YOR104W / PIN2

Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR104W / PIN2

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:4.48|P-value:7.17E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.73|P-value:1.55E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:4.52|P-value:5.99E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:3.45|P-value:4.21E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.42|P-value:7.41E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.71|P-value:1.54E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.48|P-value:7.08E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:3.31|P-value:6.88E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:10.50|P-value:1.10E-24 ID:SGTC_582|Compound:0987-0078|FD-Score:3.93|P-value:7.11E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:3.58|P-value:2.67E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.68|P-value:2.92E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:8.00|P-value:4.29E-15 ID:SGTC_733|Compound:4069-0007|FD-Score:4.35|P-value:1.27E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.44|P-value:4.41E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.90|P-value:8.04E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:7.00|P-value:5.82E-12 ID:SGTC_868|Compound:0527-0199|FD-Score:6.97|P-value:6.85E-12 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.92|P-value:7.31E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.73|P-value:1.52E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.27|P-value:1.69E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.66|P-value:2.01E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.63|P-value:2.20E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.54|P-value:3.09E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.31|P-value:1.34E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.68|P-value:1.87E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.63|P-value:3.70E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.76|P-value:2.04E-6 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.47|P-value:3.86E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.11|P-value:3.38E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.10|P-value:3.23E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.44|P-value:4.28E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.50|P-value:3.49E-4 ID:SGTC_1797|Compound:st048695|FD-Score:6.48|P-value:1.69E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.98|P-value:7.17E-7 ID:SGTC_2006|Compound:4011487|FD-Score:6.00|P-value:2.98E-9 ID:SGTC_2068|Compound:5226020|FD-Score:4.51|P-value:6.26E-6 ID:SGTC_2161|Compound:5662504|FD-Score:5.76|P-value:1.19E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.87|P-value:8.83E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.51|P-value:3.41E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.61|P-value:2.39E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.22|P-value:8.50E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.37|P-value:5.46E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.20|P-value:2.41E-5 ID:SGTC_2350|Compound:9023895|FD-Score:4.01|P-value:5.23E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.32|P-value:6.53E-4 ID:SGTC_2474|Compound:5321570|FD-Score:4.07|P-value:3.99E-5 ID:SGTC_2485|Compound:5633444|FD-Score:3.39|P-value:5.15E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.83|P-value:1.47E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.28|P-value:1.55E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.55|P-value:1.11E-10 ID:SGTC_2699|Compound:st077704|FD-Score:3.22|P-value:9.33E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.28|P-value:7.60E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.46|P-value:4.01E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.42|P-value:4.63E-4 ID:SGTC_2906|Compound:7926292|FD-Score:6.54|P-value:1.12E-10 ID:SGTC_2909|Compound:7941780|FD-Score:3.28|P-value:7.47E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.18|P-value:9.67E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.71|P-value:1.52E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.34|P-value:6.14E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.27|P-value:7.85E-4 ID:SGTC_3212|Compound:9128307|FD-Score:6.38|P-value:3.21E-10 ID:SGTC_3231|Compound:9132313|FD-Score:3.21|P-value:9.61E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-4.12|P-value:2.97E-5 ID:SGTC_3255|Compound:9139072|FD-Score:5.18|P-value:2.57E-7 ID:SGTC_3280|Compound:9140961|FD-Score:3.92|P-value:7.25E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.48|P-value:7.17E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.73|P-value:1.55E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:4.52|P-value:5.99E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:3.45|P-value:4.21E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.42|P-value:7.41E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.71|P-value:1.54E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.48|P-value:7.08E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:3.31|P-value:6.88E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:10.50|P-value:1.10E-24 ID:SGTC_582|Compound:0987-0078|FD-Score:3.93|P-value:7.11E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:3.58|P-value:2.67E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.68|P-value:2.92E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:8.00|P-value:4.29E-15 ID:SGTC_733|Compound:4069-0007|FD-Score:4.35|P-value:1.27E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.44|P-value:4.41E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.90|P-value:8.04E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:7.00|P-value:5.82E-12 ID:SGTC_868|Compound:0527-0199|FD-Score:6.97|P-value:6.85E-12 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.92|P-value:7.31E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.73|P-value:1.52E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.27|P-value:1.69E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.66|P-value:2.01E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.63|P-value:2.20E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.54|P-value:3.09E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.31|P-value:1.34E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.68|P-value:1.87E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.63|P-value:3.70E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.76|P-value:2.04E-6 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.47|P-value:3.86E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.11|P-value:3.38E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.10|P-value:3.23E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.44|P-value:4.28E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.50|P-value:3.49E-4 ID:SGTC_1797|Compound:st048695|FD-Score:6.48|P-value:1.69E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.98|P-value:7.17E-7 ID:SGTC_2006|Compound:4011487|FD-Score:6.00|P-value:2.98E-9 ID:SGTC_2068|Compound:5226020|FD-Score:4.51|P-value:6.26E-6 ID:SGTC_2161|Compound:5662504|FD-Score:5.76|P-value:1.19E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.87|P-value:8.83E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.51|P-value:3.41E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.61|P-value:2.39E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.22|P-value:8.50E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.37|P-value:5.46E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.20|P-value:2.41E-5 ID:SGTC_2350|Compound:9023895|FD-Score:4.01|P-value:5.23E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.32|P-value:6.53E-4 ID:SGTC_2474|Compound:5321570|FD-Score:4.07|P-value:3.99E-5 ID:SGTC_2485|Compound:5633444|FD-Score:3.39|P-value:5.15E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.83|P-value:1.47E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.28|P-value:1.55E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.55|P-value:1.11E-10 ID:SGTC_2699|Compound:st077704|FD-Score:3.22|P-value:9.33E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.28|P-value:7.60E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.46|P-value:4.01E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.42|P-value:4.63E-4 ID:SGTC_2906|Compound:7926292|FD-Score:6.54|P-value:1.12E-10 ID:SGTC_2909|Compound:7941780|FD-Score:3.28|P-value:7.47E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.18|P-value:9.67E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.71|P-value:1.52E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.34|P-value:6.14E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.27|P-value:7.85E-4 ID:SGTC_3212|Compound:9128307|FD-Score:6.38|P-value:3.21E-10 ID:SGTC_3231|Compound:9132313|FD-Score:3.21|P-value:9.61E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-4.12|P-value:2.97E-5 ID:SGTC_3255|Compound:9139072|FD-Score:5.18|P-value:2.57E-7 ID:SGTC_3280|Compound:9140961|FD-Score:3.92|P-value:7.25E-5

Top fitness defect scores for YOR104W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_568 1193-0097 10.50 7.5 µM 1.10E-24 ERAD & cell cycle 21 4.06E-26
2 SGTC_690 glyoxal 8.00 20.3 µM 4.29E-15 28 6.11E-16
3 SGTC_768 0384-0033 7.00 77.3 µM 5.82E-12 fatty acid desaturase (OLE1) 29 1.29E-12
4 SGTC_868 0527-0199 6.97 213.0 µM 6.85E-12 fatty acid desaturase (OLE1) 5 1.53E-12
5 SGTC_2615 purpurogallin-4-carboxylic acid 6.55 100.0 µM 1.11E-10 redox potentiating 24 2.94E-11
6 SGTC_2906 7926292 6.54 26.4 µM 1.12E-10 1 2.98E-11
7 SGTC_1797 st048695 6.48 56.8 µM 1.69E-10 NEO1 35 4.59E-11
8 SGTC_3212 9128307 6.38 49.5 µM 3.21E-10 13 9.10E-11
9 SGTC_2006 4011487 6.00 200.0 µM 2.98E-9 endomembrane recycling 44 9.68E-10
10 SGTC_2161 5662504 5.76 8.5 µM 1.19E-8 tubulin folding & SWR complex 4 4.20E-9
11 SGTC_221 trifluoperazine 5.42 10.3 µM 7.41E-8 NEO1-PIK1 147 2.92E-8
12 SGTC_1130 3454-2858 5.27 15.9 µM 1.69E-7 NEO1 53 7.00E-8
13 SGTC_3255 9139072 5.18 49.5 µM 2.57E-7 2 1.09E-7
14 SGTC_1844 rapamycin 4.98 4.0 nM 7.17E-7 116 3.25E-7
15 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.83 70.0 µM 1.47E-6 redox potentiating 46 6.95E-7
16 SGTC_1377 2944-0135 4.76 198.0 µM 2.04E-6 calcium & mitochondrial duress 19 9.86E-7
17 SGTC_637 1181-0519 4.68 7.3 µM 2.92E-6 fatty acid desaturase (OLE1) 77 1.44E-6
18 SGTC_1239 0337-0584 4.63 35.4 µM 3.70E-6 unfolded protein response 35 1.85E-6
19 SGTC_203 k066-0004 4.52 30.9 µM 5.99E-6 RSC & ERG11 12 3.09E-6
20 SGTC_2068 5226020 4.51 147.0 µM 6.26E-6 18 3.23E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 6.60E-41 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.228 7.08E-41 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.220 6.12E-38 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.219 1.41E-37 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.209 2.15E-34 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.202 2.59E-32 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.202 4.23E-32 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.197 1.40E-30 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.185 2.43E-27 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.185 4.56E-27 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.183 1.19E-26 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.183 1.45E-26 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.181 5.74E-26 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.177 4.27E-25 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.175 1.34E-24 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication