YOR114W_p

Putative protein of unknown function; null mutant is viable

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR114W / YOR114W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:-3.18|P-value:7.03E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.87|P-value:5.80E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:-3.28|P-value:4.95E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-4.88|P-value:4.76E-7 ID:SGTC_25|Compound:0118-0223|FD-Score:5.19|P-value:1.19E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.42|P-value:2.97E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.81|P-value:7.52E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:3.86|P-value:6.09E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.27|P-value:5.85E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.29|P-value:5.32E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.72|P-value:1.28E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:3.55|P-value:2.07E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:4.21|P-value:1.37E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:4.27|P-value:1.07E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:3.80|P-value:7.96E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.90|P-value:5.32E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:4.27|P-value:1.06E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:3.32|P-value:4.87E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.40|P-value:3.11E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.74|P-value:8.53E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.42|P-value:4.56E-6 ID:SGTC_1181|Compound:1222-0449|FD-Score:-4.13|P-value:1.65E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.45|P-value:3.01E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.35|P-value:7.62E-6 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.94|P-value:4.41E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.05|P-value:2.84E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.77|P-value:1.04E-6 ID:SGTC_1613|Compound:st002381|FD-Score:3.19|P-value:7.55E-4 ID:SGTC_1620|Compound:st003704|FD-Score:4.14|P-value:1.92E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.21|P-value:7.04E-4 ID:SGTC_1768|Compound:st044301|FD-Score:5.80|P-value:3.75E-9 ID:SGTC_1772|Compound:st048439|FD-Score:4.39|P-value:6.26E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:7.02|P-value:1.25E-12 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.12|P-value:2.06E-5 ID:SGTC_1797|Compound:st048695|FD-Score:4.09|P-value:2.38E-5 ID:SGTC_1810|Compound:st050138|FD-Score:4.13|P-value:1.97E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.63|P-value:1.52E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.40|P-value:3.64E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.74|P-value:8.40E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.20|P-value:1.42E-5 ID:SGTC_2121|Compound:5257820|FD-Score:3.16|P-value:8.45E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.38|P-value:3.95E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.43|P-value:3.28E-4 ID:SGTC_2207|Compound:7258803|FD-Score:4.40|P-value:5.83E-6 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.62|P-value:1.57E-4 ID:SGTC_2303|Compound:7774051|FD-Score:4.41|P-value:5.64E-6 ID:SGTC_2344|Compound:7990960|FD-Score:3.59|P-value:1.78E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.92|P-value:4.76E-7 ID:SGTC_2802|Compound:7925815|FD-Score:3.39|P-value:3.71E-4 ID:SGTC_2959|Compound:9079155|FD-Score:6.19|P-value:3.52E-10 ID:SGTC_2963|Compound:9082507|FD-Score:3.39|P-value:3.80E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-5.29|P-value:5.57E-8 ID:SGTC_2987|Compound:9018338|FD-Score:-3.25|P-value:5.51E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.14|P-value:8.95E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.08|P-value:9.65E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.60|P-value:1.73E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.89|P-value:5.53E-5 ID:SGTC_3105|Compound:9121040|FD-Score:4.50|P-value:3.73E-6 ID:SGTC_3107|Compound:9121808|FD-Score:3.47|P-value:2.82E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.61|P-value:1.66E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.96|P-value:3.97E-7 ID:SGTC_3258|Compound:9138477|FD-Score:3.82|P-value:7.21E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.18|P-value:7.03E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.87|P-value:5.80E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:-3.28|P-value:4.95E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-4.88|P-value:4.76E-7 ID:SGTC_25|Compound:0118-0223|FD-Score:5.19|P-value:1.19E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.42|P-value:2.97E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.81|P-value:7.52E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:3.86|P-value:6.09E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.27|P-value:5.85E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.29|P-value:5.32E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.72|P-value:1.28E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:3.55|P-value:2.07E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:4.21|P-value:1.37E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:4.27|P-value:1.07E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:3.80|P-value:7.96E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.90|P-value:5.32E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:4.27|P-value:1.06E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:3.32|P-value:4.87E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.40|P-value:3.11E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.74|P-value:8.53E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.42|P-value:4.56E-6 ID:SGTC_1181|Compound:1222-0449|FD-Score:-4.13|P-value:1.65E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.45|P-value:3.01E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.35|P-value:7.62E-6 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.94|P-value:4.41E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.05|P-value:2.84E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.77|P-value:1.04E-6 ID:SGTC_1613|Compound:st002381|FD-Score:3.19|P-value:7.55E-4 ID:SGTC_1620|Compound:st003704|FD-Score:4.14|P-value:1.92E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.21|P-value:7.04E-4 ID:SGTC_1768|Compound:st044301|FD-Score:5.80|P-value:3.75E-9 ID:SGTC_1772|Compound:st048439|FD-Score:4.39|P-value:6.26E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:7.02|P-value:1.25E-12 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.12|P-value:2.06E-5 ID:SGTC_1797|Compound:st048695|FD-Score:4.09|P-value:2.38E-5 ID:SGTC_1810|Compound:st050138|FD-Score:4.13|P-value:1.97E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.63|P-value:1.52E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.40|P-value:3.64E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.74|P-value:8.40E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.20|P-value:1.42E-5 ID:SGTC_2121|Compound:5257820|FD-Score:3.16|P-value:8.45E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.38|P-value:3.95E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.43|P-value:3.28E-4 ID:SGTC_2207|Compound:7258803|FD-Score:4.40|P-value:5.83E-6 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.62|P-value:1.57E-4 ID:SGTC_2303|Compound:7774051|FD-Score:4.41|P-value:5.64E-6 ID:SGTC_2344|Compound:7990960|FD-Score:3.59|P-value:1.78E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.92|P-value:4.76E-7 ID:SGTC_2802|Compound:7925815|FD-Score:3.39|P-value:3.71E-4 ID:SGTC_2959|Compound:9079155|FD-Score:6.19|P-value:3.52E-10 ID:SGTC_2963|Compound:9082507|FD-Score:3.39|P-value:3.80E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-5.29|P-value:5.57E-8 ID:SGTC_2987|Compound:9018338|FD-Score:-3.25|P-value:5.51E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.14|P-value:8.95E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.08|P-value:9.65E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.60|P-value:1.73E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.89|P-value:5.53E-5 ID:SGTC_3105|Compound:9121040|FD-Score:4.50|P-value:3.73E-6 ID:SGTC_3107|Compound:9121808|FD-Score:3.47|P-value:2.82E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.61|P-value:1.66E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.96|P-value:3.97E-7 ID:SGTC_3258|Compound:9138477|FD-Score:3.82|P-value:7.21E-5

Top fitness defect scores for YOR114W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1785 bathophenanthroline 7.02 24.0 µM 1.25E-12 heme requiring 5 1.08E-12
2 SGTC_2959 9079155 6.19 11.0 µM 3.52E-10 6 3.10E-10
3 SGTC_1768 st044301 5.80 37.2 µM 3.75E-9 3 3.32E-9
4 SGTC_25 0118-0223 5.19 35.7 µM 1.19E-7 3 1.07E-7
5 SGTC_3210 9128157 4.96 49.5 µM 3.97E-7 24 3.58E-7
6 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.92 92.6 µM 4.76E-7 11 4.29E-7
7 SGTC_1557 sumaresinolic acid 4.77 42.3 µM 1.04E-6 7 9.39E-7
8 SGTC_403 arphamenine a 4.72 50.0 µM 1.28E-6 60S ribosome export 8 1.16E-6
9 SGTC_3105 9121040 4.50 49.5 µM 3.73E-6 5 3.40E-6
10 SGTC_2303 7774051 4.41 200.0 µM 5.64E-6 13 5.15E-6
11 SGTC_2207 7258803 4.40 200.0 µM 5.83E-6 5 5.32E-6
12 SGTC_1772 st048439 4.39 82.2 µM 6.26E-6 26 5.71E-6
13 SGTC_1329 1447-1697 4.35 50.6 µM 7.62E-6 11 6.96E-6
14 SGTC_855 0428-0020 4.27 25.0 µM 1.06E-5 Golgi 17 9.72E-6
15 SGTC_497 capsazepine 4.27 133.0 µM 1.07E-5 7 9.80E-6
16 SGTC_496 calpeptin 4.21 138.0 µM 1.37E-5 13 1.26E-5
17 SGTC_2013 4024628 4.20 200.0 µM 1.42E-5 35 1.31E-5
18 SGTC_1620 st003704 4.14 16.5 µM 1.92E-5 10 1.76E-5
19 SGTC_1810 st050138 4.13 53.0 µM 1.97E-5 PDR1 8 1.81E-5
20 SGTC_1789 tunicamycin 4.12 25.0 nM 2.06E-5 unfolded protein response 41 1.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.40E-11 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.103 2.03E-9 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.102 3.10E-9 YKL192C ACP1 het Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
0.098 1.28E-8 YGL050W TYW3 hom tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
0.088 3.68E-7 YGL080W FMP37 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
0.083 1.36E-6 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.083 1.58E-6 YNL151C RPC31 het RNA polymerase III subunit C31
0.080 3.68E-6 YDR261C EXG2 hom Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.079 4.53E-6 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.076 9.74E-6 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.074 2.00E-5 YNL182C IPI3 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
0.073 2.40E-5 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.072 2.69E-5 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.072 2.72E-5 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.071 3.46E-5 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p