YOR078W / BUD21

Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR078W / BUD21

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.88|P-value:5.62E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.19|P-value:7.42E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.85|P-value:6.28E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.12|P-value:9.32E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.42|P-value:5.63E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.24|P-value:7.91E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:4.07|P-value:2.58E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:7.42|P-value:9.75E-14 ID:SGTC_726|Compound:3448-4391|FD-Score:4.08|P-value:2.43E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.24|P-value:6.20E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.93|P-value:1.92E-9 ID:SGTC_830|Compound:4076-0286|FD-Score:4.11|P-value:2.12E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.25|P-value:6.02E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.72|P-value:1.04E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.89|P-value:5.32E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:3.76|P-value:9.15E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.96|P-value:4.17E-7 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.15|P-value:2.44E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.32|P-value:5.93E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.58|P-value:1.83E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.45|P-value:2.92E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:5.32|P-value:6.21E-8 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.72|P-value:1.92E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:5.13|P-value:1.73E-7 ID:SGTC_1120|Compound:ficusin|FD-Score:6.35|P-value:1.51E-10 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.45|P-value:3.74E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.64|P-value:1.43E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.48|P-value:2.58E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.24|P-value:1.24E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.36|P-value:4.08E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.56|P-value:2.85E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:6.32|P-value:1.85E-10 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.35|P-value:5.33E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-3.49|P-value:3.29E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.42|P-value:4.11E-4 ID:SGTC_1781|Compound:st038725|FD-Score:8.02|P-value:9.16E-16 ID:SGTC_1841|Compound:st054148|FD-Score:3.15|P-value:8.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:5.15|P-value:1.58E-7 ID:SGTC_2027|Compound:5150920|FD-Score:3.49|P-value:2.57E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.91|P-value:5.35E-7 ID:SGTC_2041|Compound:5107442|FD-Score:4.48|P-value:4.27E-6 ID:SGTC_2046|Compound:4110841|FD-Score:3.78|P-value:8.42E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.37|P-value:3.94E-4 ID:SGTC_2141|Compound:5621638|FD-Score:-3.53|P-value:2.83E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.16|P-value:1.77E-5 ID:SGTC_2210|Compound:7115885|FD-Score:3.54|P-value:2.10E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.54|P-value:2.07E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.28|P-value:6.88E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.81|P-value:7.40E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.15|P-value:8.38E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.65|P-value:1.93E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:-4.58|P-value:3.67E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.25|P-value:7.41E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.41|P-value:3.37E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.11|P-value:9.67E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.53|P-value:2.79E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.74|P-value:1.21E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:8.37|P-value:5.35E-17 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-5.29|P-value:1.07E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.64|P-value:1.44E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.25|P-value:5.94E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.34|P-value:5.56E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.59|P-value:3.44E-6 ID:SGTC_2780|Compound:5215298|FD-Score:-3.48|P-value:3.41E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.96|P-value:4.10E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-3.38|P-value:4.79E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.33|P-value:4.49E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.35|P-value:5.42E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.88|P-value:5.62E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.19|P-value:7.42E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.85|P-value:6.28E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.12|P-value:9.32E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.42|P-value:5.63E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.24|P-value:7.91E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:4.07|P-value:2.58E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:7.42|P-value:9.75E-14 ID:SGTC_726|Compound:3448-4391|FD-Score:4.08|P-value:2.43E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.24|P-value:6.20E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.93|P-value:1.92E-9 ID:SGTC_830|Compound:4076-0286|FD-Score:4.11|P-value:2.12E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.25|P-value:6.02E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.72|P-value:1.04E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.89|P-value:5.32E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:3.76|P-value:9.15E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.96|P-value:4.17E-7 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.15|P-value:2.44E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.32|P-value:5.93E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.58|P-value:1.83E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.45|P-value:2.92E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:5.32|P-value:6.21E-8 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.72|P-value:1.92E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:5.13|P-value:1.73E-7 ID:SGTC_1120|Compound:ficusin|FD-Score:6.35|P-value:1.51E-10 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.45|P-value:3.74E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.64|P-value:1.43E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.48|P-value:2.58E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.24|P-value:1.24E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.36|P-value:4.08E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.56|P-value:2.85E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:6.32|P-value:1.85E-10 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.35|P-value:5.33E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-3.49|P-value:3.29E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.42|P-value:4.11E-4 ID:SGTC_1781|Compound:st038725|FD-Score:8.02|P-value:9.16E-16 ID:SGTC_1841|Compound:st054148|FD-Score:3.15|P-value:8.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:5.15|P-value:1.58E-7 ID:SGTC_2027|Compound:5150920|FD-Score:3.49|P-value:2.57E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.91|P-value:5.35E-7 ID:SGTC_2041|Compound:5107442|FD-Score:4.48|P-value:4.27E-6 ID:SGTC_2046|Compound:4110841|FD-Score:3.78|P-value:8.42E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.37|P-value:3.94E-4 ID:SGTC_2141|Compound:5621638|FD-Score:-3.53|P-value:2.83E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.16|P-value:1.77E-5 ID:SGTC_2210|Compound:7115885|FD-Score:3.54|P-value:2.10E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.54|P-value:2.07E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.28|P-value:6.88E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.81|P-value:7.40E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.15|P-value:8.38E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.65|P-value:1.93E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:-4.58|P-value:3.67E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.25|P-value:7.41E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.41|P-value:3.37E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.11|P-value:9.67E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.53|P-value:2.79E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.74|P-value:1.21E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:8.37|P-value:5.35E-17 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-5.29|P-value:1.07E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.64|P-value:1.44E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.25|P-value:5.94E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.34|P-value:5.56E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.59|P-value:3.44E-6 ID:SGTC_2780|Compound:5215298|FD-Score:-3.48|P-value:3.41E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.96|P-value:4.10E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-3.38|P-value:4.79E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.33|P-value:4.49E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.35|P-value:5.42E-4

Top fitness defect scores for YOR078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2629 bisabolol 8.37 100.0 µM 5.35E-17 2 2.81E-17
2 SGTC_1781 st038725 8.02 66.3 µM 9.16E-16 NEO1 32 5.12E-16
3 SGTC_625 k213-0058 7.42 121.0 µM 9.75E-14 translation 17 6.04E-14
4 SGTC_1120 ficusin 6.35 1.8 µM 1.51E-10 1 1.09E-10
5 SGTC_1506 4226-2149 6.32 212.0 µM 1.85E-10 3 1.35E-10
6 SGTC_800 3448-7362 5.93 155.0 µM 1.92E-9 translation 52 1.47E-9
7 SGTC_1108 betulinic acid 5.32 729.1 nM 6.21E-8 3 5.09E-8
8 SGTC_1916 st067606 5.15 49.2 µM 1.58E-7 14 1.32E-7
9 SGTC_1114 scopoletin 5.13 1.7 µM 1.73E-7 9 1.44E-7
10 SGTC_911 3456-4043 4.96 236.0 µM 4.17E-7 mitochondrial processes 11 3.55E-7
11 SGTC_2040 5100729 4.91 123.0 µM 5.35E-7 22 4.57E-7
12 SGTC_2595 hexamethylquercetagetin 4.74 100.0 µM 1.21E-6 11 1.05E-6
13 SGTC_2504 purpurogallin 4.65 52.3 µM 1.93E-6 RPP1 & pyrimidine depletion 11 1.69E-6
14 SGTC_1503 4585-0012 4.56 61.3 µM 2.85E-6 5 2.52E-6
15 SGTC_2041 5107442 4.48 45.3 µM 4.27E-6 RSC complex & mRNA processing 16 3.80E-6
16 SGTC_520 3584-0023 4.42 682.0 µM 5.63E-6 17 5.03E-6
17 SGTC_1467 k284-1082 4.24 293.0 µM 1.24E-5 12 1.12E-5
18 SGTC_2146 5545642 4.16 200.0 µM 1.77E-5 12 1.61E-5
19 SGTC_830 4076-0286 4.11 57.8 µM 2.12E-5 translation 53 1.94E-5
20 SGTC_726 3448-4391 4.08 34.2 µM 2.43E-5 10 2.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.229 3.44E-41 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.209 2.20E-34 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.168 1.22E-22 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.155 1.38E-19 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.153 4.40E-19 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.143 7.72E-17 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.142 1.40E-16 YOL121C RPS19A hom Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication
0.138 9.39E-16 YER127W LCP5 het Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
0.137 1.46E-15 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.136 3.25E-15 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.135 4.74E-15 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.133 1.26E-14 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.127 1.76E-13 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.124 4.70E-13 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.120 3.58E-12 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases