YOR109W / INP53

Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR109W / INP53

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.43|P-value:2.49E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:13.80|P-value:4.37E-45 ID:SGTC_117|Compound:lucigenin|FD-Score:3.73|P-value:7.17E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:7.29|P-value:5.67E-14 ID:SGTC_121|Compound:0557-0495|FD-Score:3.25|P-value:4.65E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:14.40|P-value:3.43E-49 ID:SGTC_163|Compound:1327-0036|FD-Score:4.83|P-value:4.28E-7 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.06|P-value:1.79E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.42|P-value:3.31E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:6.45|P-value:2.61E-11 ID:SGTC_383|Compound:2324-0395|FD-Score:6.67|P-value:5.77E-12 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.68|P-value:8.73E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.39|P-value:4.28E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:3.27|P-value:4.33E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.25|P-value:7.34E-6 ID:SGTC_624|Compound:k048-0052|FD-Score:3.06|P-value:9.16E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.77|P-value:6.17E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.34|P-value:3.32E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.36|P-value:3.09E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.03|P-value:1.98E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.10|P-value:7.93E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.40|P-value:3.76E-6 ID:SGTC_1640|Compound:st009078|FD-Score:-3.65|P-value:1.09E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.15|P-value:6.49E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.45|P-value:2.36E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.14|P-value:7.40E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.00|P-value:2.47E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.72|P-value:8.34E-7 ID:SGTC_1949|Compound:st076024|FD-Score:4.12|P-value:1.36E-5 ID:SGTC_2028|Compound:5153890|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.51|P-value:2.17E-6 ID:SGTC_2144|Compound:5628481|FD-Score:3.30|P-value:3.84E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.86|P-value:4.14E-5 ID:SGTC_2369|Compound:9071472|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.11|P-value:7.59E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.58|P-value:1.31E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:4.28E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.35|P-value:4.69E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.97|P-value:2.06E-7 ID:SGTC_2707|Compound:st078556|FD-Score:3.13|P-value:7.08E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.99|P-value:5.24E-10 ID:SGTC_2873|Compound:9040596|FD-Score:3.72|P-value:7.57E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.16|P-value:6.41E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.79|P-value:5.61E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.54|P-value:1.54E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.68|P-value:8.73E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.08|P-value:8.46E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.64|P-value:1.05E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.90|P-value:3.61E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.43|P-value:2.49E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:13.80|P-value:4.37E-45 ID:SGTC_117|Compound:lucigenin|FD-Score:3.73|P-value:7.17E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:7.29|P-value:5.67E-14 ID:SGTC_121|Compound:0557-0495|FD-Score:3.25|P-value:4.65E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:14.40|P-value:3.43E-49 ID:SGTC_163|Compound:1327-0036|FD-Score:4.83|P-value:4.28E-7 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.06|P-value:1.79E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.42|P-value:3.31E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:6.45|P-value:2.61E-11 ID:SGTC_383|Compound:2324-0395|FD-Score:6.67|P-value:5.77E-12 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.68|P-value:8.73E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.39|P-value:4.28E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:3.27|P-value:4.33E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.25|P-value:7.34E-6 ID:SGTC_624|Compound:k048-0052|FD-Score:3.06|P-value:9.16E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.77|P-value:6.17E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.34|P-value:3.32E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.36|P-value:3.09E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.03|P-value:1.98E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.10|P-value:7.93E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.40|P-value:3.76E-6 ID:SGTC_1640|Compound:st009078|FD-Score:-3.65|P-value:1.09E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.15|P-value:6.49E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.45|P-value:2.36E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.14|P-value:7.40E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.00|P-value:2.47E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.72|P-value:8.34E-7 ID:SGTC_1949|Compound:st076024|FD-Score:4.12|P-value:1.36E-5 ID:SGTC_2028|Compound:5153890|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.51|P-value:2.17E-6 ID:SGTC_2144|Compound:5628481|FD-Score:3.30|P-value:3.84E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.86|P-value:4.14E-5 ID:SGTC_2369|Compound:9071472|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.11|P-value:7.59E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.58|P-value:1.31E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:4.28E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.35|P-value:4.69E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.97|P-value:2.06E-7 ID:SGTC_2707|Compound:st078556|FD-Score:3.13|P-value:7.08E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.99|P-value:5.24E-10 ID:SGTC_2873|Compound:9040596|FD-Score:3.72|P-value:7.57E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.16|P-value:6.41E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.79|P-value:5.61E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.54|P-value:1.54E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.68|P-value:8.73E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.08|P-value:8.46E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.64|P-value:1.05E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.90|P-value:3.61E-5

Top fitness defect scores for YOR109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_124 0136-0217 14.40 7.1 µM 3.43E-49 mitochondrial stress 2 1.29E-47
2 SGTC_70 0141-0289 13.80 43.3 µM 4.37E-45 mitochondrial stress 12 1.21E-43
3 SGTC_119 0121-0043 7.29 24.8 µM 5.67E-14 mitochondrial stress 13 1.50E-13
4 SGTC_383 2324-0395 6.67 7.4 µM 5.77E-12 azole & statin 10 1.31E-11
5 SGTC_377 3970-0964 6.45 33.1 µM 2.61E-11 15 5.66E-11
6 SGTC_2737 bleomycin 5.99 30.5 nM 5.24E-10 Golgi 33 1.03E-9
7 SGTC_2651 1327-0036 4.97 5.0 µM 2.06E-7 109 3.32E-7
8 SGTC_163 1327-0036 4.83 7.5 µM 4.28E-7 71 6.74E-7
9 SGTC_2128 5255449 4.51 168.5 µM 2.17E-6 22 3.24E-6
10 SGTC_249 wiskostatin 4.42 11.2 µM 3.31E-6 8 4.87E-6
11 SGTC_1616 st002734 4.40 56.1 µM 3.76E-6 20 5.51E-6
12 SGTC_2619 obliquin 4.35 87.9 µM 4.69E-6 cell wall 126 6.82E-6
13 SGTC_528 3492-0019 4.25 172.0 µM 7.34E-6 calcium & mitochondrial duress 195 1.05E-5
14 SGTC_1949 st076024 4.12 69.1 µM 1.36E-5 20 1.90E-5
15 SGTC_240 5hr heat shock (37°C) + Streptovitacin 4.06 300.0 µM 1.79E-5 heat shock/prefoldin 36 2.49E-5
16 SGTC_949 1165-0505 4.03 146.0 µM 1.98E-5 18 2.75E-5
17 SGTC_3307 9126885 3.90 69.3 µM 3.61E-5 35 4.91E-5
18 SGTC_2230 bromochlorosalicylanilide 3.86 954.5 nM 4.14E-5 6 5.61E-5
19 SGTC_2582 agaric acid 3.86 100.0 µM 4.28E-5 redox potentiating 329 5.79E-5
20 SGTC_3018 9082602 3.79 49.5 µM 5.61E-5 53 7.52E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.323 2.50E-82 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.293 2.43E-67 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.231 6.62E-42 YPR050C_d YPR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.205 2.80E-33 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.198 4.16E-31 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.177 6.00E-25 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.177 6.05E-25 YLR342W FKS1 hom Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
0.175 1.27E-24 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.175 2.13E-24 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.173 6.34E-24 YEL053C MAK10 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.169 7.57E-23 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.168 1.30E-22 YOR068C VAM10 hom Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.166 3.53E-22 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.158 2.75E-20 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.156 1.22E-19 YPR051W MAK3 hom Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus