YOR097C_p

Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR097C / YOR097C

Click on Significant Values for Screen Details ID:SGTC_539|Compound:4859-0462|FD-Score:3.81|P-value:2.45E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.49|P-value:6.95E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.98|P-value:1.39E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.38|P-value:9.89E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.96|P-value:2.85E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.58|P-value:5.29E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:6.76|P-value:3.24E-10 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.89|P-value:1.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.17|P-value:6.75E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.48|P-value:2.08E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.85|P-value:2.13E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.71|P-value:3.43E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.86|P-value:2.11E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.19|P-value:6.37E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.89|P-value:1.90E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.74|P-value:3.18E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.74|P-value:3.06E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.57|P-value:5.57E-4 ID:SGTC_1547|Compound:harmine|FD-Score:6.37|P-value:2.87E-9 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.44|P-value:2.46E-5 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.38|P-value:9.86E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.88|P-value:1.92E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.40|P-value:9.38E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.39|P-value:9.60E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.39|P-value:2.96E-5 ID:SGTC_1835|Compound:st008666|FD-Score:5.33|P-value:5.45E-7 ID:SGTC_1853|Compound:st056710|FD-Score:4.63|P-value:1.16E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:12.00|P-value:3.42E-28 ID:SGTC_1861|Compound:st057647|FD-Score:5.63|P-value:1.31E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.44|P-value:8.19E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.39|P-value:9.80E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.51|P-value:1.86E-5 ID:SGTC_2286|Compound:7945697|FD-Score:3.84|P-value:2.23E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.51|P-value:6.70E-4 ID:SGTC_2366|Compound:9070441|FD-Score:6.06|P-value:1.46E-8 ID:SGTC_2373|Compound:9071805|FD-Score:-3.98|P-value:1.33E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.40|P-value:9.43E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.59|P-value:1.35E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-4.72|P-value:7.90E-6 ID:SGTC_2902|Compound:5787006|FD-Score:5.25|P-value:7.73E-7 ID:SGTC_2948|Compound:9070189|FD-Score:-3.40|P-value:9.32E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-4.77|P-value:6.21E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-3.46|P-value:7.68E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.42|P-value:8.73E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.81|P-value:2.48E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.46|P-value:7.71E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.73|P-value:3.21E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.81|P-value:2.45E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.49|P-value:6.95E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.98|P-value:1.39E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.38|P-value:9.89E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.96|P-value:2.85E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.58|P-value:5.29E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:6.76|P-value:3.24E-10 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.89|P-value:1.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.17|P-value:6.75E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.48|P-value:2.08E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.85|P-value:2.13E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.71|P-value:3.43E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.86|P-value:2.11E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.19|P-value:6.37E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.89|P-value:1.90E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.74|P-value:3.18E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.74|P-value:3.06E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.57|P-value:5.57E-4 ID:SGTC_1547|Compound:harmine|FD-Score:6.37|P-value:2.87E-9 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.44|P-value:2.46E-5 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.38|P-value:9.86E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.88|P-value:1.92E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.40|P-value:9.38E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.39|P-value:9.60E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.39|P-value:2.96E-5 ID:SGTC_1835|Compound:st008666|FD-Score:5.33|P-value:5.45E-7 ID:SGTC_1853|Compound:st056710|FD-Score:4.63|P-value:1.16E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:12.00|P-value:3.42E-28 ID:SGTC_1861|Compound:st057647|FD-Score:5.63|P-value:1.31E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.44|P-value:8.19E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.39|P-value:9.80E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.51|P-value:1.86E-5 ID:SGTC_2286|Compound:7945697|FD-Score:3.84|P-value:2.23E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.51|P-value:6.70E-4 ID:SGTC_2366|Compound:9070441|FD-Score:6.06|P-value:1.46E-8 ID:SGTC_2373|Compound:9071805|FD-Score:-3.98|P-value:1.33E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.40|P-value:9.43E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.59|P-value:1.35E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-4.72|P-value:7.90E-6 ID:SGTC_2902|Compound:5787006|FD-Score:5.25|P-value:7.73E-7 ID:SGTC_2948|Compound:9070189|FD-Score:-3.40|P-value:9.32E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-4.77|P-value:6.21E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-3.46|P-value:7.68E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.42|P-value:8.73E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.81|P-value:2.48E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.46|P-value:7.71E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.73|P-value:3.21E-4

Top fitness defect scores for YOR097C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 12.00 62.6 µM 3.42E-28 TSC3-RPN4 2 2.59E-33
2 SGTC_1045 1348-1485 6.76 165.0 µM 3.24E-10 3 7.12E-12
3 SGTC_1547 harmine 6.37 94.2 µM 2.87E-9 ergosterol biosynthesis 16 9.55E-11
4 SGTC_2366 9070441 6.06 60.6 µM 1.46E-8 4 6.62E-10
5 SGTC_1861 st057647 5.63 17.4 µM 1.31E-7 2 9.01E-9
6 SGTC_1835 st008666 5.33 49.2 µM 5.45E-7 10 4.90E-8
7 SGTC_2902 5787006 5.25 60.5 µM 7.73E-7 Golgi 7 7.41E-8
8 SGTC_1027 k015-0025 4.96 8.7 µM 2.85E-6 13 3.49E-7
9 SGTC_1853 st056710 4.63 91.2 µM 1.16E-5 amide catabolism 13 1.85E-6
10 SGTC_2558 carylophyllene oxide 4.59 100.0 µM 1.35E-5 4 2.22E-6
11 SGTC_2267 7931562 4.51 200.0 µM 1.86E-5 10 3.24E-6
12 SGTC_1166 k206-0078 4.48 225.0 µM 2.08E-5 10 3.69E-6
13 SGTC_1559 coumarin 343 4.44 70.1 µM 2.46E-5 5 4.52E-6
14 SGTC_1827 berberine 4.39 7.2 µM 2.96E-5 60S ribosome export 13 5.61E-6
15 SGTC_1422 4031-0024 4.19 15.5 µM 6.37E-5 iron homeostasis 13 1.39E-5
16 SGTC_1107 amlodipine 4.17 47.0 µM 6.75E-5 26 1.49E-5
17 SGTC_808 0711-0032 3.98 135.0 µM 1.39E-4 13 3.50E-5
18 SGTC_1049 3226-0134 3.89 66.0 µM 1.85E-4 30 4.92E-5
19 SGTC_1458 k015-0034 3.89 6.3 µM 1.90E-4 18 5.08E-5
20 SGTC_1565 sinapyl alcohol 3.88 95.1 µM 1.92E-4 31 5.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.45E-11 YGL058W RAD6 hom Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
0.105 1.04E-9 YMR092C AIP1 hom Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.104 1.41E-9 YCR066W RAD18 hom E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA
0.104 1.80E-9 YNL300W_p TOS6_p hom Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
0.090 1.54E-7 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.079 4.41E-6 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.071 3.93E-5 YDL016C_d YDL016C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
0.071 3.93E-5 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.070 5.06E-5 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.070 5.22E-5 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.070 5.22E-5 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.067 9.51E-5 YPR199C ARR1 hom Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
0.066 1.27E-4 YDR415C_p YDR415C_p hom Putative aminopeptidase
0.066 1.43E-4 YCR061W_p YCR061W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.065 1.67E-4 YHR151C MTC6 hom Protein of unknown function; mtc6 is synthetically sick with cdc13-1