YOR113W / AZF1

Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR113W / AZF1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.73|P-value:1.93E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:7.41|P-value:7.17E-13 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.64|P-value:1.95E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.48|P-value:3.52E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.93|P-value:9.30E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.55|P-value:3.77E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:4.31|P-value:2.01E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.56|P-value:3.64E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.43|P-value:1.23E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.62|P-value:5.28E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.91|P-value:1.42E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.37|P-value:1.51E-7 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.44|P-value:5.52E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.42|P-value:5.85E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-4.55|P-value:4.94E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.49|P-value:3.41E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-5.06|P-value:4.48E-7 ID:SGTC_1937|Compound:st074714|FD-Score:5.47|P-value:9.07E-8 ID:SGTC_2210|Compound:7115885|FD-Score:3.94|P-value:8.77E-5 ID:SGTC_2332|Compound:7982454|FD-Score:5.32|P-value:1.97E-7 ID:SGTC_2335|Compound:9018011|FD-Score:-3.61|P-value:2.19E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.82|P-value:3.52E-11 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.21|P-value:3.12E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.76|P-value:1.73E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.86|P-value:1.21E-4 ID:SGTC_3333|Compound:9141820|FD-Score:4.57|P-value:6.81E-6 ID:SGTC_3354|Compound:9151612|FD-Score:-3.20|P-value:9.14E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.73|P-value:1.93E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:7.41|P-value:7.17E-13 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.64|P-value:1.95E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.48|P-value:3.52E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.93|P-value:9.30E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.55|P-value:3.77E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:4.31|P-value:2.01E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.56|P-value:3.64E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.43|P-value:1.23E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.62|P-value:5.28E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.91|P-value:1.42E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.37|P-value:1.51E-7 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.44|P-value:5.52E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.42|P-value:5.85E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-4.55|P-value:4.94E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.49|P-value:3.41E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-5.06|P-value:4.48E-7 ID:SGTC_1937|Compound:st074714|FD-Score:5.47|P-value:9.07E-8 ID:SGTC_2210|Compound:7115885|FD-Score:3.94|P-value:8.77E-5 ID:SGTC_2332|Compound:7982454|FD-Score:5.32|P-value:1.97E-7 ID:SGTC_2335|Compound:9018011|FD-Score:-3.61|P-value:2.19E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.82|P-value:3.52E-11 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.21|P-value:3.12E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.76|P-value:1.73E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.86|P-value:1.21E-4 ID:SGTC_3333|Compound:9141820|FD-Score:4.57|P-value:6.81E-6 ID:SGTC_3354|Compound:9151612|FD-Score:-3.20|P-value:9.14E-4

Top fitness defect scores for YOR113W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_8 0354-0001 7.41 70.0 µM 7.17E-13 13 6.54E-14
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.82 3.7 µM 3.52E-11 5 4.48E-12
3 SGTC_1937 st074714 5.47 47.2 µM 9.07E-8 18 2.27E-8
4 SGTC_1282 0886-0010 5.37 32.4 µM 1.51E-7 endomembrane recycling 15 3.96E-8
5 SGTC_2332 7982454 5.32 138.9 µM 1.97E-7 24 5.27E-8
6 SGTC_1087 pterostilbene 4.91 9.1 µM 1.42E-6 7 4.53E-7
7 SGTC_1028 k015-0029 4.62 4.8 µM 5.28E-6 13 1.88E-6
8 SGTC_3333 9141820 4.57 12.1 µM 6.81E-6 10 2.48E-6
9 SGTC_1015 4130-4525 4.43 82.0 µM 1.23E-5 60S ribosome export 11 4.70E-6
10 SGTC_812 4251-0442 4.31 148.0 µM 2.01E-5 7 8.07E-6
11 SGTC_2500 5-alpha-androstan-3,17-dione 4.21 61.4 µM 3.12E-5 33 1.30E-5
12 SGTC_2210 7115885 3.94 190.4 µM 8.77E-5 cell wall signaling 33 3.99E-5
13 SGTC_550 4123-0385 3.93 25.7 µM 9.30E-5 TSC3-RPN4 24 4.26E-5
14 SGTC_2562 3',7'-dimethoxyflavone 3.86 64.9 µM 1.21E-4 35 5.68E-5
15 SGTC_2560 caryophyllene 3.76 100.0 µM 1.73E-4 21 8.34E-5
16 SGTC_6 0844-0013 3.73 19.8 µM 1.93E-4 111 9.44E-5
17 SGTC_836 0330-0104 3.56 1.4 µM 3.64E-4 25 1.88E-4
18 SGTC_756 0508-1999 3.55 28.3 µM 3.77E-4 RPP1 & pyrimidine depletion 43 1.95E-4
19 SGTC_1549 4'-methoxyflavonol 3.44 74.6 µM 5.52E-4 16 2.96E-4
20 SGTC_1631 benzylvanillin 3.42 81.9 µM 5.85E-4 Golgi 46 3.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 9.33E-32 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.191 4.62E-29 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.148 8.35E-18 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.143 8.57E-17 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.135 3.33E-15 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.134 7.72E-15 YGR236C SPG1 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.128 8.97E-14 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.125 3.60E-13 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.124 4.65E-13 YER178W PDA1 hom E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
0.123 7.05E-13 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.120 3.53E-12 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.117 1.11E-11 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.117 1.20E-11 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.117 1.25E-11 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.114 4.32E-11 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance