YOR119C / RIO1

Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR119C / RIO1

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-5.83|P-value:4.23E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:3.49|P-value:3.08E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.72|P-value:1.33E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.54|P-value:2.56E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.21|P-value:8.20E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-4.38|P-value:7.43E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.24|P-value:6.76E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-5.05|P-value:3.01E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:3.32|P-value:5.78E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-6.39|P-value:1.43E-10 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.44|P-value:3.81E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.38|P-value:4.08E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.69|P-value:1.48E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:-3.23|P-value:6.99E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.07|P-value:3.25E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.12|P-value:9.99E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.27|P-value:6.75E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-4.27|P-value:1.25E-5 ID:SGTC_2294|Compound:7971431|FD-Score:4.67|P-value:2.26E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.25|P-value:7.26E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.33|P-value:5.49E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.43|P-value:3.87E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.18|P-value:8.32E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.17|P-value:2.17E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.90|P-value:6.56E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.08|P-value:3.20E-5 ID:SGTC_2972|Compound:9093619|FD-Score:5.11|P-value:2.70E-7 ID:SGTC_3132|Compound:9126706|FD-Score:-4.84|P-value:8.65E-7 ID:SGTC_3139|Compound:9095020|FD-Score:-3.12|P-value:9.97E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.41|P-value:3.73E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.33|P-value:5.52E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.31|P-value:5.23E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.95|P-value:4.69E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:-5.83|P-value:4.23E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:3.49|P-value:3.08E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.72|P-value:1.33E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.54|P-value:2.56E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.21|P-value:8.20E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-4.38|P-value:7.43E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.24|P-value:6.76E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-5.05|P-value:3.01E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:3.32|P-value:5.78E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-6.39|P-value:1.43E-10 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.44|P-value:3.81E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.38|P-value:4.08E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.69|P-value:1.48E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:-3.23|P-value:6.99E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.07|P-value:3.25E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.12|P-value:9.99E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.27|P-value:6.75E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-4.27|P-value:1.25E-5 ID:SGTC_2294|Compound:7971431|FD-Score:4.67|P-value:2.26E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.25|P-value:7.26E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.33|P-value:5.49E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.43|P-value:3.87E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.18|P-value:8.32E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.17|P-value:2.17E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.90|P-value:6.56E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.08|P-value:3.20E-5 ID:SGTC_2972|Compound:9093619|FD-Score:5.11|P-value:2.70E-7 ID:SGTC_3132|Compound:9126706|FD-Score:-4.84|P-value:8.65E-7 ID:SGTC_3139|Compound:9095020|FD-Score:-3.12|P-value:9.97E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.41|P-value:3.73E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.33|P-value:5.52E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.31|P-value:5.23E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.95|P-value:4.69E-5

Top fitness defect scores for YOR119C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2972 9093619 5.11 59.9 µM 2.70E-7 3 1.64E-7 0.17
2 SGTC_2294 7971431 4.67 200.0 µM 2.26E-6 4 1.47E-6 0.67
3 SGTC_2786 7743617 4.17 45.5 µM 2.17E-5 5 1.53E-5 0.02
4 SGTC_2858 9025781 4.08 9.0 µM 3.20E-5 sphingolipid biosynthesis & PDR1 11 2.29E-5 0.01
5 SGTC_1442 4112-3290 4.07 3.0 µM 3.25E-5 1 2.32E-5 0.41
6 SGTC_2855 9016525 3.90 58.4 µM 6.56E-5 5 4.80E-5 0.14
7 SGTC_178 4092-0806 3.72 87.5 µM 1.33E-4 ergosterol depletion effects on membrane 20 9.99E-5 0.02
8 SGTC_1155 4088-0394 3.69 48.2 µM 1.48E-4 7 1.11E-4 0.09
9 SGTC_306 1672-3436 3.54 11.6 µM 2.56E-4 Golgi 5 1.97E-4 0.21
10 SGTC_68 0986-0284 3.49 82.8 µM 3.08E-4 17 2.38E-4 0.00
11 SGTC_1126 isoteolin 3.44 1.0 µM 3.81E-4 9 2.96E-4 0.21
12 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.43 92.6 µM 3.87E-4 15 3.01E-4 0.03
13 SGTC_2413 inermin 3.33 26.1 µM 5.49E-4 27 4.32E-4 0.19
14 SGTC_3220 9131269 3.33 49.5 µM 5.52E-4 7 4.34E-4 0.24
15 SGTC_867 0518-0118 3.32 155.0 µM 5.78E-4 DNA intercalators 18 4.55E-4 0.21
16 SGTC_1633 st005664 3.27 67.9 µM 6.75E-4 12 5.34E-4 0.07
17 SGTC_2406 ethylparaben 3.25 405.7 µM 7.26E-4 13 5.76E-4 0.01
18 SGTC_348 k064-0012 3.21 10.7 µM 8.20E-4 60S ribosome export 14 6.54E-4 0.12
19 SGTC_2416 tofa 3.15 880.0 nM 0.00100 sphingolipid biosynthesis & PDR1 12 8.04E-4 0.03
20 SGTC_1822 st052468 3.13 42.0 µM 0.00110 3 8.85E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.69E-10 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.106 8.08E-10 YFL008W SMC1 het Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
0.106 7.50E-10 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.105 1.26E-9 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.100 7.10E-9 YLL058W_p YLL058W_p hom Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
0.096 2.74E-8 YOR111W_p YOR111W_p hom Putative protein of unknown function
0.093 6.19E-8 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.093 7.08E-8 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
0.092 1.07E-7 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.091 1.46E-7 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.083 1.62E-6 YIL133C RPL16A hom Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.080 3.31E-6 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.078 5.90E-6 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.078 6.10E-6 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.078 6.78E-6 YDR003W-A_p YDR003W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry