YOR092W / ECM3

Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR092W / ECM3

Click on Significant Values for Screen Details ID:SGTC_401|Compound:neomycin|FD-Score:-3.24|P-value:2.88E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.59|P-value:8.20E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:2.98|P-value:8.91E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.24|P-value:2.79E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.53|P-value:1.04E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.95|P-value:1.64E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:5.59|P-value:2.04E-9 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.53|P-value:1.06E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.10|P-value:8.37E-6 ID:SGTC_1717|Compound:st033143|FD-Score:4.27|P-value:3.53E-6 ID:SGTC_1721|Compound:st082152|FD-Score:-2.96|P-value:8.04E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.48|P-value:1.08E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.52|P-value:1.10E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-4.19|P-value:4.26E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-3.09|P-value:5.05E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-4.12|P-value:6.19E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.54|P-value:8.50E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-4.05|P-value:8.39E-6 ID:SGTC_1931|Compound:st074438|FD-Score:-4.72|P-value:2.78E-7 ID:SGTC_1933|Compound:st074711|FD-Score:-5.36|P-value:6.35E-9 ID:SGTC_1937|Compound:st074714|FD-Score:3.92|P-value:1.95E-5 ID:SGTC_2051|Compound:5263410|FD-Score:-3.58|P-value:7.19E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.51|P-value:1.07E-6 ID:SGTC_2310|Compound:7668677|FD-Score:3.03|P-value:7.39E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.17|P-value:5.94E-6 ID:SGTC_2398|Compound:5228213|FD-Score:4.16|P-value:6.18E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.18|P-value:4.17E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.01|P-value:7.98E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.01|P-value:6.81E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.05|P-value:6.87E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.51|P-value:1.08E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.44|P-value:1.29E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.01|P-value:1.24E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.02|P-value:7.61E-4 ID:SGTC_2706|Compound:st078239|FD-Score:2.97|P-value:9.25E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-4.24|P-value:3.36E-6 ID:SGTC_2805|Compound:7950783|FD-Score:4.20|P-value:5.19E-6 ID:SGTC_2814|Compound:7977482|FD-Score:-3.38|P-value:1.64E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.69|P-value:5.39E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.70|P-value:4.23E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-5.73|P-value:6.13E-10 ID:SGTC_2878|Compound:9043973|FD-Score:-4.94|P-value:8.03E-8 ID:SGTC_2932|Compound:9016711|FD-Score:-4.54|P-value:7.04E-7 ID:SGTC_2935|Compound:9038016|FD-Score:-2.97|P-value:7.76E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.11|P-value:5.55E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.02|P-value:6.45E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-4.45|P-value:1.14E-6 ID:SGTC_3085|Compound:9117376|FD-Score:3.13|P-value:5.17E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.11|P-value:7.99E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.02|P-value:7.62E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.24|P-value:2.88E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.59|P-value:8.20E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:2.98|P-value:8.91E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.24|P-value:2.79E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.53|P-value:1.04E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.95|P-value:1.64E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:5.59|P-value:2.04E-9 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.53|P-value:1.06E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.10|P-value:8.37E-6 ID:SGTC_1717|Compound:st033143|FD-Score:4.27|P-value:3.53E-6 ID:SGTC_1721|Compound:st082152|FD-Score:-2.96|P-value:8.04E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.48|P-value:1.08E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.52|P-value:1.10E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-4.19|P-value:4.26E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-3.09|P-value:5.05E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-4.12|P-value:6.19E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.54|P-value:8.50E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-4.05|P-value:8.39E-6 ID:SGTC_1931|Compound:st074438|FD-Score:-4.72|P-value:2.78E-7 ID:SGTC_1933|Compound:st074711|FD-Score:-5.36|P-value:6.35E-9 ID:SGTC_1937|Compound:st074714|FD-Score:3.92|P-value:1.95E-5 ID:SGTC_2051|Compound:5263410|FD-Score:-3.58|P-value:7.19E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.51|P-value:1.07E-6 ID:SGTC_2310|Compound:7668677|FD-Score:3.03|P-value:7.39E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.17|P-value:5.94E-6 ID:SGTC_2398|Compound:5228213|FD-Score:4.16|P-value:6.18E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.18|P-value:4.17E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.01|P-value:7.98E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.01|P-value:6.81E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.05|P-value:6.87E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.51|P-value:1.08E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.44|P-value:1.29E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.01|P-value:1.24E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.02|P-value:7.61E-4 ID:SGTC_2706|Compound:st078239|FD-Score:2.97|P-value:9.25E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-4.24|P-value:3.36E-6 ID:SGTC_2805|Compound:7950783|FD-Score:4.20|P-value:5.19E-6 ID:SGTC_2814|Compound:7977482|FD-Score:-3.38|P-value:1.64E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.69|P-value:5.39E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.70|P-value:4.23E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-5.73|P-value:6.13E-10 ID:SGTC_2878|Compound:9043973|FD-Score:-4.94|P-value:8.03E-8 ID:SGTC_2932|Compound:9016711|FD-Score:-4.54|P-value:7.04E-7 ID:SGTC_2935|Compound:9038016|FD-Score:-2.97|P-value:7.76E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.11|P-value:5.55E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.02|P-value:6.45E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-4.45|P-value:1.14E-6 ID:SGTC_3085|Compound:9117376|FD-Score:3.13|P-value:5.17E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.11|P-value:7.99E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.02|P-value:7.62E-4

Top fitness defect scores for YOR092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1140 3229-1848 5.59 3.0 µM 2.04E-9 3 1.15E-8
2 SGTC_2053 5265679 4.51 138.0 µM 1.07E-6 12 3.26E-6
3 SGTC_2592 piperlongumine 4.51 83.3 µM 1.08E-6 TSC3-RPN4 19 3.30E-6
4 SGTC_1717 st033143 4.27 58.0 µM 3.53E-6 30 9.59E-6
5 SGTC_2805 7950783 4.20 58.4 µM 5.19E-6 24 1.36E-5
6 SGTC_2397 5161689 4.17 200.0 µM 5.94E-6 28 1.54E-5
7 SGTC_2398 5228213 4.16 48.8 µM 6.18E-6 iron homeostasis 32 1.59E-5
8 SGTC_3087 9117406 4.11 49.5 µM 7.99E-6 16 2.01E-5
9 SGTC_1716 st033144 4.10 30.6 µM 8.37E-6 19 2.09E-5
10 SGTC_623 k072-0108 4.02 16.9 µM 1.21E-5 heme biosynthesis & mitochondrial translocase 17 2.92E-5
11 SGTC_2601 securinine 4.01 100.0 µM 1.24E-5 29 2.98E-5
12 SGTC_976 1348-1067 3.95 47.6 µM 1.64E-5 60S ribosome export 30 3.86E-5
13 SGTC_1937 st074714 3.92 47.2 µM 1.95E-5 42 4.50E-5
14 SGTC_2836 9010338 3.69 19.5 µM 5.39E-5 RPP1 & pyrimidine depletion 38 1.13E-4
15 SGTC_658 3253-0951 3.59 102.0 µM 8.20E-5 calcium & mitochondrial duress 74 1.65E-4
16 SGTC_969 1313-0238 3.53 134.0 µM 1.04E-4 mitochondrial processes 37 2.05E-4
17 SGTC_1230 0170-0365 3.53 3.8 µM 1.06E-4 endomembrane recycling 88 2.08E-4
18 SGTC_1789 tunicamycin 3.52 25.0 nM 1.10E-4 unfolded protein response 63 2.17E-4
19 SGTC_2489 cantharidin 3.18 73.4 µM 4.17E-4 cell wall signaling 80 7.25E-4
20 SGTC_3085 9117376 3.13 49.5 µM 5.17E-4 37 8.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 1.08E-48 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.223 1.10E-38 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.218 4.66E-37 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.207 1.40E-33 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.176 1.17E-24 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.172 1.44E-23 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.142 2.10E-16 YDR090C_p YDR090C_p hom Putative protein of unknown function
0.141 3.03E-16 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.139 9.45E-16 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.133 1.25E-14 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
0.123 8.60E-13 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.123 1.18E-12 YDR325W YCG1 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.120 4.33E-12 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.115 2.78E-11 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.109 2.64E-10 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress