YOR096W / RPS7A

Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR096W / RPS7A

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-4.72|P-value:8.98E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-7.51|P-value:4.85E-12 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.64|P-value:1.22E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.67|P-value:5.44E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.44|P-value:2.63E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.08|P-value:1.39E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.87|P-value:2.12E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.44|P-value:3.82E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.54|P-value:2.59E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.40|P-value:9.62E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.72|P-value:4.70E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.96|P-value:2.07E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.71|P-value:4.75E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-4.91|P-value:4.00E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.63|P-value:4.60E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.90|P-value:1.92E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.58|P-value:7.36E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.52|P-value:8.61E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.62|P-value:6.50E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.54|P-value:8.19E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.40|P-value:4.69E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:-4.17|P-value:7.33E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.80|P-value:3.58E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.74|P-value:4.36E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.57|P-value:3.30E-7 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.55|P-value:7.90E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-4.14|P-value:8.29E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.82|P-value:8.64E-6 ID:SGTC_1523|Compound:st012844|FD-Score:3.54|P-value:8.34E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.81|P-value:2.59E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.89|P-value:1.95E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.72|P-value:4.67E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.54|P-value:8.23E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.66|P-value:1.11E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.47|P-value:3.32E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.88|P-value:2.75E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.49|P-value:9.57E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-4.34|P-value:3.82E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.66|P-value:5.56E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.59|P-value:2.09E-5 ID:SGTC_2174|Compound:5790901|FD-Score:-3.41|P-value:9.19E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.97|P-value:2.06E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.53|P-value:1.87E-5 ID:SGTC_2278|Compound:7948257|FD-Score:-4.75|P-value:7.93E-6 ID:SGTC_2307|Compound:7538926|FD-Score:-3.42|P-value:9.03E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.48|P-value:7.42E-4 ID:SGTC_2327|Compound:6189656|FD-Score:5.26|P-value:1.33E-6 ID:SGTC_2401|Compound:5128683|FD-Score:4.10|P-value:1.32E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.48|P-value:9.87E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.59|P-value:7.10E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.68|P-value:1.02E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-5.20|P-value:1.13E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.78|P-value:2.81E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.97|P-value:1.48E-4 ID:SGTC_2832|Compound:7992762|FD-Score:7.05|P-value:1.41E-10 ID:SGTC_2860|Compound:9025725|FD-Score:-3.66|P-value:4.23E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.70|P-value:3.70E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.46|P-value:2.26E-9 ID:SGTC_2976|Compound:9009005|FD-Score:-3.95|P-value:1.59E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.48|P-value:7.43E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.70|P-value:1.37E-5 ID:SGTC_3182|Compound:9108849|FD-Score:5.28|P-value:1.21E-6 ID:SGTC_3197|Compound:9113331|FD-Score:-3.53|P-value:6.42E-4 ID:SGTC_3352|Compound:9151559|FD-Score:4.19|P-value:9.46E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-4.72|P-value:8.98E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-7.51|P-value:4.85E-12 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.64|P-value:1.22E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.67|P-value:5.44E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.44|P-value:2.63E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.08|P-value:1.39E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.87|P-value:2.12E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.44|P-value:3.82E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.54|P-value:2.59E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.40|P-value:9.62E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.72|P-value:4.70E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.96|P-value:2.07E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.71|P-value:4.75E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-4.91|P-value:4.00E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.63|P-value:4.60E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.90|P-value:1.92E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.58|P-value:7.36E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.52|P-value:8.61E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.62|P-value:6.50E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.54|P-value:8.19E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.40|P-value:4.69E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:-4.17|P-value:7.33E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.80|P-value:3.58E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.74|P-value:4.36E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.57|P-value:3.30E-7 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.55|P-value:7.90E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-4.14|P-value:8.29E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.82|P-value:8.64E-6 ID:SGTC_1523|Compound:st012844|FD-Score:3.54|P-value:8.34E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.81|P-value:2.59E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.89|P-value:1.95E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.72|P-value:4.67E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.54|P-value:8.23E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.66|P-value:1.11E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.47|P-value:3.32E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.88|P-value:2.75E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.49|P-value:9.57E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-4.34|P-value:3.82E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.66|P-value:5.56E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.59|P-value:2.09E-5 ID:SGTC_2174|Compound:5790901|FD-Score:-3.41|P-value:9.19E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.97|P-value:2.06E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.53|P-value:1.87E-5 ID:SGTC_2278|Compound:7948257|FD-Score:-4.75|P-value:7.93E-6 ID:SGTC_2307|Compound:7538926|FD-Score:-3.42|P-value:9.03E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.48|P-value:7.42E-4 ID:SGTC_2327|Compound:6189656|FD-Score:5.26|P-value:1.33E-6 ID:SGTC_2401|Compound:5128683|FD-Score:4.10|P-value:1.32E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.48|P-value:9.87E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.59|P-value:7.10E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.68|P-value:1.02E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-5.20|P-value:1.13E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.78|P-value:2.81E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.97|P-value:1.48E-4 ID:SGTC_2832|Compound:7992762|FD-Score:7.05|P-value:1.41E-10 ID:SGTC_2860|Compound:9025725|FD-Score:-3.66|P-value:4.23E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.70|P-value:3.70E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.46|P-value:2.26E-9 ID:SGTC_2976|Compound:9009005|FD-Score:-3.95|P-value:1.59E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.48|P-value:7.43E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.70|P-value:1.37E-5 ID:SGTC_3182|Compound:9108849|FD-Score:5.28|P-value:1.21E-6 ID:SGTC_3197|Compound:9113331|FD-Score:-3.53|P-value:6.42E-4 ID:SGTC_3352|Compound:9151559|FD-Score:4.19|P-value:9.46E-5

Top fitness defect scores for YOR096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2832 7992762 7.05 52.0 µM 1.41E-10 4 9.04E-13
2 SGTC_1265 0819-1001 5.57 68.8 µM 3.30E-7 5 1.31E-8
3 SGTC_3182 9108849 5.28 49.5 µM 1.21E-6 RPP1 & pyrimidine depletion 3 6.52E-8
4 SGTC_2327 6189656 5.26 200.0 µM 1.33E-6 6 7.29E-8
5 SGTC_1514 1189-1591 4.82 158.0 µM 8.64E-6 23 7.33E-7
6 SGTC_3080 9117754 4.70 49.5 µM 1.37E-5 9 1.30E-6
7 SGTC_2064 5220758 4.59 200.0 µM 2.09E-5 17 2.18E-6
8 SGTC_273 hydroxyurea 4.54 18.1 mM 2.59E-5 heme biosynthesis & mitochondrial translocase 21 2.83E-6
9 SGTC_1874 staurosporine 4.47 7.6 µM 3.32E-5 cell wall signaling 19 3.86E-6
10 SGTC_170 4197-0004 4.44 226.0 µM 3.82E-5 11 4.58E-6
11 SGTC_3352 9151559 4.19 45.6 µM 9.46E-5 8 1.40E-5
12 SGTC_2401 5128683 4.10 200.0 µM 1.32E-4 32 2.11E-5
13 SGTC_118 0083-0097 4.08 135.3 µM 1.39E-4 translation 118 2.24E-5
14 SGTC_2238 6671620 3.97 73.2 µM 2.06E-4 31 3.65E-5
15 SGTC_625 k213-0058 3.96 121.0 µM 2.07E-4 translation 103 3.67E-5
16 SGTC_1889 st059080 3.88 5.2 µM 2.75E-4 18 5.19E-5
17 SGTC_1252 0493-0875 3.80 34.8 µM 3.58E-4 33 7.20E-5
18 SGTC_1254 0550-0035 3.74 264.0 µM 4.36E-4 28 9.18E-5
19 SGTC_1781 st038725 3.72 66.3 µM 4.67E-4 NEO1 110 9.99E-5
20 SGTC_502 l-744,832 3.72 89.3 µM 4.70E-4 calcium & mitochondrial duress 42 1.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 2.04E-14 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.130 4.21E-14 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.121 1.99E-12 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.108 3.16E-10 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.106 8.55E-10 YLR139C SLS1 hom Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
0.104 1.94E-9 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.101 4.96E-9 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.098 1.15E-8 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.098 1.36E-8 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.097 1.74E-8 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.096 2.76E-8 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.096 2.79E-8 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.095 3.66E-8 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.095 4.12E-8 YPL158C AIM44 hom Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.092 9.28E-8 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock