YOR099W / KTR1

Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR099W / KTR1

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:-2.92|P-value:8.21E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.96|P-value:9.58E-6 ID:SGTC_433|Compound:pimozide|FD-Score:-3.05|P-value:4.87E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.39|P-value:1.28E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.59|P-value:5.31E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:2.91|P-value:8.40E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.27|P-value:2.03E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.01|P-value:5.75E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:2.98|P-value:6.59E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.15|P-value:3.72E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.92|P-value:8.20E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.17|P-value:3.18E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.12|P-value:4.43E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.27|P-value:2.06E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.41|P-value:1.19E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.25|P-value:2.27E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.71|P-value:3.11E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.40|P-value:1.21E-4 ID:SGTC_1615|Compound:st002656|FD-Score:-2.94|P-value:7.37E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.59|P-value:5.32E-5 ID:SGTC_1764|Compound:st044502|FD-Score:2.91|P-value:8.49E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.12|P-value:4.38E-6 ID:SGTC_1971|Compound:st069429|FD-Score:3.17|P-value:3.20E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.02|P-value:5.65E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-2.90|P-value:8.74E-4 ID:SGTC_2110|Compound:5483698|FD-Score:2.99|P-value:6.33E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.99|P-value:8.25E-6 ID:SGTC_2445|Compound:5742597|FD-Score:3.19|P-value:2.90E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.07|P-value:5.68E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.11|P-value:3.97E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.12|P-value:3.89E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.51|P-value:1.42E-9 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-2.91|P-value:8.52E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.02|P-value:5.49E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.07|P-value:4.58E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.66|P-value:3.93E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.45|P-value:9.62E-5 ID:SGTC_3045|Compound:9092950|FD-Score:4.99|P-value:3.59E-8 ID:SGTC_3052|Compound:9092717|FD-Score:5.10|P-value:1.89E-8 ID:SGTC_3087|Compound:9117406|FD-Score:-3.33|P-value:1.61E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.58|P-value:5.45E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-4.55|P-value:4.49E-7 ID:SGTC_3347|Compound:9188721|FD-Score:3.30|P-value:1.86E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-2.92|P-value:8.21E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.96|P-value:9.58E-6 ID:SGTC_433|Compound:pimozide|FD-Score:-3.05|P-value:4.87E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.39|P-value:1.28E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.59|P-value:5.31E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:2.91|P-value:8.40E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.27|P-value:2.03E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.01|P-value:5.75E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:2.98|P-value:6.59E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.15|P-value:3.72E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.92|P-value:8.20E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.17|P-value:3.18E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.12|P-value:4.43E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.27|P-value:2.06E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.41|P-value:1.19E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.25|P-value:2.27E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.71|P-value:3.11E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.40|P-value:1.21E-4 ID:SGTC_1615|Compound:st002656|FD-Score:-2.94|P-value:7.37E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.59|P-value:5.32E-5 ID:SGTC_1764|Compound:st044502|FD-Score:2.91|P-value:8.49E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.12|P-value:4.38E-6 ID:SGTC_1971|Compound:st069429|FD-Score:3.17|P-value:3.20E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.02|P-value:5.65E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-2.90|P-value:8.74E-4 ID:SGTC_2110|Compound:5483698|FD-Score:2.99|P-value:6.33E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.99|P-value:8.25E-6 ID:SGTC_2445|Compound:5742597|FD-Score:3.19|P-value:2.90E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.07|P-value:5.68E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.11|P-value:3.97E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.12|P-value:3.89E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.51|P-value:1.42E-9 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-2.91|P-value:8.52E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.02|P-value:5.49E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.07|P-value:4.58E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.66|P-value:3.93E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.45|P-value:9.62E-5 ID:SGTC_3045|Compound:9092950|FD-Score:4.99|P-value:3.59E-8 ID:SGTC_3052|Compound:9092717|FD-Score:5.10|P-value:1.89E-8 ID:SGTC_3087|Compound:9117406|FD-Score:-3.33|P-value:1.61E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.58|P-value:5.45E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-4.55|P-value:4.49E-7 ID:SGTC_3347|Compound:9188721|FD-Score:3.30|P-value:1.86E-4

Top fitness defect scores for YOR099W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2627 acetyl isogambogic acid 5.51 100.0 µM 1.42E-9 TSC3-RPN4 21 1.83E-8
2 SGTC_3052 9092717 5.10 49.5 µM 1.89E-8 9 1.71E-7
3 SGTC_3045 9092950 4.99 49.5 µM 3.59E-8 9 2.96E-7
4 SGTC_799 1310-0557 4.27 151.0 µM 2.03E-6 superoxide 16 9.69E-6
5 SGTC_1959 st077091 4.12 55.8 µM 4.38E-6 RPP1 & pyrimidine depletion 42 1.88E-5
6 SGTC_1200 1643-0193 4.12 18.4 µM 4.43E-6 12 1.90E-5
7 SGTC_2456 5770359 4.07 74.5 µM 5.68E-6 15 2.35E-5
8 SGTC_2420 aureobasidin a 3.99 50.0 nM 8.25E-6 43 3.25E-5
9 SGTC_366 0181-0206 3.96 4.3 µM 9.58E-6 Golgi 42 3.70E-5
10 SGTC_1524 corynanthine 3.71 62.1 µM 3.11E-5 24 1.03E-4
11 SGTC_2960 9079389 3.66 6.0 µM 3.93E-5 36 1.26E-4
12 SGTC_1284 0929-0043 3.41 16.0 µM 1.19E-4 45 3.28E-4
13 SGTC_1580 hydrocortisone 21-hemisuccinate 3.40 43.2 µM 1.21E-4 35 3.32E-4
14 SGTC_621 3584-0052 3.39 32.1 µM 1.28E-4 37 3.50E-4
15 SGTC_3347 9188721 3.30 44.7 µM 1.86E-4 38 4.82E-4
16 SGTC_1391 3442-0225 3.25 151.0 µM 2.27E-4 35 5.75E-4
17 SGTC_2445 5742597 3.19 35.6 µM 2.90E-4 71 7.10E-4
18 SGTC_1170 0310-0127 3.17 64.8 µM 3.18E-4 59 7.70E-4
19 SGTC_1971 st069429 3.17 63.5 µM 3.20E-4 60S ribosome export 37 7.74E-4
20 SGTC_2624 nerol 3.12 100.0 µM 3.89E-4 33 9.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.83E-12 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.106 7.64E-10 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.102 3.01E-9 YNL279W PRM1 hom Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
0.101 4.13E-9 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.099 8.16E-9 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.091 1.22E-7 YPL229W_p YPL229W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication
0.089 2.13E-7 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.085 8.24E-7 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.081 2.97E-6 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.080 3.79E-6 YKR083C DAD2 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.079 4.55E-6 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
0.078 5.85E-6 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.077 7.02E-6 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.077 7.35E-6 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.077 8.32E-6 YLL019C KNS1 hom Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation