YOR116C / RPO31

RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR116C / RPO31

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.61|P-value:3.38E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:4.84|P-value:1.44E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.26|P-value:1.99E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.09|P-value:7.77E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:6.34|P-value:2.45E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.88|P-value:6.41E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:5.16|P-value:4.21E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:4.84|P-value:1.46E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:6.54|P-value:8.97E-9 ID:SGTC_274|Compound:sirtinol|FD-Score:8.22|P-value:8.48E-13 ID:SGTC_341|Compound:1486-1430|FD-Score:3.99|P-value:2.68E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.66|P-value:5.06E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.66|P-value:1.09E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:4.83|P-value:1.48E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.97|P-value:8.92E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.33|P-value:8.75E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:4.96|P-value:8.96E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:4.84|P-value:1.41E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.00|P-value:2.60E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:5.17|P-value:3.98E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:3.79|P-value:4.95E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.42|P-value:1.45E-6 ID:SGTC_659|Compound:k018-0002|FD-Score:6.84|P-value:2.07E-9 ID:SGTC_673|Compound:1082-0474|FD-Score:11.80|P-value:3.29E-24 ID:SGTC_678|Compound:1218-2179|FD-Score:11.30|P-value:2.66E-22 ID:SGTC_712|Compound:r015-0009|FD-Score:15.00|P-value:9.19E-38 ID:SGTC_752|Compound:1896-0090|FD-Score:4.22|P-value:1.27E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.53|P-value:4.43E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.79|P-value:1.70E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:7.51|P-value:5.48E-11 ID:SGTC_828|Compound:2074-0507|FD-Score:4.38|P-value:7.39E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:21.80|P-value:1.59E-77 ID:SGTC_839|Compound:0122-0028|FD-Score:5.61|P-value:6.68E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:4.41|P-value:6.65E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:4.69|P-value:2.53E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:5.01|P-value:7.55E-6 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.96|P-value:2.98E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.46|P-value:5.66E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:8.42|P-value:2.50E-13 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.86|P-value:4.05E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:10.40|P-value:3.14E-19 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.53|P-value:4.43E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.20|P-value:1.38E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.16|P-value:4.18E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.33|P-value:8.71E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.25|P-value:2.05E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.75|P-value:5.64E-4 ID:SGTC_1522|Compound:st012842|FD-Score:32.60|P-value:8.33E-170 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:12.90|P-value:1.68E-28 ID:SGTC_1642|Compound:st009582|FD-Score:8.86|P-value:1.47E-14 ID:SGTC_1834|Compound:st055981|FD-Score:5.71|P-value:4.21E-7 ID:SGTC_1872|Compound:amphotericin b|FD-Score:6.98|P-value:1.00E-9 ID:SGTC_1910|Compound:st062352|FD-Score:3.99|P-value:2.69E-4 ID:SGTC_1915|Compound:st067105|FD-Score:29.40|P-value:1.87E-138 ID:SGTC_1930|Compound:st074634|FD-Score:47.30|P-value:0 ID:SGTC_2018|Compound:5133068|FD-Score:4.06|P-value:2.17E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.00|P-value:2.61E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.94|P-value:9.87E-6 ID:SGTC_2179|Compound:6298986|FD-Score:4.62|P-value:3.18E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.68|P-value:6.84E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-5.32|P-value:4.29E-6 ID:SGTC_2269|Compound:7935389|FD-Score:-3.91|P-value:5.83E-4 ID:SGTC_2270|Compound:7924575|FD-Score:5.63|P-value:6.03E-7 ID:SGTC_2292|Compound:7671323|FD-Score:4.49|P-value:5.11E-5 ID:SGTC_2293|Compound:7624732|FD-Score:6.32|P-value:2.70E-8 ID:SGTC_2297|Compound:7971671|FD-Score:4.64|P-value:3.02E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-5.96|P-value:3.08E-7 ID:SGTC_2306|Compound:7482397|FD-Score:11.40|P-value:6.49E-23 ID:SGTC_2317|Compound:5986382|FD-Score:3.98|P-value:2.79E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.04|P-value:2.29E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.73|P-value:5.98E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.66|P-value:7.25E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.66|P-value:2.80E-5 ID:SGTC_2411|Compound:st077133|FD-Score:23.50|P-value:1.59E-89 ID:SGTC_2467|Compound:5474540|FD-Score:3.56|P-value:9.85E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:15.40|P-value:6.64E-40 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.75|P-value:9.13E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:46.30|P-value:0 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.16|P-value:1.55E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.94|P-value:3.19E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:32.00|P-value:1.86E-163 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.10|P-value:5.28E-6 ID:SGTC_2671|Compound:danthron|FD-Score:14.70|P-value:1.85E-36 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:5.59|P-value:7.15E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.94|P-value:5.36E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:19.10|P-value:8.71E-60 ID:SGTC_2869|Compound:9037858|FD-Score:5.38|P-value:1.69E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-4.13|P-value:2.93E-4 ID:SGTC_2890|Compound:9046729|FD-Score:5.95|P-value:1.47E-7 ID:SGTC_2897|Compound:9048598|FD-Score:3.89|P-value:3.70E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.50|P-value:8.81E-5 ID:SGTC_3103|Compound:9120822|FD-Score:5.08|P-value:5.73E-6 ID:SGTC_3178|Compound:9107506|FD-Score:4.23|P-value:1.25E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.97|P-value:8.93E-6 ID:SGTC_3196|Compound:9111891|FD-Score:3.93|P-value:3.21E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.80|P-value:7.98E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.84|P-value:4.32E-4 ID:SGTC_3247|Compound:9135149|FD-Score:22.40|P-value:9.45E-82 ID:SGTC_3353|Compound:9151644|FD-Score:5.65|P-value:5.62E-7 ID:SGTC_3355|Compound:9151058|FD-Score:3.61|P-value:8.58E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.61|P-value:3.38E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:4.84|P-value:1.44E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.26|P-value:1.99E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.09|P-value:7.77E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:6.34|P-value:2.45E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.88|P-value:6.41E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:5.16|P-value:4.21E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:4.84|P-value:1.46E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:6.54|P-value:8.97E-9 ID:SGTC_274|Compound:sirtinol|FD-Score:8.22|P-value:8.48E-13 ID:SGTC_341|Compound:1486-1430|FD-Score:3.99|P-value:2.68E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.66|P-value:5.06E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.66|P-value:1.09E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:4.83|P-value:1.48E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.97|P-value:8.92E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.33|P-value:8.75E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:4.96|P-value:8.96E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:4.84|P-value:1.41E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.00|P-value:2.60E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:5.17|P-value:3.98E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:3.79|P-value:4.95E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.42|P-value:1.45E-6 ID:SGTC_659|Compound:k018-0002|FD-Score:6.84|P-value:2.07E-9 ID:SGTC_673|Compound:1082-0474|FD-Score:11.80|P-value:3.29E-24 ID:SGTC_678|Compound:1218-2179|FD-Score:11.30|P-value:2.66E-22 ID:SGTC_712|Compound:r015-0009|FD-Score:15.00|P-value:9.19E-38 ID:SGTC_752|Compound:1896-0090|FD-Score:4.22|P-value:1.27E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.53|P-value:4.43E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.79|P-value:1.70E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:7.51|P-value:5.48E-11 ID:SGTC_828|Compound:2074-0507|FD-Score:4.38|P-value:7.39E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:21.80|P-value:1.59E-77 ID:SGTC_839|Compound:0122-0028|FD-Score:5.61|P-value:6.68E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:4.41|P-value:6.65E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:4.69|P-value:2.53E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:5.01|P-value:7.55E-6 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.96|P-value:2.98E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.46|P-value:5.66E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:8.42|P-value:2.50E-13 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.86|P-value:4.05E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:10.40|P-value:3.14E-19 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.53|P-value:4.43E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.20|P-value:1.38E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.16|P-value:4.18E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.33|P-value:8.71E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.25|P-value:2.05E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.75|P-value:5.64E-4 ID:SGTC_1522|Compound:st012842|FD-Score:32.60|P-value:8.33E-170 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:12.90|P-value:1.68E-28 ID:SGTC_1642|Compound:st009582|FD-Score:8.86|P-value:1.47E-14 ID:SGTC_1834|Compound:st055981|FD-Score:5.71|P-value:4.21E-7 ID:SGTC_1872|Compound:amphotericin b|FD-Score:6.98|P-value:1.00E-9 ID:SGTC_1910|Compound:st062352|FD-Score:3.99|P-value:2.69E-4 ID:SGTC_1915|Compound:st067105|FD-Score:29.40|P-value:1.87E-138 ID:SGTC_1930|Compound:st074634|FD-Score:47.30|P-value:0 ID:SGTC_2018|Compound:5133068|FD-Score:4.06|P-value:2.17E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.00|P-value:2.61E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.94|P-value:9.87E-6 ID:SGTC_2179|Compound:6298986|FD-Score:4.62|P-value:3.18E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.68|P-value:6.84E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-5.32|P-value:4.29E-6 ID:SGTC_2269|Compound:7935389|FD-Score:-3.91|P-value:5.83E-4 ID:SGTC_2270|Compound:7924575|FD-Score:5.63|P-value:6.03E-7 ID:SGTC_2292|Compound:7671323|FD-Score:4.49|P-value:5.11E-5 ID:SGTC_2293|Compound:7624732|FD-Score:6.32|P-value:2.70E-8 ID:SGTC_2297|Compound:7971671|FD-Score:4.64|P-value:3.02E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-5.96|P-value:3.08E-7 ID:SGTC_2306|Compound:7482397|FD-Score:11.40|P-value:6.49E-23 ID:SGTC_2317|Compound:5986382|FD-Score:3.98|P-value:2.79E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.04|P-value:2.29E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.73|P-value:5.98E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.66|P-value:7.25E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.66|P-value:2.80E-5 ID:SGTC_2411|Compound:st077133|FD-Score:23.50|P-value:1.59E-89 ID:SGTC_2467|Compound:5474540|FD-Score:3.56|P-value:9.85E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:15.40|P-value:6.64E-40 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.75|P-value:9.13E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:46.30|P-value:0 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.16|P-value:1.55E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.94|P-value:3.19E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:32.00|P-value:1.86E-163 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.10|P-value:5.28E-6 ID:SGTC_2671|Compound:danthron|FD-Score:14.70|P-value:1.85E-36 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:5.59|P-value:7.15E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.94|P-value:5.36E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:19.10|P-value:8.71E-60 ID:SGTC_2869|Compound:9037858|FD-Score:5.38|P-value:1.69E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-4.13|P-value:2.93E-4 ID:SGTC_2890|Compound:9046729|FD-Score:5.95|P-value:1.47E-7 ID:SGTC_2897|Compound:9048598|FD-Score:3.89|P-value:3.70E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.50|P-value:8.81E-5 ID:SGTC_3103|Compound:9120822|FD-Score:5.08|P-value:5.73E-6 ID:SGTC_3178|Compound:9107506|FD-Score:4.23|P-value:1.25E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.97|P-value:8.93E-6 ID:SGTC_3196|Compound:9111891|FD-Score:3.93|P-value:3.21E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.80|P-value:7.98E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.84|P-value:4.32E-4 ID:SGTC_3247|Compound:9135149|FD-Score:22.40|P-value:9.45E-82 ID:SGTC_3353|Compound:9151644|FD-Score:5.65|P-value:5.62E-7 ID:SGTC_3355|Compound:9151058|FD-Score:3.61|P-value:8.58E-4

Top fitness defect scores for YOR116C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1930 st074634 47.30 34.3 µM 0 RNA pol III & RNase P/MRP 1 0 33.70
2 SGTC_2544 sphondin 46.30 68.5 µM 0 RNA pol III & RNase P/MRP 1 0 24.30
3 SGTC_1522 st012842 32.60 45.6 µM 8.33E-170 RNA pol III & RNase P/MRP 1 3.20E-233 16.60
4 SGTC_2612 dictamnine 32.00 15.5 µM 1.86E-163 RNA pol III & RNase P/MRP 1 1.89E-224 8.09
5 SGTC_1915 st067105 29.40 30.6 µM 1.87E-138 RNA pol III & RNase P/MRP 2 6.65E-190 10.40
6 SGTC_2411 st077133 23.50 39.9 µM 1.59E-89 RNA pol III & RNase P/MRP 2 2.41E-122 2.14
7 SGTC_3247 9135149 22.40 49.5 µM 9.45E-82 DNA damage response 1 1.29E-111 11.40
8 SGTC_829 1635-0120 21.80 117.0 µM 1.59E-77 DNA damage response 1 8.71E-106 4.34
9 SGTC_2738 aclarubicin 19.10 5.5 µM 8.71E-60 RNA pol III & RNase P/MRP 1 2.53E-81 8.18
10 SGTC_2522 biochanin a 15.40 4.9 µM 6.64E-40 RNA pol III & RNase P/MRP 1 6.17E-54 4.19
11 SGTC_712 r015-0009 15.00 80.6 µM 9.19E-38 2 5.45E-51 8.75
12 SGTC_2671 danthron 14.70 100.0 µM 1.85E-36 DNA damage response 1 3.39E-49 3.99
13 SGTC_1525 8-methoxypsoralen 12.90 92.5 µM 1.68E-28 DNA damage response 1 2.98E-38 4.85
14 SGTC_673 1082-0474 11.80 110.0 µM 3.29E-24 RSC complex & mRNA processing 7 2.32E-32 0.67
15 SGTC_2306 7482397 11.40 179.5 µM 6.49E-23 RPP1 & pyrimidine depletion 2 1.39E-30 1.19
16 SGTC_678 1218-2179 11.30 85.9 µM 2.66E-22 RNA pol III & RNase P/MRP 1 9.62E-30 7.51
17 SGTC_1168 k815-0004 10.40 80.5 µM 3.14E-19 DNA damage response 2 1.57E-25 1.80
18 SGTC_1642 st009582 8.86 77.7 µM 1.47E-14 RPP1 & pyrimidine depletion 2 3.87E-19 3.34
19 SGTC_1133 3473-0247 8.42 50.0 µM 2.50E-13 RSC complex & mRNA processing 11 1.87E-17 0.13
20 SGTC_274 sirtinol 8.22 40.1 µM 8.48E-13 2 9.87E-17 0.96

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.432 1.20E-152 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.431 5.06E-152 YDL150W RPC53 het RNA polymerase III subunit C53
0.391 8.08E-123 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.365 3.62E-106 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.341 4.25E-92 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.333 1.76E-87 YNL248C RPA49 hom RNA polymerase I subunit A49
0.329 1.79E-85 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.269 9.64E-57 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.239 6.94E-45 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.238 1.56E-44 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.236 1.48E-43 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.231 6.26E-42 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.225 6.92E-40 YNL250W RAD50 hom Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress
0.223 5.91E-39 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.208 4.72E-34 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p