YOR118W / RTC5

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR118W / RTC5

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:5.67|P-value:1.29E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.92|P-value:1.87E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.61|P-value:5.27E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.58|P-value:5.85E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.73|P-value:3.26E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.87|P-value:2.22E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.53|P-value:6.73E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.10|P-value:9.90E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.95|P-value:1.68E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.84|P-value:2.46E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.59|P-value:5.56E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.38|P-value:3.55E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.59|P-value:1.93E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.14|P-value:1.55E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.79|P-value:6.83E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.57|P-value:1.67E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.53|P-value:6.88E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.52|P-value:7.14E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-4.03|P-value:1.13E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.70|P-value:3.91E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.43|P-value:8.58E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.58|P-value:1.58E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.87|P-value:2.25E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.41|P-value:9.93E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.74|P-value:3.41E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.78|P-value:3.02E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.59|P-value:1.55E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.91|P-value:3.97E-8 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.56|P-value:5.59E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.77|P-value:3.15E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.67|P-value:1.29E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.92|P-value:1.87E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.61|P-value:5.27E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.58|P-value:5.85E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.73|P-value:3.26E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.87|P-value:2.22E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.53|P-value:6.73E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.10|P-value:9.90E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.95|P-value:1.68E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.84|P-value:2.46E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.59|P-value:5.56E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.38|P-value:3.55E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.59|P-value:1.93E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.14|P-value:1.55E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.79|P-value:6.83E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.57|P-value:1.67E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.53|P-value:6.88E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.52|P-value:7.14E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-4.03|P-value:1.13E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.70|P-value:3.91E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.43|P-value:8.58E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.58|P-value:1.58E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.87|P-value:2.25E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.41|P-value:9.93E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.74|P-value:3.41E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.78|P-value:3.02E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.59|P-value:1.55E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.91|P-value:3.97E-8 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.56|P-value:5.59E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.77|P-value:3.15E-4

Top fitness defect scores for YOR118W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 5.91 92.6 µM 3.97E-8 8 1.72E-9
2 SGTC_44 0929-0055 5.67 61.2 µM 1.29E-7 11 7.11E-9
3 SGTC_1127 asiatic acid 5.59 681.4 nM 1.93E-7 5 1.15E-8
4 SGTC_1128 3448-9350 5.14 235.0 µM 1.55E-6 9 1.41E-7
5 SGTC_1131 3454-3128 4.79 32.3 µM 6.83E-6 17 8.35E-7
6 SGTC_2314 7727897 4.59 200.0 µM 1.55E-5 8 2.23E-6
7 SGTC_1914 st062367 4.58 72.6 µM 1.58E-5 12 2.28E-6
8 SGTC_1243 0416-0003 4.57 5.7 µM 1.67E-5 PDR1 13 2.43E-6
9 SGTC_1070 indatraline 4.38 8.8 µM 3.55E-5 60S ribosome export 18 6.04E-6
10 SGTC_622 1348-1566 4.10 26.3 µM 9.90E-5 16 2.06E-5
11 SGTC_697 0508-1955 3.95 564.0 µM 1.68E-4 32 3.88E-5
12 SGTC_45 0kpi-0036 3.92 14.9 µM 1.87E-4 excess fatty acid 27 4.42E-5
13 SGTC_154 3389-1638 3.87 511.1 µM 2.22E-4 24 5.43E-5
14 SGTC_2005 4024620 3.87 188.0 µM 2.25E-4 22 5.52E-5
15 SGTC_699 0375-0592 3.84 111.0 µM 2.46E-4 iron homeostasis 24 6.14E-5
16 SGTC_2276 7947513 3.78 42.1 µM 3.02E-4 26 7.83E-5
17 SGTC_2929 9013348 3.77 24.6 µM 3.15E-4 29 8.25E-5
18 SGTC_2157 5649910 3.74 96.4 µM 3.41E-4 27 9.05E-5
19 SGTC_1686 st019653 3.70 115.5 µM 3.91E-4 mitochondrial processes 13 1.07E-4
20 SGTC_73 0327-0325 3.61 16.2 µM 5.27E-4 DNA damage response 64 1.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.27E-11 YOR360C PDE2 hom High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
0.099 9.60E-9 YDL168W SFA1 hom Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress
0.095 3.99E-8 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.087 4.05E-7 YBL014C RRN6 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.086 5.55E-7 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.083 1.61E-6 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.083 1.63E-6 YIL132C CSM2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis
0.081 2.30E-6 YBR116C_d YBR116C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
0.079 4.73E-6 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.079 5.19E-6 YLR376C PSY3 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
0.078 6.03E-6 YHR126C_p ANS1_p hom Putative GPI protein; transcription dependent upon Azf1p
0.074 1.60E-5 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.074 1.84E-5 YOR161C PNS1 hom Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
0.073 2.35E-5 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.072 2.64E-5 YFL030W AGX1 hom Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases