YOR115C / TRS33

One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR115C / TRS33

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:5.28|P-value:2.29E-8 ID:SGTC_57|Compound:miconazole|FD-Score:3.05|P-value:7.96E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.12|P-value:6.07E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.12|P-value:6.19E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.05|P-value:7.95E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.70|P-value:6.45E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:5.16|P-value:4.53E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:7.23|P-value:3.50E-14 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.92|P-value:2.44E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:18.40|P-value:6.21E-81 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.12|P-value:6.12E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.86|P-value:2.35E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.86|P-value:3.31E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:8.99|P-value:6.44E-21 ID:SGTC_320|Compound:4092-0846|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.50|P-value:1.44E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:8.22|P-value:8.71E-18 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.16|P-value:5.22E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.09|P-value:6.76E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.72|P-value:5.86E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.38|P-value:2.28E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.59|P-value:9.92E-7 ID:SGTC_689|Compound:0833-0039|FD-Score:4.49|P-value:1.62E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:3.49|P-value:1.51E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.60|P-value:9.29E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:9.23|P-value:5.99E-22 ID:SGTC_823|Compound:0417-1665|FD-Score:3.21|P-value:4.43E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.03|P-value:8.33E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.27|P-value:3.47E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.44|P-value:1.88E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.77|P-value:4.73E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.39|P-value:2.31E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-4.51|P-value:1.53E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:-4.09|P-value:1.17E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.06|P-value:1.79E-10 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.18|P-value:5.05E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.65|P-value:7.83E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.14|P-value:5.89E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.35|P-value:2.55E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.22|P-value:4.30E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.71|P-value:5.96E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.19|P-value:7.05E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:10.20|P-value:2.42E-26 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.43|P-value:2.33E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.54|P-value:1.25E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.39|P-value:2.79E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.32|P-value:3.87E-6 ID:SGTC_1547|Compound:harmine|FD-Score:3.93|P-value:2.39E-5 ID:SGTC_1672|Compound:st016598|FD-Score:9.84|P-value:1.12E-24 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.19|P-value:7.24E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.64|P-value:7.52E-7 ID:SGTC_1754|Compound:st042065|FD-Score:9.66|P-value:7.68E-24 ID:SGTC_1760|Compound:st045453|FD-Score:7.20|P-value:4.53E-14 ID:SGTC_1800|Compound:st050079|FD-Score:7.01|P-value:1.90E-13 ID:SGTC_1801|Compound:st050089|FD-Score:8.63|P-value:2.02E-19 ID:SGTC_1803|Compound:st050068|FD-Score:10.60|P-value:2.75E-28 ID:SGTC_1809|Compound:st050081|FD-Score:-3.31|P-value:3.12E-4 ID:SGTC_1818|Compound:st052136|FD-Score:8.00|P-value:5.95E-17 ID:SGTC_1866|Compound:st057638|FD-Score:3.30|P-value:3.10E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.01|P-value:9.24E-4 ID:SGTC_1925|Compound:st057770|FD-Score:2.99|P-value:9.67E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.24|P-value:5.56E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.70|P-value:6.46E-5 ID:SGTC_2006|Compound:4011487|FD-Score:6.22|P-value:5.91E-11 ID:SGTC_2021|Compound:4019055|FD-Score:6.69|P-value:2.15E-12 ID:SGTC_2029|Compound:5175081|FD-Score:3.36|P-value:2.48E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.23|P-value:3.06E-8 ID:SGTC_2075|Compound:5212009|FD-Score:3.68|P-value:6.85E-5 ID:SGTC_2114|Compound:5491910|FD-Score:-3.00|P-value:9.56E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.20|P-value:7.10E-6 ID:SGTC_2237|Compound:6667747|FD-Score:3.64|P-value:8.09E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.01|P-value:9.17E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.99|P-value:6.31E-17 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.36|P-value:2.30E-11 ID:SGTC_2257|Compound:7960413|FD-Score:5.82|P-value:8.46E-10 ID:SGTC_2329|Compound:6138490|FD-Score:-3.64|P-value:8.19E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.81|P-value:4.03E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.09|P-value:6.73E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.61|P-value:9.27E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.74|P-value:4.60E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.68|P-value:6.23E-7 ID:SGTC_2808|Compound:7946468|FD-Score:5.81|P-value:9.15E-10 ID:SGTC_2810|Compound:7959871|FD-Score:5.03|P-value:9.55E-8 ID:SGTC_2882|Compound:9058044|FD-Score:3.63|P-value:8.34E-5 ID:SGTC_2896|Compound:9052656|FD-Score:6.51|P-value:7.96E-12 ID:SGTC_3037|Compound:9091026|FD-Score:5.23|P-value:2.98E-8 ID:SGTC_3067|Compound:9117431|FD-Score:3.31|P-value:3.08E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.01|P-value:9.41E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.57|P-value:1.11E-6 ID:SGTC_3152|Compound:9099253|FD-Score:5.35|P-value:1.54E-8 ID:SGTC_3194|Compound:9111903|FD-Score:-4.40|P-value:2.61E-6 ID:SGTC_3199|Compound:9111318|FD-Score:-3.05|P-value:7.96E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.56|P-value:1.12E-4 ID:SGTC_3226|Compound:9131256|FD-Score:-3.84|P-value:3.57E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-3.04|P-value:8.34E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.09|P-value:7.07E-4 ID:SGTC_3255|Compound:9139072|FD-Score:5.34|P-value:1.61E-8 ID:SGTC_3257|Compound:9139206|FD-Score:3.33|P-value:2.84E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.69|P-value:6.74E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:5.28|P-value:2.29E-8 ID:SGTC_57|Compound:miconazole|FD-Score:3.05|P-value:7.96E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.12|P-value:6.07E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.12|P-value:6.19E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.05|P-value:7.95E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.70|P-value:6.45E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:5.16|P-value:4.53E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:7.23|P-value:3.50E-14 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.92|P-value:2.44E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:18.40|P-value:6.21E-81 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.12|P-value:6.12E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.86|P-value:2.35E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.86|P-value:3.31E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:8.99|P-value:6.44E-21 ID:SGTC_320|Compound:4092-0846|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.50|P-value:1.44E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:8.22|P-value:8.71E-18 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.16|P-value:5.22E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.09|P-value:6.76E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.72|P-value:5.86E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.38|P-value:2.28E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.59|P-value:9.92E-7 ID:SGTC_689|Compound:0833-0039|FD-Score:4.49|P-value:1.62E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:3.49|P-value:1.51E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.60|P-value:9.29E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:9.23|P-value:5.99E-22 ID:SGTC_823|Compound:0417-1665|FD-Score:3.21|P-value:4.43E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.03|P-value:8.33E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.27|P-value:3.47E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.44|P-value:1.88E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.77|P-value:4.73E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.39|P-value:2.31E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-4.51|P-value:1.53E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:-4.09|P-value:1.17E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.06|P-value:1.79E-10 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.18|P-value:5.05E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.65|P-value:7.83E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.14|P-value:5.89E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.35|P-value:2.55E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.22|P-value:4.30E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.71|P-value:5.96E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.19|P-value:7.05E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:10.20|P-value:2.42E-26 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.43|P-value:2.33E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.54|P-value:1.25E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.39|P-value:2.79E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.32|P-value:3.87E-6 ID:SGTC_1547|Compound:harmine|FD-Score:3.93|P-value:2.39E-5 ID:SGTC_1672|Compound:st016598|FD-Score:9.84|P-value:1.12E-24 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.19|P-value:7.24E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.64|P-value:7.52E-7 ID:SGTC_1754|Compound:st042065|FD-Score:9.66|P-value:7.68E-24 ID:SGTC_1760|Compound:st045453|FD-Score:7.20|P-value:4.53E-14 ID:SGTC_1800|Compound:st050079|FD-Score:7.01|P-value:1.90E-13 ID:SGTC_1801|Compound:st050089|FD-Score:8.63|P-value:2.02E-19 ID:SGTC_1803|Compound:st050068|FD-Score:10.60|P-value:2.75E-28 ID:SGTC_1809|Compound:st050081|FD-Score:-3.31|P-value:3.12E-4 ID:SGTC_1818|Compound:st052136|FD-Score:8.00|P-value:5.95E-17 ID:SGTC_1866|Compound:st057638|FD-Score:3.30|P-value:3.10E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.01|P-value:9.24E-4 ID:SGTC_1925|Compound:st057770|FD-Score:2.99|P-value:9.67E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.24|P-value:5.56E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.70|P-value:6.46E-5 ID:SGTC_2006|Compound:4011487|FD-Score:6.22|P-value:5.91E-11 ID:SGTC_2021|Compound:4019055|FD-Score:6.69|P-value:2.15E-12 ID:SGTC_2029|Compound:5175081|FD-Score:3.36|P-value:2.48E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.23|P-value:3.06E-8 ID:SGTC_2075|Compound:5212009|FD-Score:3.68|P-value:6.85E-5 ID:SGTC_2114|Compound:5491910|FD-Score:-3.00|P-value:9.56E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.20|P-value:7.10E-6 ID:SGTC_2237|Compound:6667747|FD-Score:3.64|P-value:8.09E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.01|P-value:9.17E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.99|P-value:6.31E-17 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.36|P-value:2.30E-11 ID:SGTC_2257|Compound:7960413|FD-Score:5.82|P-value:8.46E-10 ID:SGTC_2329|Compound:6138490|FD-Score:-3.64|P-value:8.19E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.81|P-value:4.03E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.09|P-value:6.73E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.61|P-value:9.27E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.74|P-value:4.60E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.68|P-value:6.23E-7 ID:SGTC_2808|Compound:7946468|FD-Score:5.81|P-value:9.15E-10 ID:SGTC_2810|Compound:7959871|FD-Score:5.03|P-value:9.55E-8 ID:SGTC_2882|Compound:9058044|FD-Score:3.63|P-value:8.34E-5 ID:SGTC_2896|Compound:9052656|FD-Score:6.51|P-value:7.96E-12 ID:SGTC_3037|Compound:9091026|FD-Score:5.23|P-value:2.98E-8 ID:SGTC_3067|Compound:9117431|FD-Score:3.31|P-value:3.08E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.01|P-value:9.41E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.57|P-value:1.11E-6 ID:SGTC_3152|Compound:9099253|FD-Score:5.35|P-value:1.54E-8 ID:SGTC_3194|Compound:9111903|FD-Score:-4.40|P-value:2.61E-6 ID:SGTC_3199|Compound:9111318|FD-Score:-3.05|P-value:7.96E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.56|P-value:1.12E-4 ID:SGTC_3226|Compound:9131256|FD-Score:-3.84|P-value:3.57E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-3.04|P-value:8.34E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.09|P-value:7.07E-4 ID:SGTC_3255|Compound:9139072|FD-Score:5.34|P-value:1.61E-8 ID:SGTC_3257|Compound:9139206|FD-Score:3.33|P-value:2.84E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.69|P-value:6.74E-5

Top fitness defect scores for YOR115C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 18.40 10.3 µM 6.21E-81 NEO1-PIK1 14 1.15E-75
2 SGTC_1803 st050068 10.60 52.4 µM 2.75E-28 NEO1-PIK1 22 1.61E-26
3 SGTC_1230 0170-0365 10.20 3.8 µM 2.42E-26 endomembrane recycling 4 1.05E-24
4 SGTC_1672 st016598 9.84 6.5 µM 1.12E-24 endomembrane recycling 8 3.77E-23
5 SGTC_1754 st042065 9.66 16.1 µM 7.68E-24 NEO1-PIK1 31 2.28E-22
6 SGTC_788 1182-0090 9.23 188.0 µM 5.99E-22 endomembrane recycling 16 1.33E-20
7 SGTC_312 4092-0653 8.99 6.8 µM 6.44E-21 ergosterol depletion effects on membrane 16 1.23E-19
8 SGTC_1801 st050089 8.63 28.4 µM 2.02E-19 NEO1-PIK1 20 3.05E-18
9 SGTC_439 amiodarone 8.22 34.4 µM 8.71E-18 NEO1-PIK1 22 1.03E-16
10 SGTC_1818 st052136 8.00 56.3 µM 5.95E-17 NEO1-PIK1 3 6.19E-16
11 SGTC_2249 haloperidol 7.99 116.4 µM 6.31E-17 ergosterol depletion effects on membrane 25 6.54E-16
12 SGTC_207 4185-0010 7.23 4.5 µM 3.50E-14 endomembrane recycling 35 2.39E-13
13 SGTC_1760 st045453 7.20 10.4 µM 4.53E-14 NEO1-PIK1 66 3.04E-13
14 SGTC_1800 st050079 7.01 29.1 µM 1.90E-13 NEO1-PIK1 23 1.16E-12
15 SGTC_2021 4019055 6.69 173.0 µM 2.15E-12 endomembrane recycling 32 1.12E-11
16 SGTC_2896 9052656 6.51 71.4 µM 7.96E-12 endomembrane recycling 33 3.80E-11
17 SGTC_2250 alverine citrate 6.36 130.0 µM 2.30E-11 44 1.02E-10
18 SGTC_2006 4011487 6.22 200.0 µM 5.91E-11 endomembrane recycling 41 2.48E-10
19 SGTC_1006 4099-6547 6.06 255.0 µM 1.79E-10 5 6.97E-10
20 SGTC_2257 7960413 5.82 200.0 µM 8.46E-10 NEO1-PIK1 16 2.98E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.590 1.39E-312 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.579 7.20E-300 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.490 5.60E-202 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.484 7.68E-197 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.474 1.21E-187 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.457 3.57E-173 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.431 3.72E-152 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.430 4.93E-151 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.429 1.16E-150 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.423 3.89E-146 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.423 1.28E-145 YEL048C TCA17 hom Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
0.400 4.72E-129 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.399 3.33E-128 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.399 3.91E-128 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.398 1.99E-127 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription