YOR121C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR121C / YOR121C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.01|P-value:9.17E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.34|P-value:2.74E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.18|P-value:5.09E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.09|P-value:6.86E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.30|P-value:1.93E-8 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.94|P-value:2.25E-5 ID:SGTC_264|Compound:promethazine|FD-Score:4.30|P-value:4.26E-6 ID:SGTC_276|Compound:colchicine|FD-Score:4.48|P-value:1.70E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:4.15|P-value:8.67E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.05|P-value:7.94E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.74|P-value:5.46E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:3.43|P-value:1.91E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.49|P-value:1.52E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.28|P-value:3.40E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.07|P-value:1.11E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.05|P-value:7.91E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.86|P-value:3.18E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.34|P-value:2.73E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.41|P-value:2.49E-6 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.14|P-value:9.03E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.18|P-value:4.93E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.58|P-value:1.06E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.45|P-value:1.79E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.32|P-value:2.72E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.18|P-value:5.02E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.05|P-value:8.12E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.67|P-value:7.36E-5 ID:SGTC_1668|Compound:st014914|FD-Score:3.66|P-value:7.71E-5 ID:SGTC_1726|Compound:st035556|FD-Score:-3.40|P-value:1.97E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.60|P-value:8.74E-5 ID:SGTC_1757|Compound:st041620|FD-Score:4.07|P-value:1.23E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.34|P-value:2.76E-4 ID:SGTC_2015|Compound:5119600|FD-Score:6.04|P-value:1.91E-10 ID:SGTC_2056|Compound:5235370|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.03|P-value:8.53E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.18|P-value:4.99E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.12|P-value:5.76E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.09|P-value:6.38E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.35|P-value:2.41E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.69|P-value:6.62E-5 ID:SGTC_2505|Compound:galangin|FD-Score:4.14|P-value:8.87E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.54|P-value:1.30E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.82|P-value:3.82E-5 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.18|P-value:4.96E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.61|P-value:9.16E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.66|P-value:7.52E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.55|P-value:1.20E-6 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.91|P-value:2.58E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.38|P-value:2.35E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.85|P-value:2.16E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.31|P-value:3.57E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.14|P-value:5.87E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.66|P-value:7.66E-5 ID:SGTC_3070|Compound:9117005|FD-Score:3.44|P-value:1.88E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.36|P-value:1.38E-8 ID:SGTC_3264|Compound:9137442|FD-Score:-3.13|P-value:5.58E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.54|P-value:1.10E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.01|P-value:9.17E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.34|P-value:2.74E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.18|P-value:5.09E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.09|P-value:6.86E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.30|P-value:1.93E-8 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.94|P-value:2.25E-5 ID:SGTC_264|Compound:promethazine|FD-Score:4.30|P-value:4.26E-6 ID:SGTC_276|Compound:colchicine|FD-Score:4.48|P-value:1.70E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:4.15|P-value:8.67E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.05|P-value:7.94E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.74|P-value:5.46E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:3.43|P-value:1.91E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.49|P-value:1.52E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.28|P-value:3.40E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.07|P-value:1.11E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.05|P-value:7.91E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.86|P-value:3.18E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.34|P-value:2.73E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.41|P-value:2.49E-6 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.14|P-value:9.03E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.18|P-value:4.93E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.58|P-value:1.06E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.45|P-value:1.79E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.32|P-value:2.72E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.18|P-value:5.02E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.05|P-value:8.12E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.67|P-value:7.36E-5 ID:SGTC_1668|Compound:st014914|FD-Score:3.66|P-value:7.71E-5 ID:SGTC_1726|Compound:st035556|FD-Score:-3.40|P-value:1.97E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.60|P-value:8.74E-5 ID:SGTC_1757|Compound:st041620|FD-Score:4.07|P-value:1.23E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.34|P-value:2.76E-4 ID:SGTC_2015|Compound:5119600|FD-Score:6.04|P-value:1.91E-10 ID:SGTC_2056|Compound:5235370|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.03|P-value:8.53E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.18|P-value:4.99E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.12|P-value:5.76E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.09|P-value:6.38E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.35|P-value:2.41E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.69|P-value:6.62E-5 ID:SGTC_2505|Compound:galangin|FD-Score:4.14|P-value:8.87E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.54|P-value:1.30E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.82|P-value:3.82E-5 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.18|P-value:4.96E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.61|P-value:9.16E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.66|P-value:7.52E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.55|P-value:1.20E-6 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.91|P-value:2.58E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.38|P-value:2.35E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.85|P-value:2.16E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.31|P-value:3.57E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.14|P-value:5.87E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.66|P-value:7.66E-5 ID:SGTC_3070|Compound:9117005|FD-Score:3.44|P-value:1.88E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.36|P-value:1.38E-8 ID:SGTC_3264|Compound:9137442|FD-Score:-3.13|P-value:5.58E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.54|P-value:1.10E-4

Top fitness defect scores for YOR121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2015 5119600 6.04 184.0 µM 1.91E-10 9 7.70E-10
2 SGTC_3137 9097352 5.36 49.5 µM 1.38E-8 13 4.14E-8
3 SGTC_145 3737-0113 5.30 38.4 µM 1.93E-8 DNA intercalators 35 5.64E-8
4 SGTC_2729 fluphenazine 4.55 10.7 µM 1.20E-6 4 2.65E-6
5 SGTC_2552 juarezic acid 4.54 87.0 µM 1.30E-6 TSC3-RPN4 20 2.85E-6
6 SGTC_276 colchicine 4.48 750.0 µM 1.70E-6 9 3.67E-6
7 SGTC_977 1348-1378 4.41 135.0 µM 2.49E-6 13 5.23E-6
8 SGTC_264 promethazine 4.30 12.5 mM 4.26E-6 DNA intercalators 42 8.62E-6
9 SGTC_359 0081-0058 4.15 15.9 µM 8.67E-6 60S ribosome export 38 1.67E-5
10 SGTC_2505 galangin 4.14 7.9 µM 8.87E-6 RPP1 & pyrimidine depletion 7 1.71E-5
11 SGTC_1012 4112-3522 4.14 18.0 µM 9.03E-6 22 1.74E-5
12 SGTC_1757 st041620 4.07 31.8 µM 1.23E-5 29 2.31E-5
13 SGTC_256 clotrimazole 3.94 625.0 nM 2.25E-5 ergosterol depletion effects on membrane 25 4.07E-5
14 SGTC_2738 aclarubicin 3.91 5.5 µM 2.58E-5 RNA pol III & RNase P/MRP 7 4.63E-5
15 SGTC_876 0720-0963 3.86 56.8 µM 3.18E-5 20 5.62E-5
16 SGTC_2659 sanguinarine 3.82 24.2 µM 3.82E-5 27 6.66E-5
17 SGTC_551 k048-0028 3.74 34.9 µM 5.46E-5 20 9.30E-5
18 SGTC_2410 aloe-emodin-8-o-glycoside 3.69 46.3 µM 6.62E-5 mitochondrial processes 41 1.11E-4
19 SGTC_1626 st003712 3.67 1.8 µM 7.36E-5 29 1.23E-4
20 SGTC_2725 haloperidol 3.66 53.2 µM 7.52E-5 plasma membrane duress 46 1.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 3.76E-21 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.156 1.17E-19 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.151 1.80E-18 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.146 2.10E-17 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.146 2.35E-17 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.143 1.12E-16 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.137 1.97E-15 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.135 4.53E-15 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.132 2.12E-14 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.124 6.10E-13 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.119 4.07E-12 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.118 6.52E-12 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.117 1.07E-11 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 3.62E-11 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.114 4.01E-11 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin