YOR091W / TMA46

Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR091W / TMA46

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-3.45|P-value:2.66E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.96|P-value:5.12E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.50|P-value:3.04E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.00|P-value:3.18E-19 ID:SGTC_81|Compound:0411-0046|FD-Score:4.69|P-value:1.95E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.06|P-value:3.38E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:6.99|P-value:2.68E-12 ID:SGTC_159|Compound:3970-0959|FD-Score:8.73|P-value:3.31E-18 ID:SGTC_168|Compound:3970-0862|FD-Score:4.17|P-value:2.13E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.91|P-value:6.83E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.35|P-value:6.79E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.00|P-value:4.21E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:4.72|P-value:1.71E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.50|P-value:3.02E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.48|P-value:5.31E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.67|P-value:1.62E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:14.70|P-value:2.43E-48 ID:SGTC_568|Compound:1193-0097|FD-Score:3.26|P-value:7.14E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.49|P-value:5.10E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.34|P-value:4.09E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.87|P-value:5.21E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.49|P-value:5.01E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:4.15|P-value:2.34E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.61|P-value:1.50E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.35|P-value:9.79E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:6.08|P-value:1.08E-9 ID:SGTC_861|Compound:0443-0273|FD-Score:3.18|P-value:9.28E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.16|P-value:0.00100 ID:SGTC_916|Compound:4466-0038|FD-Score:4.53|P-value:4.32E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:4.39|P-value:7.91E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:4.15|P-value:2.25E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.25|P-value:7.22E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.59|P-value:2.12E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.52|P-value:4.53E-6 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.52|P-value:2.10E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.26|P-value:5.42E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.16|P-value:1.89E-7 ID:SGTC_1418|Compound:3966-3099|FD-Score:-4.27|P-value:9.86E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.39|P-value:4.52E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.44|P-value:6.32E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.22|P-value:8.01E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.13|P-value:8.52E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-6.07|P-value:7.05E-10 ID:SGTC_1624|Compound:st003710|FD-Score:7.73|P-value:1.18E-14 ID:SGTC_1625|Compound:st003711|FD-Score:5.23|P-value:1.32E-7 ID:SGTC_1707|Compound:st032323|FD-Score:3.81|P-value:9.36E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.85|P-value:7.83E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.80|P-value:6.96E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-4.77|P-value:9.12E-7 ID:SGTC_1798|Compound:st045719|FD-Score:3.38|P-value:4.69E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.10|P-value:2.02E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.30|P-value:6.11E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.33|P-value:5.53E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.26|P-value:5.29E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.25|P-value:7.15E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.22|P-value:7.97E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.86|P-value:5.62E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.37|P-value:4.71E-4 ID:SGTC_2340|Compound:7987427|FD-Score:6.18|P-value:5.77E-10 ID:SGTC_2342|Compound:7990637|FD-Score:-3.58|P-value:1.66E-4 ID:SGTC_2348|Compound:9022543|FD-Score:8.41|P-value:5.22E-17 ID:SGTC_2349|Compound:9023730|FD-Score:3.72|P-value:1.30E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.70|P-value:1.89E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.25|P-value:1.20E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:6.19|P-value:5.48E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:9.16|P-value:7.79E-20 ID:SGTC_2646|Compound:retinol|FD-Score:3.25|P-value:7.16E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.14|P-value:2.39E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.24|P-value:7.62E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.47|P-value:3.39E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-4.01|P-value:2.98E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.11|P-value:9.10E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.70|P-value:1.05E-4 ID:SGTC_3184|Compound:9108758|FD-Score:-3.11|P-value:8.86E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.39|P-value:4.44E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.32|P-value:5.62E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.98|P-value:3.31E-5 ID:SGTC_3311|Compound:9131146|FD-Score:7.80|P-value:6.81E-15 ID:SGTC_3350|Compound:9150499|FD-Score:3.90|P-value:6.57E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.45|P-value:2.66E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.96|P-value:5.12E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.50|P-value:3.04E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.00|P-value:3.18E-19 ID:SGTC_81|Compound:0411-0046|FD-Score:4.69|P-value:1.95E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.06|P-value:3.38E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:6.99|P-value:2.68E-12 ID:SGTC_159|Compound:3970-0959|FD-Score:8.73|P-value:3.31E-18 ID:SGTC_168|Compound:3970-0862|FD-Score:4.17|P-value:2.13E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.91|P-value:6.83E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.35|P-value:6.79E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.00|P-value:4.21E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:4.72|P-value:1.71E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.50|P-value:3.02E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.48|P-value:5.31E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.67|P-value:1.62E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:14.70|P-value:2.43E-48 ID:SGTC_568|Compound:1193-0097|FD-Score:3.26|P-value:7.14E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.49|P-value:5.10E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.34|P-value:4.09E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.87|P-value:5.21E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.49|P-value:5.01E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:4.15|P-value:2.34E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.61|P-value:1.50E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.35|P-value:9.79E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:6.08|P-value:1.08E-9 ID:SGTC_861|Compound:0443-0273|FD-Score:3.18|P-value:9.28E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.16|P-value:0.00100 ID:SGTC_916|Compound:4466-0038|FD-Score:4.53|P-value:4.32E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:4.39|P-value:7.91E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:4.15|P-value:2.25E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.25|P-value:7.22E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.59|P-value:2.12E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.52|P-value:4.53E-6 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.52|P-value:2.10E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.26|P-value:5.42E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.16|P-value:1.89E-7 ID:SGTC_1418|Compound:3966-3099|FD-Score:-4.27|P-value:9.86E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.39|P-value:4.52E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.44|P-value:6.32E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.22|P-value:8.01E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.13|P-value:8.52E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-6.07|P-value:7.05E-10 ID:SGTC_1624|Compound:st003710|FD-Score:7.73|P-value:1.18E-14 ID:SGTC_1625|Compound:st003711|FD-Score:5.23|P-value:1.32E-7 ID:SGTC_1707|Compound:st032323|FD-Score:3.81|P-value:9.36E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.85|P-value:7.83E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.80|P-value:6.96E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-4.77|P-value:9.12E-7 ID:SGTC_1798|Compound:st045719|FD-Score:3.38|P-value:4.69E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.10|P-value:2.02E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.30|P-value:6.11E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.33|P-value:5.53E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.26|P-value:5.29E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.25|P-value:7.15E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.22|P-value:7.97E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.86|P-value:5.62E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.37|P-value:4.71E-4 ID:SGTC_2340|Compound:7987427|FD-Score:6.18|P-value:5.77E-10 ID:SGTC_2342|Compound:7990637|FD-Score:-3.58|P-value:1.66E-4 ID:SGTC_2348|Compound:9022543|FD-Score:8.41|P-value:5.22E-17 ID:SGTC_2349|Compound:9023730|FD-Score:3.72|P-value:1.30E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.70|P-value:1.89E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.25|P-value:1.20E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:6.19|P-value:5.48E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:9.16|P-value:7.79E-20 ID:SGTC_2646|Compound:retinol|FD-Score:3.25|P-value:7.16E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.14|P-value:2.39E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.24|P-value:7.62E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.47|P-value:3.39E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-4.01|P-value:2.98E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.11|P-value:9.10E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.70|P-value:1.05E-4 ID:SGTC_3184|Compound:9108758|FD-Score:-3.11|P-value:8.86E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.39|P-value:4.44E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.32|P-value:5.62E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.98|P-value:3.31E-5 ID:SGTC_3311|Compound:9131146|FD-Score:7.80|P-value:6.81E-15 ID:SGTC_3350|Compound:9150499|FD-Score:3.90|P-value:6.57E-5

Top fitness defect scores for YOR091W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 14.70 2.6 nM 2.43E-48 cell wall 8 2.20E-49
2 SGTC_2619 obliquin 9.16 87.9 µM 7.79E-20 cell wall 30 2.67E-20
3 SGTC_58 0957-0393 9.00 9.0 µM 3.18E-19 cell wall 97 1.13E-19
4 SGTC_159 3970-0959 8.73 50.0 µM 3.31E-18 10 1.23E-18
5 SGTC_2348 9022543 8.41 33.4 µM 5.22E-17 mitochondrial processes 2 2.06E-17
6 SGTC_3311 9131146 7.80 2.9 µM 6.81E-15 cell wall 34 2.98E-15
7 SGTC_1624 st003710 7.73 6.2 µM 1.18E-14 calcium & mitochondrial duress 6 5.24E-15
8 SGTC_149 3970-0822 6.99 46.1 µM 2.68E-12 tubulin folding & SWR complex 20 1.34E-12
9 SGTC_2584 androsterone 6.19 48.7 µM 5.48E-10 cell wall 54 3.09E-10
10 SGTC_2340 7987427 6.18 183.4 µM 5.77E-10 6 3.25E-10
11 SGTC_852 0418-0143 6.08 439.0 µM 1.08E-9 calcium & mitochondrial duress 25 6.19E-10
12 SGTC_2582 agaric acid 5.25 100.0 µM 1.20E-7 redox potentiating 209 7.65E-8
13 SGTC_1625 st003711 5.23 30.1 µM 1.32E-7 calcium & mitochondrial duress 16 8.44E-8
14 SGTC_1353 1498-1206 5.16 8.1 µM 1.89E-7 mitochondrial response to ROS 27 1.22E-7
15 SGTC_214 4373-3496 4.91 70.0 µM 6.83E-7 33 4.55E-7
16 SGTC_312 4092-0653 4.72 6.8 µM 1.71E-6 ergosterol depletion effects on membrane 66 1.16E-6
17 SGTC_2479 5617353 4.70 43.9 µM 1.89E-6 17 1.29E-6
18 SGTC_81 0411-0046 4.69 10.0 µM 1.95E-6 15 1.33E-6
19 SGTC_916 4466-0038 4.53 42.0 nM 4.32E-6 cell wall 48 3.01E-6
20 SGTC_1133 3473-0247 4.52 50.0 µM 4.53E-6 RSC complex & mRNA processing 33 3.16E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.499 2.04E-210 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.485 5.36E-198 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.401 1.00E-129 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.369 5.15E-109 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.361 8.05E-104 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.352 1.75E-98 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.348 6.86E-96 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.332 2.77E-87 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.332 5.39E-87 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.313 2.36E-77 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.312 2.20E-76 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.289 1.48E-65 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.273 1.51E-58 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.272 6.55E-58 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.272 1.07E-57 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP