YOR100C / CRC1

Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR100C / CRC1

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:4.40|P-value:5.11E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:2.91|P-value:6.08E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:2.82|P-value:8.66E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.29|P-value:1.26E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.02|P-value:3.95E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.50|P-value:4.94E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:-2.78|P-value:9.90E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.62|P-value:2.76E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.03|P-value:3.85E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:2.96|P-value:5.09E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:2.88|P-value:6.76E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.43|P-value:6.80E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.63|P-value:2.67E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.37|P-value:5.97E-7 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.97|P-value:4.82E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.15|P-value:2.26E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-4.75|P-value:6.29E-8 ID:SGTC_1459|Compound:k035-0031|FD-Score:2.83|P-value:8.15E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.12|P-value:2.57E-4 ID:SGTC_1710|Compound:st031758|FD-Score:3.15|P-value:2.33E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.41|P-value:7.38E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.59|P-value:3.27E-5 ID:SGTC_1964|Compound:st076914|FD-Score:-3.08|P-value:3.00E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.01|P-value:4.01E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.39|P-value:8.15E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-3.12|P-value:2.62E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.24|P-value:1.58E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.22|P-value:1.32E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-3.83|P-value:9.95E-6 ID:SGTC_2295|Compound:7971645|FD-Score:-3.45|P-value:6.05E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.96|P-value:5.32E-6 ID:SGTC_2332|Compound:7982454|FD-Score:-4.34|P-value:7.00E-7 ID:SGTC_2339|Compound:9000433|FD-Score:-2.95|P-value:5.11E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.29|P-value:1.29E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.96|P-value:4.89E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.39|P-value:8.08E-5 ID:SGTC_2806|Compound:7952793|FD-Score:4.80|P-value:4.85E-8 ID:SGTC_2829|Compound:7992743|FD-Score:3.37|P-value:9.01E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.53|P-value:4.34E-5 ID:SGTC_2921|Compound:7974240|FD-Score:2.86|P-value:7.34E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.66|P-value:2.36E-5 ID:SGTC_2983|Compound:9022671|FD-Score:3.89|P-value:7.66E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.54|P-value:4.18E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.33|P-value:1.08E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.05|P-value:3.43E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.40|P-value:5.11E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:2.91|P-value:6.08E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:2.82|P-value:8.66E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.29|P-value:1.26E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.02|P-value:3.95E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.50|P-value:4.94E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:-2.78|P-value:9.90E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.62|P-value:2.76E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.03|P-value:3.85E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:2.96|P-value:5.09E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:2.88|P-value:6.76E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.43|P-value:6.80E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.63|P-value:2.67E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.37|P-value:5.97E-7 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.97|P-value:4.82E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.15|P-value:2.26E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-4.75|P-value:6.29E-8 ID:SGTC_1459|Compound:k035-0031|FD-Score:2.83|P-value:8.15E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.12|P-value:2.57E-4 ID:SGTC_1710|Compound:st031758|FD-Score:3.15|P-value:2.33E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.41|P-value:7.38E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.59|P-value:3.27E-5 ID:SGTC_1964|Compound:st076914|FD-Score:-3.08|P-value:3.00E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.01|P-value:4.01E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.39|P-value:8.15E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-3.12|P-value:2.62E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.24|P-value:1.58E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.22|P-value:1.32E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-3.83|P-value:9.95E-6 ID:SGTC_2295|Compound:7971645|FD-Score:-3.45|P-value:6.05E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.96|P-value:5.32E-6 ID:SGTC_2332|Compound:7982454|FD-Score:-4.34|P-value:7.00E-7 ID:SGTC_2339|Compound:9000433|FD-Score:-2.95|P-value:5.11E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.29|P-value:1.29E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.96|P-value:4.89E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.39|P-value:8.08E-5 ID:SGTC_2806|Compound:7952793|FD-Score:4.80|P-value:4.85E-8 ID:SGTC_2829|Compound:7992743|FD-Score:3.37|P-value:9.01E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.53|P-value:4.34E-5 ID:SGTC_2921|Compound:7974240|FD-Score:2.86|P-value:7.34E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.66|P-value:2.36E-5 ID:SGTC_2983|Compound:9022671|FD-Score:3.89|P-value:7.66E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.54|P-value:4.18E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.33|P-value:1.08E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.05|P-value:3.43E-4

Top fitness defect scores for YOR100C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2806 7952793 4.80 58.4 µM 4.85E-8 10 8.12E-7
2 SGTC_135 0933-0004 4.40 26.4 µM 5.11E-7 60S ribosome export 12 5.53E-6
3 SGTC_1186 1319-0216 4.37 26.0 µM 5.97E-7 11 6.28E-6
4 SGTC_2290 7904846 4.22 200.0 µM 1.32E-6 16 1.20E-5
5 SGTC_2303 7774051 3.96 200.0 µM 5.32E-6 19 3.74E-5
6 SGTC_2983 9022671 3.89 13.0 µM 7.66E-6 60S ribosome export 11 5.04E-5
7 SGTC_2968 9090663 3.66 33.4 µM 2.36E-5 42 1.26E-4
8 SGTC_1125 tnp00248 3.63 1.3 µM 2.67E-5 42 1.40E-4
9 SGTC_3194 9111903 3.54 49.5 µM 4.18E-5 32 2.02E-4
10 SGTC_1741 st038134 3.41 10.2 µM 7.38E-5 47 3.21E-4
11 SGTC_2829 7992743 3.37 58.4 µM 9.01E-5 59 3.78E-4
12 SGTC_3271 9137798 3.33 49.5 µM 1.08E-4 16 4.39E-4
13 SGTC_2351 9026858 3.29 72.3 µM 1.29E-4 RNA processing & uracil transport 47 5.08E-4
14 SGTC_2286 7945697 3.24 125.0 µM 1.58E-4 90 6.00E-4
15 SGTC_1452 4194-0072 3.15 190.0 µM 2.26E-4 42 8.03E-4
16 SGTC_1710 st031758 3.15 61.5 µM 2.33E-4 32 8.24E-4
17 SGTC_1667 st014849 3.12 34.6 µM 2.57E-4 Golgi 22 8.93E-4
18 SGTC_3330 9141424 3.05 71.4 µM 3.43E-4 amide catabolism 53 0.00113
19 SGTC_803 4488-1585 3.03 147.0 µM 3.85E-4 45 0.00124
20 SGTC_716 1683-5115 3.02 658.0 µM 3.95E-4 63 0.00127

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 8.47E-17 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.130 4.00E-14 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.111 1.18E-10 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.104 1.69E-9 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.101 4.35E-9 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.096 2.63E-8 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.095 3.03E-8 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.095 3.67E-8 YER065C ICL1 hom Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
0.093 7.00E-8 YKL005C BYE1 hom Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
0.087 4.36E-7 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.086 6.24E-7 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.084 1.17E-6 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.083 1.50E-6 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.083 1.65E-6 YPR003C_p YPR003C_p hom Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
0.082 1.84E-6 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response