YOR089C / VPS21

Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR089C / VPS21

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:5.44|P-value:2.47E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.35|P-value:2.37E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:7.25|P-value:3.30E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:7.02|P-value:8.29E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:4.56|P-value:3.32E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:7.22|P-value:3.66E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:4.89|P-value:1.31E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.13|P-value:6.40E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.25|P-value:7.66E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.37|P-value:2.18E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:6.73|P-value:2.57E-7 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.30|P-value:3.90E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:4.26|P-value:7.35E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:6.83|P-value:1.79E-7 ID:SGTC_300|Compound:r073-0011|FD-Score:4.41|P-value:5.04E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.22|P-value:8.27E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.58|P-value:1.69E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-7.56|P-value:9.55E-9 ID:SGTC_313|Compound:3474-0040|FD-Score:4.66|P-value:2.54E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-6.35|P-value:1.19E-6 ID:SGTC_318|Compound:1488-0629|FD-Score:5.29|P-value:4.01E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.88|P-value:1.44E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.21|P-value:5.13E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.47|P-value:4.29E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-7.45|P-value:1.51E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.86|P-value:1.52E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:14.10|P-value:3.88E-26 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.13|P-value:6.54E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.68|P-value:2.37E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.26|P-value:3.44E-8 ID:SGTC_459|Compound:nigericin|FD-Score:6.91|P-value:1.31E-7 ID:SGTC_524|Compound:r073-0010|FD-Score:5.16|P-value:6.00E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:6.19|P-value:1.93E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:7.93|P-value:1.73E-9 ID:SGTC_535|Compound:2293-4129|FD-Score:6.81|P-value:1.94E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:4.71|P-value:2.23E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:8.09|P-value:8.26E-10 ID:SGTC_584|Compound:0986-0246|FD-Score:4.42|P-value:4.83E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:8.55|P-value:9.33E-11 ID:SGTC_733|Compound:4069-0007|FD-Score:4.52|P-value:3.68E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:6.05|P-value:3.17E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.24|P-value:8.27E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:8.26|P-value:3.71E-10 ID:SGTC_879|Compound:0831-1030|FD-Score:6.17|P-value:2.11E-6 ID:SGTC_882|Compound:0843-0131|FD-Score:4.31|P-value:6.48E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:6.37|P-value:1.03E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.52|P-value:3.68E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.33|P-value:6.15E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.94|P-value:1.14E-7 ID:SGTC_1138|Compound:3761-0006|FD-Score:-5.73|P-value:1.03E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:-6.64|P-value:4.05E-7 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.10|P-value:7.16E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:6.83|P-value:1.79E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.98|P-value:1.02E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:7.51|P-value:1.09E-8 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.36|P-value:2.08E-8 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.37|P-value:5.55E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-4.92|P-value:1.31E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.63|P-value:2.79E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.27|P-value:4.19E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:12.60|P-value:2.86E-21 ID:SGTC_1320|Compound:1313-0481|FD-Score:-5.20|P-value:5.67E-5 ID:SGTC_1323|Compound:1348-1351|FD-Score:4.27|P-value:7.22E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.87|P-value:1.39E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-6.55|P-value:5.71E-7 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.61|P-value:2.88E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:6.58|P-value:4.70E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.05|P-value:8.17E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:9.69|P-value:2.61E-13 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.27|P-value:7.16E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.62|P-value:6.76E-9 ID:SGTC_1658|Compound:st012944|FD-Score:10.40|P-value:5.25E-15 ID:SGTC_1660|Compound:st012960|FD-Score:5.50|P-value:2.07E-5 ID:SGTC_1687|Compound:st020778|FD-Score:9.34|P-value:1.67E-12 ID:SGTC_1711|Compound:st032263|FD-Score:4.34|P-value:6.05E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.76|P-value:2.04E-4 ID:SGTC_1754|Compound:st042065|FD-Score:13.60|P-value:1.93E-24 ID:SGTC_1759|Compound:st043059|FD-Score:-4.67|P-value:2.65E-4 ID:SGTC_1760|Compound:st045453|FD-Score:13.00|P-value:2.11E-22 ID:SGTC_1773|Compound:st048542|FD-Score:6.81|P-value:1.89E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.17|P-value:5.67E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:9.22|P-value:3.14E-12 ID:SGTC_1800|Compound:st050079|FD-Score:7.65|P-value:5.93E-9 ID:SGTC_1801|Compound:st050089|FD-Score:4.36|P-value:5.68E-4 ID:SGTC_1803|Compound:st050068|FD-Score:12.60|P-value:2.92E-21 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.62|P-value:1.39E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-4.35|P-value:6.21E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.92|P-value:5.11E-6 ID:SGTC_2242|Compound:6630449|FD-Score:5.48|P-value:2.16E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.19|P-value:5.70E-5 ID:SGTC_2275|Compound:7947463|FD-Score:8.35|P-value:2.44E-10 ID:SGTC_2291|Compound:7917025|FD-Score:8.78|P-value:3.04E-11 ID:SGTC_2292|Compound:7671323|FD-Score:-4.24|P-value:8.26E-4 ID:SGTC_2322|Compound:7413319|FD-Score:8.07|P-value:8.95E-10 ID:SGTC_2389|Compound:9091542|FD-Score:4.31|P-value:6.45E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.62|P-value:3.98E-7 ID:SGTC_2526|Compound:patulin|FD-Score:5.26|P-value:4.35E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:11.40|P-value:7.56E-18 ID:SGTC_2569|Compound:tetrandrine|FD-Score:6.77|P-value:2.22E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:10.40|P-value:5.68E-15 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-6.75|P-value:2.66E-7 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-6.12|P-value:2.73E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.80|P-value:2.73E-11 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.81|P-value:1.65E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.54|P-value:1.81E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.35|P-value:3.31E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.40|P-value:5.07E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.46|P-value:2.35E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.34|P-value:3.38E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:6.24|P-value:1.62E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-6.77|P-value:2.45E-7 ID:SGTC_2796|Compound:7949634|FD-Score:5.65|P-value:1.27E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-4.29|P-value:7.32E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.03|P-value:8.88E-5 ID:SGTC_2857|Compound:9024691|FD-Score:4.34|P-value:6.04E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-4.92|P-value:1.31E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.99|P-value:9.93E-5 ID:SGTC_3037|Compound:9091026|FD-Score:7.14|P-value:5.07E-8 ID:SGTC_3219|Compound:9131112|FD-Score:5.36|P-value:3.21E-5 ID:SGTC_3223|Compound:9129970|FD-Score:5.09|P-value:7.27E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-4.88|P-value:1.46E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.44|P-value:2.47E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.35|P-value:2.37E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:7.25|P-value:3.30E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:7.02|P-value:8.29E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:4.56|P-value:3.32E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:7.22|P-value:3.66E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:4.89|P-value:1.31E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.13|P-value:6.40E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.25|P-value:7.66E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.37|P-value:2.18E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:6.73|P-value:2.57E-7 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.30|P-value:3.90E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:4.26|P-value:7.35E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:6.83|P-value:1.79E-7 ID:SGTC_300|Compound:r073-0011|FD-Score:4.41|P-value:5.04E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.22|P-value:8.27E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.58|P-value:1.69E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-7.56|P-value:9.55E-9 ID:SGTC_313|Compound:3474-0040|FD-Score:4.66|P-value:2.54E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-6.35|P-value:1.19E-6 ID:SGTC_318|Compound:1488-0629|FD-Score:5.29|P-value:4.01E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.88|P-value:1.44E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.21|P-value:5.13E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.47|P-value:4.29E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-7.45|P-value:1.51E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.86|P-value:1.52E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:14.10|P-value:3.88E-26 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.13|P-value:6.54E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.68|P-value:2.37E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.26|P-value:3.44E-8 ID:SGTC_459|Compound:nigericin|FD-Score:6.91|P-value:1.31E-7 ID:SGTC_524|Compound:r073-0010|FD-Score:5.16|P-value:6.00E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:6.19|P-value:1.93E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:7.93|P-value:1.73E-9 ID:SGTC_535|Compound:2293-4129|FD-Score:6.81|P-value:1.94E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:4.71|P-value:2.23E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:8.09|P-value:8.26E-10 ID:SGTC_584|Compound:0986-0246|FD-Score:4.42|P-value:4.83E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:8.55|P-value:9.33E-11 ID:SGTC_733|Compound:4069-0007|FD-Score:4.52|P-value:3.68E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:6.05|P-value:3.17E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.24|P-value:8.27E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:8.26|P-value:3.71E-10 ID:SGTC_879|Compound:0831-1030|FD-Score:6.17|P-value:2.11E-6 ID:SGTC_882|Compound:0843-0131|FD-Score:4.31|P-value:6.48E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:6.37|P-value:1.03E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.52|P-value:3.68E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.33|P-value:6.15E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.94|P-value:1.14E-7 ID:SGTC_1138|Compound:3761-0006|FD-Score:-5.73|P-value:1.03E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:-6.64|P-value:4.05E-7 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.10|P-value:7.16E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:6.83|P-value:1.79E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.98|P-value:1.02E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:7.51|P-value:1.09E-8 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.36|P-value:2.08E-8 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.37|P-value:5.55E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-4.92|P-value:1.31E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.63|P-value:2.79E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.27|P-value:4.19E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:12.60|P-value:2.86E-21 ID:SGTC_1320|Compound:1313-0481|FD-Score:-5.20|P-value:5.67E-5 ID:SGTC_1323|Compound:1348-1351|FD-Score:4.27|P-value:7.22E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.87|P-value:1.39E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-6.55|P-value:5.71E-7 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.61|P-value:2.88E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:6.58|P-value:4.70E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.05|P-value:8.17E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:9.69|P-value:2.61E-13 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.27|P-value:7.16E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.62|P-value:6.76E-9 ID:SGTC_1658|Compound:st012944|FD-Score:10.40|P-value:5.25E-15 ID:SGTC_1660|Compound:st012960|FD-Score:5.50|P-value:2.07E-5 ID:SGTC_1687|Compound:st020778|FD-Score:9.34|P-value:1.67E-12 ID:SGTC_1711|Compound:st032263|FD-Score:4.34|P-value:6.05E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.76|P-value:2.04E-4 ID:SGTC_1754|Compound:st042065|FD-Score:13.60|P-value:1.93E-24 ID:SGTC_1759|Compound:st043059|FD-Score:-4.67|P-value:2.65E-4 ID:SGTC_1760|Compound:st045453|FD-Score:13.00|P-value:2.11E-22 ID:SGTC_1773|Compound:st048542|FD-Score:6.81|P-value:1.89E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.17|P-value:5.67E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:9.22|P-value:3.14E-12 ID:SGTC_1800|Compound:st050079|FD-Score:7.65|P-value:5.93E-9 ID:SGTC_1801|Compound:st050089|FD-Score:4.36|P-value:5.68E-4 ID:SGTC_1803|Compound:st050068|FD-Score:12.60|P-value:2.92E-21 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.62|P-value:1.39E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-4.35|P-value:6.21E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.92|P-value:5.11E-6 ID:SGTC_2242|Compound:6630449|FD-Score:5.48|P-value:2.16E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.19|P-value:5.70E-5 ID:SGTC_2275|Compound:7947463|FD-Score:8.35|P-value:2.44E-10 ID:SGTC_2291|Compound:7917025|FD-Score:8.78|P-value:3.04E-11 ID:SGTC_2292|Compound:7671323|FD-Score:-4.24|P-value:8.26E-4 ID:SGTC_2322|Compound:7413319|FD-Score:8.07|P-value:8.95E-10 ID:SGTC_2389|Compound:9091542|FD-Score:4.31|P-value:6.45E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.62|P-value:3.98E-7 ID:SGTC_2526|Compound:patulin|FD-Score:5.26|P-value:4.35E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:11.40|P-value:7.56E-18 ID:SGTC_2569|Compound:tetrandrine|FD-Score:6.77|P-value:2.22E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:10.40|P-value:5.68E-15 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-6.75|P-value:2.66E-7 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-6.12|P-value:2.73E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.80|P-value:2.73E-11 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.81|P-value:1.65E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.54|P-value:1.81E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.35|P-value:3.31E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.40|P-value:5.07E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.46|P-value:2.35E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.34|P-value:3.38E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:6.24|P-value:1.62E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-6.77|P-value:2.45E-7 ID:SGTC_2796|Compound:7949634|FD-Score:5.65|P-value:1.27E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-4.29|P-value:7.32E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.03|P-value:8.88E-5 ID:SGTC_2857|Compound:9024691|FD-Score:4.34|P-value:6.04E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-4.92|P-value:1.31E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.99|P-value:9.93E-5 ID:SGTC_3037|Compound:9091026|FD-Score:7.14|P-value:5.07E-8 ID:SGTC_3219|Compound:9131112|FD-Score:5.36|P-value:3.21E-5 ID:SGTC_3223|Compound:9129970|FD-Score:5.09|P-value:7.27E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-4.88|P-value:1.46E-4

Top fitness defect scores for YOR089C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_439 amiodarone 14.10 34.4 µM 3.88E-26 NEO1-PIK1 6 1.67E-45
2 SGTC_1754 st042065 13.60 16.1 µM 1.93E-24 NEO1-PIK1 11 1.88E-42
3 SGTC_1760 st045453 13.00 10.4 µM 2.11E-22 NEO1-PIK1 19 8.53E-39
4 SGTC_1306 1185-0270 12.60 9.0 µM 2.86E-21 Golgi 8 9.18E-37
5 SGTC_1803 st050068 12.60 52.4 µM 2.92E-21 NEO1-PIK1 8 9.57E-37
6 SGTC_2567 aureobasidin a 11.40 60.0 nM 7.56E-18 9 1.26E-30
7 SGTC_1658 st012944 10.40 20.0 µM 5.25E-15 iron homeostasis 2 1.56E-25
8 SGTC_2571 chrysanthemic acid 10.40 100.0 µM 5.68E-15 1 1.80E-25
9 SGTC_1495 4469-0029 9.69 237.0 µM 2.61E-13 18 1.69E-22
10 SGTC_1687 st020778 9.34 55.4 µM 1.67E-12 55 4.70E-21
11 SGTC_1789 tunicamycin 9.22 25.0 nM 3.14E-12 unfolded protein response 8 1.45E-20
12 SGTC_2582 agaric acid 8.80 100.0 µM 2.73E-11 redox potentiating 87 6.91E-19
13 SGTC_2291 7917025 8.78 104.3 µM 3.04E-11 iron homeostasis 12 8.36E-19
14 SGTC_690 glyoxal 8.55 20.3 µM 9.33E-11 23 6.18E-18
15 SGTC_221 trifluoperazine 8.37 10.3 µM 2.18E-10 NEO1-PIK1 80 2.80E-17
16 SGTC_2275 7947463 8.35 200.0 µM 2.44E-10 iron homeostasis 6 3.44E-17
17 SGTC_805 3852-0218 8.26 479.0 µM 3.71E-10 ERAD & cell cycle 11 7.27E-17
18 SGTC_576 1073-0113 8.09 22.7 µM 8.26E-10 redox potentiating 4 3.03E-16
19 SGTC_2322 7413319 8.07 38.2 µM 8.95E-10 ERAD & cell cycle 33 3.49E-16
20 SGTC_528 3492-0019 7.93 172.0 µM 1.73E-9 calcium & mitochondrial duress 73 1.13E-15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.465 1.19E-179 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.450 1.30E-166 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.443 3.57E-161 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.438 3.91E-157 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.406 1.46E-133 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.346 1.03E-94 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.340 9.65E-92 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.324 5.18E-83 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.316 9.72E-79 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.315 6.38E-78 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.314 2.26E-77 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.299 2.59E-70 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.276 6.79E-60 YPL120W VPS30 hom Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1
0.274 1.17E-58 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.265 6.39E-55 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress