value:1.51E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:2.71|P-value:5.45E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.12|P-value:1.24E-4 ID:SGTC_2080|Compound:5212524|FD-Score:2.75|P-value:4.58E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-2.68|P-value:8.26E-4 ID:SGTC_2211|Compound:7117706|FD-Score:-2.80|P-value:5.03E-4 ID:SGTC_2238|Compound:6671620|FD-Score:2.61|P-value:8.07E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.07|P-value:1.07E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.25|P-value:4.51E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.74|P-value:5.91E-12 ID:SGTC_2433|Compound:5607874|FD-Score:2.95|P-value:1.87E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.10|P-value:9.46E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.46|P-value:1.62E-5 ID:SGTC_2818|Compound:7996756|FD-Score:2.94|P-value:1.95E-4 ID:SGTC_2881|Compound:9058953|FD-Score:2.78|P-value:3.98E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.17|P-value:6.77E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.06|P-value:1.13E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.05|P-value:1.21E-4 ID:SGTC_3033|Compound:9090887|FD-Score:2.76|P-value:4.41E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:2.85|P-value:2.94E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-2.66|P-value:8.97E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.90|P-value:1.39E-6 ID:SGTC_3109|Compound:9122853|FD-Score:-2.73|P-value:6.89E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-2.95|P-value:2.73E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.14|P-value:7.73E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:-2.87|P-value:3.74E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:2.95|P-value:1.89E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.02|P-value:6.78E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:7.20|P-value:3.55E-18 ID:SGTC_174|Compound:3553-0389|FD-Score:3.44|P-value:1.75E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.08|P-value:1.49E-4 ID:SGTC_276|Compound:colchicine|FD-Score:2.91|P-value:2.30E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.17|P-value:9.78E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.08|P-value:1.04E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.21|P-value:2.16E-7 ID:SGTC_732|Compound:3970-1727|FD-Score:2.78|P-value:4.04E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.63|P-value:6.40E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:2.70|P-value:5.53E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.34|P-value:4.26E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:-4.95|P-value:2.52E-9 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.09|P-value:9.76E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.64|P-value:7.19E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:-2.67|P-value:8.76E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:2.69|P-value:5.80E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.62|P-value:7.89E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.18|P-value:2.64E-7 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-2.76|P-value:6.04E-4 ID:SGTC_1704|Compound:st028805|FD-Score:2.70|P-value:5.66E-4 ID:SGTC_1737|Compound:st035557|FD-Score:2.94|P-value:1.95E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.15|P-value:7.29E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-4.35|P-value:1.51E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:2.71|P-value:5.45E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.12|P-value:1.24E-4 ID:SGTC_2080|Compound:5212524|FD-Score:2.75|P-value:4.58E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-2.68|P-value:8.26E-4 ID:SGTC_2211|Compound:7117706|FD-Score:-2.80|P-value:5.03E-4 ID:SGTC_2238|Compound:6671620|FD-Score:2.61|P-value:8.07E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.07|P-value:1.07E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.25|P-value:4.51E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.74|P-value:5.91E-12 ID:SGTC_2433|Compound:5607874|FD-Score:2.95|P-value:1.87E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.10|P-value:9.46E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.46|P-value:1.62E-5 ID:SGTC_2818|Compound:7996756|FD-Score:2.94|P-value:1.95E-4 ID:SGTC_2881|Compound:9058953|FD-Score:2.78|P-value:3.98E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.17|P-value:6.77E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.06|P-value:1.13E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.05|P-value:1.21E-4 ID:SGTC_3033|Compound:9090887|FD-Score:2.76|P-value:4.41E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:2.85|P-value:2.94E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-2.66|P-value:8.97E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.90|P-value:1.39E-6 ID:SGTC_3109|Compound:9122853|FD-Score:-2.73|P-value:6.89E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-2.95|P-value:2.73E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.14|P-value:7.73E-5

Top fitness defect scores for YOR077W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_145 3737-0113 7.20 38.4 µM 3.55E-18 DNA intercalators 8 2.95E-13 0.40
2 SGTC_581 0958-0271 4.21 211.0 µM 2.16E-7 4 1.27E-5 0.26
3 SGTC_1499 4480-0877 4.18 67.3 µM 2.64E-7 1 1.47E-5 0.80
4 SGTC_144 4161-2749 4.02 112.4 µM 6.78E-7 DNA intercalators 17 2.87E-5 0.06
5 SGTC_3094 9117742 3.90 49.5 µM 1.39E-6 3 4.79E-5 0.11
6 SGTC_905 2-aminofluorene 3.63 215.0 µM 6.40E-6 cell wall signaling 7 1.42E-4 0.20
7 SGTC_2627 acetyl isogambogic acid 3.46 100.0 µM 1.62E-5 TSC3-RPN4 11 2.75E-4 0.01
8 SGTC_174 3553-0389 3.44 74.3 µM 1.75E-5 6 2.91E-4 0.12
9 SGTC_2398 5228213 3.25 48.8 µM 4.51E-5 iron homeostasis 23 5.71E-4 0.04
10 SGTC_2884 9058502 3.17 52.0 µM 6.77E-5 5 7.63E-4 0.05
11 SGTC_1865 st057639 3.15 52.2 µM 7.29E-5 8 8.04E-4 0.02
12 SGTC_3202 9113761 3.14 49.5 µM 7.73E-5 25 8.39E-4 0.01
13 SGTC_2620 irigenin 3.10 100.0 µM 9.46E-5 26 9.69E-4 0.02
14 SGTC_1273 0849-0096 3.09 14.1 µM 9.76E-5 RPP1 & pyrimidine depletion 15 9.91E-4 0.08
15 SGTC_557 1315-0110 3.08 16.2 µM 1.04E-4 Golgi 14 0.00104 0.05
16 SGTC_2307 7538926 3.07 6.3 µM 1.07E-4 38 0.00106 0.02
17 SGTC_2920 7982904 3.06 15.8 µM 1.13E-4 24 0.00110 0.04
18 SGTC_2968 9090663 3.05 33.4 µM 1.21E-4 27 0.00116 0.05
19 SGTC_2433 5607874 2.95 27.8 µM 1.87E-4 12 0.00158 0.13
20 SGTC_128 0906-2981 2.95 13.4 µM 1.89E-4 24 0.00159 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.64E-41 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.206 1.38E-33 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.200 1.22E-31 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.197 1.23E-30 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.192 2.48E-29 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.180 6.61E-26 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.176 7.89E-25 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.175 2.15E-24 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.168 9.81E-23 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.160 1.05E-20 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.159 1.68E-20 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.159 1.96E-20 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.154 2.58E-19 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.153 5.78E-19 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.153 7.10E-19 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress