YOR102W_d

Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR102W / YOR102W

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.28|P-value:7.67E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-5.59|P-value:2.56E-8 ID:SGTC_175|Compound:3793-3120|FD-Score:3.87|P-value:9.20E-5 ID:SGTC_186|Compound:3455-3465|FD-Score:-3.45|P-value:3.83E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.46|P-value:3.67E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.94|P-value:6.83E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.38|P-value:5.33E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.24|P-value:8.61E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:4.13|P-value:3.27E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.31|P-value:6.23E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:5.06|P-value:4.81E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.13|P-value:3.25E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.78|P-value:1.83E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.61|P-value:2.40E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.04|P-value:4.54E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-3.54|P-value:2.82E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.03|P-value:4.79E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.23|P-value:9.03E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.80|P-value:1.19E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.62|P-value:2.35E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.60|P-value:2.96E-8 ID:SGTC_1923|Compound:st058458|FD-Score:3.23|P-value:8.93E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.92|P-value:7.53E-5 ID:SGTC_2153|Compound:5569715|FD-Score:-3.24|P-value:7.89E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.93|P-value:7.09E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.21|P-value:9.46E-4 ID:SGTC_2423|Compound:st077119|FD-Score:4.64|P-value:3.49E-6 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-4.24|P-value:1.81E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.54|P-value:2.83E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-6.04|P-value:2.08E-9 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.88|P-value:7.81E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.44|P-value:8.45E-6 ID:SGTC_2780|Compound:5215298|FD-Score:-3.31|P-value:6.30E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.19|P-value:9.25E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.36|P-value:5.73E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.80|P-value:1.04E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.42|P-value:9.34E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_3094|Compound:9117742|FD-Score:5.88|P-value:5.93E-9 ID:SGTC_3156|Compound:9099931|FD-Score:3.37|P-value:5.58E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.31|P-value:6.92E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.28|P-value:7.67E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-5.59|P-value:2.56E-8 ID:SGTC_175|Compound:3793-3120|FD-Score:3.87|P-value:9.20E-5 ID:SGTC_186|Compound:3455-3465|FD-Score:-3.45|P-value:3.83E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.46|P-value:3.67E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.94|P-value:6.83E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.38|P-value:5.33E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.24|P-value:8.61E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:4.13|P-value:3.27E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.31|P-value:6.23E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:5.06|P-value:4.81E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.13|P-value:3.25E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.78|P-value:1.83E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.61|P-value:2.40E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.04|P-value:4.54E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-3.54|P-value:2.82E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.03|P-value:4.79E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.23|P-value:9.03E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.80|P-value:1.19E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.62|P-value:2.35E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.60|P-value:2.96E-8 ID:SGTC_1923|Compound:st058458|FD-Score:3.23|P-value:8.93E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.92|P-value:7.53E-5 ID:SGTC_2153|Compound:5569715|FD-Score:-3.24|P-value:7.89E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.93|P-value:7.09E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.21|P-value:9.46E-4 ID:SGTC_2423|Compound:st077119|FD-Score:4.64|P-value:3.49E-6 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-4.24|P-value:1.81E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.54|P-value:2.83E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-6.04|P-value:2.08E-9 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.88|P-value:7.81E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.44|P-value:8.45E-6 ID:SGTC_2780|Compound:5215298|FD-Score:-3.31|P-value:6.30E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.19|P-value:9.25E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.36|P-value:5.73E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.80|P-value:1.04E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.42|P-value:9.34E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_3094|Compound:9117742|FD-Score:5.88|P-value:5.93E-9 ID:SGTC_3156|Compound:9099931|FD-Score:3.37|P-value:5.58E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.31|P-value:6.92E-4

Top fitness defect scores for YOR102W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3094 9117742 5.88 49.5 µM 5.93E-9 1 1.99E-9 1.82
2 SGTC_1847 st056231 5.60 15.0 µM 2.96E-8 2 1.09E-8 0.90
3 SGTC_1177 0983-0204 5.06 23.6 µM 4.81E-7 1 2.11E-7 0.45
4 SGTC_1254 0550-0035 4.78 264.0 µM 1.83E-6 4 8.72E-7 0.37
5 SGTC_2423 st077119 4.64 87.2 µM 3.49E-6 1 1.73E-6 0.55
6 SGTC_2739 tacrine 4.44 100.9 µM 8.45E-6 heme requiring 4 4.41E-6 0.38
7 SGTC_2927 9011802 4.42 47.9 µM 9.34E-6 7 4.91E-6 0.19
8 SGTC_1189 1431-2119 4.13 7.3 µM 3.25E-5 8 1.84E-5 0.02
9 SGTC_515 4092-1064 4.13 102.0 µM 3.27E-5 plasma membrane duress 16 1.85E-5 0.09
10 SGTC_1368 1852-0141 4.04 284.0 µM 4.54E-5 ERG2 2 2.62E-5 0.20
11 SGTC_1744 st037937 4.03 38.9 µM 4.79E-5 7 2.78E-5 0.40
12 SGTC_197 4544-0043 3.94 41.6 µM 6.83E-5 endomembrane recycling 22 4.05E-5 0.09
13 SGTC_2282 7944268 3.93 200.0 µM 7.09E-5 RPP1 & pyrimidine depletion 8 4.21E-5 0.04
14 SGTC_1990 st072050 3.92 59.8 µM 7.53E-5 3 4.49E-5 0.22
15 SGTC_175 3793-3120 3.87 23.7 µM 9.20E-5 6 5.55E-5 0.02
16 SGTC_2985 9022375 3.82 71.4 µM 1.09E-4 RPP1 & pyrimidine depletion 8 6.66E-5 0.15
17 SGTC_1780 st038448 3.80 24.5 µM 1.19E-4 iron homeostasis 9 7.27E-5 0.28
18 SGTC_1820 st053765 3.62 18.6 µM 2.35E-4 RPP1 & pyrimidine depletion 8 1.50E-4 0.22
19 SGTC_1259 0671-0132 3.61 43.0 µM 2.40E-4 9 1.53E-4 0.01
20 SGTC_285 1486-1325 3.38 46.0 µM 5.33E-4 9 3.58E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.35E-8 YDL175C AIR2 hom RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication
0.087 5.14E-7 YHR200W RPN10 hom Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
0.083 1.62E-6 YPL247C_p YPL247C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
0.079 4.62E-6 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.078 6.10E-6 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.075 1.23E-5 YML004C GLO1 hom Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
0.073 2.15E-5 YGL080W FMP37 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
0.073 2.18E-5 YJL002C OST1 het Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.071 3.65E-5 YDR490C PKH1 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
0.071 3.75E-5 YJL030W MAD2 hom Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I
0.069 7.15E-5 YAR031W PRM9 hom Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
0.068 7.86E-5 YJL123C MTC1 hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1
0.067 9.22E-5 YMR089C YTA12 hom Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
0.066 1.21E-4 YLR059C REX2 hom 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease
0.064 1.95E-4 YJR024C MDE1 hom 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant