YOR117W / RPT5

One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR117W / RPT5

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:5.83|P-value:2.33E-7 ID:SGTC_171|Compound:k064-0041|FD-Score:7.18|P-value:2.73E-10 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.76|P-value:5.43E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.71|P-value:6.28E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.51|P-value:4.64E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.86|P-value:2.02E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:5.31|P-value:2.13E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:4.50|P-value:4.77E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.66|P-value:7.36E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-4.35|P-value:1.08E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.85|P-value:1.34E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.78|P-value:5.21E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.94|P-value:3.14E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.43|P-value:6.05E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.94|P-value:1.30E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.86|P-value:5.18E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.65|P-value:7.70E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.39|P-value:7.15E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.82|P-value:4.50E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.84|P-value:4.34E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.84|P-value:4.23E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.51|P-value:4.64E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.70|P-value:8.41E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.70|P-value:8.43E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:11.10|P-value:6.28E-22 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.56|P-value:9.87E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-6.02|P-value:1.38E-7 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.63|P-value:8.01E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.61|P-value:8.66E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.60|P-value:8.85E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.69|P-value:6.69E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-4.10|P-value:2.41E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.28|P-value:1.03E-4 ID:SGTC_1775|Compound:st081588|FD-Score:6.53|P-value:8.36E-9 ID:SGTC_1797|Compound:st048695|FD-Score:4.13|P-value:1.69E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.90|P-value:3.55E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.91|P-value:4.37E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.80|P-value:4.88E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.90|P-value:3.53E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.77|P-value:5.26E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.42|P-value:6.31E-5 ID:SGTC_2071|Compound:5230951|FD-Score:5.23|P-value:2.99E-6 ID:SGTC_2073|Compound:5212005|FD-Score:5.52|P-value:8.96E-7 ID:SGTC_2124|Compound:5246320|FD-Score:12.10|P-value:7.63E-26 ID:SGTC_2128|Compound:5255449|FD-Score:3.65|P-value:7.60E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:13.10|P-value:8.78E-30 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.90|P-value:1.09E-5 ID:SGTC_2228|Compound:7354201|FD-Score:3.69|P-value:6.80E-4 ID:SGTC_2231|Compound:micatex|FD-Score:4.60|P-value:3.29E-5 ID:SGTC_2256|Compound:7954252|FD-Score:5.20|P-value:3.31E-6 ID:SGTC_2258|Compound:7960471|FD-Score:4.42|P-value:6.34E-5 ID:SGTC_2259|Compound:7964009|FD-Score:4.53|P-value:4.35E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.90|P-value:3.54E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.98|P-value:2.79E-4 ID:SGTC_2320|Compound:7373003|FD-Score:5.93|P-value:1.42E-7 ID:SGTC_2322|Compound:7413319|FD-Score:-6.63|P-value:7.62E-9 ID:SGTC_2326|Compound:6164455|FD-Score:4.70|P-value:2.32E-5 ID:SGTC_2333|Compound:9017922|FD-Score:4.62|P-value:3.16E-5 ID:SGTC_2334|Compound:9017922|FD-Score:4.34|P-value:8.28E-5 ID:SGTC_2336|Compound:9001819|FD-Score:9.29|P-value:5.34E-16 ID:SGTC_2344|Compound:7990960|FD-Score:5.39|P-value:1.51E-6 ID:SGTC_2348|Compound:9022543|FD-Score:6.07|P-value:7.65E-8 ID:SGTC_2389|Compound:9091542|FD-Score:3.76|P-value:5.40E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.36|P-value:7.70E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.12|P-value:1.77E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.97|P-value:3.72E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.96|P-value:8.70E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-3.78|P-value:6.50E-4 ID:SGTC_3142|Compound:9086498|FD-Score:18.30|P-value:2.98E-56 ID:SGTC_3181|Compound:9108277|FD-Score:4.05|P-value:2.20E-4 ID:SGTC_3252|Compound:9135871|FD-Score:7.20|P-value:2.42E-10 ID:SGTC_3254|Compound:9136651|FD-Score:3.60|P-value:8.76E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.82|P-value:4.56E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:5.83|P-value:2.33E-7 ID:SGTC_171|Compound:k064-0041|FD-Score:7.18|P-value:2.73E-10 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.76|P-value:5.43E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.71|P-value:6.28E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.51|P-value:4.64E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.86|P-value:2.02E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:5.31|P-value:2.13E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:4.50|P-value:4.77E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.66|P-value:7.36E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-4.35|P-value:1.08E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.85|P-value:1.34E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.78|P-value:5.21E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.94|P-value:3.14E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.43|P-value:6.05E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.94|P-value:1.30E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.86|P-value:5.18E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.65|P-value:7.70E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.39|P-value:7.15E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.82|P-value:4.50E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.84|P-value:4.34E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.84|P-value:4.23E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.51|P-value:4.64E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.70|P-value:8.41E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.70|P-value:8.43E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:11.10|P-value:6.28E-22 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.56|P-value:9.87E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-6.02|P-value:1.38E-7 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.63|P-value:8.01E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.61|P-value:8.66E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.60|P-value:8.85E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.69|P-value:6.69E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-4.10|P-value:2.41E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.28|P-value:1.03E-4 ID:SGTC_1775|Compound:st081588|FD-Score:6.53|P-value:8.36E-9 ID:SGTC_1797|Compound:st048695|FD-Score:4.13|P-value:1.69E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.90|P-value:3.55E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.91|P-value:4.37E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.80|P-value:4.88E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.90|P-value:3.53E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.77|P-value:5.26E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.42|P-value:6.31E-5 ID:SGTC_2071|Compound:5230951|FD-Score:5.23|P-value:2.99E-6 ID:SGTC_2073|Compound:5212005|FD-Score:5.52|P-value:8.96E-7 ID:SGTC_2124|Compound:5246320|FD-Score:12.10|P-value:7.63E-26 ID:SGTC_2128|Compound:5255449|FD-Score:3.65|P-value:7.60E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:13.10|P-value:8.78E-30 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.90|P-value:1.09E-5 ID:SGTC_2228|Compound:7354201|FD-Score:3.69|P-value:6.80E-4 ID:SGTC_2231|Compound:micatex|FD-Score:4.60|P-value:3.29E-5 ID:SGTC_2256|Compound:7954252|FD-Score:5.20|P-value:3.31E-6 ID:SGTC_2258|Compound:7960471|FD-Score:4.42|P-value:6.34E-5 ID:SGTC_2259|Compound:7964009|FD-Score:4.53|P-value:4.35E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.90|P-value:3.54E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.98|P-value:2.79E-4 ID:SGTC_2320|Compound:7373003|FD-Score:5.93|P-value:1.42E-7 ID:SGTC_2322|Compound:7413319|FD-Score:-6.63|P-value:7.62E-9 ID:SGTC_2326|Compound:6164455|FD-Score:4.70|P-value:2.32E-5 ID:SGTC_2333|Compound:9017922|FD-Score:4.62|P-value:3.16E-5 ID:SGTC_2334|Compound:9017922|FD-Score:4.34|P-value:8.28E-5 ID:SGTC_2336|Compound:9001819|FD-Score:9.29|P-value:5.34E-16 ID:SGTC_2344|Compound:7990960|FD-Score:5.39|P-value:1.51E-6 ID:SGTC_2348|Compound:9022543|FD-Score:6.07|P-value:7.65E-8 ID:SGTC_2389|Compound:9091542|FD-Score:3.76|P-value:5.40E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.36|P-value:7.70E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.12|P-value:1.77E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.97|P-value:3.72E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.96|P-value:8.70E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-3.78|P-value:6.50E-4 ID:SGTC_3142|Compound:9086498|FD-Score:18.30|P-value:2.98E-56 ID:SGTC_3181|Compound:9108277|FD-Score:4.05|P-value:2.20E-4 ID:SGTC_3252|Compound:9135871|FD-Score:7.20|P-value:2.42E-10 ID:SGTC_3254|Compound:9136651|FD-Score:3.60|P-value:8.76E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.82|P-value:4.56E-4

Top fitness defect scores for YOR117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3142 9086498 18.30 49.5 µM 2.98E-56 iron homeostasis 2 4.07E-75 4.30
2 SGTC_2129 girgensonine 13.10 121.0 µM 8.78E-30 heme biosynthesis & mitochondrial translocase 1 2.11E-39 2.17
3 SGTC_2124 5246320 12.10 200.0 µM 7.63E-26 heme biosynthesis & mitochondrial translocase 6 4.27E-34 2.35
4 SGTC_1255 0566-0045 11.10 221.0 µM 6.28E-22 excess fatty acid 2 8.01E-29 3.03
5 SGTC_2336 9001819 9.29 198.7 µM 5.34E-16 heme biosynthesis & mitochondrial translocase 12 7.56E-21 0.55
6 SGTC_3252 9135871 7.20 49.5 µM 2.42E-10 1 2.93E-13 1.86
7 SGTC_171 k064-0041 7.18 9.7 µM 2.73E-10 heme requiring 5 3.45E-13 0.25
8 SGTC_1775 st081588 6.53 35.2 µM 8.36E-9 60S ribosome export 3 3.35E-11 0.15
9 SGTC_2348 9022543 6.07 33.4 µM 7.65E-8 mitochondrial processes 20 6.46E-10 0.13
10 SGTC_2320 7373003 5.93 200.0 µM 1.42E-7 1 1.47E-9 0.49
11 SGTC_273 hydroxyurea 5.86 18.1 mM 2.02E-7 heme biosynthesis & mitochondrial translocase 5 2.36E-9 0.12
12 SGTC_148 3253-0744 5.83 288.0 µM 2.33E-7 1 2.85E-9 0.71
13 SGTC_2073 5212005 5.52 126.0 µM 8.96E-7 1 1.72E-8 0.86
14 SGTC_2344 7990960 5.39 77.0 µM 1.51E-6 22 3.46E-8 0.06
15 SGTC_339 3091-4833 5.31 71.4 µM 2.13E-6 iron homeostasis 3 5.43E-8 0.29
16 SGTC_2071 5230951 5.23 39.9 µM 2.99E-6 TSC3-RPN4 4 8.54E-8 0.94
17 SGTC_2256 7954252 5.20 200.0 µM 3.31E-6 mitochondrial processes 4 9.80E-8 0.11
18 SGTC_2962 9082311 4.96 13.2 µM 8.70E-6 6 3.54E-7 0.60
19 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 4.90 49.5 µM 1.09E-5 10 4.76E-7 0.01
20 SGTC_475 α-linolenic acid 4.85 10.0 µM 1.34E-5 excess fatty acid 4 6.29E-7 0.63

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.383 2.68E-117 YGL048C RPT6 het ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress
0.355 4.18E-100 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.344 2.33E-93 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.309 6.95E-75 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
0.301 2.83E-71 YDL147W RPN5 het Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
0.282 4.84E-62 YFR004W RPN11 het Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress
0.277 4.45E-60 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.277 5.39E-60 YDL097C RPN6 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
0.215 2.09E-36 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.199 3.57E-31 YOR259C RPT4 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization
0.197 1.65E-30 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.196 2.88E-30 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.174 4.01E-24 YFR052W RPN12 het Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
0.163 3.07E-21 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.157 7.51E-20 YMR290W-A_d YMR290W-A_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase