YOR112W / CEX1

Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR112W / CEX1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.17|P-value:7.59E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.87|P-value:5.14E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.08|P-value:9.79E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.37|P-value:3.75E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.24|P-value:6.10E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.34|P-value:3.99E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.92|P-value:4.44E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.73|P-value:1.03E-6 ID:SGTC_877|Compound:0771-0151|FD-Score:-4.15|P-value:1.53E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:5.60|P-value:1.08E-8 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.03|P-value:2.64E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.62|P-value:1.38E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.96|P-value:3.82E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:4.28|P-value:9.39E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.81|P-value:7.40E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.59|P-value:1.15E-8 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.05|P-value:2.55E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.45|P-value:4.38E-14 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.22|P-value:6.60E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:5.72|P-value:5.35E-9 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.86|P-value:5.35E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.26|P-value:5.56E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.90|P-value:4.39E-7 ID:SGTC_1774|Compound:st048371|FD-Score:3.12|P-value:9.11E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.45|P-value:2.55E-8 ID:SGTC_1818|Compound:st052136|FD-Score:-4.09|P-value:1.97E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.17|P-value:7.20E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.44|P-value:2.97E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.97|P-value:3.58E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.53|P-value:2.13E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.34|P-value:4.29E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.13|P-value:8.83E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.16|P-value:8.02E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.24|P-value:5.68E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.16|P-value:7.87E-4 ID:SGTC_2840|Compound:9008771|FD-Score:5.19|P-value:1.05E-7 ID:SGTC_2842|Compound:9000675|FD-Score:-3.13|P-value:8.18E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.67|P-value:1.23E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.35|P-value:3.78E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.79|P-value:8.20E-7 ID:SGTC_2992|Compound:9074591|FD-Score:-3.71|P-value:9.83E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.74|P-value:9.21E-5 ID:SGTC_3198|Compound:9112019|FD-Score:3.30|P-value:4.96E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.60|P-value:1.49E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.32|P-value:4.63E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.17|P-value:7.59E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.87|P-value:5.14E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.08|P-value:9.79E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.37|P-value:3.75E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.24|P-value:6.10E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.34|P-value:3.99E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.92|P-value:4.44E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.73|P-value:1.03E-6 ID:SGTC_877|Compound:0771-0151|FD-Score:-4.15|P-value:1.53E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:5.60|P-value:1.08E-8 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.03|P-value:2.64E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.62|P-value:1.38E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.96|P-value:3.82E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:4.28|P-value:9.39E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.81|P-value:7.40E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.59|P-value:1.15E-8 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.05|P-value:2.55E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.45|P-value:4.38E-14 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.22|P-value:6.60E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:5.72|P-value:5.35E-9 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.86|P-value:5.35E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.26|P-value:5.56E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.90|P-value:4.39E-7 ID:SGTC_1774|Compound:st048371|FD-Score:3.12|P-value:9.11E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.45|P-value:2.55E-8 ID:SGTC_1818|Compound:st052136|FD-Score:-4.09|P-value:1.97E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.17|P-value:7.20E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.44|P-value:2.97E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.97|P-value:3.58E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.53|P-value:2.13E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.34|P-value:4.29E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.13|P-value:8.83E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.16|P-value:8.02E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.24|P-value:5.68E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.16|P-value:7.87E-4 ID:SGTC_2840|Compound:9008771|FD-Score:5.19|P-value:1.05E-7 ID:SGTC_2842|Compound:9000675|FD-Score:-3.13|P-value:8.18E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.67|P-value:1.23E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.35|P-value:3.78E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.79|P-value:8.20E-7 ID:SGTC_2992|Compound:9074591|FD-Score:-3.71|P-value:9.83E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.74|P-value:9.21E-5 ID:SGTC_3198|Compound:9112019|FD-Score:3.30|P-value:4.96E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.60|P-value:1.49E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.32|P-value:4.63E-4

Top fitness defect scores for YOR112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1026 k007-1105 7.45 30.6 µM 4.38E-14 ERAD & cell cycle 24 4.52E-14
2 SGTC_1223 0764-0573 5.72 147.0 µM 5.35E-9 1 5.37E-9
3 SGTC_945 3381-0768 5.60 11.3 µM 1.08E-8 endomembrane recycling 9 1.09E-8
4 SGTC_1000 4048-0884 5.59 8.7 µM 1.15E-8 copper-dependent oxidative stress 10 1.15E-8
5 SGTC_1789 tunicamycin 5.45 25.0 nM 2.55E-8 unfolded protein response 23 2.56E-8
6 SGTC_2840 9008771 5.19 71.4 µM 1.05E-7 2 1.05E-7
7 SGTC_995 3931-2021 4.81 34.6 µM 7.40E-7 RPP1 & pyrimidine depletion 7 7.37E-7
8 SGTC_2981 9013952 4.79 39.0 µM 8.20E-7 24 8.17E-7
9 SGTC_978 1416-0512 4.28 87.4 µM 9.39E-6 redox potentiating 25 9.32E-6
10 SGTC_1006 4099-6547 4.05 255.0 µM 2.55E-5 18 2.53E-5
11 SGTC_2106 5357045 3.97 167.3 µM 3.58E-5 17 3.55E-5
12 SGTC_968 1309-0633 3.96 340.0 µM 3.82E-5 12 3.78E-5
13 SGTC_745 0469-0705 3.92 296.0 µM 4.44E-5 mitochondrial processes 22 4.40E-5
14 SGTC_3044 9093193 3.74 49.5 µM 9.21E-5 30 9.12E-5
15 SGTC_980 1473-0395 3.72 201.0 µM 1.02E-4 15 1.01E-4
16 SGTC_1831 st055328 3.72 12.0 µM 1.02E-4 heme biosynthesis & mitochondrial translocase 35 1.01E-4
17 SGTC_2920 7982904 3.67 15.8 µM 1.23E-4 31 1.22E-4
18 SGTC_24 0417-1663 3.64 219.0 µM 1.39E-4 25 1.38E-4
19 SGTC_2453 5731132 3.53 22.2 µM 2.13E-4 30 2.10E-4
20 SGTC_2058 5236698 3.44 133.0 µM 2.97E-4 41 2.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.75E-20 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.147 1.42E-17 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.132 1.56E-14 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.132 1.72E-14 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.101 5.04E-9 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.100 6.46E-9 YNL130C CPT1 hom Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication
0.100 6.87E-9 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.100 7.49E-9 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.088 2.93E-7 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.085 7.49E-7 YGR092W DBF2 hom Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis
0.085 8.85E-7 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.084 1.02E-6 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.083 1.49E-6 YMR255W GFD1 hom Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress
0.082 2.27E-6 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.080 3.20E-6 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)